메뉴 건너뛰기




Volumn 69, Issue , 2007, Pages 511-534

Physiological roles of G protein-coupled receptor kinases and arrestins

Author keywords

Brain; GPCR; GRK; Heart; Immunity; Lung

Indexed keywords

BETA ARRESTIN 1; BETA ARRESTIN 2; CHEMOKINE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 3; G PROTEIN COUPLED RECEPTOR KINASE 4; G PROTEIN COUPLED RECEPTOR KINASE 5; G PROTEIN COUPLED RECEPTOR KINASE 6; GUANINE NUCLEOTIDE BINDING PROTEIN; HORMONE; NEUROTRANSMITTER; RETINA S ANTIGEN; UNCLASSIFIED DRUG;

EID: 33947375174     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.69.022405.154731     Document Type: Review
Times cited : (411)

References (130)
  • 2
    • 25844477611 scopus 로고    scopus 로고
    • Composition and function of G protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity
    • Luttrell LM. 2005. Composition and function of G protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity. J. Mol. Neurosci. 26:253-64
    • (2005) J. Mol. Neurosci , vol.26 , pp. 253-264
    • Luttrell, L.M.1
  • 3
    • 17644402459 scopus 로고    scopus 로고
    • Transduction of receptor signals by β-arrestins
    • Lefkowitz RJ, Shenoy SK. 2005. Transduction of receptor signals by β-arrestins. Science 308:512-17
    • (2005) Science , vol.308 , pp. 512-517
    • Lefkowitz, R.J.1    Shenoy, S.K.2
  • 4
    • 0025223081 scopus 로고
    • Turning off the signal: Desensitization of β-adrenergic receptor function
    • Hausdorff WP, Caron MG, Lefkowitz RJ. 1990. Turning off the signal: desensitization of β-adrenergic receptor function. FASEB J. 4:2881-89
    • (1990) FASEB J , vol.4 , pp. 2881-2889
    • Hausdorff, W.P.1    Caron, M.G.2    Lefkowitz, R.J.3
  • 5
    • 24644471019 scopus 로고    scopus 로고
    • Once and future signaling: G protein-coupled receptor kinase control of neuronal sensitivity
    • Premont RT. 2005. Once and future signaling: G protein-coupled receptor kinase control of neuronal sensitivity. Neuromol. Med. 7:129-47
    • (2005) Neuromol. Med , vol.7 , pp. 129-147
    • Premont, R.T.1
  • 7
    • 0035101820 scopus 로고    scopus 로고
    • Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
    • Ferguson SS. 2001. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol. Rev. 53:1-24
    • (2001) Pharmacol. Rev , vol.53 , pp. 1-24
    • Ferguson, S.S.1
  • 8
    • 0141629679 scopus 로고    scopus 로고
    • Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases
    • Penela P, Ribas C, Mayor FJ. 2003. Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal 15:973-81
    • (2003) Cell Signal , vol.15 , pp. 973-981
    • Penela, P.1    Ribas, C.2    Mayor, F.J.3
  • 10
    • 0842331059 scopus 로고    scopus 로고
    • The molecular acrobatics of arrestin activation
    • Gurevich W, Gurevich EV. 2004. The molecular acrobatics of arrestin activation. Trends Pharmacol. Sci. 25:105-11
    • (2004) Trends Pharmacol. Sci , vol.25 , pp. 105-111
    • Gurevich, W.1    Gurevich, E.V.2
  • 12
    • 0036983163 scopus 로고    scopus 로고
    • Recoverin and rhodopsin kinase
    • Chen CK. 2002. Recoverin and rhodopsin kinase. Adv. Exp. Med. Biol. 514:101-7
    • (2002) Adv. Exp. Med. Biol , vol.514 , pp. 101-107
    • Chen, C.K.1
  • 13
    • 0036498379 scopus 로고    scopus 로고
    • Rhodopsin phosphorylation: From terminating single photon responses to photoreceptor dark adaptation
    • Arshavsky VY. 2002. Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation. Trends Neurosci. 25:124-6
    • (2002) Trends Neurosci , vol.25 , pp. 124-126
    • Arshavsky, V.Y.1
  • 15
    • 4544323023 scopus 로고    scopus 로고
    • Genetic and phenotypic targeting of β-adrenergic signaling in heart failure
    • Koch WJ. 2004. Genetic and phenotypic targeting of β-adrenergic signaling in heart failure. Mol. Cell Biochem. 263:5-9
    • (2004) Mol. Cell Biochem , vol.263 , pp. 5-9
    • Koch, W.J.1
  • 16
    • 3142651901 scopus 로고    scopus 로고
    • Genetic manipulation of myocardial β-adrenergic receptor activation and desensitization
    • Hata JA, Williams ML, Koch WJ. 2004. Genetic manipulation of myocardial β-adrenergic receptor activation and desensitization. J. Mol. Cell Cardiol. 37:11-21
    • (2004) J. Mol. Cell Cardiol , vol.37 , pp. 11-21
    • Hata, J.A.1    Williams, M.L.2    Koch, W.J.3
  • 17
    • 4344632193 scopus 로고    scopus 로고
    • Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets
    • Iaccarino G, Koch WJ. 2003. Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets. Assay Drug Dev. Technol. 1:347-55
    • (2003) Assay Drug Dev. Technol , vol.1 , pp. 347-355
    • Iaccarino, G.1    Koch, W.J.2
  • 18
    • 0032540893 scopus 로고    scopus 로고
    • Control of myocardial contractile function by the level of β-adrenergic receptor kinase 1 in gene-targeted mice
    • Rockman HA, Choi DJ, Akhter SA, Jaber M, Giros B, et al. 1998. Control of myocardial contractile function by the level of β-adrenergic receptor kinase 1 in gene-targeted mice. J. Biol. Chem. 273:18180-84
    • (1998) J. Biol. Chem , vol.273 , pp. 18180-18184
    • Rockman, H.A.1    Choi, D.J.2    Akhter, S.A.3    Jaber, M.4    Giros, B.5
  • 19
    • 10544242967 scopus 로고    scopus 로고
    • Essential role of β-adrenergic receptor kinase 1 in cardiac development and function
    • Jaber M, Koch WJ, Rockman H, Smith B, Bond RA, et al. 1996. Essential role of β-adrenergic receptor kinase 1 in cardiac development and function. Proc. Natl. Acad. Sci. USA 93:12974-79
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 12974-12979
    • Jaber, M.1    Koch, W.J.2    Rockman, H.3    Smith, B.4    Bond, R.A.5
  • 20
    • 0032938105 scopus 로고    scopus 로고
    • Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3
    • Walker JK, Peppel K, Lefkowitz RJ, Caron MG, Fisher JT. 1999. Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. Am. J. Physiol. 276:R1214-21
    • (1999) Am. J. Physiol , vol.276
    • Walker, J.K.1    Peppel, K.2    Lefkowitz, R.J.3    Caron, M.G.4    Fisher, J.T.5
  • 21
    • 0030732503 scopus 로고    scopus 로고
    • β-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to β-adrenergic stimulation
    • Conner DA, Mathier MA, Mortensen RM, Christe M, Vatner SF, et al. 1997. β-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to β-adrenergic stimulation. Circ. Res. 81:1021-26
    • (1997) Circ. Res , vol.81 , pp. 1021-1026
    • Conner, D.A.1    Mathier, M.A.2    Mortensen, R.M.3    Christe, M.4    Vatner, S.F.5
  • 23
    • 0031000256 scopus 로고    scopus 로고
    • G-protein-coupled receptor kinase activity is increased in hypertension
    • Gros R, Benovic JL, Tan CM, Feldman RD. 1997. G-protein-coupled receptor kinase activity is increased in hypertension. J. Clin. Invest. 99:2087-93
    • (1997) J. Clin. Invest , vol.99 , pp. 2087-2093
    • Gros, R.1    Benovic, J.L.2    Tan, C.M.3    Feldman, R.D.4
  • 24
    • 0033954751 scopus 로고    scopus 로고
    • G-Protein-coupled receptor kinase activity in hypertension: Increased vascular and lymphocyte G-protein receptor kinase-2 protein expression
    • Gros R, Chorazyczewski J, Meek MD, Benovic JL, Ferguson SS, Feldman RD. 2000. G-Protein-coupled receptor kinase activity in hypertension: increased vascular and lymphocyte G-protein receptor kinase-2 protein expression. Hypertension 35:38-42
    • (2000) Hypertension , vol.35 , pp. 38-42
    • Gros, R.1    Chorazyczewski, J.2    Meek, M.D.3    Benovic, J.L.4    Ferguson, S.S.5    Feldman, R.D.6
  • 25
    • 0036209075 scopus 로고    scopus 로고
    • Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates β-adrenergic receptor signaling and increases resting blood pressure
    • Eckhart AD, Ozaki T, Tevaearai H, Rockman HA, Koch WJ. 2002. Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates β-adrenergic receptor signaling and increases resting blood pressure. Mol. Pharmacol. 61:749-58
    • (2002) Mol. Pharmacol , vol.61 , pp. 749-758
    • Eckhart, A.D.1    Ozaki, T.2    Tevaearai, H.3    Rockman, H.A.4    Koch, W.J.5
  • 28
    • 0031769531 scopus 로고    scopus 로고
    • Renal dopamine receptors in health and hypertension
    • Jose PA, Eisner GM, Felder RA. 1998. Renal dopamine receptors in health and hypertension. Pharmacol. Ther. 80:149-82
    • (1998) Pharmacol. Ther , vol.80 , pp. 149-182
    • Jose, P.A.1    Eisner, G.M.2    Felder, R.A.3
  • 29
    • 0037133693 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 4 gene variants in human essential hypertension
    • Felder RA, Sanada H, Xu J, Yu PY, Wang Z, et al. 2002. G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc. Natl. Acad. Sci. USA 99:3872-77
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3872-3877
    • Felder, R.A.1    Sanada, H.2    Xu, J.3    Yu, P.Y.4    Wang, Z.5
  • 30
    • 33644841768 scopus 로고    scopus 로고
    • The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4
    • Rankin ML, Marinec PS, Cabrera DM, Wang Z, Jose PA, Sibley DR. 2006. The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4. Mol. Pharmacol. 69:759-69
    • (2006) Mol. Pharmacol , vol.69 , pp. 759-769
    • Rankin, M.L.1    Marinec, P.S.2    Cabrera, D.M.3    Wang, Z.4    Jose, P.A.5    Sibley, D.R.6
  • 31
    • 33744972107 scopus 로고    scopus 로고
    • Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression
    • Sanada H, Yatabe J, Midorikawa S, Katoh T, Hashimoto S, et al. 2006. Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression. Hypertension 47:1131-39
    • (2006) Hypertension , vol.47 , pp. 1131-1139
    • Sanada, H.1    Yatabe, J.2    Midorikawa, S.3    Katoh, T.4    Hashimoto, S.5
  • 32
    • 33644547657 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension
    • Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Watanabe T, et al. 2006. Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clin. Chem. 52:352-60
    • (2006) Clin. Chem , vol.52 , pp. 352-360
    • Sanada, H.1    Yatabe, J.2    Midorikawa, S.3    Hashimoto, S.4    Watanabe, T.5
  • 33
    • 33644817798 scopus 로고    scopus 로고
    • Patterns of genetic variation in the hypertension candidate gene GRK4: Ethnic variation and haplotype structure
    • Lohmueller KE, Wong LJ, Mauney MM, Jiang L, Felder RA, et al. 2006. Patterns of genetic variation in the hypertension candidate gene GRK4: ethnic variation and haplotype structure. Ann. Hum. Genet. 70:27-41
    • (2006) Ann. Hum. Genet , vol.70 , pp. 27-41
    • Lohmueller, K.E.1    Wong, L.J.2    Mauney, M.M.3    Jiang, L.4    Felder, R.A.5
  • 34
    • 33745000313 scopus 로고    scopus 로고
    • Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese
    • Gu D, Su S, Ge D, Chen S, Huang J, et al. 2006. Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese. Hypertension 47:1147-54
    • (2006) Hypertension , vol.47 , pp. 1147-1154
    • Gu, D.1    Su, S.2    Ge, D.3    Chen, S.4    Huang, J.5
  • 35
    • 24744444714 scopus 로고    scopus 로고
    • A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension
    • Liu S, Premont RT, Kontos CD, Zhu S, Rockey DC. 2005. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat. Med. 11:952-58
    • (2005) Nat. Med , vol.11 , pp. 952-958
    • Liu, S.1    Premont, R.T.2    Kontos, C.D.3    Zhu, S.4    Rockey, D.C.5
  • 36
    • 0347379916 scopus 로고    scopus 로고
    • Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein βγ subunit signaling to protein kinase B/Akt
    • Liu S, Premont RT, Kontos CD, Huang J, Rockey DC. 2003. Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein βγ subunit signaling to protein kinase B/Akt J. Biol. Chem. 278:49929-35
    • (2003) J. Biol. Chem , vol.278 , pp. 49929-49935
    • Liu, S.1    Premont, R.T.2    Kontos, C.D.3    Huang, J.4    Rockey, D.C.5
  • 37
    • 0028985273 scopus 로고
    • Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of β-adrenergic receptor kinase 1 and 2
    • De Blasi A, Parruti G, Sallese M. 1995. Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of β-adrenergic receptor kinase 1 and 2. J. Clin. Invest. 95:203-10
    • (1995) J. Clin. Invest , vol.95 , pp. 203-210
    • De Blasi, A.1    Parruti, G.2    Sallese, M.3
  • 38
    • 0029956610 scopus 로고    scopus 로고
    • Differentially regulated expression of the G-protein-coupled receptor kinases, βARK and GRK6, during myelomonocytic cell development in vitro
    • Loudon RP, Perussia B, Benovic JL. 1996. Differentially regulated expression of the G-protein-coupled receptor kinases, βARK and GRK6, during myelomonocytic cell development in vitro. Blood 88:4547-57
    • (1996) Blood , vol.88 , pp. 4547-4557
    • Loudon, R.P.1    Perussia, B.2    Benovic, J.L.3
  • 39
    • 0032919035 scopus 로고    scopus 로고
    • Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis
    • Lombardi MS, Kavelaars A, Sehedlowski M, Bijlsma JW, Okihara KL, et al. 1999. Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. FASEB J. 13:715-25
    • (1999) FASEB J , vol.13 , pp. 715-725
    • Lombardi, M.S.1    Kavelaars, A.2    Sehedlowski, M.3    Bijlsma, J.W.4    Okihara, K.L.5
  • 40
    • 0036070773 scopus 로고    scopus 로고
    • Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism
    • Lombardi MS, Kavelaars A, Penela P, Scholtens EJ, Roccio M, et al. 2002. Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism. Mol. Pharmacol. 62:379-88
    • (2002) Mol. Pharmacol , vol.62 , pp. 379-388
    • Lombardi, M.S.1    Kavelaars, A.2    Penela, P.3    Scholtens, E.J.4    Roccio, M.5
  • 42
    • 0037377235 scopus 로고    scopus 로고
    • Changes in the G-protein-coupled receptor desensitization machinery during relapsing- progressive experimental allergic encephalomyelitis
    • Vroon A, Lombardi MS, Kavelaars A, Heijnen CJ. 2003. Changes in the G-protein-coupled receptor desensitization machinery during relapsing- progressive experimental allergic encephalomyelitis. J. Neuroimmunol. 137:79-86
    • (2003) J. Neuroimmunol , vol.137 , pp. 79-86
    • Vroon, A.1    Lombardi, M.S.2    Kavelaars, A.3    Heijnen, C.J.4
  • 43
    • 23744461827 scopus 로고    scopus 로고
    • Chronic beta-adrenergic receptor stimulation enhances the expression of G-protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes
    • Oyama N, Urasawa K, Kaneta S, Sakai H, Saito T, et al. 2005. Chronic beta-adrenergic receptor stimulation enhances the expression of G-protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes. Circ. J. 69:987-90
    • (2005) Circ. J , vol.69 , pp. 987-990
    • Oyama, N.1    Urasawa, K.2    Kaneta, S.3    Sakai, H.4    Saito, T.5
  • 45
    • 0344585389 scopus 로고    scopus 로고
    • Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6
    • Kavelaars A, Vroon A, Raatgever RP, Fong AM, Premont RT, et al. 2003. Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. J. Immunol. 171:6128-34
    • (2003) J. Immunol , vol.171 , pp. 6128-6134
    • Kavelaars, A.1    Vroon, A.2    Raatgever, R.P.3    Fong, A.M.4    Premont, R.T.5
  • 46
    • 1642506294 scopus 로고    scopus 로고
    • GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo
    • Vroon A, Heijnen CJ, Raatgever R, Touw IP, Ploemacher RE, et al. 2004. GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo. J. Leukoc. Biol. 75:698-704
    • (2004) J. Leukoc. Biol , vol.75 , pp. 698-704
    • Vroon, A.1    Heijnen, C.J.2    Raatgever, R.3    Touw, I.P.4    Ploemacher, R.E.5
  • 47
    • 2342519446 scopus 로고    scopus 로고
    • Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4
    • Vroon A, Heijnen CJ, Lombardi MS, Cobelens PM, Mayor FJ, et al. 2004. Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4. J. Leukoc. Biol. 75:901-9
    • (2004) J. Leukoc. Biol , vol.75 , pp. 901-909
    • Vroon, A.1    Heijnen, C.J.2    Lombardi, M.S.3    Cobelens, P.M.4    Mayor, F.J.5
  • 48
    • 15444372618 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis
    • Vroon A, Kavelaars A, Limmroth V, Lombardi MS, Goebel MU, et al. 2005. G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis. J. Immunol. 174:4400-6
    • (2005) J. Immunol , vol.174 , pp. 4400-4406
    • Vroon, A.1    Kavelaars, A.2    Limmroth, V.3    Lombardi, M.S.4    Goebel, M.U.5
  • 49
    • 31344463886 scopus 로고    scopus 로고
    • Association of β-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
    • Wang Y, Tang Y, Teng L, Wu Y, Zhao X, Pei G. 2006. Association of β-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. 7:139-47
    • (2006) Nat. Immunol , vol.7 , pp. 139-147
    • Wang, Y.1    Tang, Y.2    Teng, L.3    Wu, Y.4    Zhao, X.5    Pei, G.6
  • 53
    • 0029945199 scopus 로고    scopus 로고
    • β-adrenergic receptor kinase-like activity and β-arrestin are expressed in osteoblastic cells
    • Bliziotes M, Murtagh J, Wiren K. 1996. β-adrenergic receptor kinase-like activity and β-arrestin are expressed in osteoblastic cells. J. Bone Miner. Res. 11:820-26
    • (1996) J. Bone Miner. Res , vol.11 , pp. 820-826
    • Bliziotes, M.1    Murtagh, J.2    Wiren, K.3
  • 54
    • 0036100052 scopus 로고    scopus 로고
    • Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts
    • Spurney RF, Flannery PJ, Garner SC, Athirakul K, Liu S, et al. 2002. Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts. J. Clin. Invest. 109:1361-71
    • (2002) J. Clin. Invest , vol.109 , pp. 1361-1371
    • Spurney, R.F.1    Flannery, P.J.2    Garner, S.C.3    Athirakul, K.4    Liu, S.5
  • 55
    • 21644439556 scopus 로고    scopus 로고
    • Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34)
    • Wang L, Quarles LD, Spurney RF. 2004. Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34). J. Bone Miner. Res. 19:1661-70
    • (2004) J. Bone Miner. Res , vol.19 , pp. 1661-1670
    • Wang, L.1    Quarles, L.D.2    Spurney, R.F.3
  • 56
    • 15344347049 scopus 로고    scopus 로고
    • β-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice
    • Bouxsein ML, Pierroz DD, Glatt V, Goddard DS, Cavat F, et al. 2005. β-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice. J. Bone Miner. Res. 20:635-43
    • (2005) J. Bone Miner. Res , vol.20 , pp. 635-643
    • Bouxsein, M.L.1    Pierroz, D.D.2    Glatt, V.3    Goddard, D.S.4    Cavat, F.5
  • 57
    • 15444367508 scopus 로고    scopus 로고
    • Bone response to intermittent parathyroid hormone is altered in mice null for β-arrestin2
    • Ferrari SL, Pierroz DD, Glatt V, Goddard DS, Bianchi EN, et al. 2005. Bone response to intermittent parathyroid hormone is altered in mice null for β-arrestin2. Endocrinology 146:1854-62
    • (2005) Endocrinology , vol.146 , pp. 1854-1862
    • Ferrari, S.L.1    Pierroz, D.D.2    Glatt, V.3    Goddard, D.S.4    Bianchi, E.N.5
  • 59
    • 22444435145 scopus 로고    scopus 로고
    • Inhibition of signal termination-related kinases by membrane-permeant bitter and sweet tastants: Potential role in taste signal termination
    • Zubare-Samuelov M, Shaul ME, Peri I, Aliluiko A, Tirosh O, Nairn M. 2005. Inhibition of signal termination-related kinases by membrane-permeant bitter and sweet tastants: potential role in taste signal termination. Am. J. Physiol. Cell Physiol. 289:C483-92
    • (2005) Am. J. Physiol. Cell Physiol , vol.289
    • Zubare-Samuelov, M.1    Shaul, M.E.2    Peri, I.3    Aliluiko, A.4    Tirosh, O.5    Nairn, M.6
  • 60
    • 0026658663 scopus 로고
    • The G-protein-coupled receptor kinases βARK1 and βARK2 are widely distributed at synapses in rat brain
    • Arriza JL, Dawson TM, Simerly RB, Martin LJ, Caron MG, et al. 1992. The G-protein-coupled receptor kinases βARK1 and βARK2 are widely distributed at synapses in rat brain. J. Neurosci. 12:4045-55
    • (1992) J. Neurosci , vol.12 , pp. 4045-4055
    • Arriza, J.L.1    Dawson, T.M.2    Simerly, R.B.3    Martin, L.J.4    Caron, M.G.5
  • 61
    • 0035500377 scopus 로고    scopus 로고
    • Distribution of G-protein-coupled receptor kinase (GRK) isoforms 2, 3, 5 and 6 mRNA in the rat brain
    • Erdtmann-Vourliotis M, Mayer P, Amnon S, Riechert U, Hollt V. 2001. Distribution of G-protein-coupled receptor kinase (GRK) isoforms 2, 3, 5 and 6 mRNA in the rat brain. Br. Res. Mol. Br. Res. 95:129-37
    • (2001) Br. Res. Mol. Br. Res , vol.95 , pp. 129-137
    • Erdtmann-Vourliotis, M.1    Mayer, P.2    Amnon, S.3    Riechert, U.4    Hollt, V.5
  • 62
    • 0141582501 scopus 로고    scopus 로고
    • Expression patterns of the regulatory proteins G protein-coupled receptor kinase 2 and β-arrestin 1 during rat postnatal brain development: Effect of hypothyroidism
    • Penela P, Alvarez-Dolado M, Munoz A, Mayor FJ. 2000. Expression patterns of the regulatory proteins G protein-coupled receptor kinase 2 and β-arrestin 1 during rat postnatal brain development: effect of hypothyroidism. Eur. J. Biochem. 267:4390-96
    • (2000) Eur. J. Biochem , vol.267 , pp. 4390-4396
    • Penela, P.1    Alvarez-Dolado, M.2    Munoz, A.3    Mayor, F.J.4
  • 63
    • 0347926482 scopus 로고    scopus 로고
    • Regulation of GRK 2 and 6, β-arrestin-2 and associated proteins in the prefrontal cortex of drug-free and antidepressant drug-treated subjects with major depression
    • Grange-Midroit M, Garcia-Sevilla JA, Ferrer-Alcon M, La Harpe R, Huguelet P, Guimon J. 2003. Regulation of GRK 2 and 6, β-arrestin-2 and associated proteins in the prefrontal cortex of drug-free and antidepressant drug-treated subjects with major depression. Br. Res. Mol. Br. Res. 111:31-41
    • (2003) Br. Res. Mol. Br. Res , vol.111 , pp. 31-41
    • Grange-Midroit, M.1    Garcia-Sevilla, J.A.2    Ferrer-Alcon, M.3    La Harpe, R.4    Huguelet, P.5    Guimon, J.6
  • 65
    • 0036813090 scopus 로고    scopus 로고
    • Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor
    • Kabbani N, Negyessy L, Lin R, Goldman-Rakic P, Levenson R. 2002. Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor. J. Neurosci. 22:8476-86
    • (2002) J. Neurosci , vol.22 , pp. 8476-8486
    • Kabbani, N.1    Negyessy, L.2    Lin, R.3    Goldman-Rakic, P.4    Levenson, R.5
  • 66
    • 15944407993 scopus 로고    scopus 로고
    • Bezard E, Gross CE, Qin L, Gurevich VV, Benovic JL, Gurevich EV. 2005. L-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain. Neurobiol. Dis. 18:323-35
    • Bezard E, Gross CE, Qin L, Gurevich VV, Benovic JL, Gurevich EV. 2005. L-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain. Neurobiol. Dis. 18:323-35
  • 67
    • 0027945014 scopus 로고
    • Chronic morphine administration increases β-adrenergic receptor kinase (βARK) levels in the rat locus coeruleus
    • Terwilliger RZ, Ortiz J, Guitart X, Nestler EJ. 1994. Chronic morphine administration increases β-adrenergic receptor kinase (βARK) levels in the rat locus coeruleus. J. Neurochem. 63:1983-86
    • (1994) J. Neurochem , vol.63 , pp. 1983-1986
    • Terwilliger, R.Z.1    Ortiz, J.2    Guitart, X.3    Nestler, E.J.4
  • 68
    • 0031892145 scopus 로고    scopus 로고
    • Regulation of G protein-coupled receptor kinase 2 in brains of opiate-treated rats and human opiate addicts
    • Ozaita A, Escriba PV, Ventayol P, Murga C, Mayor FJ, Garcia-Sevilla JA. 1998. Regulation of G protein-coupled receptor kinase 2 in brains of opiate-treated rats and human opiate addicts. J. Neurochem. 70:1249-57
    • (1998) J. Neurochem , vol.70 , pp. 1249-1257
    • Ozaita, A.1    Escriba, P.V.2    Ventayol, P.3    Murga, C.4    Mayor, F.J.5    Garcia-Sevilla, J.A.6
  • 69
    • 0035049085 scopus 로고    scopus 로고
    • Changes in the expression of G protein-coupled receptor kinases and β-arrestin 2 in rat brain during opioid tolerance and supersensitivity
    • Hurle MA. 2001. Changes in the expression of G protein-coupled receptor kinases and β-arrestin 2 in rat brain during opioid tolerance and supersensitivity. J. Neurochem. 77:486-92
    • (2001) J. Neurochem , vol.77 , pp. 486-492
    • Hurle, M.A.1
  • 70
    • 0037129917 scopus 로고    scopus 로고
    • Regulation of μ-opioid receptors, G-protein-coupled receptor kinases and β-arrestin 2 in the rat brain after chronic opioid receptor antagonism
    • Diaz A, Pazos A, Florez J, Ayesta FJ, Santana V, Hurle MA. 2002. Regulation of μ-opioid receptors, G-protein-coupled receptor kinases and β-arrestin 2 in the rat brain after chronic opioid receptor antagonism. Neuroscience 112:345-53
    • (2002) Neuroscience , vol.112 , pp. 345-353
    • Diaz, A.1    Pazos, A.2    Florez, J.3    Ayesta, F.J.4    Santana, V.5    Hurle, M.A.6
  • 71
    • 32844463166 scopus 로고    scopus 로고
    • μ-Opioid receptor internalization-dependent and -independent mechanisms of the development of tolerance to μ-opioid receptor agonists: Comparison between etorphine and morphine
    • Narita M, Suzuki M, Narita M, Niikura K, Nakamura A, et al. 2006. μ-Opioid receptor internalization-dependent and -independent mechanisms of the development of tolerance to μ-opioid receptor agonists: comparison between etorphine and morphine. Neuroscience 138:609-19
    • (2006) Neuroscience , vol.138 , pp. 609-619
    • Narita, M.1    Suzuki, M.2    Narita, M.3    Niikura, K.4    Nakamura, A.5
  • 72
    • 0035048317 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 mediates μ-opioid receptor desensitization in GABAergic neurons of the nucleus raphe magnus
    • Li AH, Wang HL. 2001. G protein-coupled receptor kinase 2 mediates μ-opioid receptor desensitization in GABAergic neurons of the nucleus raphe magnus. J. Neurochem. 77:435-44
    • (2001) J. Neurochem , vol.77 , pp. 435-444
    • Li, A.H.1    Wang, H.L.2
  • 73
    • 0036801618 scopus 로고    scopus 로고
    • Acute and chronic morphine treatments and morphine withdrawal differentially regulate GRK2 and GRK5 gene expression in rat brain
    • Fan X, Zhang J, Zhang X, Yue W, Ma L. 2002. Acute and chronic morphine treatments and morphine withdrawal differentially regulate GRK2 and GRK5 gene expression in rat brain. Neuropharmacology 43:809-16
    • (2002) Neuropharmacology , vol.43 , pp. 809-816
    • Fan, X.1    Zhang, J.2    Zhang, X.3    Yue, W.4    Ma, L.5
  • 74
    • 12444278905 scopus 로고    scopus 로고
    • Morphine-induced changes of gene expression in the brain
    • Ammon-Treiber S, Hollt V. 2005. Morphine-induced changes of gene expression in the brain. Addict. Biol. 10:81-89
    • (2005) Addict. Biol , vol.10 , pp. 81-89
    • Ammon-Treiber, S.1    Hollt, V.2
  • 75
    • 1642371042 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: Psychostimulant and opiate studies in knockout mice
    • Bohn LM, Gainetdinov RR, Caron MG. 2004. G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice. Neuromol. Med. 5:41-50
    • (2004) Neuromol. Med , vol.5 , pp. 41-50
    • Bohn, L.M.1    Gainetdinov, R.R.2    Caron, M.G.3
  • 76
    • 0034714204 scopus 로고    scopus 로고
    • Synucleins are a novel class of substrates for G protein-coupled receptor kinases
    • Pronin AN, Morris AJ, Surguchov A, Benovic JL. 2000. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 275:26515-22
    • (2000) J. Biol. Chem , vol.275 , pp. 26515-26522
    • Pronin, A.N.1    Morris, A.J.2    Surguchov, A.3    Benovic, J.L.4
  • 77
    • 1842506382 scopus 로고    scopus 로고
    • Abnormality of G-protein-coupled receptor kinases at prodromal and early stages of Alzheimer's disease: An association with early β-amyloid accumulation
    • Suo Z, Wu M, Citron BA, Wong GT, Festoff BW. 2004. Abnormality of G-protein-coupled receptor kinases at prodromal and early stages of Alzheimer's disease: an association with early β-amyloid accumulation. J. Neurosci. 24:3444-52
    • (2004) J. Neurosci , vol.24 , pp. 3444-3452
    • Suo, Z.1    Wu, M.2    Citron, B.A.3    Wong, G.T.4    Festoff, B.W.5
  • 78
    • 1842523247 scopus 로고    scopus 로고
    • Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and β-arrestin-1 levels in the neonatal rat brain
    • Lombardi MS, van den Tweel E, Kavelaars A, Groenendaal F, van Bel F, Heijnen CJ. 2004. Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and β-arrestin-1 levels in the neonatal rat brain. Stroke 35:981-86
    • (2004) Stroke , vol.35 , pp. 981-986
    • Lombardi, M.S.1    van den Tweel, E.2    Kavelaars, A.3    Groenendaal, F.4    van Bel, F.5    Heijnen, C.J.6
  • 79
    • 21444461126 scopus 로고    scopus 로고
    • Roles of phosphorylation- dependent and -independent mechanisms in the regulation of M1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 in hippocampal neurons
    • Willets JM, Nahorski SR, Challiss RA. 2005. Roles of phosphorylation- dependent and -independent mechanisms in the regulation of M1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 in hippocampal neurons. J. Biol. Chem. 280:18950-58
    • (2005) J. Biol. Chem , vol.280 , pp. 18950-18958
    • Willets, J.M.1    Nahorski, S.R.2    Challiss, R.A.3
  • 80
    • 29344474479 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 involvement in desensitization of corticotropin-releasing factor (CRF) receptor type 1 by CRF in murine corticotrophs
    • Kageyama K, Hanada K, Moriyama T, Nigawara T, Sakihara S, Suda T. 2006. G protein-coupled receptor kinase 2 involvement in desensitization of corticotropin-releasing factor (CRF) receptor type 1 by CRF in murine corticotrophs. Endoainology 147:441-50
    • (2006) Endoainology , vol.147 , pp. 441-450
    • Kageyama, K.1    Hanada, K.2    Moriyama, T.3    Nigawara, T.4    Sakihara, S.5    Suda, T.6
  • 81
    • 0028154118 scopus 로고
    • Olfactory desensitization requires membrane targeting of receptor kinase mediated by βγ-subunits of heterotrimeric G proteins
    • Boekhoff I, Inglese J, Schleicher S, Koch WJ, Lefkowitz RJ, Breer H. 1994. Olfactory desensitization requires membrane targeting of receptor kinase mediated by βγ-subunits of heterotrimeric G proteins. J. Biol. Chem. 269:37-40
    • (1994) J. Biol. Chem , vol.269 , pp. 37-40
    • Boekhoff, I.1    Inglese, J.2    Schleicher, S.3    Koch, W.J.4    Lefkowitz, R.J.5    Breer, H.6
  • 83
    • 0030845179 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization
    • Peppel K, Boekhoff I, McDonald P, Breer H, Caron MG, Lefkowitz RJ. 1997. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. J. Biol. Chem. 272:25425-28
    • (1997) J. Biol. Chem , vol.272 , pp. 25425-25428
    • Peppel, K.1    Boekhoff, I.2    McDonald, P.3    Breer, H.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 84
    • 0347710163 scopus 로고    scopus 로고
    • Identifying a series of candidate genes for mania and psychosis: A convergent functional genomics approach
    • Niculescu AB, Segal DS, Kuczenski R, Barrett T, Hauger RL, Kelsoe JR. 2000. Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiol. Genom. 4:83-91
    • (2000) Physiol. Genom , vol.4 , pp. 83-91
    • Niculescu, A.B.1    Segal, D.S.2    Kuczenski, R.3    Barrett, T.4    Hauger, R.L.5    Kelsoe, J.R.6
  • 85
    • 10744223787 scopus 로고    scopus 로고
    • Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder
    • Barrett TB, Hauger RL, Kennedy JL, Sadovnick AD, Remick RA, et al. 2003. Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. Mol. Psychiat. 8:546-57
    • (2003) Mol. Psychiat , vol.8 , pp. 546-557
    • Barrett, T.B.1    Hauger, R.L.2    Kennedy, J.L.3    Sadovnick, A.D.4    Remick, R.A.5
  • 86
    • 33846347362 scopus 로고    scopus 로고
    • Lymphocyte G-protein receptor kinase (GRK)3 mRNA levels in bipolar disorder
    • doi: 10.1017/S146114570500636X
    • Shaltiel G, Shamir A, Levi I, Bersudsky Y, Again G. 2006. Lymphocyte G-protein receptor kinase (GRK)3 mRNA levels in bipolar disorder. Int. J. Neuropsychopharmacol. 9:761-66 doi: 10.1017/S146114570500636X
    • (2006) Int. J. Neuropsychopharmacol , vol.9 , pp. 761-766
    • Shaltiel, G.1    Shamir, A.2    Levi, I.3    Bersudsky, Y.4    Again, G.5
  • 87
    • 10744222037 scopus 로고    scopus 로고
    • Mutation screening and association study of the β-adrenergic receptor kinase 2 gene in schizophrenia families
    • Yu SY, Takahashi S, Arinami T, Ohkubo T, Nemoto Y, et al. 2004. Mutation screening and association study of the β-adrenergic receptor kinase 2 gene in schizophrenia families. Psychiat. Res. 125:95-104
    • (2004) Psychiat. Res , vol.125 , pp. 95-104
    • Yu, S.Y.1    Takahashi, S.2    Arinami, T.3    Ohkubo, T.4    Nemoto, Y.5
  • 88
    • 0033555898 scopus 로고    scopus 로고
    • Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity
    • Gainetdinov RR, Wetsel WC, Jones SR, Levin ED, Jaber M, Caron MG. 1999. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 283:397-401
    • (1999) Science , vol.283 , pp. 397-401
    • Gainetdinov, R.R.1    Wetsel, W.C.2    Jones, S.R.3    Levin, E.D.4    Jaber, M.5    Caron, M.G.6
  • 89
    • 16844377622 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-β-arrestin complex. A case of autoreceptor regulation
    • Kim KM, Gainetdinov RR, Laporte SA, Caron MG, Barak LS. 2005. G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-β-arrestin complex. A case of autoreceptor regulation. J. Biol. Chem. 280:12774-80
    • (2005) J. Biol. Chem , vol.280 , pp. 12774-12780
    • Kim, K.M.1    Gainetdinov, R.R.2    Laporte, S.A.3    Caron, M.G.4    Barak, L.S.5
  • 90
    • 1242341368 scopus 로고    scopus 로고
    • G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal
    • Terman GW, Jin W, Cheong YP, Lowe J, Caron MG, et al. 2004. G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. Br. J. Pharmacol. 141:55-64
    • (2004) Br. J. Pharmacol , vol.141 , pp. 55-64
    • Terman, G.W.1    Jin, W.2    Cheong, Y.P.3    Lowe, J.4    Caron, M.G.5
  • 91
    • 2442659170 scopus 로고    scopus 로고
    • Neuropathic pain activates the endogenous K opioid system in mouse spinal cord and induces opioid receptor tolerance
    • Xu M, Petraschka M, McLaughlin JP, Westenbroek RE, Caron MG, et al. 2004. Neuropathic pain activates the endogenous K opioid system in mouse spinal cord and induces opioid receptor tolerance. J. Neurosci. 24:4576-84
    • (2004) J. Neurosci , vol.24 , pp. 4576-4584
    • Xu, M.1    Petraschka, M.2    McLaughlin, J.P.3    Westenbroek, R.E.4    Caron, M.G.5
  • 92
    • 0346457178 scopus 로고    scopus 로고
    • Prolonged K opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance
    • McLaughlin JP, Myers LC, Zarek PE, Caron MG, Lefkowitz RJ, et al. 2004. Prolonged K opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. J. Biol. Chem. 279:1810-18
    • (2004) J. Biol. Chem , vol.279 , pp. 1810-1818
    • McLaughlin, J.P.1    Myers, L.C.2    Zarek, P.E.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 93
    • 0033669923 scopus 로고    scopus 로고
    • The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1
    • Sallese M, Salvatore L, D'Urbano E, Sala G, Storto M, et al. 2000. The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1. FASEB J. 14:2569-80
    • (2000) FASEB J , vol.14 , pp. 2569-2580
    • Sallese, M.1    Salvatore, L.2    D'Urbano, E.3    Sala, G.4    Storto, M.5
  • 94
    • 0038823625 scopus 로고    scopus 로고
    • Role of G protein-coupled receptor kinase 4 and β-arrestin 1 in agonist-stimulated metabotropic glutamate receptor 1 internalization and activation of mitogen-activated protein kinases
    • Iacovelli L, Salvatore L, Capobianco L, Picascia A, Barletta E, et al. 2003. Role of G protein-coupled receptor kinase 4 and β-arrestin 1 in agonist-stimulated metabotropic glutamate receptor 1 internalization and activation of mitogen-activated protein kinases. J. Biol. Chem. 278:12433-42
    • (2003) J. Biol. Chem , vol.278 , pp. 12433-12442
    • Iacovelli, L.1    Salvatore, L.2    Capobianco, L.3    Picascia, A.4    Barletta, E.5
  • 95
    • 0042575596 scopus 로고    scopus 로고
    • Phosphorylation-independent desensitization of GABA(B) receptor by GRK4
    • Perroy J, Adam L, Qanbar R, Chenier S, Bouvier M. 2003. Phosphorylation-independent desensitization of GABA(B) receptor by GRK4. EMBO J. 22:3816-24
    • (2003) EMBO J , vol.22 , pp. 3816-3824
    • Perroy, J.1    Adam, L.2    Qanbar, R.3    Chenier, S.4    Bouvier, M.5
  • 96
    • 10644254689 scopus 로고    scopus 로고
    • Arrestin2 expression selectively increases during neural differentiation
    • Gurevich EV, Benovic JL, Gurevich VV. 2004. Arrestin2 expression selectively increases during neural differentiation. J. Neurochem. 91:1404-16
    • (2004) J. Neurochem , vol.91 , pp. 1404-1416
    • Gurevich, E.V.1    Benovic, J.L.2    Gurevich, V.V.3
  • 97
    • 0033391143 scopus 로고    scopus 로고
    • Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice
    • Gainetdinov RR, Bohn LM, Walker JK, Laporte SA, Macrae AD, et al. 1999. Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. Neuron 24:1029-36
    • (1999) Neuron , vol.24 , pp. 1029-1036
    • Gainetdinov, R.R.1    Bohn, L.M.2    Walker, J.K.3    Laporte, S.A.4    Macrae, A.D.5
  • 98
    • 0033573915 scopus 로고    scopus 로고
    • Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice
    • Gomeza J, Shannon H, Kostenis E, Felder C, Zhang L, et al. 1999. Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc. Natl. Acad. Sci. USA 96:1692-97
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1692-1697
    • Gomeza, J.1    Shannon, H.2    Kostenis, E.3    Felder, C.4    Zhang, L.5
  • 99
    • 0030657022 scopus 로고    scopus 로고
    • Molecular cloning of rat G-protein-coupled receptor kinase 6 (GRK6) from brain tissue, and its mRNA expression in different brain regions and peripheral tissues
    • Fehr C, Fickova M, Hiemke C, Reuss S, Dahmen N. 1997. Molecular cloning of rat G-protein-coupled receptor kinase 6 (GRK6) from brain tissue, and its mRNA expression in different brain regions and peripheral tissues. Br. Res. Mol. Br. Res. 49:278-82
    • (1997) Br. Res. Mol. Br. Res , vol.49 , pp. 278-282
    • Fehr, C.1    Fickova, M.2    Hiemke, C.3    Reuss, S.4    Dahmen, N.5
  • 100
    • 0038702375 scopus 로고    scopus 로고
    • Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice
    • Gainetdinov RR, Bohn LM, Sotnikova TD, Cyr M, Laakso A, et al. 2003. Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. Neuron 38:291-303
    • (2003) Neuron , vol.38 , pp. 291-303
    • Gainetdinov, R.R.1    Bohn, L.M.2    Sotnikova, T.D.3    Cyr, M.4    Laakso, A.5
  • 104
    • 1242328763 scopus 로고    scopus 로고
    • Decreased immunodensities of μ-opioid receptors, receptor kinases GRK 2/6 and β-arrestin-2 in postmortem brains of opiate addicts
    • Ferrer-Alcon M, La Harpe R, Garcia-Sevilla JA. 2004. Decreased immunodensities of μ-opioid receptors, receptor kinases GRK 2/6 and β-arrestin-2 in postmortem brains of opiate addicts. Br. Res. Mol. Br. Res. 121:114-22
    • (2004) Br. Res. Mol. Br. Res , vol.121 , pp. 114-122
    • Ferrer-Alcon, M.1    La Harpe, R.2    Garcia-Sevilla, J.A.3
  • 105
    • 0026730336 scopus 로고
    • β-Arrestin2, a novel member of the arrestin/β-arrestin gene family
    • Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J, et al. 1992. β-Arrestin2, a novel member of the arrestin/β-arrestin gene family. J. Biol. Chem. 267:17882-90
    • (1992) J. Biol. Chem , vol.267 , pp. 17882-17890
    • Attramadal, H.1    Arriza, J.L.2    Aoki, C.3    Dawson, T.M.4    Codina, J.5
  • 106
    • 0027182590 scopus 로고
    • Molecular cloning, functional expression and mRNA analysis of human β-adrenergic receptor kinase 2
    • Parruti G, Ambrosini G, Sallese M, De Blasi A. 1993. Molecular cloning, functional expression and mRNA analysis of human β-adrenergic receptor kinase 2. Biochem. Biophys. Res. Commun. 190:475-81
    • (1993) Biochem. Biophys. Res. Commun , vol.190 , pp. 475-481
    • Parruti, G.1    Ambrosini, G.2    Sallese, M.3    De Blasi, A.4
  • 107
    • 0037074928 scopus 로고    scopus 로고
    • Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development
    • Gurevich EV, Benovic JL, Gurevich W. 2002. Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Neuroscience 109:421-36
    • (2002) Neuroscience , vol.109 , pp. 421-436
    • Gurevich, E.V.1    Benovic, J.L.2    Gurevich, W.3
  • 108
    • 0033523590 scopus 로고    scopus 로고
    • Ultrastructural localization of β-arrestin-1 and -2 in rat lumbar spinal cord
    • Kittel A, Komori N. 1999. Ultrastructural localization of β-arrestin-1 and -2 in rat lumbar spinal cord. J. Comp. Neurol. 412:649-55
    • (1999) J. Comp. Neurol , vol.412 , pp. 649-655
    • Kittel, A.1    Komori, N.2
  • 109
    • 0037459804 scopus 로고    scopus 로고
    • Differential regulation of β-arrestin 1 and β-arrestin 2 gene expression in rat brain by morphine
    • Fan XL, Zhang JS, Zhang XQ, Yue W, Ma L. 2003. Differential regulation of β-arrestin 1 and β-arrestin 2 gene expression in rat brain by morphine. Neuroscience 117:383-89
    • (2003) Neuroscience , vol.117 , pp. 383-389
    • Fan, X.L.1    Zhang, J.S.2    Zhang, X.Q.3    Yue, W.4    Ma, L.5
  • 110
    • 7444243161 scopus 로고    scopus 로고
    • β-Arrestin-1 levels: Reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain
    • Avissar S, Matuzany-Ruban A, Tzukert K, Schreiber G. 2004. β-Arrestin-1 levels: reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain. Am. J. Psychiat. 161:2066-72
    • (2004) Am. J. Psychiat , vol.161 , pp. 2066-2072
    • Avissar, S.1    Matuzany-Ruban, A.2    Tzukert, K.3    Schreiber, G.4
  • 111
    • 0038722028 scopus 로고    scopus 로고
    • Involvement of β-arrestin-2 in modulation of the spinal antinociception induced by μ-opioid receptor agonists in the mouse
    • Ohsawa M, Mizoguchi H, Narita M, Nagase H, Dun NJ, Tseng LF. 2003. Involvement of β-arrestin-2 in modulation of the spinal antinociception induced by μ-opioid receptor agonists in the mouse. Neurosci. Lett. 346:13-16
    • (2003) Neurosci. Lett , vol.346 , pp. 13-16
    • Ohsawa, M.1    Mizoguchi, H.2    Narita, M.3    Nagase, H.4    Dun, N.J.5    Tseng, L.F.6
  • 112
    • 0032499738 scopus 로고    scopus 로고
    • Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness
    • Zhang J, Ferguson SS, Barak LS, Bodduluri SR, Laporte SA, et al. 1998. Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness. Proc. Natl. Acad. Sci. USA 95:7157-62
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7157-7162
    • Zhang, J.1    Ferguson, S.S.2    Barak, L.S.3    Bodduluri, S.R.4    Laporte, S.A.5
  • 113
    • 0032544061 scopus 로고    scopus 로고
    • Morphine-activated opioid receptors elude desensitization by β-arrestin
    • Whistler JL, von Zastrow M. 1998. Morphine-activated opioid receptors elude desensitization by β-arrestin. Proc. Natl. Acad. Sci. USA 95:9914-19
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9914-9919
    • Whistler, J.L.1    von Zastrow, M.2
  • 114
    • 0031726194 scopus 로고    scopus 로고
    • Agonist induced homologous desensitization of μ-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy
    • Kovoor A, Celver JP, Wu A, Chavkin C. 1998. Agonist induced homologous desensitization of μ-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy. Mol. Pharmacol. 54:704-11
    • (1998) Mol. Pharmacol , vol.54 , pp. 704-711
    • Kovoor, A.1    Celver, J.P.2    Wu, A.3    Chavkin, C.4
  • 115
    • 23944437411 scopus 로고    scopus 로고
    • Morphine promotes rapid, arrestin-dependent endocytosis of μ-opioid receptors in striatal neurons
    • Haberstock-Debic H, Kim KA, Yu YJ, von Zastrow M. 2005. Morphine promotes rapid, arrestin-dependent endocytosis of μ-opioid receptors in striatal neurons. J. Neurosci. 25:7847-57
    • (2005) J. Neurosci , vol.25 , pp. 7847-7857
    • Haberstock-Debic, H.1    Kim, K.A.2    Yu, Y.J.3    von Zastrow, M.4
  • 117
    • 0034619796 scopus 로고    scopus 로고
    • μ-opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
    • Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG. 2000. μ-opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence. Nature 408:720-23
    • (2000) Nature , vol.408 , pp. 720-723
    • Bohn, L.M.1    Gainetdinov, R.R.2    Lin, F.T.3    Lefkowitz, R.J.4    Caron, M.G.5
  • 118
    • 27744468952 scopus 로고    scopus 로고
    • Morphine-induced μ-opioid receptor internalization: A paradox solved in neurons
    • Beaulieu JM. 2005. Morphine-induced μ-opioid receptor internalization: a paradox solved in neurons. J. Neurosci. 25:10061-63
    • (2005) J. Neurosci , vol.25 , pp. 10061-10063
    • Beaulieu, J.M.1
  • 119
    • 0036895747 scopus 로고    scopus 로고
    • Differential mechanisms of morphine antinociceptive tolerance revealed in βarrestin-2 knock-out mice
    • Bohn LM, Lefkowitz RJ, Caron MG. 2002. Differential mechanisms of morphine antinociceptive tolerance revealed in βarrestin-2 knock-out mice. J. Neurosci. 22:10494-500
    • (2002) J. Neurosci , vol.22 , pp. 10494-10500
    • Bohn, L.M.1    Lefkowitz, R.J.2    Caron, M.G.3
  • 120
    • 3042665659 scopus 로고    scopus 로고
    • Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery
    • Bohn LM, Dykstra LA, Lefkowitz RJ, Caron MG, Barak LS. 2004. Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. Mol. Pharmacol. 66:106-12
    • (2004) Mol. Pharmacol , vol.66 , pp. 106-112
    • Bohn, L.M.1    Dykstra, L.A.2    Lefkowitz, R.J.3    Caron, M.G.4    Barak, L.S.5
  • 121
  • 122
    • 33646494493 scopus 로고    scopus 로고
    • Decreased morphine analgesia in rat overexpressing β-arrestin 2 at periaqueductal gray
    • Jiang B, Shi Y, Li H, Kang L, Ma L. 2006. Decreased morphine analgesia in rat overexpressing β-arrestin 2 at periaqueductal gray. Neurosci. Lett. 400:150-53
    • (2006) Neurosci. Lett , vol.400 , pp. 150-153
    • Jiang, B.1    Shi, Y.2    Li, H.3    Kang, L.4    Ma, L.5
  • 123
    • 16244406201 scopus 로고    scopus 로고
    • Induction of δ-opioid receptor function in the midbrain after chronic morphine treatment
    • Hack SP, Bagley EE, Chieng BC, Christie MJ. 2005. Induction of δ-opioid receptor function in the midbrain after chronic morphine treatment. J. Neurosci. 25:3192-98
    • (2005) J. Neurosci , vol.25 , pp. 3192-3198
    • Hack, S.P.1    Bagley, E.E.2    Chieng, B.C.3    Christie, M.J.4
  • 124
    • 14544269885 scopus 로고    scopus 로고
    • β-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids
    • Bradaia A, Berton F, Ferrari S, Luscher C. 2005. β-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids. Proc. Natl. Acad. Sci. USA 102:3034-39
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 3034-3039
    • Bradaia, A.1    Berton, F.2    Ferrari, S.3    Luscher, C.4
  • 125
    • 4243870644 scopus 로고    scopus 로고
    • Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out mice
    • Elmer GI, Pieper JO, Rubinstein M, Low MJ, Grandy DK, Wise RA. 2002. Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out mice. J. Neurosci. 22:RC224
    • (2002) J. Neurosci , vol.22
    • Elmer, G.I.1    Pieper, J.O.2    Rubinstein, M.3    Low, M.J.4    Grandy, D.K.5    Wise, R.A.6
  • 126
    • 0344824657 scopus 로고    scopus 로고
    • Enhanced rewarding properties of morphine, but not cocaine, in βarrestin-2 knock-out mice
    • Bohn LM, Gainetdinov RR, Sotnikova TD, Medvedev IO, Lefkowitz RJ, et al. 2003. Enhanced rewarding properties of morphine, but not cocaine, in βarrestin-2 knock-out mice. J. Neurosci. 23:10265-73
    • (2003) J. Neurosci , vol.23 , pp. 10265-10273
    • Bohn, L.M.1    Gainetdinov, R.R.2    Sotnikova, T.D.3    Medvedev, I.O.4    Lefkowitz, R.J.5
  • 127
    • 0029032517 scopus 로고
    • Involvement of the dorsal raphe but not median raphe nucleus in morphine-induced increases in serotonin release in the rat forebrain
    • Tao R, Auerbach SB. 1995. Involvement of the dorsal raphe but not median raphe nucleus in morphine-induced increases in serotonin release in the rat forebrain. Neuroscience 68:553-61
    • (1995) Neuroscience , vol.68 , pp. 553-561
    • Tao, R.1    Auerbach, S.B.2
  • 128
  • 130
    • 1842787936 scopus 로고    scopus 로고
    • Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
    • Beaulieu JM, Sotnikova TD, Yao WD, Kockeritz L, Woodgett JR, et al. 2004. Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc. Natl. Acad. Sci. USA 101:5099-104
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 5099-5104
    • Beaulieu, J.M.1    Sotnikova, T.D.2    Yao, W.D.3    Kockeritz, L.4    Woodgett, J.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.