Molecular identification of high and low affinity receptors for nicotinic acid

Journal of Biological Chemistry

Volumn 278, Issue 11, 2003, Pages 9869-9874

  Wise, Alan ^a   Foord, Steven M ^a   Fraser, Neil J ^a,c   Barnes, Ashley A ^a   Elshourbagy, Nabil ^b   Eilert, Michelle ^b   Ignar, Diane M ^b   Murdock, Paul R ^a   Steplewski, Klaudia ^a   Green, Andrew ^a   Brown, Andrew J ^a   Dowell, Simon J ^a   Szekeres, Philip G ^a   Hassalli, David G ^a   Marshall, Fiona H ^a,d   Wilson, Shelagh ^a   Pike, Nicholas B ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c LEXICON PHARMACEUTICALS INC   (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; LIPIDS; PROTEINS; TISSUE;

MOLECULAR IDENTIFICATION;

BIOCHEMISTRY;

G PROTEIN COUPLED RECEPTOR; HIGH DENSITY LIPOPROTEIN; NICOTINIC ACID; PROTEIN HM74; PROTEIN HM74A; UNCLASSIFIED DRUG; ACIFRAN; ACIPIMOX; ANTILIPEMIC AGENT; COMPLEMENTARY DNA; FURAN DERIVATIVE; MESSENGER RNA; NICOTINIC RECEPTOR; PYRAZINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOINFORMATICS; CARDIOVASCULAR RISK; DYSLIPIDEMIA; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; AMINO ACID SEQUENCE; ANIMAL; CELL MEMBRANE; CHEMISTRY; CHO CELL; DATA BASE; DOSE RESPONSE; FEMALE; HAMSTER; HYPERLIPIDEMIA; IC 50; MALE; METABOLISM; MOLECULAR GENETICS; OOCYTE; PROTEIN BINDING; RAT; SEQUENCE HOMOLOGY; TISSUE DISTRIBUTION; XENOPUS;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; ANTILIPEMIC AGENTS; CELL MEMBRANE; CHO CELLS; CRICETINAE; DATABASES; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FURANS; HUMANS; HYPERLIPIDEMIAS; INHIBITORY CONCENTRATION 50; MALE; MOLECULAR SEQUENCE DATA; NIACIN; OOCYTES; PROTEIN BINDING; PYRAZINES; RATS; RECEPTORS, NICOTINIC; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION; XENOPUS;

EID: 0003293442     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M210695200     Document Type: Article

References (23)

1. Tavintharan, S., and Kashyap, M. L. (2001) Curr. Atheroscler. Rep. 3, 74-82
2. Aktories, K., Schultz, G., and Jakobs, K. H. (1980) Arzneimittelforschung 33, 1525-1527
3. Aktories, K., Schultz, G., and Jakobs, K. H. (1983) FEBS Lett. 156, 88-92
4. Green, A., Milligan, G., and Dobias, S. B. (1992) J. Biol. Chem. 267, 3223-3229
5. Lorenzen, A., Stannek, C., Lang, H., Andrianov, V., Kalvinsh, I., and Schwabe, U. (2001) Mol. Pharmacol. 59, 349-357
6. Chapman, C. G., Meadows, H. J., Godden, R. J., Campbell, D. A., Duckworth, M., Kelsell, R. E., Murdock, P. R., Randall, A. D., Rennie, G. I., and Gloger, I. S. (2000) Mol. Brain Res. 82, 74-83
7. Wieland, T., and Jakobs, K. H. (1994) Methods Enzymol. 237, 3-13
8. Goldin, A. L. (1992) Methods Enzymol. 207, 266-279
9. Mumberg, D., Muller, R., and Funk, M. (1995) Gene (Amst.) 156, 119-122
10. Olesnicky, N. S., Brown, A. J., Dowell, S. J., and Casselton, L. A. (1999) EMBO J. 18, 2756-2763
11. Brown, A. J., Dyos, S. L., Whiteway, M. S., White, J. H. M., Watson, M.-A., Marzioch, M., Clare, J. J., Cousens, D. J., Paddon, C. J., Plumpton, C., Romanos, M. A., and Dowell, S. J. (2000) Yeast 16, 11-22
12. Lee, D. K., Nguyen, T., Lynch, K. R., Cheng, R., Vanti, W. B., Arkhitko, O., Lewis, T., Evans, J. F., George, S. R., and O'Dowd, B. F. (2001) Gene (Amst.) 275, 83-91
13. Uezono, Y., Bradley, J., Min, C., McCarty, N. A., Quick, M, Riordan, J. R., Chavkin, C., Zinn, K., Lester, H. A., and Davidson, N. (1993) Receptors Channels 1, 233-241
14. Lovisolo, P. P., Briatico-Vangosa, G., Orsini, G., Ronchi, R., and Angelucci, R. (1981) Pharmacol. Res. Commun. 13, 163-174
15. Crepaldi, G., Avogaro, P., Descovich, G. C., DiPerri, T., Postiglione, A., Sirtori, C. R., Strano, A., Ventura, S., and Musatti, L. (1988) Atherosclerosis 70, 115-121
16. Cayen, M. N., Kallai-Sanfacon, M. A., Dubec, J., Greselin, E., and Dvornik, D. (1982) Atherosclerosis 45, 267-279
17. Hunninghake, D. B., Edwards, D. G., Sopko, G. S., and Tosiello, R. L. (1985) Clin. Pharmacol. Ther. 38, 313-317
18. Nomura, H., Nielsen, B. W., and Matsushima, K. (1993) Int. Immunol. 5, 1239-1249
19. Schaub, A., Futterer, A., and Pfeffer, K. (2001) Eur. J. Immunol. 31, 3714-3725
20. Lorenzen, A., Stannek, C., Burmeister, A., Kalvinsh, I., and Schwabe, U. (2002) Biochem. Pharmacol. 64, 645-648
21. Stern, R. H., Spence, J. D., Freeman, D. J., and Parbtani, A. (1991) Clin. Pharmacol. Ther. 50, 66-70
22. Morrow, J. D., Awad, J. A., Oates, J. A., and Jackson-Roberts, L. (1992) J. Invest. Dermatol. 98, 812-815
23. Credner, K., Tauscher, M., Jozie, L., and Brenner, G. (1981) Arzneimittelforschung 31, 2096-2100