Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14

Nature

Volumn 401, Issue 6750, 1999, Pages 282-286

  Ames, Robert S ^a   Sarau, Henry M ^a   Chambers, Jonathan K ^a   Willette, Robert N ^a   Alyar, Nambl V ^a   Romanic, Anne M ^a   Louden, Calvert S ^a   Foley, James J ^a   Sauermelch, Charles F ^a   Coatney, Robert W ^a   Ao, Zhaohul ^a   Disa, Jyoti ^a   Holmes, Stephen D ^a   Stadel, Jeffrey M ^a   Martin, John D ^a   Liu, Wu Schyong ^a   Glover, George I ^a   Wilson, Shelagh ^a   McNulty, Dean E ^a   Ellis, Catherine E ^a   Elshourbagy, Nabil A ^a   Shabon, Usman ^a   Trill, John J ^a,b   Hay, Douglas W P ^a   Ohlstein, Eliot H ^a   Bergsma, Derk J ^a   Douglas, Stephen A ^a   more..

^a GLAXOSMITHKLINE   (United Kingdom)

^b NONE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; RECEPTOR; UROTENSIN II;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CALCIUM MOBILIZATION; CONTROLLED STUDY; HEART HEMODYNAMICS; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SHOCK; VASOCONSTRICTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CALCIUM; CELL LINE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; GTP-BINDING PROTEINS; HUMANS; MACACA FASCICULARIS; MALE; MOLECULAR SEQUENCE DATA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION; UROTENSINS; VASOCONSTRICTOR AGENTS;

ANIMALIA; CALLOGOBIUS ATRATUS; MAMMALIA; PRIMATES;

EID: 0033575930     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/45809     Document Type: Article

References (19)

1. Bern, H. A., Pearson, D., Larson, B. A. & Nishioka, R. S. Neurohormones from fish tails: the caudal neurosecretory system. I. "Urophysiology" and the caudal neurosecretory system of fishes. Recent Prog. Horm. Res. 41, 533-552 (1985).
2. Conlon, J. M., Yano, K., Waugh, D. & Hazon, N. Distribution and molecular forms of urotensin II and its role in cardiovascular regulation in vertebrates. J. Exp. Zool. 275, 226-238 (1996).
3. Coulouarn, Y. et al. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. Proc. Natl Acad. Sci. USA 95, 15803-15808 (1998).
4. Marchese, A. et al. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. Genomics 29, 335-344 (1995).
5. Tal, M. et al. A novel putative neuropeptide receptor expressed in neural tissue, including sensory epithelia. Biochem. Biophys. Res. Commun. 209, 752-759 (1995).
6. Stadel, J. M., Wilson, S. & Bergsma, D. J. Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery. Trends Pharmacol. Sci. 18, 430-437 (1997).
7. Libert, F., Vassart, G. & Parmentier, M. Current developments in G-protein-coupled receptors. Curr. Opin. Cell Biol. 3, 218-223 (1991).
8. O'Dowd, B. F. et al. The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. Genomics 28, 84-91 (1995).
9. Ohsako, S., Ishida, I., Ichikawa, T. & Deguchi, T. Cloning and sequence analysis of cDNAs encoding precursors of urotensin II-alpha and -gamma. J. Neurosci. 6, 2730-2735 (1986).
10. Itoh, H., McMaster, D. & Lederis, K. Functional receptors for fish neuropeptide urotensin II in major rat arteries. Eur. J. Pharmacol. 149, 61-66 (1988).
11. Pearson, D. et al. Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes. Proc. Natl Acad. Sci. USA 77, 5021-5024 (1980).
12. Gibson, A., Wallace, P. & Bern, H. A. Cardiovascular effects of urotensin II in anesthetized and pithed rats. Gen. Camp. Endocrinol. 64, 435-439 (1986).
13. Hasegawa, J., Kobayashi, Y. & Kobayashi, H. Vasodepressor effects of urotensin II in rats. Neuroendocrinol. Lett. 14, 357-363 (1992).
14. Yanagisawa, M. et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332, 411-415 (1988).
15. Aiyar, N. et al. Human AT1 receptor is a single copy gene: characterization in a stable cell line. Mol. Cell Biochem. 131, 75-86 (1994).
16. King, D. S., Fields, C. G. & Fields, G. B. A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis. Int. J. Pept. Protein Res. 36, 255-266 (1990).
17. Chambers, J. et al. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature 400, 261-265 (1999).
18. Elshourbagy, N. A. et al. Molecular cloning and characterization of the porcine calcitonin gene-related peptide receptor. Endocrinology 139, 1678-1683 (1998).
19. Douglas, S. A. & Hiley, C. R. Endothelium-dependent mesenteric vasorelaxant effects and systemic actions of endothelin (16-21) and other endothelin-related peptides in the rat. Br. J. Pharmacol. 104, 311-320 (1991).