p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13

Science

Volumn 280, Issue 5372, 1998, Pages 2109-2111

  Kozasa, Tohru ^a   Jiang, Xuejun ^a   Hart, Matthew J ^b   Sternweis, Pamela M ^a   Singer, William D ^a   Gilman, Alfred G ^a   Bollag, Gideon ^b   Sternweis, Paul C ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b ONYX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; RHO FACTOR;

AMINO TERMINAL SEQUENCE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; SIGNAL TRANSDUCTION;

ALUMINUM COMPOUNDS; AMINO ACID SEQUENCE; ANIMALS; FLUORIDES; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTP-BINDING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROLYSIS; MOLECULAR SEQUENCE DATA; PROTEINS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

EID: 0032569051     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5372.2109     Document Type: Review

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37. We thank J. Laidlaw and S. Gutowski for technical assistance, J. Tesmer for critically reading the manuscript, and J. Hepler for initiating contact between the groups. Supported by American Heart Association grant 96G105 (T.K.), the Bayer Corporation (Onyx), NIH grant GM34497 and the Raymond and Ellen Willie Distinguished Chair in Molecular Neuropharmacology (A.G.G.), and NIH grant GM31954, the Robert A. Welch Foundation, and the Alfred and Mabel Gilman Professorship in Molecular Pharmacology (P.C.S.).