Analysis of agonist function at fusion proteins between the IP prostanoid receptor and cognate, unnatural and chimaeric G-proteins

Biochemical Journal

Volumn 342, Issue 2, 1999, Pages 457-463

  Fong, Chee Wai ^a   Milligan, Graeme ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Adenylate cyclase; cAMP; GTPase activity; Signal transduction

Indexed keywords

ADENYLATE CYCLASE; ANTIBODY; CHOLERA TOXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; HYBRID PROTEIN; ILOPROST; PERTUSSIS TOXIN; PROSTANOID RECEPTOR; TRITIUM;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIGAND BINDING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE TOXIN; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CHOLERA TOXIN; DNA, COMPLEMENTARY; ENZYME ACTIVATION; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HUMANS; ILOPROST; KINETICS; RATS; RECEPTORS, PROSTAGLANDIN; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; VIRULENCE FACTORS, BORDETELLA;

EID: 0033199356     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3420457     Document Type: Article

References (27)

1. Birnbaumer, L. (1990) Annu. Rev. Pharmacol. Toxicol. 30, 675-705
2. Bourne, H. R., Sanders, D. A. and McCormick, F. (1990) Nature (London) 348, 125-132
3. Wieland, T. and Jakobs, K. H. (1994) Methods Enzymol. 237, 3-13
4. Gierschik, P., Bouillon, T. and Jakobs, K. H. (1994) Methods Enzymol. 237, 13-26
5. Milligan, G. (1988) Biochem. J. 255, 1-13
6. Berstein, G., Blank, J. L., Smrcka, A. V., Higashijima, T., Sternweis, P. C., Exton, J. H. and Ross, E. M. (1992) J. Biol. Chem. 267, 8081-8088
7. Cassel, D. and Selinger, Z. (1976) Biochim. Biophys. Acta 452, 538-551
8. Cassel, D. and Selinger, Z. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 3307-3311
9. Wise, A., Carr, I. C. and Milligan, G. (1997) Biochem. J. 325, 17-21
10. Wise, A. and Milligan, G. (1997) J. Biol. Chem. 272, 24673-24678
11. Wise, A., Carr, I. C., Groarke, D. A. and Milligan, G. (1997) FEBS Lett. 419, 141-146
12. Boie, Y., Rushmore, T. H., Darmon-Goodwin, A., Grygorczyk, R., Slipetz, D. M., Metters, K. M. and Abramovitz, M. (1994) J. Biol. Chem. 269, 12173-12178
13. Fong, C. W., Bahia, D. S., Rees, S. and Milligan, G. (1998) Mol. Pharmacol. 54, 249-257
14. Levis, M. J. and Bourne, H. R. (1992) J. Cell Biol. 119, 1297-1307
15. Mullaney, I. and Milligan, G. (1994) FEBS Lett. 353, 231-234
16. McKenzie, F. R. and Milligan, G. (1990) Biochem. J. 267, 391-398
17. Merkouris, M., Mullaney, I., Georgoussi, Z. and Milligan, G. (1997) J. Neurochem. 69, 2115-2122
18. Milligan, G. and Unson, C. G. (1989) Biochem. J. 261, 837-841
19. Burt, A. R., Sautel, M., Wilson, M. A., Rees, S., Wise, A. and Milligan, G. (1998) J. Biol. Chem. 273, 10367-10375
20. McKenzie, F. R. and Milligan, G. (1990) J. Biol. Chem. 265, 17084-17093
21. Milligan, G. (1993) Trends Pharmacol. Sci. 14, 413-418
22. Pierce, K. L., Gil, D. W., Woodward, D. F. and Regan, J. W. (1995) Trends Pharmacol. Sci. 16, 253-256
23. Milligan, G., Jackson, V. N., Sautel, M., Kellett, E., Stevens, P. A., Bahia, D. S., McCoull, D., Fong, C. W., Rees. S. and Wise, A. (1999) in Principles of Agonism. 1st IUPHAR (International Union of Pharmacology) Conference on Receptor Mechanisms, IUPHAR Media, London, in the press
24. Seifert, R., Wenzel-Seifert, K., Gether, U., Lam, V. T. and Kobilka, B. K. (1999) Eur. J. Biochem. 260, 661-666
25. Conklin, B. R., Farfel, Z., Lustig, K.D, Julius, D. and Bourne, H. R. (1993) Nature (London) 363, 274-276
26. Medici, R., Blanchi, E., Di Segni, G. and Tocchini-Valentini, G. P. (1997) EMBO J. 16, 7241-7249
27. Seifert, R., Wenzel-Seifert, K., Lee, T. W., Gether, U., Sanders-Bush, E. and Kobilka, B. K. (1998) J. Biol. Chem. 273, 5109-5116