Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents

Cell Metabolism

Volumn 3, Issue 3, 2006, Pages 167-175

  Overton, Hilary A ^a   Babbs, Adam J ^a   Doel, Sheila M ^a   Fyfe, Matthew C T ^a   Gardner, Lisa S ^a   Griffin, Graeme ^b   Jackson, Helen C ^c   Procter, Martin J ^a   Rasamison, Chrystelle M ^a   Tang Christensen, Mads ^d   Widdowson, Peter S ^a   Williams, Geoffery M ^a   Reynet, Christine ^a  

^a Prosidion Limited   (United Kingdom)

^b OSI PHARMACEUTICALS INC   (United States)

^c RenaSci Ltd   (United Kingdom)

^d Rheoscience A/S   (Denmark)

Author keywords

Humdisease; Signaling

Indexed keywords

ANOREXIGENIC AGENT; G PROTEIN COUPLED RECEPTOR; N OLEOYLETHANOLAMINE; PSN 632408; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; FEEDING; FOOD INTAKE; HUMAN; HUMAN CELL; LIPID DIET; MALE; METABOLIC DISORDER; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WEIGHT GAIN; WEIGHT REDUCTION;

ANIMALS; APPETITE DEPRESSANTS; CYCLIC AMP; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; HUMANS; MALE; MICE; MOLECULAR SEQUENCE DATA; OBESITY; OLEIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; SUBSTRATE SPECIFICITY; TIME FACTORS; YEASTS;

ANIMALIA; RODENTIA;

EID: 33644627958     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2006.02.004     Document Type: Article

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