Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists

Neuropharmacology

Volumn 44, Issue 7, 2003, Pages 873-881

  Wurch, T ^a   Colpaert, F C ^a   Pauwels, P J ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

5 HT1A receptor; Ca2+ response; Efficacious and partial agonists; Fusion protein; PKC phosphorylation site

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 CARBAMOYLTRYPTAMINE; BUSPIRONE; CALCIUM ION; F 13640; F 14679; FLESINOXAN; G ACTIN; HYBRID PROTEIN; N (3 CHLORO 4 FLUOROBENZOYL) 4 FLUORO 4 [(5 METHYL 6 METHYLAMINOPYRIDIN 2 YL)METHYLAMINOMETHYL]PIPERIDINE; N (3 CHLORO 4 FLUOROBENZOYL) 4 FLUORO 4 [(5 METHYLPYRIDIN 2 YL)METHYLAMINOMETHYL]PIPERIDINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; LIGAND BINDING; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

EID: 0037410528     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(03)00097-2     Document Type: Article

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