Promiscuous coupling at receptor-Gα fusion proteins: The receptor of one covalent complex interacts with the α-subunit of another

Journal of Biological Chemistry

Volumn 278, Issue 18, 2003, Pages 15778-15788

  Molinari, Paola ^a   Ambrosio, Caterina ^a   Riitano, Daniela ^a   Sbraccia, Maria ^a   Grò, Maria Cristina ^a   Costa, Tommaso ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; CHEMICAL ACTIVATION; CHEMICAL BONDS; MOLECULAR STRUCTURE;

FUSION PROTEINS; HEPTAHELICAL RECEPTORS;

PROTEINS;

BETA 2 ADRENERGIC RECEPTOR; DOPAMINE 1 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HYBRID PROTEIN; MUTANT PROTEIN; OPIATE RECEPTOR; POLYANION; RECEPTOR; DEXTRAN SULFATE; ENKEPHALIN[2 ALANINE 5 LEUCINE]; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; COVALENT BOND; EMBRYO; ENTROPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MEMBRANE BINDING; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; ANIMAL; CELL STRAIN COS1; CHEMISTRY; METABOLISM; PROTEIN SECONDARY STRUCTURE;

ANIMALIA;

ANIMALS; COS CELLS; DEXTRAN SULFATE; ENKEPHALIN, LEUCINE-2-ALANINE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, DOPAMINE D1; RECEPTORS, OPIOID; RECOMBINANT FUSION PROTEINS;

EID: 0038521270     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300731200     Document Type: Article

References (55)

1. Bertin, B., Freissmuth, M., Jockers, R., Strosberg, A. D., and Marullo, S. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 8827-8831
2. Seifert, R., Seifert-Wenzel, K., and Kobilka, B. K. (1999) Trends Pharmacol. Sci. 21, 383-389
3. Milligan, G. (2000) Trends Pharmacol. Sci. 21, 24-28
4. Wurch, T., and Pauwels, P. J. (2001) J. Pharmacol. Toxicol. Methods 45, 3-16
5. Wise, A. Carr, C., and Milligan, G. (1997) Biochem. J. 325, 17-21
6. Wenzel-Seifert, K., Lee, T. W., Seifert, R., and Kobilka, B. K. (1998) Biochem. J. 334, 519-524
7. Seifert, R., Lee, T. W., Lam, W. T., and Kobilka, B. K. (1998) Eur. J. Biochem. 255, 369-382
8. Seifert, R., Wenzel-Seifert, K., Lee, T. W., Gether, U., Sanders-Bush, E., and Kobilka, B. K. (1998) J. Biol. Chem. 273, 5109-5116
9. Waldhoer, M., Wise, A., Milligan, G., Freissmuth, M., and Nanoff, C. (1999) J. Biol. Chem. 274, 30571-30579
10. Wise, A., Sheehan, M., Rees, S., Lee, M., and Milligan, G. (1999) Biochemistry 38, 2272-2278
11. MacAllister, G., Stanton, J. A., Salim, K., Handford, E. J., and Beer, M. S. (2000) Mol. Pharmacol. 58, 407-412
12. Small, K. M., Forbes, S. L., Rahman, F. F., and Liggett, S. B. (2000) Biochemistry 39, 2815-2821
13. Medici, R., Bianchi, E., Di Segni, G., and Tocchini-Valentini, G. P. (1997) EMBO J 16, 7241-7249
14. Seifert-Wenzel, K., and Seifert, R. (2000) Mol. Pharmacol. 58, 954-966
15. Holst, B., Hastrup, H., Raffetseder, U., Martini, L., and Schwartz, T. W. (2001) J. Biol. Chem. 276, 19793-19799
16. Fong, C. W., and Milligan, G. (1999) Biochem. J. 342, 457-463
17. Wang, Y., Windh, R. T., Chen, C. A., and Manning, D. R. (1999) J. Biol. Chem. 274, 37435-37442
18. Ward, R. J., and Milligan, G. (1999) FEBS Letters 462, 459-463
19. Wenzel-Seifert, K., Arthur, J. M., Liu, H-Y., and Seifert, R. (1999) J. Biol. Chem. 274, 33259-33266
20. Pauwels, P. J., Wurch, T., Tardif, S., Finana, F., and Colpaert, F. C. (2001) Naunyn-Schmiedberg's Archiv Pharmacol. 363, 526-536
21. Burt, A. R., Sautel, M., Wilson, M. A., Rees, S., Wise, A., and Milligan, G. (1998) J. Biol. Chem. 273, 10367-10375
22. Guzzi, F., Zanchetta, D., Chini, B., and Parenti, M. (2001) Biochem. J. 355, 323-331
23. Scheer, A., Costa, T., Fanelli, F., De Benedetti, P. G., Mhaouty-Kodja, S., Abuin, L., Nenniger-Tosato, M., and Cotecchia, S. (2000) Mol. Pharmacol. 57, 219-231
24. Bahia, D. S., Wise, A., Fanelli, F., Lee M., Rees, S., and Milligan G. (1998) Biochemistry 37, 11555-11562
25. Kroll, S., Chen, J., De Vivo, M., Carty, D. J., Buku, A., Premont, R. T., and Iyenga, R. (1992) J. Biol. Chem. 267, 23183-23188
26. Yu, B., Slepak, V. Z., and Simon, M. I. (1997) J. Biol. Chem. 272, 18015-18019
27. Yu, B., and Simon, M. I. (1998) J. Biol. Chem. 273, 30183-30188
28. Vachon, L., Costa, T., and Herz, A. (1987) Mol. Pharmacol. 31, 159-168
29. Ambrosio, C., Molinari, P., Cotecchia, S., and Costa, T. (2000) Mol. Pharmacol. 57, 198-210
30. DeLean, A., Munson, P. J., and Rodbard, D. (1978) Am. J. Physiol. 235, E97-E102
31. Munson, P. J., and Rodbard, D. (1980) Anal. Biochem. 107, 220-239
32. Petäjä-Repo, U. E., Hogue, M., Laperrière, A., Bhalla, S., Walkers, P., and Bouvier, M. (2001) J. Biol. Chem. 276, 4416-4423
33. Abood, M. E., Herley, J. B., Pappone, M.-C., Bourne, H. R., and Stryer, L. (1982) J. Biol. Chem. 257, 10540-10543
34. Aksamit, R. R., Backlund, P. S. Jr., and Cantoni, G. L. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 7475-7479
35. Klinz, F.-J., and Costa, T. (1989) Biochem. Biophys. Res. Commun. 165, 554-560
36. Ogino, Y., Fraser, C. M., and Costa, T. (1992) Mol. Pharmacol. 42, 6-9
37. Kellett, E., Carr, C., and Milligan, G. (1999) Mol. Pharmacol 56, 684-692
38. Butler, S., Kelly, E. C. H., McKenzie, F., Guild, S., Wakelam, M. O., and Milligan, G. (1988) Biochem. J. 251, 201-205
39. Huang, R.-RC., Dehaven, R. N., Cheung, A. H., Diehl, R. E., Dixon, R. A. F., and Strader, C. D. (1990) Mol. Pharmacol. 37, 304-310
40. Freissmuth, M., Boehm, S., Beindl, W., Nickel, P., Ijzerman, A. P., Hohenegger, M., and Nanoff, C. (1996) Mol. Pharmacol. 49, 602-611
41. Fanelli, F., Menziani, C., Scheer, A., Cotecchia, S., and De Benedetti, P. G. (1999) Proteins 37, 145-156
42. Kisselev, O., Ermolaeva, M. V., and Gautam, N. (1994) J. Biol. Chem. 269, 21399-213402
43. Taylor, J. M., Jacob-Mosier, G. G., Lawton, R. G., Vandort, M., and Neubig, R. R. (1996) J. Biol. Chem. 271, 3336-3339
44. Yasuda, H., Lindorfer, M., Woodfork, K., Fletcher, J., and Garrison, J. (1996) J. Biol. Chem. 271, 18588-18595
45. Kisselev, O. G., Meyer, C. K., Heck, M., Ernst, O. P., and Hofman, K. P. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4898-4903
46. Hamm, H. E. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 4819-4821
47. Neubig, R. R. (1994) FASEB J. 8, 939-946
48. Rodbell, M. (1997) Adv. Enzyme Regul. 37, 427-435
49. Angers, S., Salahpour, A., and Bouvier, M. (2002) Annu. Rev. Pharmacol. Toxicol. 42, 409-435
50. Gomes, I., Jordan, B. A., Gupta, A., Trapaidze, N., and Devi, L. A. (2001) J. Mol. Med. 79, 226-242
51. Jordan, B. A., and Devi, L. A. (1999) Nature 399, 697-700
52. Angers, S., Salahpour, A., Joly, E., Hilairet, S., Chelsky, D., Dennis, M., and Bouvier, M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 3684-3689
53. Lee, T. W., Seifert, R., Guan, X., and Kobilka, B. K. (1999) Biochemistry 38, 13801-13809
54. Lisanti, M. P., Tang, Z., Scherer, P. E., Kubler, E., Koleske, A. J., and Sargiacomo, M. (1995) Mol. Membr. Biol. 12, 121-124
55. Wise, A., and Milligan, G. (1997) J. Biol. Chem. 272, 24673-24678