Proton-sensing G-protein-coupled receptors

Nature

Volumn 425, Issue 6953, 2003, Pages 93-98

  Ludwig, Marie Gabrielle ^a   Vanek, Miroslava ^a   Guerini, Danllo ^a   Gasser, Jürg A ^a   Jones, Carol E ^b   Junker, Uwe ^a   Hofstetter, Hans ^a   Wolf, Romain M ^a   Seuwen, Klaus ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NOVARTIS HORSHAM RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELLS; IMMUNOLOGY; MUTAGENESIS; PH; RESPIRATORY MECHANICS; TISSUE;

RENAL ACID;

PROTEINS;

BUFFER; CARBACHOL; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 4; HISTIDINE; INOSITOL PHOSPHATE; LITHIUM; PERTUSSIS TOXIN; PROTON; SPHINGOSYLPHOSPHORYLCHOLINE; THROMBIN; UNCLASSIFIED DRUG;

BIOLOGY; BLOOD; PH;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD PH; CONTROLLED STUDY; EXTRACELLULAR SPACE; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOCYTE; OSTEOSARCOMA; OSTEOSARCOMA CELL; OVARY CANCER; PRECURSOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SITE DIRECTED MUTAGENESIS; SKELETON; TISSUE SECTION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CRICETINAE; CYCLIC AMP; HETEROTRIMERIC GTP-BINDING PROTEINS; HISTIDINE; HOMEOSTASIS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOHISTOCHEMISTRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OSTEOBLASTS; OSTEOSARCOMA; PHOSPHATIDYLINOSITOLS; PROTEIN CONFORMATION; PROTONS; RATS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; SECOND MESSENGER SYSTEMS;

ANIMALIA; FALLOPIA;

EID: 0042322842     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01905     Document Type: Article

References (29)

1. Feldman, J. L., Mitchell, G. S. & Nattie, E. E. Breathing: rhythmicity, plasticity, chemosensitivity Annu. Rev. Neurosci. 26, 239-266 (2003).
2. Swenson, E. R. Metabolic acidosis. Respir. Care 46, 342-353 (2001).
3. Xu, Y. et al. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. Nature Cell Biol. 2, 261-267 (2000).
4. Krieger, N. S., Parker, W. R., Alexander, K. M. & Bushinsky, D. A. Prostaglandins regulate acid-induced cell-mediated bone resorption. Am. J. Physiol. Renal Physiol. 279, F1077-F1082 (2000).
5. Berridge, M. J., Downes, C. P. & Hanley, M. R. Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem. J. 206, 587-595 (1982).
6. Berridge, M. J. & Irvine, R. F. Inositol phosphates and cell signalling. Nature 341, 197-205 (1989).
7. + exchange in hamster fibroblasts. EMBO 1 J. 5, 55-60 (1986).
8. Simon, M. I., Strathmann, M.P. & Gautam, N. Diversity of G proteins in signal transduction. Science 252, 802-808 (1991).
9. Smith, G. D. et al. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418, 186-190 (2002).
10. Elling, C. E., Nielsen, S. M. & Schwartz, T. W. Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor. Nature 374, 74-77 (1995).
11. Sheikh, S. P., Zvyaga, T. A., Lichtarge, O., Sakmar, T. P. & Bourne, H. R. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature 383, 347-350 (1996).
12. Zhu, K. et al. Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. J. Biol. Chem. 276, 41325-41335 (2001).
13. Brechter, A. B. & Lerner, U. H. Characterization of bradykinin receptors in a human osteoblastic cell line. Regul. Pept. 103, 39-51 (2002).
14. Bushinsky, D. A. Acid-base imbalance and the skeleton. Eur. J. Nutr. 40, 238-244 (2001).
15. + stimulation of cell-mediated bone resorption in tissue culture. Am. J. Physiol. 253, E90-E98 (1987).
16. Meghji, S., Morrison, M. S., Henderson, B. & Arnett, T. R. pH dependence of bone resorption: Mouse calvarial osteoclasts are activated by acidosis. Am. J. Physiol. Endocrinol. Metab. 280, E112-E119 (2001).
17. Gijon, M. A. & Leslie, C. C. Regulation of arachidonic acid release and cytosolic phospholipase A2 activation. J. Leucoc. Biol. 65, 330-336 (1999).
18. +-gated cation channels. Ann. NY Acad. Sci. 868, 67-76 (1999).
19. Caterina, M. J. et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306-313 (2000).
20. An, S., Tsai, C. & Goetzl, E. J. Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue. FEBS Lett. 375, 121-124 (1995).
21. Ishizaka, H., Gudi, S. R., Frangos, J. A. & Kuo, L. Coronary arterior dilation to acidosis: role of ATP-sensitive potassium channels and pertussis toxin-sensitive G proteins. Circulation 99, 558-563 (1999).
22. Reeh, P. W. & Steen, K. H. Tissue acidosis in nociception and pain. Prog. Brain Res. 113, 143-151 (1996).
23. Heming, T. A. et al. Effects of extracellular pH on tumour necrosis factor-α production by resident alveolar macrophages. Clin. Sci. (Lond.) 101, 267-274 (2001).
24. Sottile, V., Halleux, C., Bassilana, F., Keller, H. & Seuwen, K. Stem cell characteristics of human trabecular bone-derived cells. Bone 30, 699-704 (2002).
25. Seuwen, K., Lagarde, A. & Pouyssegur, J. Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C. EMBO J. 7, 161-168 (1988).
26. Salomon, Y. Adenylate cyclase assay. Adv. Cycl. Nucleot. Res. 10, 35-55 (1979).
27. Palczewski, K. et al. Crystal structure of rhodopsin: A G protein-coupled receptor. Science 289, 739-745 (2000).
28. Bower, M. I., Cohen, F. E. & Dunbrack, R. L. Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: A new homology modeling tool. J. Mol. Biol. 267, 1268-1282 (1997).
29. Cornell, W. D. et al. A second generation force field for the simulation of proteins, nucleic acids, and organic molecules. J. Am. Chem. Soc. 117, 5179-5197 (1995).