-
2
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
(2001)
Nature
, vol.409
, pp. 860-922
-
-
-
3
-
-
0035800032
-
Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs)
-
(2001)
Biochemistry
, vol.40
, pp. 7761-7772
-
-
Teller, D.C.1
-
4
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
(2000)
Science
, vol.289
, pp. 739-745
-
-
Palczewski, K.1
-
5
-
-
77957055780
-
Integrated methods for the construction of three dimensional models and computational probing of structure-function relations in G-protein-coupled receptors
-
(1995)
Methods Neurosci.
, vol.25
, pp. 366-428
-
-
Ballesteros, J.A.1
Weinstein, H.2
-
7
-
-
0029035661
-
Mapping light-dependent structural changes in the cytoplasmic loop connecting helices C and D in rhodopsin: A site-directed spin labeling study
-
(1995)
Biochemistry
, vol.34
, pp. 8812-8819
-
-
Farahbakhsh, Z.T.1
-
8
-
-
0029818551
-
Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: A site-directed spin-labelling study
-
(1996)
Biochemistry
, vol.35
, pp. 12470-12478
-
-
Altenbach, C.1
-
9
-
-
0033594869
-
Single-cysteine substitution mutants at amino acid positions 55-75, the sequence connecting the cytoplasmic end of helices I and II in rhodopsin: Reactivity of the sulfhydryl groups and their derivatives identifies a tertiary structure that changes upon light activation
-
(2000)
Biochemistry
, vol.38
, pp. 7938-7944
-
-
Klein-Seetharaman, J.1
-
10
-
-
0031565726
-
An α-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors
-
(1997)
J. Mol. Biol.
, vol.272
, pp. 144-164
-
-
Baldwin, J.M.1
-
12
-
-
0034948696
-
Structural mimicry in G protein-coupled receptors: Implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 1-19
-
-
Ballesteros, J.A.1
-
13
-
-
0031037632
-
The Role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: Mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling
-
(1997)
Mol. Pharmacol.
, vol.51
, pp. 234-241
-
-
Lu, Z.-L.1
-
14
-
-
0035336676
-
Activation of rhodopsin: New insights from structural and biochemical studies
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 318-324
-
-
Okada, T.1
-
15
-
-
0034095059
-
A network of conserved intramolecular contacts defines the off-state of the transmembrane switch mechanism in a seven-transmembrane receptor
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 5682-5686
-
-
Lu, Z.-L.1
Hulme, E.C.2
-
16
-
-
0028944574
-
Activating and inactivating mutations in N- and C-terminal i3 loop junctions of muscarinic acetylcholine Hm1 receptors
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7405-7410
-
-
Hogger, P.1
-
17
-
-
0035823524
-
1 muscarinic actylcholine receptor are critical for ligand binding and the receptor activation switch
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 34098-34104
-
-
Lu, Z.-L.1
-
19
-
-
0032879688
-
The functional microdomain in transmembrane helices 2 and 7 regulates expression, activation, and coupling pathways of the gonadotropin-releasing hormone receptor
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 28880-28886
-
-
Flanagan, C.A.1
-
20
-
-
0034464742
-
Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
-
(2001)
Endocr. Rev.
, vol.21
, pp. 90-113
-
-
Gether, U.1
-
23
-
-
0032756999
-
1 muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function
-
(1999)
Mol. Pharmacol.
, vol.56
, pp. 1031-1041
-
-
Ward, S.D.C.1
-
24
-
-
0033932599
-
1 muscarinic receptor that participate in binding the acetyl methyl group of acetylcholine
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 175-184
-
-
Allman, K.1
-
25
-
-
0033945117
-
3H]-scopolamine and acetylcholine at muscarinic receptor subtypes: Identification of a second allosteric site
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 194-207
-
-
Lazareno, S.1
-
26
-
-
0035902009
-
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
-
(2001)
Nature
, vol.411
, pp. 269-276
-
-
Brejc, K.1
-
28
-
-
0025881062
-
Three-dimensional models of neurotransmitter G-binding protein-coupled receptors
-
(1991)
Mol. Pharmacol.
, vol.40
, pp. 8-15
-
-
Hibert, M.1
-
29
-
-
0032504237
-
G protein-coupled receptors. I. Diversity of receptor-ligand interactions
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 17299-17302
-
-
Ji, T.H.1
-
31
-
-
0033522643
-
1B-adrenergic receptor is a key switch residue involved in activation and catecholamine ring aromatic bonding
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 16320-16330
-
-
Chen, S.1
-
32
-
-
0034634690
-
Genetic mapping of the human C5a receptor: Identification of transmembrane amino acids critical for receptor function
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35393-35401
-
-
Geva, A.1
-
33
-
-
0035793604
-
An activation switch in the ligand binding pocket of the C5a receptor
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3394-3400
-
-
Gerber, B.O.1
-
34
-
-
0028351937
-
Structure and function in rhodopsin: Replacement by alanine of cysteine residues 110 and 187, components of a conserved disulfide bond in rhodopsin, affects the light-activated metarhodopsin II state
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 4029-4033
-
-
Davidson, F.F.1
-
35
-
-
0025121206
-
Muscarinic acetylcholine receptors: Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 13702-13708
-
-
Kurtenbach, E.1
-
36
-
-
0026639831
-
Site-directed mutagenesis of the rat m1 muscarinic acetylcholine receptor: Role of conserved cysteines in receptor function
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 11439-11448
-
-
Savarese, T.M.1
-
37
-
-
0033011632
-
3 muscarinic acetylcholine receptor is necessary for proper receptor cell surface localization, but not for G protein coupling
-
(1999)
J. Neurochem.
, vol.72
, pp. 2404-2414
-
-
Zeng, F.-Y.1
-
38
-
-
0028815463
-
Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis
-
(1995)
Mol. Pharmacol.
, vol.47
, pp. 88-98
-
-
Matsui, H.1
-
39
-
-
0034705362
-
Evidence for a tandem two-site model of ligand binding to muscarinic acetylcholine receptors
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 18836-18844
-
-
Jakubik, J.1
-
40
-
-
0035064796
-
35S]thio-triphosphate binding through M1 muscarinic receptors in transfected chinese hamster ovary cell membranes: 1. Mathematical analysis of catalytic G protein activation
-
(2001)
Mol. Pharmacol.
, vol.59
, pp. 875-885
-
-
Waelbroeck, M.1
-
41
-
-
0035058763
-
1 muscarinic receptors in transfected chinese hamster ovary cell membranes: 2. Testing the 'two-states' model of receptor activation
-
(2001)
Mol. Pharmacol.
, vol.59
, pp. 886-893
-
-
Waelbroeck, M.1
-
42
-
-
0032770658
-
2-adrenergic receptor/Gs interaction: Evidence for multiple receptor conformations
-
(1999)
Mol. Pharmacol.
, vol.56
, pp. 348-358
-
-
Seifert, R.1
-
44
-
-
0034705612
-
Movement of retinal along the visual transduction path
-
(2000)
Science
, vol.288
, pp. 2209-2212
-
-
Borhan, B.1
-
46
-
-
0033944938
-
Partial agonism through a zinc-ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 263-270
-
-
Holst, B.1
-
47
-
-
0032474444
-
Constitutive activation of opsin by mutation of methionine 257 on transmembrane helix 6
-
(1998)
Biochemistry
, vol.37
, pp. 8253-8261
-
-
Han, M.1
-
48
-
-
0032555649
-
Identification of a ligand-dependent switch within a muscarinic receptor
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21563-21568
-
-
Spalding, T.A.1
-
49
-
-
0034465336
-
Constitutive activation of G protein-coupled receptors as a result of selective substitution of a conserved leucine residue in transmembrane helix III
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 1272-1282
-
-
Tao, Y.-X.1
-
50
-
-
0031872001
-
A proposed structure for transmembrane segment 7 of G protein-coupled receptor incorporating an Asn-Pro/Asp-Pro motif
-
(1998)
Biophys. J.
, vol.75
, pp. 601-611
-
-
Konvicka, K.1
-
51
-
-
0032983090
-
The conformational switch in 7-transmembrane receptors: The muscarinic receptor paradigm
-
(1999)
Eur. J. Pharmacol.
, vol.375
, pp. 247-260
-
-
Hulme, E.C.1
-
52
-
-
0031446595
-
Structure and function in rhodopsin: Rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 14273-14278
-
-
Kim, J.-M.1
-
54
-
-
0033061256
-
Mutation of a highly conserved aspartic acid in the β2 adrenergic receptor: Constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6
-
(1999)
Mol. Pharmacol.
, vol.56
, pp. 175-184
-
-
Rasmussen, S.G.F.1
-
56
-
-
0033555936
-
Conformational changes in rhodopsin: Movement of helix F detected by site-specific chemical labeling and fluorescence spectroscopy
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 1683-1690
-
-
Dunham, T.D.1
Farrens, D.L.2
-
57
-
-
0035937786
-
Agonist-induced conformational changes at the cytoplasmic side of TM6 in the β2 adrenergic receptor mapped by site-selective fluorescent labeling
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9279-9290
-
-
Jensen, A.D.1
-
58
-
-
0033546197
-
Similar structures and shared switch mechanisms of the β2-adrenoceptor and the parathyroid hormone receptor: Zn(II) bridges between helices III and VI block activation
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17033-17041
-
-
Sheikh, S.P.1
-
60
-
-
0033594988
-
Structural features and light-dependent changes in the sequence 306-322 extending from helix VII to the palmitoylation sites in rhodopsin: A site-directed spin-labeling study
-
(1999)
Biochemistry
, vol.38
, pp. 7931-7937
-
-
Altenbach, C.1
-
62
-
-
0033554396
-
State-dependent disulfide cross-linking in rhodopsin
-
(1999)
Biochemistry
, vol.38
, pp. 12028-12032
-
-
Yu, H.1
-
63
-
-
0029953103
-
Alanine scanning mutagenesis of conserved arginine/lysine-arginine/lysine-x-x-arginine/lysine G protein-activating motifs on m1 muscarinic acetylcholine receptors
-
(1996)
Mol. Pharmacol.
, vol.50
, pp. 140-148
-
-
Lee, N.H.1
-
64
-
-
0027328071
-
Charged amino acids required for signal transduction by the m3 muscarinic acetylcholine receptor
-
(1993)
EMBO J.
, vol.12
, pp. 3809-3815
-
-
Kunkel, M.T.1
Peralta, E.G.2
-
66
-
-
0027245830
-
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
-
(1993)
Nature
, vol.363
, pp. 274-276
-
-
Conklin, B.R.1
-
69
-
-
0033583051
-
Roles of the transducin α-subunit α4-helix/α4-β6 loop in the receptor and effector interactions
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7865-7869
-
-
Natochin, M.1
-
70
-
-
0035942238
-
Mapping of contact sites in complex formation between transducin and light-activated rhodopsin by covalent crosslinking: Use of a photoactivatable agent
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 4877-4882
-
-
Cai, K.1
-
71
-
-
0035942229
-
Mapping of contact sites in complex formation between transducin and light-activated rhodopsin by covalent crosslinking: Use of a chemically preactivated reagent
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 4883-4887
-
-
Itoh, Y.1
-
72
-
-
0026786080
-
Rhodopsin/transducin interactions: 1. Characterization of the binding of the transducin-βγ subunit complex to rhodopsin using fluorescence spectroscopy
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 17032-17039
-
-
Phillips, W.J.1
Cerione, R.A.2
-
73
-
-
0029664589
-
The 2.0 Å crystal structure of a heterotrimeric G protein
-
(1996)
Nature
, vol.379
, pp. 311-319
-
-
Lambright, D.G.1
-
75
-
-
0030851384
-
q is critical for constraining the selectivity of receptor coupling
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 19107-19110
-
-
Kostenis, E.1
-
76
-
-
0034695482
-
Mutation of the fourth cytoplasmic loop of rhodopsin affects binding of transducin and peptides derived from the carboxyl terminal sequences of transducin α and γ subunits
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 1937-1943
-
-
Ernst, O.P.1
-
77
-
-
0034695476
-
The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 1930-1936
-
-
Marin, E.P.1
-
78
-
-
0030064529
-
Receptor and membrane interaction sites on Gβ: A receptor-derived peptide binds to the carboxyl terminus
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 3336-3339
-
-
Taylor, J.M.1
-
79
-
-
0034708266
-
3-muscarinic receptor and their role in receptor regulation
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9026-9034
-
-
Wu, G.1
|