A transmembrane intracellular estrogen receptor mediates rapid cell signaling

Science

Volumn 307, Issue 5715, 2005, Pages 1625-1630

  Revankar, Chetana M ^a,b   Cimino, Daniel F ^a,b   Sklar, Larry A ^a,b   Arterburn, Jeffrey B ^c   Prossnitz, Eric R ^a,b  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c NEW MEXICO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BIOLOGICAL MEMBRANES; CELLS; DERIVATIVES; SIGNALING; TISSUE;

CLASSICAL NUCLEAR ESTROGEN; ESTROGEN RECEPTOR; NONGENOMIC SIGNALING; TRANSCRIPTIONAL ACTIVATION;

HORMONES;

ESTROGEN; ESTROGEN RECEPTOR ALPHA; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 30; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; UNCLASSIFIED DRUG;

CELLS AND CELL COMPONENTS; PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CELL COMMUNICATION; CELL NUCLEUS MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ESTROGEN BINDING; LIPOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTISENSE ELEMENTS (GENETICS); CALCIUM; CELL LINE; CELL LINE, TUMOR; CELL MEMBRANE; CELL NUCLEUS; ENDOPLASMIC RETICULUM; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; HUMANS; NUCLEAR ENVELOPE; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN TRANSPORT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

ANIMALIA;

EID: 14844343093     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1106943     Document Type: Article

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25. This work was supported by NIH grant AI36357 and a University of New Mexico Cancer Research and Treatment Center Translational Research Grant to E.R.P. and by NIH grant EB00264 to L.A.S. We thank S. Kamat for excellent technical assistance and K. Leslie for helpful discussions. Flow cytometry data and confocal images in this study were generated in the Flow Cytometry and Fluorescence Microscopy Facilities, respectively, at the University of New Mexico Health Sciences Center, which received support from NCRR 1 S10 RR14668, NSF MCB9982161, NCRR P20 RR11830, NCI R24 CA88339, the University of New Mexico Health Sciences Center, and the University of New Mexico Cancer Center.