Pharmacological comparison of a recombinant CB1 cannabinoid receptor with its Gα16 fusion product

Journal of Biomolecular Screening

Volumn 7, Issue 3, 2002, Pages 281-289

  Martin, Renée S ^a   Reynen, Paul H ^a   Calixto, Joyce J ^b   Reyes, Christian L ^a   Chang, Thomas K ^a   Dietrich, Paul S ^a   Bonhaus, Douglas W ^c   Maclennan, Stephen J ^a,b,c  

^a ROCHE BIOSCIENCE   (United States)

^b THERAVANCE INC   (United States)

^c 0SI Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 3 (1 NAPHTHOYL) 1 PROPYLINDOLE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AGONIST; DEXANABINOL; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HYBRID PROTEIN; PROTEIN SUBUNIT; RECOMBINANT RECEPTOR; RIMONABANT; CALCIUM; CANNABINOID RECEPTOR; CYCLIC AMP; CYCLOHEXANOL DERIVATIVE; DRUG RECEPTOR; G PROTEIN ALPHA 16; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; SULFUR; TRITIUM;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CALCIUM CELL LEVEL; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; GENE EXPRESSION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; COMPARATIVE STUDY; METABOLISM;

CALCIUM; COMPARATIVE STUDY; CYCLIC AMP; CYCLOHEXANOLS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HETEROTRIMERIC GTP-BINDING PROTEINS; HUMAN; RECEPTORS, DRUG; RECOMBINANT FUSION PROTEINS; SULFUR RADIOISOTOPES; TRITIUM; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; RECEPTORS, CANNABINOID;

EID: 0035991342     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1089/108705702760047781     Document Type: Article

References (16)

1. 1 and CB2 receptors
2. Differential requirements of sodium for coupling of cannabinoid receptors to adenylyl cyclase in rat brain membranes
3. Cannabinoid inhibition of adenylate cyclase: Biochemistry of the response in neuroblastoma cell membranes
4. Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones
5. Paradoxical action of the cannabinoid WIN 55,212-2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices
6. Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: Evidence for agonist-specific trafficking of intracellular responses
7. i-family G proteins: Studies with pertussis toxin-resistant G protein mutants
8. i/oα fusion proteins
9. α fusion protein
10. Analysis of agonist function at fusion proteins between the IP prostanoid receptor and cognate, unnatural and chimeric G-proteins
11. α16 couple a wide variety of receptors to phospholipase C
12. The G protein-coupling profile of metabotropic glutamate receptors, as determined with exogenous G proteins, is independent of their ligand recognition domain
13. 50) of an enzymatic reaction
14. 2 receptors
15. 2): Identification of cannabinoid receptor subtype selective ligands
16. i proteins