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Volumn 23, Issue 3, 2002, Pages 140-146

Seven-transmembrane receptors: Crystals clarify

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; MEMBRANE RECEPTOR; METHYLSCOPOLAMINE; MUSCARINIC RECEPTOR; OPSIN; RHODOPSIN;

EID: 0036499727     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01973-8     Document Type: Review
Times cited : (156)

References (79)
  • 2
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • (2001) Nature , vol.409 , pp. 860-922
  • 3
    • 0035800032 scopus 로고    scopus 로고
    • Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs)
    • (2001) Biochemistry , vol.40 , pp. 7761-7772
    • Teller, D.C.1
  • 4
    • 0034604451 scopus 로고    scopus 로고
    • Crystal structure of rhodopsin: A G protein-coupled receptor
    • (2000) Science , vol.289 , pp. 739-745
    • Palczewski, K.1
  • 5
    • 77957055780 scopus 로고
    • Integrated methods for the construction of three dimensional models and computational probing of structure-function relations in G-protein-coupled receptors
    • (1995) Methods Neurosci. , vol.25 , pp. 366-428
    • Ballesteros, J.A.1    Weinstein, H.2
  • 7
    • 0029035661 scopus 로고
    • Mapping light-dependent structural changes in the cytoplasmic loop connecting helices C and D in rhodopsin: A site-directed spin labeling study
    • (1995) Biochemistry , vol.34 , pp. 8812-8819
    • Farahbakhsh, Z.T.1
  • 8
    • 0029818551 scopus 로고    scopus 로고
    • Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: A site-directed spin-labelling study
    • (1996) Biochemistry , vol.35 , pp. 12470-12478
    • Altenbach, C.1
  • 9
    • 0033594869 scopus 로고    scopus 로고
    • Single-cysteine substitution mutants at amino acid positions 55-75, the sequence connecting the cytoplasmic end of helices I and II in rhodopsin: Reactivity of the sulfhydryl groups and their derivatives identifies a tertiary structure that changes upon light activation
    • (2000) Biochemistry , vol.38 , pp. 7938-7944
    • Klein-Seetharaman, J.1
  • 10
    • 0031565726 scopus 로고    scopus 로고
    • An α-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors
    • (1997) J. Mol. Biol. , vol.272 , pp. 144-164
    • Baldwin, J.M.1
  • 12
    • 0034948696 scopus 로고    scopus 로고
    • Structural mimicry in G protein-coupled receptors: Implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors
    • (2001) Mol. Pharmacol. , vol.60 , pp. 1-19
    • Ballesteros, J.A.1
  • 13
    • 0031037632 scopus 로고    scopus 로고
    • The Role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: Mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling
    • (1997) Mol. Pharmacol. , vol.51 , pp. 234-241
    • Lu, Z.-L.1
  • 14
  • 15
    • 0034095059 scopus 로고    scopus 로고
    • A network of conserved intramolecular contacts defines the off-state of the transmembrane switch mechanism in a seven-transmembrane receptor
    • (2000) J. Biol. Chem. , vol.275 , pp. 5682-5686
    • Lu, Z.-L.1    Hulme, E.C.2
  • 16
    • 0028944574 scopus 로고
    • Activating and inactivating mutations in N- and C-terminal i3 loop junctions of muscarinic acetylcholine Hm1 receptors
    • (1995) J. Biol. Chem. , vol.270 , pp. 7405-7410
    • Hogger, P.1
  • 17
    • 0035823524 scopus 로고    scopus 로고
    • 1 muscarinic actylcholine receptor are critical for ligand binding and the receptor activation switch
    • (2001) J. Biol. Chem. , vol.276 , pp. 34098-34104
    • Lu, Z.-L.1
  • 19
    • 0032879688 scopus 로고    scopus 로고
    • The functional microdomain in transmembrane helices 2 and 7 regulates expression, activation, and coupling pathways of the gonadotropin-releasing hormone receptor
    • (1999) J. Biol. Chem. , vol.274 , pp. 28880-28886
    • Flanagan, C.A.1
  • 20
    • 0034464742 scopus 로고    scopus 로고
    • Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
    • (2001) Endocr. Rev. , vol.21 , pp. 90-113
    • Gether, U.1
  • 23
    • 0032756999 scopus 로고    scopus 로고
    • 1 muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function
    • (1999) Mol. Pharmacol. , vol.56 , pp. 1031-1041
    • Ward, S.D.C.1
  • 24
    • 0033932599 scopus 로고    scopus 로고
    • 1 muscarinic receptor that participate in binding the acetyl methyl group of acetylcholine
    • (2000) Mol. Pharmacol. , vol.58 , pp. 175-184
    • Allman, K.1
  • 25
    • 0033945117 scopus 로고    scopus 로고
    • 3H]-scopolamine and acetylcholine at muscarinic receptor subtypes: Identification of a second allosteric site
    • (2000) Mol. Pharmacol. , vol.58 , pp. 194-207
    • Lazareno, S.1
  • 26
    • 0035902009 scopus 로고    scopus 로고
    • Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
    • (2001) Nature , vol.411 , pp. 269-276
    • Brejc, K.1
  • 28
    • 0025881062 scopus 로고
    • Three-dimensional models of neurotransmitter G-binding protein-coupled receptors
    • (1991) Mol. Pharmacol. , vol.40 , pp. 8-15
    • Hibert, M.1
  • 29
    • 0032504237 scopus 로고    scopus 로고
    • G protein-coupled receptors. I. Diversity of receptor-ligand interactions
    • (1998) J. Biol. Chem. , vol.273 , pp. 17299-17302
    • Ji, T.H.1
  • 31
    • 0033522643 scopus 로고    scopus 로고
    • 1B-adrenergic receptor is a key switch residue involved in activation and catecholamine ring aromatic bonding
    • (1999) J. Biol. Chem. , vol.274 , pp. 16320-16330
    • Chen, S.1
  • 32
    • 0034634690 scopus 로고    scopus 로고
    • Genetic mapping of the human C5a receptor: Identification of transmembrane amino acids critical for receptor function
    • (2000) J. Biol. Chem. , vol.275 , pp. 35393-35401
    • Geva, A.1
  • 33
    • 0035793604 scopus 로고    scopus 로고
    • An activation switch in the ligand binding pocket of the C5a receptor
    • (2001) J. Biol. Chem. , vol.276 , pp. 3394-3400
    • Gerber, B.O.1
  • 34
    • 0028351937 scopus 로고
    • Structure and function in rhodopsin: Replacement by alanine of cysteine residues 110 and 187, components of a conserved disulfide bond in rhodopsin, affects the light-activated metarhodopsin II state
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 4029-4033
    • Davidson, F.F.1
  • 35
    • 0025121206 scopus 로고
    • Muscarinic acetylcholine receptors: Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation
    • (1990) J. Biol. Chem. , vol.265 , pp. 13702-13708
    • Kurtenbach, E.1
  • 36
    • 0026639831 scopus 로고
    • Site-directed mutagenesis of the rat m1 muscarinic acetylcholine receptor: Role of conserved cysteines in receptor function
    • (1992) J. Biol. Chem. , vol.267 , pp. 11439-11448
    • Savarese, T.M.1
  • 37
    • 0033011632 scopus 로고    scopus 로고
    • 3 muscarinic acetylcholine receptor is necessary for proper receptor cell surface localization, but not for G protein coupling
    • (1999) J. Neurochem. , vol.72 , pp. 2404-2414
    • Zeng, F.-Y.1
  • 38
    • 0028815463 scopus 로고
    • Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis
    • (1995) Mol. Pharmacol. , vol.47 , pp. 88-98
    • Matsui, H.1
  • 39
    • 0034705362 scopus 로고    scopus 로고
    • Evidence for a tandem two-site model of ligand binding to muscarinic acetylcholine receptors
    • (2000) J. Biol. Chem. , vol.275 , pp. 18836-18844
    • Jakubik, J.1
  • 40
    • 0035064796 scopus 로고    scopus 로고
    • 35S]thio-triphosphate binding through M1 muscarinic receptors in transfected chinese hamster ovary cell membranes: 1. Mathematical analysis of catalytic G protein activation
    • (2001) Mol. Pharmacol. , vol.59 , pp. 875-885
    • Waelbroeck, M.1
  • 41
    • 0035058763 scopus 로고    scopus 로고
    • 1 muscarinic receptors in transfected chinese hamster ovary cell membranes: 2. Testing the 'two-states' model of receptor activation
    • (2001) Mol. Pharmacol. , vol.59 , pp. 886-893
    • Waelbroeck, M.1
  • 42
    • 0032770658 scopus 로고    scopus 로고
    • 2-adrenergic receptor/Gs interaction: Evidence for multiple receptor conformations
    • (1999) Mol. Pharmacol. , vol.56 , pp. 348-358
    • Seifert, R.1
  • 44
    • 0034705612 scopus 로고    scopus 로고
    • Movement of retinal along the visual transduction path
    • (2000) Science , vol.288 , pp. 2209-2212
    • Borhan, B.1
  • 46
    • 0033944938 scopus 로고    scopus 로고
    • Partial agonism through a zinc-ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor
    • (2000) Mol. Pharmacol. , vol.58 , pp. 263-270
    • Holst, B.1
  • 47
    • 0032474444 scopus 로고    scopus 로고
    • Constitutive activation of opsin by mutation of methionine 257 on transmembrane helix 6
    • (1998) Biochemistry , vol.37 , pp. 8253-8261
    • Han, M.1
  • 48
    • 0032555649 scopus 로고    scopus 로고
    • Identification of a ligand-dependent switch within a muscarinic receptor
    • (1998) J. Biol. Chem. , vol.273 , pp. 21563-21568
    • Spalding, T.A.1
  • 49
    • 0034465336 scopus 로고    scopus 로고
    • Constitutive activation of G protein-coupled receptors as a result of selective substitution of a conserved leucine residue in transmembrane helix III
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1272-1282
    • Tao, Y.-X.1
  • 50
    • 0031872001 scopus 로고    scopus 로고
    • A proposed structure for transmembrane segment 7 of G protein-coupled receptor incorporating an Asn-Pro/Asp-Pro motif
    • (1998) Biophys. J. , vol.75 , pp. 601-611
    • Konvicka, K.1
  • 51
    • 0032983090 scopus 로고    scopus 로고
    • The conformational switch in 7-transmembrane receptors: The muscarinic receptor paradigm
    • (1999) Eur. J. Pharmacol. , vol.375 , pp. 247-260
    • Hulme, E.C.1
  • 52
    • 0031446595 scopus 로고    scopus 로고
    • Structure and function in rhodopsin: Rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 14273-14278
    • Kim, J.-M.1
  • 54
    • 0033061256 scopus 로고    scopus 로고
    • Mutation of a highly conserved aspartic acid in the β2 adrenergic receptor: Constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6
    • (1999) Mol. Pharmacol. , vol.56 , pp. 175-184
    • Rasmussen, S.G.F.1
  • 56
    • 0033555936 scopus 로고    scopus 로고
    • Conformational changes in rhodopsin: Movement of helix F detected by site-specific chemical labeling and fluorescence spectroscopy
    • (1999) J. Biol. Chem. , vol.274 , pp. 1683-1690
    • Dunham, T.D.1    Farrens, D.L.2
  • 57
    • 0035937786 scopus 로고    scopus 로고
    • Agonist-induced conformational changes at the cytoplasmic side of TM6 in the β2 adrenergic receptor mapped by site-selective fluorescent labeling
    • (2001) J. Biol. Chem. , vol.276 , pp. 9279-9290
    • Jensen, A.D.1
  • 58
    • 0033546197 scopus 로고    scopus 로고
    • Similar structures and shared switch mechanisms of the β2-adrenoceptor and the parathyroid hormone receptor: Zn(II) bridges between helices III and VI block activation
    • (1999) J. Biol. Chem. , vol.274 , pp. 17033-17041
    • Sheikh, S.P.1
  • 60
    • 0033594988 scopus 로고    scopus 로고
    • Structural features and light-dependent changes in the sequence 306-322 extending from helix VII to the palmitoylation sites in rhodopsin: A site-directed spin-labeling study
    • (1999) Biochemistry , vol.38 , pp. 7931-7937
    • Altenbach, C.1
  • 62
    • 0033554396 scopus 로고    scopus 로고
    • State-dependent disulfide cross-linking in rhodopsin
    • (1999) Biochemistry , vol.38 , pp. 12028-12032
    • Yu, H.1
  • 63
    • 0029953103 scopus 로고    scopus 로고
    • Alanine scanning mutagenesis of conserved arginine/lysine-arginine/lysine-x-x-arginine/lysine G protein-activating motifs on m1 muscarinic acetylcholine receptors
    • (1996) Mol. Pharmacol. , vol.50 , pp. 140-148
    • Lee, N.H.1
  • 64
    • 0027328071 scopus 로고
    • Charged amino acids required for signal transduction by the m3 muscarinic acetylcholine receptor
    • (1993) EMBO J. , vol.12 , pp. 3809-3815
    • Kunkel, M.T.1    Peralta, E.G.2
  • 66
    • 0027245830 scopus 로고
    • Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
    • (1993) Nature , vol.363 , pp. 274-276
    • Conklin, B.R.1
  • 69
    • 0033583051 scopus 로고    scopus 로고
    • Roles of the transducin α-subunit α4-helix/α4-β6 loop in the receptor and effector interactions
    • (1999) J. Biol. Chem. , vol.274 , pp. 7865-7869
    • Natochin, M.1
  • 70
    • 0035942238 scopus 로고    scopus 로고
    • Mapping of contact sites in complex formation between transducin and light-activated rhodopsin by covalent crosslinking: Use of a photoactivatable agent
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 4877-4882
    • Cai, K.1
  • 71
    • 0035942229 scopus 로고    scopus 로고
    • Mapping of contact sites in complex formation between transducin and light-activated rhodopsin by covalent crosslinking: Use of a chemically preactivated reagent
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 4883-4887
    • Itoh, Y.1
  • 72
    • 0026786080 scopus 로고
    • Rhodopsin/transducin interactions: 1. Characterization of the binding of the transducin-βγ subunit complex to rhodopsin using fluorescence spectroscopy
    • (1992) J. Biol. Chem. , vol.267 , pp. 17032-17039
    • Phillips, W.J.1    Cerione, R.A.2
  • 73
    • 0029664589 scopus 로고    scopus 로고
    • The 2.0 Å crystal structure of a heterotrimeric G protein
    • (1996) Nature , vol.379 , pp. 311-319
    • Lambright, D.G.1
  • 75
    • 0030851384 scopus 로고    scopus 로고
    • q is critical for constraining the selectivity of receptor coupling
    • (1997) J. Biol. Chem. , vol.272 , pp. 19107-19110
    • Kostenis, E.1
  • 76
    • 0034695482 scopus 로고    scopus 로고
    • Mutation of the fourth cytoplasmic loop of rhodopsin affects binding of transducin and peptides derived from the carboxyl terminal sequences of transducin α and γ subunits
    • (2000) J. Biol. Chem. , vol.275 , pp. 1937-1943
    • Ernst, O.P.1
  • 77
    • 0034695476 scopus 로고    scopus 로고
    • The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction
    • (2000) J. Biol. Chem. , vol.275 , pp. 1930-1936
    • Marin, E.P.1
  • 78
    • 0030064529 scopus 로고    scopus 로고
    • Receptor and membrane interaction sites on Gβ: A receptor-derived peptide binds to the carboxyl terminus
    • (1996) J. Biol. Chem. , vol.271 , pp. 3336-3339
    • Taylor, J.M.1
  • 79
    • 0034708266 scopus 로고    scopus 로고
    • 3-muscarinic receptor and their role in receptor regulation
    • (2000) J. Biol. Chem. , vol.275 , pp. 9026-9034
    • Wu, G.1


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