Allosteric modulation and constitutive activity of fusion proteins between the adenosine A 1 receptor and different 351Cys-mutated G i α-subunits

European Journal of Pharmacology

Volumn 499, Issue 1-2, 2004, Pages 91-98

  Klaasse, Elisabeth ^a   De Ligt, Rianne A F ^b   Roerink, Sophie F ^a   Lorenzen, Anna ^c   Milligan, Graeme ^d   Leurs, Rob ^e   IJzerman, Ad P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Adenosine A 1 receptor; Allosteric modulation; Constitutive activity; Fusion protein; G protein; Inverse agonism

Indexed keywords

2 AMINO 4,5 DIMETHYL 3 (3 TRIFLUOROMETHYLBENZOYL)THIOPHENE; 6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYLTHEOPHYLLINE; ADENOSINE A1 RECEPTOR; AMINO ACID; ARGININE; CYSTEINE; GLYCINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HISTIDINE; HYBRID PROTEIN; ISOLEUCINE; PHENYLALANINE; PROLINE; RADIOLIGAND; SERINE; SODIUM ION; SULFUR 35; VALINE;

ALLOSTERISM; ALPHA CHAIN; ANIMAL CELL; ARTICLE; CERCOPITHECIDAE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ADENOSINE; ALLOSTERIC SITE; ANIMALS; BINDING, COMPETITIVE; CELL MEMBRANE; COS CELLS; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MUTATION; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A1; RECOMBINANT FUSION PROTEINS; SODIUM CHLORIDE; SULFUR RADIOISOTOPES; THIOPHENES; TRANSFECTION; TRITIUM; XANTHINES;

EID: 19344366866     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.07.108     Document Type: Article

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