Discovery of novel peptide/receptor interactions: Identification of PHM-27 as a potent agonist of the human calcitonin receptor

Biochemical Pharmacology

Volumn 67, Issue 7, 2004, Pages 1279-1284

  Ma, Jian Nong ^a   Currier, Erika A ^a   Essex, Anthony ^a   Feddock, Michele ^a   Spalding, Tracy A ^a   Nash, Norman R ^a   Brann, Mark R ^a,b   Burstein, Ethan S ^a  

^a ACADIA PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Calcitonin; Corticotropin releasing factor; CRF; CT; G protein coupled receptor; GLP; Glucagon like peptide; GPCR; High throughput screen; Parathyroid hormone; PTH; R SAT; Receptor selection and amplification technology

Indexed keywords

CALCITONIN; CALCITONIN DERIVATIVE; CALCITONIN RECEPTOR; CALCITONIN RECEPTOR ANTAGONIST; CALCITONIN[8-32]; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CYCLIC AMP; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; PARATHYROID HORMONE RECEPTOR; PEPTIDE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASSAY; BINDING COMPETITION; CELL MEMBRANE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG RESPONSE; DRUG SELECTIVITY; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR UPREGULATION;

3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CELLS, CULTURED; CYCLIC AMP; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDE PHI; RECEPTORS, CALCITONIN;

EID: 1542375435     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2003.11.008     Document Type: Article

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