The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

Journal of Biological Chemistry

Volumn 278, Issue 13, 2003, Pages 11312-11319

  Brown, Andrew J ^a   Goldsworthy, Susan M ^b   Barnes, Ashley A ^a   Eilert, Michelle M ^b   Tcheang, Lili ^a,c   Daniels, Dion ^a   Muir, Alison I ^a   Wigglesworth, Mark J ^a   Kinghorn, Ian ^a   Fraser, Neil J ^a,d   Pike, Nicholas B ^a   Strum, Jay C ^b   Steplewski, Klaudia M ^b   Murdock, Paul R ^a   Holder, Julie C ^a   Marshall, Fiona H ^a,e   Szekeres, Philip G ^a   Wilson, Shelagh ^a   Ignar, Diane M ^b   Foord, Steve M ^a   Wise, Alan ^a   Dowell, Simon J ^a   more..

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d ASTRAZENECA   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BRAIN; CARBOXYLIC ACIDS; CELLS; NEGATIVE IONS; PROTEINS; TISSUE;

PROTEIN-COUPLED RECEPTORS;

BIOCHEMISTRY;

ACETIC ACID; ANION; BUTYRIC ACID; CARBOXYLIC ACID; FORMIC ACID; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MEMBRANE PROTEIN; POTASSIUM CHANNEL; PROPIONIC ACID; PROTEIN GIRK; PROTEIN GPR41; PROTEIN GPR43; SULFUR 35; UNCLASSIFIED DRUG; VALERIC ACID; CELL SURFACE RECEPTOR; FFAR3 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR 43, HUMAN; G-PROTEIN COUPLED RECEPTOR 43, HUMAN; PRIMER DNA; PROPIONIC ACID DERIVATIVE; RECOMBINANT PROTEIN;

ADIPOSE TISSUE; ANIMAL CELL; ARTICLE; BINDING ASSAY; CALCIUM MOBILIZATION; CONTROLLED STUDY; GENE DUPLICATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PSEUDOGENE; XENOPUS LAEVIS; AMINO ACID SEQUENCE; ANIMAL; DRUG EFFECT; DRUG POTENTIATION; IMMUNOHISTOCHEMISTRY; METABOLISM; MOLECULAR GENETICS;

ANIMALIA; MAMMALIA; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; CARBOXYLIC ACIDS; DNA PRIMERS; HUMANS; IMMUNOHISTOCHEMISTRY; MOLECULAR SEQUENCE DATA; PROPIONIC ACIDS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 0038363378     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211609200     Document Type: Article

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