Direct protein-protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors

Nature

Volumn 403, Issue 6767, 2000, Pages 274-280

  Liu, Fang ^a,b,d   Wan, Qi ^c   Pristupa, Zdenek B ^a,d   Yu, Xian Min ^a,d   Wang, Yu Tian ^c   Niznik, Hyman B ^a,b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROTRANSMITTER RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; CELL CULTURE; ELECTROPHYSIOLOGY; FETUS; HIPPOCAMPUS; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PSYCHOMOTOR DISORDER; RAT; RECEPTOR BINDING; SECOND MESSENGER; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

AMINO ACID MOTIFS; ANIMALS; BENZAZEPINES; CELL LINE; CELLS, CULTURED; CYCLIC AMP; DOPAMINE; DOPAMINE AGONISTS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; HUMANS; LIGANDS; NEURONS; RATS; RECEPTOR CROSS-TALK; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D5; RECEPTORS, GABA-A; RECOMBINANT FUSION PROTEINS; SYNAPTIC TRANSMISSION; TRANSFECTION;

ANIMALIA;

EID: 0034688225     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35002014     Document Type: Article

References (49)

1. Dohlman, H. G., Thorner, J., Caron, M. G. & Lefkowitz, R. J. Model systems for the study of seven transmembrane segment receptors. Annu. Rev. Biochem. 60, 653-688 (1991).
2. Unwin, N. Neurotransmitter action: opening of ligand gated ion channels. Cell 72 (suppl.), 655-688 (1991).
3. Neer, E. J. Heterotrimeric G proteins: organizers of transmembrane signals. Cell 80, 249-257 (1995).
4. A receptor channels. Annu. Rev. Neurosci. 17, 569-602 (1994).
5. Mody, I., DeKoninck, Y., Otis, T. S. & Soltesz, I. Bridging the cleft at GABA synapses in the brain. Trends Neurosci. 17, 517-525 (1994).
6. A receptors: classification on the basis of subunit structure and receptor function. Pharmacol. Rev. 50, 291-313 (1998).
7. Costa, E. From GABA receptor diversity emerges a unified vision of GABAergic inhibition. Annu. Rev. Pharmacol. Toxicol. 38, 321-350 (1998).
8. A receptor subtypes really occur in the brain? Trends Neurosci. 19, 139-143 (1996).
9. A receptor subtype. J. Neurosci. 17, 2728-2737 (1997).
10. Missale, C., Nash, S. R., Robinson, S. W., Jaber, M. & Caron, M. G. Dopamine receptors: from structure to function. Physiol. Rev. 78, 189-225 (1998).
11. Sunahara, R. K. et al. Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Nature 347, 80-83 (1990).
12. Sunahara, R. K. et al. Cloning of a gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature 350, 614-619 (1991).
13. Niznik, H. B., Sugamori, K. S., Clifford, J. J. & Waddington, J. L. in Handbook of Experimental Pharmacology - Dopamine in the CNS. (ed. Di Chiara, G.) (Springer, Berlin, in the press).
14. Sidhu, A. Coupling of D1 and D5 dopamine receptors to multiple G proteins. Mol. Neurobiol. 16, 125-134 (1998).
15. Sibley, D. R. New insights into dopaminergic function using anti-sense and genetically altered animals. Annu. Rev. Pharmacol. Toxicol. 39, 313-341 (1999).
16. Smart, T. G. Regulation of excitatory and inhibitory neurotransmitter-gated ion channels by protein phosphorylation. Curr. Opin. Neurobiol. 7, 358-367 (1997).
17. A receptor function by PKA and PKC in adult hippocampal neurons. J. Neurosci. 19, 674-683 (1999).
18. Swope, S. L., Moss, S. I., Raymond, L. A. & Huganir, R. L. Regulation of ligand gated ion channels by protein phosphorylation. Adv. Second Messenger Phosphoprot. Res. 33, 49-78 (1999).
19. A currents in striatal cholinergic interneurons through a PKA/PP1 cascade. Neuron 19, 1115-1126 (1997).
20. A synaptic currents in the rat subtantia nigra pars reticulata. J. Neurosci. 18, 2009-2016 (1998).
21. Moniyama, T. & Sim, J. A. Modulation of inhibitory transmission by dopamine in rat basal forebrain nuclei: activation of presynaptic D1 like dopaminergic receptors. J. Neurosci. 16, 7502-7512 (1996).
22. Brunig, I., Sommer, M., Hatt, H. & Bormann, J. Dopamine receptor subtypes modulate olfactory bulb γ-aminobutyric acid type A receptors. Proc. Natl Acad. Sci. USA 96, 2456-2460 (1999).
23. Bergson, C. et al. Regional cellular and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain. J. Neurosci. 15, 7821-7836 (1995).
24. Buhl, E. H., Halasy, K. & Somogyi, P. Diverse sources of hippocampal unitary inhibitory postsynaptic potentials and the number of postsynaptic release sites. Nature 368, 823-828 (1994).
25. A receptor in relation to specific GABAergic synapses in the dendate gyrus. Eur. J. Neurosci. 7, 630-636 (1995).
26. Hall, R. A., Premont, R. T. & Lefkowitz, R. J. Heptahelical receptor signalling: beyond the G-protein paradigm. J. Cell Biol. 145, 927-932 (1999).
27. A receptor subunits in the rat hippocampus: 1. Immunocytochemical distribution of 13 subunits. Neuroscience 80, 987-1000 (1997).
28. A receptor subtypes requires the γ2 subunit and gephyrin. Nature Neurosci. 1, 563-571 (1998).
29. A receptors and the cytoskeleton. Nature 397, 69-72 (1999).
30. A receptors composed of α1 and β2 subunits in both cultured neurons and fibroblasts. J. Neurosci. 17, 6587-6596 (1997).
31. A receptor function by tyrosine phosphorylation of β subunits. J. Neurosci. 17, 5062-5069 (1997).
32. Luttrell, L. M., Ostrowski, J., Cotecchia, S., Kendall, H. & Lefkowitz, R. J. Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. Science 259, 1453-1557 (1993).
33. Sugamori, K. S., Scheideler, M. A., Vernier, P. & Niznik, H. B. Dopamine D1B receptor chimeras reveal modulation of partial agonist activity by carboxyl terminal tail sequences. J. Neurochem. 71, 2593-2599 (1998).
34. A receptor β-subunits determine regulation by cAMP-dependent protein kinase. Nature Neurosci. 1, 23-28 (1998).
35. Hebert, T. E. & Bouvier, M. Structural and functional aspects of GPCR oligomerization. Biochem. Cell Biol. 76, 1-11 (1998).
36. A receptors - the first 7TM heterodimers. Trends Pharmacol. Sci. 10, 369-399 (1999).
37. Jordan, B. A. & Devi, L. A. G-protein coupled receptor heterodimerization modulates receptor function. Nature 399, 697-700 (1999).
38. Benes, F. M. The role of stress and dopamine-GABA interactions in the vulnerability for schizophrenia. J. Psychiat. Res. 31, 257-275 (1997).
39. A receptor in prefrontal cortex of schizophrenics. Proc. Natl Acad. Sci. USA 95, 15066-15071 (1998).
40. Keverne, E. B. GABA-ergic neurons and the neurobiology of schizophrenia and other psychosis. Brain Res. Bull. 48, 467-473 (1999).
41. Okubo, Y. et al. Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET. Nature 385, 634-636 (1997).
42. Goldman-Rakic, P. S. & Selemon, L. D. Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizo. Bull. 23, 437-458 (1997).
43. Moore, H. West, A. R. & Grace, A. A. The regulation of forebrain dopamine transmission. Biol. Psychiat. 46, 40-55 (1999).
44. Ng, G. Y. K. et al. Agonist induced desensitization of dopamine D1 receptor stimulated adenylyl cyclase activity is temporally and biochemically separated from D1 receptor internalization. Proc. Natl Acad. Sci. USA 92, 10157-10161 (1995).
45. A receptors underlies potentiation at hippocampal inhibitory synapse. Nature 395, 172-177 (1998).
46. A receptors to postsynaptic domains by insulin. Nature 388, 686-690 (1997).
47. A receptor clustering in gephyrin deficient mice. J. Neurosci. 19, 9289-9297 (1999).
48. + exchange. Nature 392, 626-630 (1998).
49. Yu, X.-M. & Salter, M. W. Gain control of NMDA receptor currents by intracellular sodium. Nature 396, 469-474 (1998).