Regulation of G protein-coupled receptor kinases

Trends in Cardiovascular Medicine

Volumn 10, Issue 2, 2000, Pages 81-89

  Penn, Raymond B ^a   Pronin, Alexey N ^a   Benovic, Jeffrey L ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; CALCIUM BINDING PROTEIN; CAVEOLIN; G PROTEIN COUPLED RECEPTOR; ISOENZYME; PHOSPHOTRANSFERASE; RHODOPSIN KINASE;

CELLULAR DISTRIBUTION; ENZYME ACTIVITY; ENZYME STRUCTURE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HEART FAILURE; HEART MUSCLE CONTRACTILITY; HUMAN; HYPERTENSION; MEMBRANE BINDING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CATALYSIS; GTP-BINDING PROTEINS; HEART DISEASES; HUMANS; HYPERTENSION; PHOSPHOTRANSFERASES; PROTEIN BINDING; RECEPTORS, CELL SURFACE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034535304     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(00)00053-0     Document Type: Review

References (52)

1. Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase
2. Mutational analysis of Gβγ and phospholipid interaction with G protein-coupled receptor kinase 2
3. Regulation of G protein-coupled receptor kinases by caveolin
4. Selective regulation of Gq/11alpha by an RGS domain in the G protein-coupled receptor kinase GRK2
5. Binding and phosphorylation of tubulin by G protein-coupled receptor kinases
6. β-adrenergic receptor kinase; agonist-dependent receptor binding promotes kinase activation
7. Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine
8. Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase
9. Phosphorylation and activation of β-adrenergic receptor kinase by protein kinase C
10. +/calmodulin
11. Lipid-mediated regulation of G protein-coupled receptor kinases 2 and 3
12. Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor
13. Assessment of the beta-adrenergic receptor pathway in the intact failing human heart; progressive receptor down-regulation and subsensitivity to agonist response
14. Mechanistic studies on the phosphorylation of photoexcited rhodopsin
15. Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin
16. G-protein-coupled receptor kinase activity is increased in hypertension
17. G-protein-coupled receptor kinase activity in hypertension; increased vascular and lymphocyte G-protein receptor kinase-2 protein expression
18. G-protein-coupled receptor kinase expression in hypertension
19. Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
20. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic re-ceptor stimulation and blockade
21. Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
22. Rhodopsin phosphorylation as a mechanism of cyclic GMP phosphodiesterase regulation by S-modulin
23. Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice
24. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor
25. 2+-binding proteins on G protein-coupled receptor kinases
26. Molecular beta-adrenergic signaling abnormalities in failing rabbit hearts after infarction
27. 2-adrenergic receptor
28. Caveolins, a family of scaffolding proteins for organizing 'preassembled signaling complexes' at the plasma membrane
29. The β-adrenergic receptor kinase (GRK2) is regulated by phospholipids
30. Mechanism of rhodopsin kinase activation
31. Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin
32. Structure of the human gene encoding the β-adrenergic receptor kinase
33. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure
34. Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity
35. G protein-coupled receptor kinases
36. The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin
37. Role of βγ subunits of G proteins in targeting the β-adrenergic receptor kinase to membrane-bound receptors
38. Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases
39. Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C
40. Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation
41. Regulation of G protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain
42. Synucleins are a novel class of substrates for G protein-coupled receptor kinases
43. Analysis of human G protein-coupled receptor kinase 2 (GRK2) gene promoter. Regulation of signal transduction system in vascular smooth muscle
44. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
45. Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice
46. Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice
47. Agonist-dependent phosphorylation of the G protein-coupled receptor kinase2 (GRK2) by Src tyrosine kinase
48. Enhanced GRK5 expression in the hearts of cardiomyopathic hamsters, J2N-k
49. Altered expression of the β-adrenergic receptor kinase and β1-adrenergic receptors in failing human heart
50. Activation of beta-adrenergic receptor kinase during myocardial ischemia
51. Protein kinase cross-talk; membrane targeting of the beta-adrenergic receptor kinase by protein kinase C