Orphan G-protein-coupled receptors and natural ligand discovery

Trends in Pharmacological Sciences

Volumn 22, Issue 3, 2001, Pages 132-140

  Howard, Andrew D ^a   McAllister, George ^b   Feighner, Scott D ^a   Liu, Qingyun ^a   Nargund, Ravi P ^a   Van der Ploeg, Lex H T ^a   Patchett, Arthur A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LIGAND; MEMBRANE PROTEIN;

ARTICLE; CELL ACTIVATION; CELL MEMBRANE; CONTROLLED STUDY; HUMAN; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

EID: 0035283073     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01636-9     Document Type: Review

References (104)

1. Molecular tinkering of G protein-coupled receptors: An evolutionary success
2. Heptahelical receptor signaling: Beyond the G protein paradigm
3. Sequence alignment of the G-protein coupled receptor superfamily
4. Physiological regulation of G protein-linked signaling
5. Seven-transmembrane proteins as odorant and chemosensory receptors
6. Ghrelin: A step forward in the understanding of somatotroph cell function and growth regulation
7. Discovering new hormones, receptors, and signaling mediators in the genomic era
8. Orphan receptors, novel neuropeptides and reverse pharmaceutical research
9. The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors
10. Novel GPCRs and their endogenous ligands: Expanding the boundaries of physiology and pharmacology
11. Functional genomics: The search for novel neurotransmitters and neuropeptides
12. Orphan G-protein-coupled receptors: The next generation of drug targets?
13. Orphan G protein-coupled receptors: A neglected opportunity for pioneer drug discovery
14. Orphan G-protein coupled receptors: Novel targets for the pharmaceutical industry
15. RAMPs: Accessory proteins for seven transmembrane domain receptors
16. Direct protein-protein coupling enables cross-talk between dopamine D5 and GABA receptors
17. B receptors make it to the top - As dimers
18. G-protein-coupled receptor heterodimerization modulates receptor function
19. Edg3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from edg1 and agr16
20. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors edg3 and edg5
21. Sphingosine 1-phosphate signaling in mammalian cells
22. 3 receptor
23. Molecular cloning and characterization of novel type of histamine receptor preferentially expressed in leukocytes
24. 2 receptor with physiological constitutive activity
25. 1 adenosine receptor
26. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
27. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
28. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
29. Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
30. Hypocretin (orexin) deficiency in human narcolepsy
31. Current developments in G-protein-coupled receptors
32. Tools for investigating functional interactions between ligands and G-protein-coupled receptors
33. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor
34. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals
35. Differential coupling of G protein α subunits to seven-helix receptors expressed in Xenopus oocytes
36. Chimeric Gα proteins: Their potential use in drug discovery
37. i-coupled receptor
38. G16 as a universal G protein adapter: Implications for agonist screening strategies
39. Gα15 and Gα16 couple a wide variety of receptors to phospholipase C
40. A receptor in pituitary and hypothalamus that functions in growth hormone release
41. A cDNA encoding the calcitonin gene-related peptide type 1 receptor
42. RAMPS regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
43. Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product
44. The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1a receptor
45. Orphanin FQ: A neuropeptide that activates an opioid-like G protein-coupled receptor
46. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
47. Molecular cloning and characterization of the human anaphylatoxin C3a receptor
48. A prolactin-releasing peptide in the brain
49. Cloning and characterization of a new subtype of thyrotropin-releasing hormone receptors
50. Cloning and characterization of a cDNA encoding a novel subtype of rat thyrotropin-releasing hormone receptor
51. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor
52. 1 receptor
53. 2) receptor
54. A novel hepatointestinal leukotriene B4 receptor: Cloning and functional characterization
55. Receptor for motilin identified in the human gastrointestinal system
56. Molecular characterization of the melanin-concentrating-hormone receptor
57. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1
58. Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor
59. Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1)
60. The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor
61. Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14
62. Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GPR14)
63. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
64. Identification of the natural ligand of an orphan G protein-coupled receptor involved in the regulation of vasoconstriction
65. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor edg-1
66. Characterization of a novel sphingosine 1-phosphate receptor, edg-8
67. Molecular cloning and characterization of a lysophosphatidic acid receptor, edg-7, expressed in prostate
68. A single receptor encoded by vzg-1/lpa1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid
69. Molecular cloning and characterization of another leukotriene B4 receptor
70. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
71. Reverse physiology in Drosophila: Identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family
72. Molecular cloning and genomic organization of a second probable allatostatin receptor from Drosophila melanogaster
73. Cutting edge: Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine eskine
74. A G protein-coupled receptor for UDP-glucose
75. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1
76. Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3
77. Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system
78. Identification of receptors for neuromedin U and its role in feeding
79. Identification and functional characterization of a novel subtype of neuromedin U receptor
80. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3
81. Identification of a novel neuromedin U receptor subtype expressed in the central nervous system
82. Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U
83. Receptor for the pain modulatory neuropeptides NPFF and NPAF is an orphan G-protein-coupled receptor
84. Identification and characterization of two G protein-coupled receptors for neuropeptide FF
85. Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction
86. The hypocretin/orexin story
87. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
88. Growth hormone-releasing peptide (GHRP)
89. Design and biological activities of L-163,191 (MK-0677): A potent, orally active growth hormone secretagogue
90. Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors
91. Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors
92. Peptidomimetic regulation of growth hormone secretion
93. Methods for drug discovery: Development of potent, selective, orally effective cholecystokinin antagonists
94. Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2
95. A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization
96. Spiropiperidine derivatives as melanocortin receptor agonists
97. New 4-point pharmacophore method for molecular similarity and diversity applications: Overview of the method and applications, including a novel approach to the design of combinatorial libraries containing privileged substructures
98. Identification of a new G protein-linked receptor for growth hormone secretagogues
99. Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from puffer fish to humans
100. Motilin homologs
101. Identification and characterization of a novel gastric peptide hormone: The motilin-related peptide
102. Purification and characterization of rat des-gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor
103. Adenosine is an agonist of the growth hormone secretagogue receptor
104. Adenosine: A partial agonist of the growth hormone secretagogue receptor