Herbal Modulation of P-Glycoprotein

Drug Metabolism Reviews

Volumn 36, Issue 1, 2004, Pages 57-104

  Zhou, Shufeng ^a   Lim, Lee Yong ^a   Chowbay, Balram ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b DIVISION OF MEDICAL ONCOLOGY   (Singapore)

Author keywords

Drug interactions; Grapefruit juice; Herb; P glycoprotein; St. John's wort

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CRATAEGUS EXTRACT; CURCUMIN; CYCLOSPORIN; CYTOCHROME P450; CYTOCHROME P450 3A4; DIGOXIN; DOXORUBICIN; FEXOFENADINE; FLAVONOL; GINSENOSIDE; GLYCOPROTEIN P; HERBACEOUS AGENT; HYPERFORIN; HYPERICIN; HYPERICUM PERFORATUM EXTRACT; INDINAVIR; MULTIDRUG RESISTANCE PROTEIN 1; ORAL CONTRACEPTIVE AGENT; PHENYTOIN; PIPERINE; PLANT EXTRACT; POLYPHENOL; QUERCETIN; RIFAMPICIN; RITONAVIR; SAQUINAVIR; TACROLIMUS; UNINDEXED DRUG; VINBLASTINE;

AREA UNDER THE CURVE; BINDING SITE; CRATAEGUS; DOSE TIME EFFECT RELATION; DRUG TRANSPORT; ENZYME ASSAY; FOOD DRUG INTERACTION; GARLIC; GENE; GINSENG; GRAPEFRUIT; HERB; HERB DRUG INTERACTION; HERBAL MEDICINE; HUMAN; HYPERICUM PERFORATUM; MDR 1 GENE; NONHUMAN; RED WINE; REVIEW; RHIZOME; ROSEMARY; SILYBUM MARIANUM; TEA; WOODY STEM; XENOBIOTIC METABOLISM;

ANIMALS; HERB-DRUG INTERACTIONS; HUMANS; P-GLYCOPROTEIN; PHYTOTHERAPY; PLANTS, MEDICINAL;

EID: 1642360726     PISSN: 03602532     EISSN: None     Source Type: Journal    
DOI: 10.1081/DMR-120028427     Document Type: Review

References (336)

1. Aggarwal, B. B., Kumar, A., Bharti, A. C. (2003). Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 23:363-398.
2. Amagase, H., Petesch, B. L., Matsuura, H., Kasuga, S., Itakura, Y. (2001). Intake of garlic and its bioactive components. J. Nutr. 131:955S-962S.
3. Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ramachandra, M., Pastan, I., Gottesman, M. M. (1999). Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu. Rev. Pharmacol. Toxicol. 39:361-398.
4. Ammon, H. P. T., Wahl, M. A. (1991). Pharmacology of Curcuma longa. Planta Med. 57:1-7.
5. Anuchapreeda, S., Leechanachai, P., Smith, M. M., Ambudkar, S. V., Limtrakul, P. N. (2002). Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Biochem. Pharmacol. 64:573-582.
6. Ayrton, A., Morgan, P. (2001). Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica 31:469-497.
7. Baba, S., Osakabe, N., Yasuda, A., Natsume, M., Takizawa, T., Nakamura, T., Terao, J. (2000). Bioavailability of (-)-epicatechin upon intake of chocolate and Cocoa in human volunteers. Free Radic. Res. 33:635-641.
8. Babu, P. S., Srinivasan, K. (1997). Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Mol. Cell. Biochem. 166:169-175.
9. Badmaev, V. V., Majeed, M., Prakash, L. (2000). Piperine derived from black pepper increases the plasma levels of coenzyme q10 following oral supplementation. J. Nutr. Biochem 11:109-113.
10. Bae, E. A., Han, M. J., Choo, M. K., Park, S. Y., Kim, D. H. (2002). Metabolism of 20(S)- and 20(R)-ginsenoside R-g3 by human intestinal bacteria and its relation to in vitro biological activities. Biol. Pharm. Bull. 25:58-63.
11. Bahorun, T., Gressier, B., Trotin, F., Brunet, C., Dine, T., Luyckx, M., Vasseur, J., Cazin, M., Cazin, J. C., Pinkas, M. (1996). Oxygen species scavenging activity of phenolic extracts from hawthorn fresh plant organs and pharmaceutical preparations. Arzneimittel-Forschung 46:1086-1089.
12. Bai, Y. F., Xu, H. (2000). Protective action of piperine against experimental gastric ulcer. Zhongguo Yaoli Xuebao - Acta Pharmacologica Sinica 21:357-359.
13. Bailey, D. G., Spence, J. D., Munoz, C., Arnold, J. M. O. (1991). Interaction of citrus juices with felodipine and nifedipine. Lancet 337:268-269.
14. Bailey, D. G., Arnold, J. M. O., Munoz, C., Spence, J. D. (1993). Grapefruit juice-felodipine interaction: mechanism, predictability, and effect of naringin. Clin. Pharmacol. Ther. 53:637-642.
15. Bailey, D. G., Arnold, J. M. O., Bend, J. R., Tran, L. T., Spence, J. D. (1995). Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation. Br. J. Clin. Pharmacol. 40:135-140.
16. Bailey, D. G., Bend, J. R., Arnold, J. M. O., Tran, L. T., Spence, J. D. (1996). Erythromycin-felodipine interaction: magnitude, mechanism, and comparison with grapefruit juice. Clin. Pharmacol. Ther. 60:25-33.
17. Bailey, D. G., Malcolm, J., Arnold, O., Spence, J. D. (1998). Grapefruit juice-drug interactions. Br. J. Clin. Pharmacol. 46:101-110.
18. Bailey, D. G., Dresser, G. R., Kreeft, J. H., Munoz, C., Freeman, D. J., Bend, J. R. (2000). Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. Clin. Pharmacol. Ther. 68:468-477.
19. Bailey, D. G., Dresser, G. K., Bend, J. R. (2003). Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3a4 activity: comparison with grapefruit juice. Clin. Pharmacol. Ther. 73:529-537.
20. Bajad, S., Bedi, K. L., Singla, A. K., Johri, R. K. (2001a). Antidiarrhoeal activity of piperine in mice. Planta Med. 67:284-287.
21. Bajad, S., Bedi, K. L., Singla, A. K., Johri, R. K. (2001b). Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice. Planta Med. 67:176-179.
22. Bajpai, M., Roskos, L. K., Shen, D. D., Levy, R. H. (1996). Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite. Drug Metab. Dispos. 24:1401-1414.
23. Balentine, D. A., Wiseman, S. A., Bouwens, L. C. (1997). The chemistry of tea flavonoids. Crit. Rev. Food Sci. Nutr. 37:693-704.
24. Banfield, C., Gupta, S., Marino, M., Lim, J., Affrime, M. (2002). Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine. Clin. Pharmacokinet. 41:311-318.
25. Bano, G., Amla, V., Raina, R. K., Zutshi, U., Chopra, C. L. (1987). The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med. 53:568-569.
26. Bardelmeijer, H. A., Beijnen, J. H., Brouwer, K. R., Rosing, H., Nooijen, W. J., Schellens, J. H., van Tellingen, O. (2000). Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein. Clin. Cancer Res. 6:4416-4421.
27. Bames, J., Anderson, L. A., Phillipson, J. D. (2001). St. John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J. Pharm. Pharmacol. 53:583-600.
28. Barone, G. W., Gurley, B. J., Ketel, B. L., Lightfoot, M. L., Abul-Ezz, S. R. (2000). Drug interaction between St. John's wort and cyclosporine. Ann. Pharmacother. 34:1013-1016.
29. Barreto, J., Wallace, S., Carrier, D., Clausen, E. (2003). Extraction of nutraceuticals from milk thistle: I. Hot water extraction. Appl. Biochem. Biotechnol. 108:881-890.
30. Bauer, S., Stormer, E., Johne, A., Kruger, H., Budde, K., Neumayer, H. H., Roots, I., Mai, I. (2003). Alterations in cyclosporin A pharmacokinetics and metabolism during treatment with St. John's wort in renal transplant patients. Br. J. Clin. Pharmacol. 55:203-211.
31. Beckmann-Knopp, S., Rietbrock, S., Weyhenmeyer, R., Bocker, R. H., Beckurts, K. T., Lang, W., Hunz, M., Fuhr, U. (2000). Inhibitory effects of silibinin on cytochrome P-450 enzymes in human liver microsomes. Pharmacol. Toxicol. 86:250-256.
32. Becquemont, L., Verstuyft, C., Kerb, R., Brinkmann, U., Lebot, M., Jaillon, P., Funck-Brentano, C. (2001). Effect of grapefruit juice on digoxin pharmacokinetics in humans. Clin. Pharmacol. Ther. 70:311-316.
33. Benton, R. E., Honig, P. K., Zamani, K., Cantilena, L. R., Woosley, R. L. (1996). Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram. Clin. Pharmacol. Ther. 59:383-388.
34. Bertilsson, G., Heidrich, J., Svensson, K., Osman, M., Jendeberg, L., Sydow-Bäckman, M., Ohlsson, R., Postlind, H., Blomquist, P., Berkenstam, A. (1998). Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc. Natl. Acad. Sci. U. S. A. 95:12208-12213.
35. Bhardwaj, R. K., Glaeser, H., Becquemont, L., Klotz, U., Gupta, S. K., Fromm, M. F. (2002). Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J. Pharmacol. Exp. Ther. 302:645-650.
36. Biber, A., Fischer, H., Romer, A., Chatterjee, S. S. (1998). Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers. Pharmacopsychiatry 31:36-43.
37. Bilia, A. R., Gallori, S., Vincieri, F. F. (2002). St. John's wort and depression: efficacy, safety and tolerability-an update. Life Sci. 70:3077-3096.
38. Bistrup, C., Nielsen, F. T., Jeppesen, U. E., Dieperink, H. (2001). Effect of grapefruit juice on Sandimmun Neoral absorption among stable renal allograft recipients. Nephrol. Dial. Transplant. 16:373-377.
39. Bodo, A., Bakos, E., Szeri, F., Varadi, A., Sarkadi, B. (2003). The role of multidrug transporters in drug availability, metabolism and toxicity. Toxicol. Lett. 140-141:133-143.
40. Borek, C. (2001). Antioxidant health effects of aged garlic extract. J. Nutr. 131:1010S-1015S.
41. Borst, P., Elferink, R. O. (2002). Mammalian ABC transporters in health and disease. Ann. Rev. Biochem. 71:537-592.
42. Borst, P., Evers, R., Kool, M., Wijnholds, J. (1999). The multidrug resistance protein family. Biochim. Biophys. Acta 1461:347-357.
43. Borst, P., Evers, R., Kool, M., Wijnholds, J. (2000). A family of drug transporters: the multidrug resistance-associated proteins. J. Natl. Cancer Inst. 92:1295-1302.
44. Boumendjel, A., Di Pietro, A., Dumontet, C., Barron, D. (2002). Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance. Med. Res. Rev. 22:512-529.
45. Brace, L. D. (2002). Cardiovascular benefits of garlic (Allium sativum L). J. Cardiovasc. Nurs. 16:33-49.
46. Breidenbach, T., Kliem, V., Burg, M., Radermacher, J., Hoffmann, M. W., Klempnauer, J. (2000). Profound drop of cyclosporin A whole blood trough levels caused by St. John's wort (Hypericum perforatum). Transplantation 69:2229-2230.
47. Brenner, R., Azbel, V., Madhusoodanan, S., Pawlowska, M. (2000). Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: a double-blind, randomized pilot study. Clin. Ther. 22:411-419.
48. Brown, M. D. (1999). Green tea (Camellia sinensis) extract and its possible role in the prevention of cancer. Altern. Med. Rev. 4:360-370.
49. Burstein, A. H., Horton, R. L., Dunn, T., Alfaro, R. M., Piscitelli, S. C., Theodore, W. (2000). Lack of effect of St. John's wort on carbamazepine pharmacokinetics in healthy volunteers. Clin. Pharmacol. Ther. 68:605-612.
50. Callen, D. F., Baker, E., Simmers, R. N., Seshadri, R., Roninson, I. B. (1987). Localization of the human multiple drug resistance gene, MDR1, to 7q21.1. Hum. Genet. 77:142-144.
51. Carini, R., Comoglio, A., Albano, E., Poli, G. (1992). Lipid peroxidation and irreversible damage in the rat hepatocyte model. Protection by the silybin-phospholipid complex IdB 1016. Biochem. Pharmacol. 43:2111-2115.
52. Chainani-Wu, N. (2003). Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J. Altern. Complement. Med. 9:161-168.
53. Chang, Q., Zhu, M., Zuo, Z., Chow, M., Ho, W. K. (2001). High-performance liquid chromatographic method for simultaneous determination of hawthorn active components in rat plasma. J. Chromatogr., B, Biomed. Sci. Appl. 760:227-235.
54. Chang, Q., Zuo, Z., Harrison, F., Chow, M. S. (2002). Hawthorn. J. Clin. Pharmacol. 42:605-612.
55. Chen, C.-J., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., Roninson, I. B. (1996). Internal duplication and homology with bacterial transport proteins in mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47:381-389.
56. Chen, L., Lee, M. J., Li, H., Yang, C. S. (1997). Absorption, distribution, elimination of tea polyphenols in rats. Drug Metab. Dispos. 25:1045-1050.
57. Chen, Z. Y., Zhang, Z. S., Kwan, K. Y., Zhu, M., Ho, W. K. K., Huang, Y. (1998). Endothelium-dependent relaxation induced by hawthorn extract in rat mesenteric artery. Life Sci. 63:1983-1991.
58. Cheng, A. L., Hsu, C. H., Lin, J. K., Hsu, M. M., Ho, Y. F., Shen, T. S., Ko, J. Y., Lin, J. T., Lin, B. R., Ming-Shiang, W., Yu, H. S., Jee, S. H., Chen, G. S., Chen, T. M., Chen, C. A., Lai, M. K., Pu, Y. S., Pan, M. H., Wang, Y. J., Tsai, C. C., Hsieh, C. Y. (2001). Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 21:2895-2900.
59. Chi, J. G. (2001). Cancer chemoprevention of INSAM (Ginseng)-Foreword. J. Korean Med. Sci. 16:S1.
60. Choi, C. H., Kang, G., Min, Y. D. (2003). Reversal of P-glycoprotein-mediated multidrug resistance by protopanaxatriol ginsenosides from Korean red ginseng. Planta Med. 69:235-240.
61. Choudhri, S. H., Gallicano, K., Foster, B., LeClaire, T. (2000). A study of pharmacokinetic interactions between garlic supplements and ritonavir in healthy volunteers (abstract 1637). In: The 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society for Microbiology.
62. Chowbay, B., Cumaraswamy, S., Cheung, Y. B., Zhou, Q., Lee, E. J. (2003). Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients. Pharmacogenetics 13:89-95.
63. Christensen, H., Asberg, A., Holmboe, A. B., Berg, K. J. (2002). Coadministration of grapefruit juice increases systemic exposure of diltiazem in healthy volunteers. Eur. J. Clin. Pharmacol. 58:515-520.
64. Chu, D.-C., Juneja, L. R. (1997). Yamamoto, T., Juneja, L. R., Chu, D.-C., Kim, M., eds. Chemistry and Applications of Green Tea. New York: CRC Press.
65. Clifford, C. P., Adams, D. A., Murray, S., Taylor, G. W., Wilkins, M. R., Boobis, A. R., Davies, D. S. (1997). The cardiac effects of terfenadine after inhibition of its metabolism by grapefruit juice. Eur. J. Clin. Pharmacol. 52:311-315.
66. Coon, J. T., Ernst, E. (2002). Panax ginseng: a systematic review of adverse effects and drug interactions. Drug Safety 25:323-344.
67. Critchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. (1994). Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism. Biochem. Pharmacol. 48:1437-1445.
68. Cummins, C. L., Jacobsen, W., Benet, L. Z. (2002). Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. J. Pharmacol. Exp. Ther. 300:1036-1045.
69. Cuttle, L., Munns, A. J., Hogg, N. A., Scott, J. R., Hooper, W. D., Dickinson, R. G., Gillam, E. M. (2000). Phenytoin metabolism by human cytochrome P450: involvement of P450 3A and 2C forms in secondary metabolism and drug-protein adduct formation. Drug Metab. Dispos. 28:945-950.
70. Cvetkovic, M., Leake, B., Fromm, M. F., Wilkinson, G. R., Kim, R. B. (1999). OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab. Dispos. 27:866-871.
71. Dausch, J. G., Nixon, D. W. (1990). Garlic: a review of its relationship to malignant disease. Prev. Med. 19:346-361.
72. Degenring, F. H., Suter, A., Weber, M., Saller, R. (2003). A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan) in the treatment of patients with congestive heart failure NYHA II. Phytomedicine 10:363-369.
73. de Maat, M. M., Hoetelmans, R. M., Mathot, R. A., van Gorp, E. C., Meenhorst, P. L., Mulder, J. W., Beijnen, J. H. (2001). Drug interaction between St. John's wort and nevirapine. AIDS 15:420-421.
74. Demeule, M., Regina, A., Jodoin, J., Laplante, A., Dagenais, C., Berthelet, F., Moghrabi, A., Beliveau, R. (2002). Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier. Vasc. Pharmacol. 38:339-348.
75. Desta, Z., Kivisto, K. T., Lilja, J. J., Backman, J. T., Soukhova, N., Neuvonen, P. J., Flockhart, D. A. (2001). Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice. Br. J. Clin. Pharmacol. 52:399-407.
76. Deyama, T., Nishibe, S., Nakazawa, Y. (2001). Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacol. Sin. 22:1057-1070.
77. D'Hooge, R., Pei, Y. Q., Raes, A., Lebrun, P., van Bogaert, P. P., de Deyn, P. P. (1996). Anticonvulsant activity of piperine on seizures induced by excitatory amino acid receptor agonists. Arzneim.-Forsch. 46:557-560.
78. DiCenzo, R., Shelton, M., Jordan, K., Koval, C., Forrest, A., Reichman, R., Morse, G. (2003). Coadministration of milk thistle and indinavir in healthy subjects. Pharmacotherapy 23:866-870.
79. Dillon, S. A., Burmi, R. S., Lowe, G. M., Billington, D., Rahman, K. (2003). Antioxidant properties of aged garlic extract: an in vitro study incorporating human low density lipoprotein. Life Sci. 72:1583-1594.
80. Di Marco, M. P., Edwards, D. J., Wainer, I. W., Ducharme, M. P. (2002). The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein. Life Sci. 71:1149-1160.
81. Ding, T., Tian, S., Zhang, Z., Gu, D., Chen, Y., Shi, Y., Sun, Z. (2001). Determination of active component in silymarin by RP-LC and LC/MS. J. Pharm. Biomed. Anal. 26:155-161.
82. Dresser, G. K., Bailey, D. G., Leake, B. F., Schwarz, U. I., Dawson, P. A., Freeman, D. J., Kim, R. B. (2002). Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin. Pharmacol. Ther. 71:11-20.
83. Dresser, G. K., Schwarz, U. I., Wilkinson, G. R., Kim, R. B. (2003). Coordinate induction of both cytochrome P4503A and MDR1 by St. John's wort in healthy subjects. Clin. Pharmacol. Ther. 73:41-50.
84. Ducharme, M. P., Warbasse, L. H., Edwards, D. J. (1995). Disposition of intravenous and oral cyclosporine after administration with grapefruit juice. Clin. Pharmacol. Ther. 57:485-491.
85. Durr, D., Stieger, B., Kullak-Ublick, G. A., Rentsch, K. M., Steinert, H. C., Meier, P. J., Fattinger, K. (2000). St. John's wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clin. Pharmacol. Ther. 68:598-604.
86. Eagling, V. A., Profit, L., Back, D. J. (1999). Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br. J. Clin. Pharmacol. 48:543-552.
87. Efferth, T., Davey, M., Olbrich, A., Rucker, G., Gebhart, E., Davey, R. (2002). Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells. Blood Cells Mol. Diseases 28:160-168.
88. Egashira, K., Fukuda, E., Onga, T., Yogi, Y., Matsuya, F., Koyabu, N., Ohtani, H., Sawada, Y. (2003). Pomelo-induced increase in the blood level of tacrolimus in a renal transplant patient. Transplantation 75:1057.
89. Eich-Hochli, D., Oppliger, R., Golay, K. P., Baumann, P., Eap, C. B. (2003). Methadone maintenance treatment and St. John's wort-a case report. Pharmacopsychiatry 36:35-37.
90. Ekins, S., Schuetz, E. (2002). The PXR crystal structure: the end of the beginning. Trends Pharmacol. Sci. 23:49-50.
91. Erdelmeier, C. A. J. (1998). Hyperforin, possibly the major non-nitrogenous secondary metabolite of Hypericum perforatum L. Pharmacopsychiatry 31S:2-6.
92. Ernst, E. (1997). Complementary AIDS therapies: the good, the bad, and the ugly. Int. J. STD AIDS 8:281-285.
93. Ernst, E. (1999). Second thoughts about safety of St. John's wort. Lancet 354:2014-2016.
94. Evans, A. M. (2000). Influence of dietary components on the gastrointestinal metabolism and transport of drugs. Ther. Drug Monit. 22:131-136.
95. Fitzsimmons, M. E., Collins, J. M. (1997). Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P450 3A4: potential contribution to high first-pass metabolism. Drug Metab. Dispos. 25:256-266.
96. Flora, K., Hahn, M., Rosen, H., Benner, K. (1998). Milk thistle (Silybum marianum) for the therapy of liver disease. Am. J. Gastroenterol. 93:139-143.
97. Fong, H. H., Bauman, J. L. (2002). Hawthorn. J. Cardiovasc. Nurs. 16:1-8.
98. Foster, B. C., Foster, M. S., Vandenhoek, S., Krantis, A., Budzinski, J. W., Arnason, J. T., Gallicano, K. D., Choudri, S. (2001). An in vitro evaluation of human cytochrome P450 3A4 and P-glycoprotein inhibition by garlic. J. Pharm. Pharm. Sci. 4:176-184.
99. Fromm, M. F. (2002). The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans. Adv. Drug Deliv. Rev. 54:1295-1310.
100. Fromm, M. F., Kim, R. B., Stein, C. M., Wilkinson, G. R., Roden, D. M. (1999). Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine. Circulation 99:552-557.
101. Fu, L. W., Deng, Z. A., Pan, Q. C., Fan, W. (2001). Screening and discovery of novel MDR modifiers from naturally occurring bisbenzylisoquinoline alkaloids. Anticancer Res. 21:2273-2280.
102. Fugh-Berman, A. (2000). Herb-drug interactions. Lancet 355:134-138.
103. Fugh-Berman, A., Ernst, E. (2001). Herb-drug interactions: review and assessment of report reliability. Br. J. Clin. Pharmacol. 52:587-595.
104. Fuhr, U., Maier, A., Keller, A., Steinijans, V. W., Sauter, R., Staib, A. H. (1995). Lacking effect of grapefruit juice on theophylline pharmacokinetics. Int. J. Clin. Pharmacol. Ther. 33:311-314.
105. Fuhr, U., Müller-Peltzer, H., Kern, R., Lopez-Rojas, P., Jünemann, M., Harder, S., Staib, A. H. (2002). Effects of grapefruit juice and smoking on verapamil concentrations in steady state. Eur. J. Clin. Pharmacol. 58:45-53.
106. Gallicano, K., Foster, B., Choudhri, S. (2003). Effect of short-term administration of garlic supplements on single-dose ritonavir pharmacokinetics in healthy volunteers. Br. J. Clin. Pharmacol. 55:199-202.
107. Gatti, G., Perucca, E. (1994). Plasma concentrations of free and conjugated silybin after oral intake of a silybin-phosphatidylcholine complex (silipide) in healthy volunteers. Int. J. Clin. Pharmacol. Ther. 32:614-617.
108. Geick, A., Eichelbaum, M., Burk, O. (2001). Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J. Biol. Chem. 276:14581-14587.
109. Gisolf, E. H., van Heeswijk, R. P., Hoetelmans, R. W., Danner, S. A. (2000). Decreased exposure to saquinavir in HIV-1 infected patients after long-term antiretroviral therapy including ritonavir and saquinavir. AIDS 14:8015.
110. Goh, B. C., Lee, S. C., Wang, L. Z., Fan, L., Guo, J. Y., Lamba, J., Schuetz, E., Lim, R., Lim, H. L., Ong, A. B., Lee, H. S. (2002). Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies. J. Clin. Oncol. 20:3683-3690.
111. Goodwin, B., Moore, L. B., Stoltz, C. M., McKee, D. D., Kliewer, S. A. (2001). Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor. Mol. Pharmacol. 60:427-431.
112. Goodwin, B., Redinbo, M. R., Kliewer, S. A. (2002). Regulation of CYP3A gene transcription by the pregnane X receptor. Annu. Rev. Pharmacol. Toxicol. 42:1-23.
113. Gottesman, M. M. (2002). Mechanisms of cancer drug resistance. Annu. Rev. Med. 53:615-627.
114. Gottesman, M. M., Pastan, I. (1993). Biochemistry of multidrug resistance mediated by the multidrug transporter. Ann. Rev. Biochem. 62:385-427.
115. Gottesman, M. M., Fojo, T., Bates, S. E. (2002). Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev., Cancer 2:48-58.
116. Govindarajan, V. S. (1980). Turmeric: chemistry, technology and quality. Crit. Rev. Food Sci. Nutr. 12:199-301.
117. Gray, A. I. (1983). Structural diversity and distribution of coumarins and chromones in the rutales. In: Waterman, P. G., Grundon, M. F., eds. Chemistry and Chemical Taxonomy of the Rutales. London: Academic Press, pp. 97-146.
118. Greenblatt, D. J., von Moltke, L. L., Harmatz, J. S., Chen, G., Weemhoff, J. L., Jen, C., Kelley, C. J., LeDuc, B. W., Zinny, M. A. (2003). Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice. Clin. Pharmacol. Ther. 74:121-129.
119. Gross, A. S., Goh, Y. D., Addison, R. S., Shenfield, G. M. (1999). Influence of grapefruit juice on cisapride pharmacokinetics. Clin. Pharmacol. Ther. 65:395-401.
120. Gupta, S. K., Bansal, P., Bhardwaj, R. K., Velpandian, T. (2000). Comparative antinociceptive, anti-inflammatory and toxicity profile of nimesulide vs. nimesulide and piperine combination. Pharm. Res. 41:657-662.
121. Han, S. S., Chung, S. T., Robertson, D. A., Ranjan, D., Bondada, S. (1999). Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53. Clin. Immunol. 93:152-161.
122. Han, B. H., Han, Y. N., Park, M. H., Lee, E. S., Suh, D. Y. (2001). Chemistry and biochemistry of ginseng components: ginsenosides and antioxidants. In: Emerging Drugs: Molecular Aspects of Asian Medicines. Singapore: World Scientific Publisher, pp. 387-398.
123. Harbour, R., Miller, J. (2001). A new system for grading recommendations in evidence based guidelines. BMJ 323:334-336.
124. Harris, J. C., Cottrell, S. L., Plummer, S., Lloyd, D. (2001). Antimicrobial properties of Allium sativum (garlic). Appl. Microbiol. Biotechnol. 57:282-286.
125. Hasegawa, H., Sung, J. H., Matsumiya, S., Uchiyama, M., Inouye, Y., Kasai, R., Yamasaki, K. (1995). Reversal of daunomycin and vinblastine resistance in multidrug-resistant P388 leukemia in vitro through enhanced cytotoxicity by triterpenoids. Planta Med. 61:409-413.
126. He, L., Liu, G. Q. (2002). Effects of various principles from Chinese herbal medicine on rhodamine123 accumulation in brain capillary endothelial cells. Acta Pharm. Sin. 23:591-596.
127. He, K., Iyer, K. R., Hayes, R. N., Sinz, M. W., Woolf, T. F., Hollenberg, P. F. (1998). Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice. Chem. Res. Toxicol. 11:252-259.
128. Hennessy, M., Kelleher, D., Spiers, J. P., Barry, M., Kavanagh, P., Back, D., Mulcahym, F., Feely, J. (2002). St. John's wort increases expression of P-glycoprotein: implications for drug interactions. Br. J. Clin. Pharmacol. 53:75-82.
129. Hermann, M., Asberg, A., Reubsaet, J. L., Sather, S., Berg, K. J., Christensen, H. (2002). Intake of grapefruit juice alters the metabolic pattern of cyclosporin A in renal transplant recipients. Int. J. Clin. Pharmacol. Ther. 40:451-456.
130. Hiwale, A. R., Dhuley, J. N., Naik, S. R. (2002). Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian J. Exp. Biol. 40:277-281.
131. Ho, P. C., Ghose, K., Saville, D., Wanwimolruk, S. (2000a). Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers. Eur. J. Clin. Pharmacol. 56:693-698.
132. Ho, P. C., Saville, D. J., Coville, P. C., Wanwimolruk, S. (2000b). Content of CYP3A4 inhibitors, naringin, naringinen and bergapten in grapefruit and grapefruit juice products. Pharm. Acta Helv. 74:379-385.
133. Hollander, A. A. M. J., van Rooij, J., Lentjes, E. G. W., Arbouw, F., van Bree, J. B., Schoemaker, R. C., van Es, L. A., van der Woude, F. J., Cohen, A. F. (1995). The effect of grapefruit juice on cyclosporin and prednisone metabolism in transplant patients. Clin. Pharmacol. Ther. 57:318-324.
134. Holubarsch, C. J. F., Colucci, W. S., Meinertz, T., Gaus, W., Tendera, M. (2000). Survival and prognosis: investigations of Crataegus extract WS 1442 in congestive heart failure (SPICE): rationale, study design, and study protocol. Eur. J. Heart Fail. 2:431-437.
135. Honig, P. K., Wortham, D. C., Lazarev, A., Cantilena, L. R. (1996). Grapefruit juice alters the systemic bioavailability and cardiac repolarization of terfenadine in poor metabolizers of terfenadine. J. Clin. Pharmacol. 36:345-351.
136. Hour, T. C., Chen, J., Huang, C. Y., Guan, J. Y., Lu, S. H., Pu, Y. S. (2002). Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation. Prostate 51:211-218.
137. Hsu, A., Granneman, G. R., Bertz, R. J. (1998). Ritonavir. Clinical pharmacokinetics and interactions with other anti-HIV agents. Clin. Pharmacokinet. 35:275-291.
138. Hukkinen, S. K., Varhe, A., Olkkola, K. T., Neuvonen, P. J. (1995). Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice. Clin. Pharmacol. Ther. 58:127-131.
139. Ikegawa, T., Ushigome, F., Koyabu, N., Morimoto, S., Shoyama, Y., Naito, M., Tsuruo, T., Ohtani, H., Sawada, Y. (2000). Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. Cancer Lett. 160:21-28.
140. Ioannides, C. (2002). Pharmacokinetic interactions between herbal remedies and medicinal drugs. Xenobiotica 32:451-478.
141. Ireson, C. R., Jones, D. J., Orr, S., Coughtrie, M. W., Boocock, D. J., Williams, M. L., Farmer, P. B., Steward, W. P., Gescher, A. J. (2002). Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol. Biomark. Prev. 11:105-111.
142. Jacobs, B. P., Dennehy, C., Ramirez, G., Sapp, J., Lawrence, V. A. (2002). Milk thistle for the treatment of liver disease: a systematic review and meta-analysis. Am. J. Med. 113:506-515.
143. Jensen-Jarolim, E., Gajdzik, L., Haberl, I., Kraft, D., Scheiner, O., Graf, J. (1998). Hot spices influence permeability of human intestinal epithelial monolayers. J. Nutr. 128:577-581.
144. Jodoin, J., Demeule, M., Beliveau, R. (2002). Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim. Biophys. Acta 1542:149-159.
145. Johne, A., Brockmoller, J., Bauer, S., Maurer, A., Langheinrich, M., Roots, I. (1999). Pharmacokinetic interaction of digoxin with an herbal extract from St. John's wort (Hypericum perforatum). Clin. Pharmacol. Ther. 66:338-345.
146. Johne, A., Schmider, J., Brockmoller, J., Stadelmann, A. M., Stormer, E., Bauer, S., Scholler, G., Langheinrich, M., Roots, I. (2002). Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort (Hypericum perforatum). J. Clin. Psychopharmacol. 22:46-54.
147. Jones, S. A., Moore, L. B., Shenk, J. L., Wisely, G. B., Hamilton, G. A., McKee, D. D., Tomkinson, N. C., LeCluyse, E. L., Lambert, M. H., Willson, T. M., Kliewer, S. A., Moore, J. T. (2000). The pregnane x receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol. Endocrinol. 14:27-39.
148. Jonker, J. W., Wagenaar, E., van Deemter, L., Gottschlich, R., Bender, H. M., Dasenbrock, J., Schinkel, A. H. (1999). Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug. Br. J. Pharmacol. 127:43-50.
149. Josefsson, M., Zackrisson, A. L., Ahlner, J. (1996). Effect of grapefruit juice on the pharmacokinetics of amlodipine in healthy volunteers. Eur. J. Clin. Pharmacol. 51:189-193.
150. Kalb, R., Trautmann-Sponsel, R. D., Kieser, M. (2001). Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial. Pharmacopsychiatry 34:96-103.
151. Kane, G. C., Lipsky, J. J. (2000). Drug-grapefruit juice interactions. Mayo Clin. Proc. 75:933-942.
152. Karliova, M., Treichel, U., Malago, M., Frilling, A., Gerken, G., Broelsch, C. E. (2000). Interaction of Hypericum perforatum (St. John's wort) with cyclosporin A metabolism in a patient after liver transplantation. J. Hepatol. 33:853-855.
153. Kerb, R., Hoffmeyer, S., Brinkmann, U. (2001). ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2. Pharmacogenomics 2:51-64.
154. Kim, A. E., Dintaman, J. M., Waddell, D. S. (1998). Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein. J. Pharmacol. Exp. Ther. 286:143-149.
155. Kim, S. H., Kang, K. W., Kim, K. W., Kim, N. D. (2000). Procyanidins in Crataegus extract evoke endothelium-dependent vasorelaxation in rat aorta. Life Sci. 67:121-131.
156. Kim, S. W., Kwon, H. Y., Chi, D. W., Shim, J. H., Park, J. D., Lee, Y. H., Pyo, S., Rhee, D. K. (2003). Reversal of P-glycoprotein-mediated multidrug resistance by ginsenoside Rg(3). Biochem. Pharmacol. 65:75-82.
157. Kiso, S., Cai, S. H., Kitaichi, K., Furui, N., Takagi, K., Nabeshima, T., Hasegawa, T. (2000). Inhibitory effect of erythromycin on P-glycoprotein-mediated biliary excretion of doxorubicin in rats. Anticancer Res. 20:2827-2834.
158. Kitagawa, I., Yoshikawa, M., Yoshihara, M., Hayashi, T., Taniyama, T. (1983). [Chemical studies of crude drugs (1). Constituents of Ginseng radix rubra]. Yakugaku Zasshi 103:612-622.
159. Kivisto, K. T., Lilja, J. J., Backman, J. T., Neuvonen, P. J. (1999). Repeated consumption of grapefruit juice considerably increases plasma concentrations of cisapride. Clin. Pharmacol. Ther. 66:448-453.
160. Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterstrom, R. H., Perlmann, T., Lehmann, J. M. (1998). An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92:73-82.
161. Komatsu, T., Yamazaki, H., Asahi, S., Gillam, E. M. J., Guengerich, F. P., Nakajima, M., Yokoi, T. (2000). Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P4502C9, 2C19, and 3A4. Drug Metab. Dispos. 28:1361-1368.
162. Kosina, P., Kren, V., Gebhardt, R., Grambal, F., Ulrichova, J., Walterova, D. (2002). Antioxidant properties of silybin glycosides. Phytother. Res. 16:S33-S39.
163. Koul, I. B., Kapil, A. (1993). Evaluation of the liver protective potential of piperine, an active principle of black and long peppers. Planta Med. 59:413-417.
164. Kren, V., Ulrichova, J., Kosina, P., Stevenson, D., Sedmera, P., Prikrylova, V., Halada, P., Simanek, V. (2000). Chemoenzymatic preparation of silybin beta-glucuronides and their biological evaluation. Drug Metab. Dispos. 28:1513-1517.
165. Kuhnau, J. (1976). The flavonoids: a class of semi-essential food components. Their role in human nutrition. World Rev. Nutr. 24:117-191.
166. Kunchandy, E., Rao, M. N. A. (1990). Oxygen radical scavenging activity of curcumin. Int. J. Pharm. 58:237-240.
167. Kuo, M. L., Huang, T. S., Lin, J. K. (1996). Curcumin, an antioxidant and antitumor promoter, induces apoptosis in human leukemia cells. Biochim. Biophys. Acta 1317:95-100.
168. Kupferschmidt, H. H., Ha, H. R., Ziegler, W. H., Meier, P. J., Krahenbuhl, S. (1995). Interaction between grapefruit juice and midazolam in humans. Clin. Pharmacol. Ther. 58:20-28.
169. Kupferschmidt, H. H., Fattinger, K. E., Ha, H. R., Follath, F., Krahenbuhl, S. (1998). Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man. Br. J. Clin. Pharmacol. 45:355-359.
170. Kvasnicka, F., Biba, B., Sevcik, R., Voldrich, M., Kratka, J. (2003). Analysis of the active components of silymarin. J. Chromatogr., A 990:239-245.
171. Kyo, E., Uda, N., Kasuga, S., Itakura, Y. (2001). Immunomodulatory effects of aged garlic extract. J. Nutr. 131:S1075-S1079.
172. Lambert, J. D., Yang, C. S. (2003). Cancer chemopreventive activity and bioavailability of tea and tea polyphenols. Mutat. Res. 523-524:201-208.
173. Lampen, A., Christians, U., Guengerich, F. P., Watkins, P. B., Kolars, J. C., Bader, A., Gonschior, A. K., Dralle, H., Hackbarth, I., Sewing, K. F. (1995). Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. Drug Metab. Dispos. 23:1315-1324.
174. Laroche, M., Choudhri, S., Gallicano, K., Foster, B. (1998). Severe gastrointestinal toxicity with concomitant ingestion of ritonavir and garlic. Can. J. Infect. Dis. 9:471P.
175. Lecrubier, Y., Clerc, G., Didi, R., Kieser, M. (2002). Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial. Am. J. Psychiatry 159:1361-1366.
176. Lee, M., Min, D. I., Ku, Y. M., Flanigan, M. (2001). Effect of grapefruit juice on pharmacokinetics of microemulsion cyclosporine in African American subjects compared with Caucasian subjects: does ethnic difference matter? J. Clin. Pharmacol. 41:317-323.
177. Lehmann, J. M., McKee, D. D., Watson, M. A., Willson, T. M., Moore, J. T., Kliewer, S. A. (1998). The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J. Clin. Invest. 102:1016-1023.
178. Lesser, P. F. (1997). Florida grapefruit juice developments. In: Proceedings of Food News Second International Fruit-Juice Conference, Food News Second International Fruit-Juice Conference Committee. Amsterdam, The Netherlands.
179. Leu, T. H., Maa, M. C. (2002). The molecular mechanisms for the antitumorigenic effect of curcumin. Curr. Med. Chem. Anti-Cancer Agents 2:357-370.
180. Liao, B. S., Newmark, H., Zhou, R. P. (2002). Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Exp. Neurol. 173:224-234.
181. Lilja, J. J., Kivisto, K. T., Backman, J. T., Neuvonen, P. J. (2000). Effect of grapefruit juice dose on grapefruit juice-triazolam interaction: repeated consumption prolongs triazolam half-life. Eur. J. Clin. Pharmacol. 56:411-415.
182. Lilja, J. J., Backman, J. T., Laitila, J., Luurila, H., Neuvonen, P. J. (2003). Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol. Clin. Pharmacol. Ther. 73:192-198.
183. Limtrakul, P., Lipigorngoson, S., Namwong, O., Apisariyakul, A., Dunn, F. W. (1997). Inhibitory effect of dietary curcumin on skin carcinogenesis in mice. Cancer Lett. 116:197-203.
184. Limtrakul, P., Anuchapreeda, S., Lipigorngoson, S., Dunn, F. W. (2001). Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin. BMC Cancer 1:1-7.
185. Lin, J. H., Yamazaki, M. (2003). Role of P-glycoprotein in pharmacokinetics: clinical implications. Clin. Pharmacokinet. 41:59-98.
186. Lin, Z., Hoult, J. R., Bennett, D. C., Raman, A. (1999). Stimulation of mouse melanocyte proliferation by Piper nigrum fruit extract and its main alkaloid, piperine. Planta Med. 65:600-603.
187. Linde, K., Ramirez, G., Mulrow, C. D., Pauls, A., Weidenhammer, W., Melchart, D. (1996). St. John's wort for depression - an overview and meta-analysis of randomised clinical trials. Br. Med. J. 313:253-258.
188. Lippert, C., Ling, J., Brown, P., Burmaster, S., Eller, M., Cheng, L., Thompson, R., Weir, S. (1995). Mass balance and pharmacokinetics of MDL 16455A in healthy male volunteers. Pharm. Res. 12:S390.
189. Liu, W., Chen, G., Cui, T. (2003). Determination of flavones in Crataegus pinnatifida by capillary zone electrophoresis. J. Chromatogr. Sci. 41:87-91.
190. Loo, T. W., Clarke, D. M. (1994). Functional consequences of glycine mutations in the predicted cytoplasmic loops of P-glycoprotein. J. Biol. Chem. 269:7243-7248.
191. Lorenz, D. (1982). [Untersuchungen zur elimination von silymarin bei cholezystektomiertan patientsten 2. Mitteilung: Biliaere elimination nach mehrfacher oraler Gabe]. Planta Med. 45:216-223.
192. Lown, K. S., Bailey, D. G., Fontana, R. J., Janardan, S. K., Adair, C. H., Fortlage, L. A., Brown, M. B., Guo, W., Watkins, P. B. (1997a). Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression. J. Clin. Invest. 99:2297-2298.
193. Lown, K. S., Mayo, R. R., Leichtman, A. B., Hsiao, H. L., Turgeon, D. K., Schmiedlin-Ren, P., Brown, M. B., Guo, W., Rossi, S. J., Benet, L. Z., Watkins, P. B. (1997b). Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin. Pharmacol. Ther. 62:248.
194. Lucena, M. I., Andrade, R. J., de la Cruz, J. P., Rodriguez-Mendizabal, M., Blanco, E., Sanchez de la Cuesta, F. (2002). Effects of silymarin MZ-80 on oxidative stress in patients with alcoholic cirrhosis. Results of a randomized, double-blind, placebo-controlled clinical study. Int. J. Clin. Pharmacol. Ther. 40:2-8.
195. Lundahl, J., Regardh, C. G., Edgar, B., Johnsson, G. (1995). Relationship between time of intake of grapefruit juice and its effect on pharmacokinetics and pharmacodynamics of felodipine in healthy subjects. Eur. J. Clin. Pharmacol. 49:61-67.
196. Mai, I., Kruger, H., Budde, K., Johne, A., Brockmoller, J., Neumayer, H. H., Roots, I. (2000). Hazardous pharmacokinetic interaction of Saint John's wort (Hypericum perforatum) with the immunosuppressant cyclosporin. Int. J. Clin. Pharmacol. Ther. 38:500-502.
197. Mai, I., Stormer, E., Bauer, S., Kruger, H., Budde, K., Roots, I. (2003). Impact of St. John's wort treatment on the pharmacokinetics of tacrolimus and mycophenolic acid in renal transplant patients. Nephrol. Dial. Transplant. 18:819-822.
198. Maitrejean, M., Comte, G., Barron, D., El Kirat, K., Conseil, G., Di Pietro, A. (2000). The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein. Bioorg. Med. Chem. Lett. 10:157-160.
199. Markham, A., Wagstaff, A. J. (1998). Fexofenadine. Drugs 55:269-274.
200. Markowitz, J. S., DeVane, C. L., Boulton, D. W., Carson, S. W., Nahas, Z., Risch, S. C. (2000). Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers. Life Sci. 66:PL133-PL139.
201. Mathijssen, R. H., Verweij, J., de Bruijn, P., Loos, W. J., Sparreboom, A. (2002). Effects of St. John's wort on irinotecan metabolism. J. Natl. Cancer Inst. 94:1247-1249.
202. Maurer, A., Johne, A., Bauer, S. (1999). Interaction of St. John's wort extract with phenprocoumon. Eur. J. Clin. Pharmacol. 55:A22.
203. Mayer, U., Wagenaar, E., Dorobek, B., Beijnen, J. H., Borst, P., Schinkel, A. H. (1997). Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833. J. Clin. Invest. 100:2430-2436.
204. McLeod, H. L., Evans, W. E. (2001). Pharmacogenomics: unlocking the human genome for better drug therapy. Annu. Rev. Pharmacol. Toxicol. 41:101-121.
205. Meerum Terwogt, J. M., Malingre, M. M., Beijnen, J. H., ten Bokkel Huinink, W. W., Rosing, H., Koopman, F. J., van Tellingen, O., Swart, M., Schellens, J. H. (1999). Coadministration of oral cyclosporin A enables oral therapy with paclitaxel. Clin. Cancer Res. 5:3379-3384.
206. Min, D. I., Ellingrod, V. L. (2003). Association of the CYP3A4*1B 5′-flanking region polymorphism with cyclosporine pharmacokinetics in healthy subjects. Ther. Drug Monit. 25:305-309.
207. Min, D. I., Ku, Y.-M., Geraets, D. R., Lee, H.-C. (1996). Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers. J. Clin. Pharmacol. 36:469-476.
208. Mitsunaga, Y., Takanaga, H., Matsuo, H., Naito, M., Tsuruo, T., Ohtani, H., Sawada, Y. (2000). Effect of bioflavonoids on vincristine transport across blood-brain barrier. Eur. J. Pharmacol. 395:193-201.
209. Mittal, R., Gupta, R. L. (2000). In vitro antioxidant activity of piperine. Methods Find. Exp. Clin. Pharmacol. 22:271-274.
210. Mohri, K., Uesawa, Y. (2001). Effects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats. Pharm. Res. 18:177-182.
211. Molnar, J., Szabo, D., Pusztai, R., Mucsi, I., Berek, L., Ocsovszki, I., Kawata, E., Shoyama, Y. (2000). Membrane associated antitumor effects of crocine-, ginsenoside-and cannabinoid derivatives. Anticancer Res. 20:861-867.
212. Moore, L. B., Goodwin, B., Jones, S. A., Wisely, G. B., Serabjit-Singh, C. J., Willson, T. M. (2000). St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc. Natl. Acad. Sci. U. S. A. 97:7500-7502.
213. Morazzoni, P., Bombardelli, E. (1995). [Silybum marianum (Carduus marianus)]. Fitoterapia 66:3-42.
214. Moschella, C., Jaber, B. L. (2001). Interaction between cyclosporine and Hypericum perforatum (St. John's wort) after organ transplantation. Am. J. Kidney Dis. 38:1105-1107.
215. Mujumdar, A. M., Dhuley, J. N., Deshmukh, V. K., Raman, P. H., Thorat, S. L., Naik, S. R. (1990). Effect of piperine on pentobarbitone induced hypnosis in rats. Indian J. Exp. Biol. 28:486-487.
216. Munch, G., Brixius, K., Frank, K., Erdmann, E. (1997). WS 1442 (extract of Crataegus species) increases force of contraction in human failing myocardium by inhibition of the Na+/K+-ATPase. Circulation 96:4090.
217. Munns, A. J., De Voss, J. J., Hooper, W. D., Dickinson, R. G., Gillam, E. M. (1997). Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation. Chem. Res. Toxicol. 10:1049-1058.
218. Muriel, P., Mourelle, M. (1990). Prevention by silymarin of membrane alterations in acute CCL4 liver damage. J. Appl. Toxicol. 10:275-279.
219. Nagabhushan, M., Amonkar, A. J., Bhide, S. V. (1987). In vitro antimutagenicity of curcumin against environmental mutagens. Food Chem. Toxicol. 25:545-547.
220. Nahrstedt, A., Butterweck, V. (1997). Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry 30S:129-134.
221. Nebel, A., Schneider, B. J., Baker, R. K., Kroll, D. J. (1999). Potential metabolic interaction between St. John's wort and theophylline. Ann. Pharmacother. 33:502.
222. Nishino, H., Tokuda, H., Li, T., Takemura, M., Kuchide, M., Kanazawa, M., Mou, X. Y., Bu, P., Takayasu, J., Onozuka, M., Masuda, M., Satomi, Y., Konoshima, T., Kishi, N., Baba, M., Okada, Y., Okuyama, T. (2001). Cancer chemoprevention by ginseng in mouse liver and other organs. J. Korean Med. Sci. 16:S66-S69.
223. Obach, R. S. (2000). Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression. J. Pharmacol. Exp. Ther. 294:88-95.
224. Offman, E. M., Freeman, D. J., Dresser, G. K., Munoz, C., Bend, J. R., Bailey, D. G. (2001). Red wine-cisapride interaction: comparison with grapefruit juice. Clin. Pharmacol. Ther. 70:17-23.
225. Ohnishi, A., Matsuo, H., Yamada, S., Takanaga, H., Morimoto, S., Shoyama, Y., Ohtani, H., Sawada, Y. (2000). Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4. Br. J. Pharmacol. 130:1369-1377.
226. Owen, A., Pirmohamed, M., Tettey, J. N., Morgan, P., Chadwick, D., Park, B. K. (2001). Carbamazepine is not a substrate for P-glycoprotein. Br. J. Clin. Pharmacol. 51:345-349.
227. Pares, A., Planas, R., Torres, M., Caballeria, J., Viver, J. M., Acero, D., Panes, J., Rigau, J., Santos, J., Rodes, J. (1998). Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial. J. Hepatol. 28:615-621.
228. Park, J. D., Kim, D. S., Kwon, H. Y., Son, S. K., Lee, Y. H., Baek, N. I., Kim, S. I., Rhee, D. K. (1996). Effects of ginseng saponin on modulation of multidrug resistance. Arch. Pharm. Res. 19:213-218.
229. Parker, R. B., Yates, C. R., Soberman, J. E., Laizure, S. C. (2003). Effects of grapefruit juice on intestinal P-glycoprotein: evaluation using digoxin in humans. Pharmacotherapy 23:979-987.
230. Penzak, S. R., Acosta, E. P., Turner, M., Edwards, D. J., Hon, Y. Y., Desai, H. D., Jann, M. W. (2002). Effect of Seville orange juice and grapefruit juice on indinavir pharmacokinetics. J. Clin. Pharmacol. 42:1165-1170.
231. Perloff, M. D., von Moltke, L. L., Stormer, E., Shader, R. I., Greenblatt, D. J. (2001). Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure. Br. J. Pharmacol. 134:1601-1608.
232. Phang, J. M., Poore, C. M., Lopaczynska, J., Yeh, G. C. (1993). Flavonol-stimulated efflux of 7,12-dimethylbenz(a)anthracene in multidrug-resistant breast cancer cells. Cancer Res. 53:5977-5978.
233. Pietrangelo, A., Borella, F., Casalgrandi, G., Montosi, G., Ceccarelli, D., Gallesi, D., Giovannini, F., Gasparetto, A., Masini, A. (1995). Antioxidant activity of silybin in vivo during long-term iron overload in rats. Gastroenterology 109:1941-1949.
234. Piscitelli, S. C., Burstein, A. H., Chaitt, D., Alfaro, R. M., Falloon, J. (2000). Indinavir concentrations and St. John's wort. Lancet 355:547-548.
235. Piscitelli, S. C., Burstein, A. H., Welden, N., Gallicano, K. D., Falloon, J. (2001). The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin. Infect. Dis. 34:234-238.
236. Piscitelli, S. C., Formentini, E., Burstein, A. H., Alfaro, R., Jagannatha, S., Falloon, J. (2002). Effect of milk thistle on the pharmacokinetics of indinavir in healthy volunteers. Pharmacotherapy 22:551-556.
237. Pittler, M. H., Schmidt, K., Ernst, E. (2003). Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials. Am. J. Med. 114:665-674.
238. Plouzek, C. A., Ciolino, H. P., Clarke, R., Yeh, G. C. (1999). Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract. Eur. J. Cancer 35:1541-1545.
239. Plummer, S. M., Holloway, K. A., Manson, M. M., Munks, R. J. L., Kaptein, A., Farrow, S., Howells, L. (1999). Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-B activation via the NIK/IKK signaling complex. Oncogene 18:6013-6020.
240. Quaglia, M. G., Bossu, E., Donati, E., Mazzanti, G., Brandt, A. (1999). Determination of silymarine in the extract from the dried silybum marianum fruits by high performance liquid chromatography and capillary electrophoresis. J. Pharm. Biomed. Anal. 19:435-442.
241. Rahman, K. (2001). Historical perspective on garlic and cardiovascular disease. J. Nutr. 131:977S-979S.
242. Rao, U. S., Scarborough, G. A. (1994). Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein. Mol. Pharmacol. 45:773-776.
243. Raucy, J. L. (2003). Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products. Drug Metab. Dispos. 31:533-539.
244. Ray, S., Chattopadhyay, N., Mitra, A., Siddiqi, M., Chatterjee, A. (2003). Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin. J. Environ. Pathol. Toxicol. Oncol. 22:49-58.
245. Rietz, B., Isensee, H., Strobach, H., Makdessi, S., Jacob, R. (1993). Cardioprotective actions of wild garlic (Allium ursinum) in ischemia and reperfusion. Mol. Cell. Biochem. 119:143-150.
246. Rigelsky, J. M., Sweet, B. V. (2002). Hawthorn: pharmacology and therapeutic uses. Am. J. Health-Syst. Pharm. 59:417-422.
247. Roby, C. A., Anderson, G. D., Kantor, E., Dryer, D. A., Burstein, A. H. (2000). St. John's wort: effect on CYP3A4 activity. Clin. Pharmacol. Ther. 67:451-457.
248. Romiti, N., Tongiani, R., Cervelli, F., Chieli, E. (1998). Effects of curcumin on P-glycoprotein in primary cultures of rat hepatocytes. Life Sci. 62:2349-2358.
249. Ruschitzka, F., Meier, P. J., Turina, M., Luscher, T. F., Noll, G. (2000). Acute heart transplant rejection due to Saint John's wort. Lancet 355:548-549.
250. Sadeque, A. J., Wandel, C., He, H., Shah, S., Wood, A. J. (2000). Increased drug delivery to the brain by P-glycoprotein inhibition. Clin. Pharmacol. Ther. 68:231-237.
251. Sadzuka, Y., Sugiyama, T., Sonobe, T. (2000). Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance. Toxicol. Lett. 114:155-162.
252. Sakaeda, T., Nakamura, T., Horinouchi, M., Kakumoto, M., Ohmoto, N., Sakai, T., Morita, Y., Tamura, T., Aoyama, N., Hirai, M., Kasuga, M., Okumura, K. (2001). MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects. Pharm. Res. 18:1400-1404.
253. Saller, R., Meier, R., Brignoli, R. (2001). The use of silymarin in the treatment of liver diseases. Drugs 61:2035-2063.
254. Sattler, M., Guengerich, F. P., Yun, C. H., Christians, U., Sewing, K. F. (1992). Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. Drug Metab. Dispos. 20:753-761.
255. Schandalik, R., Gatti, G., Perucca, E. (1992). [Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients]. Arzneim.-Forsch. 42:964-968.
256. Schinkel, A. H. (1997). The physiological function of drug-transporting P-glycoproteins. Semin. Cancer Biol. 8:161-170.
257. Schinkel, A. H. (1998). Pharmacological insights from P-glycoprotein knockout mice. Int. J. Clin. Pharmacol. Ther. 36:9-13.
258. Schinkel, A. H., Jonker, J. W. (2003). Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv. Drug Deliv. Rev. 55:3-29.
259. Schinkel, A. H., Smit, J. J., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A., van der Valk, M. A., Robanus-Maandag, E. C., te Riele, H. P. (1994). Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502.
260. Schinkel, A. H., Wagenaar, E., van Deemter, L., Mol, C. A., Borst, P. (1995). Absence of the mdrla P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest. 96:1698-1705.
261. Schinkel, A. H., Wagenaar, E., Mol, C. A., van Deemter, L. (1996a). P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J. Clin. Invest. 97:2517-2524.
262. Schinkel, A. H., Wagenaar, E., Mol, C. A., van Deemter, L. (1996b). P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J. Clin. Invest. 97:2517-2524.
263. Schmiedlin-Ren, P., Edwards, D. J., Fitzsimmons, M. E., He, K., Lown, K. S., Woster, P. M., Rahman, A., Thummel, K. E., Fisher, J. M., Hollenberg, P. F., Watkins, P. B. (1997). Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. Drug Metab. Dispos. 25:1228-1233.
264. Schrader, E. (2000). Equivalence of St. John's wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression. Int. Clin. Psychopharmacol. 15:61-68.
265. Schubert, W., Cullberg, G., Edgar, B., Hedner, T. (1994). Inhibition of 17-estradiol metabolism by grapefruit juice in ovariectomized women. Maturitas 20:155-163.
266. Schuetz, E. G., Schinkel, A. H., Relling, M. V., Schuetz, J. D. (1996). P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. Proc. Natl. Acad. Sci. U. S. A. 93:4001-4005.
267. Schussler, M., Holzl, J., Fricke, W. (1995). Myocardial effects of flavonoids from Crataegus species. Arzneim.-Forsch. 45:842-845.
268. Schwarz, U. I., Buschel, B., Kirch, W. (2003). Unwanted pregnancy on self-medication with St. John's wort despite hormonal contraception. Br. J. Clin. Pharmacol. 55:112-113.
269. Shapiro, A. B., Ling, V. (1997). Effect of quercetin on Hoechst 33342 transport by purified and reconstituted P-glycoprotein. Biochem. Pharmacol. 53:587-596.
270. Shapiro, A. B., Ling, V. (1998). Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein. Eur. J. Biochem. 254:189-193.
271. Sharma, R. A., McLelland, H. R., Hill, K. A., Ireson, C. R., Euden, S. A., Manson, M. M., Pirmohamed, M., Mamett, L. J., Gescher, A. J., Steward, W. P. (2001). Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin. Cancer Res. 7:1894-1900.
272. Shelton, M. J., Wynn, H. E., Newitt, R. G., DiFrancesco, R. (2001). Effects of grapefruit juice on pharmacokinetic exposure to indinavir in HIV-positive subjects. J. Clin. Pharmacol. 41:435-442.
273. Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., Srinivas, P. S. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 64:353-356.
274. Sigusch, H., Henschel, L., Kraul, H., Merkel, U., Hoffmann, A. (1994). Lack of effect of grapefruit juice on diltiazem bioavailability in normal subjects. Pharmazie 49:675-679.
275. Singh, U. P., Prithiviraj, B., Sarma, B. K., Singh, M., Ray, A. B. (2001). Role of garlic (Allium sativum L.) in human and plant diseases. Indian J. Exp. Biol. 39:310-322.
276. Soldner, A., Christians, U., Susanto, M., Wacher, V. J., Silverman, J. A., Benet, L. Z. (1999). Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm. Res. 16:478-485.
277. Soleas, G. J., Diamandis, E. P., Goldberg, D. M. (1997). Wine as a biological fluid: history, production, and role in disease prevention. J. Clin. Lab. Anal. 11:287-313.
278. Song, S., Suzuki, H., Kawai, R., Sugiyama, Y. (1999). Effect of PSC 833, a P-glycoprotein modulator, on the disposition of vincristine and digoxin in rats. Drug Metab. Dispos. 27:689-694.
279. Soudamini, K. K., Kuttan, R. (1989). Inhibition of chemical carcinogenesis by curcumin. J. Ethnopharmacol. 27:227-233.
280. Spahn-Langguth, H., Langguth, P. (2001a). Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol. Eur. J. Pharm. Sci. 12:361-367.
281. Spahn-Langguth, H., Langguth, P. (2001b). Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol. Eur. J. Pharm. Sci. 12:361-367.
282. Spigelski, D., Jones, P. J. (2001). Efficacy of garlic supplementation in lowering serum cholesterol levels. Nutr. Rev. 59:236-241.
283. Stein, W. D. (2002). Reversers of the multidrug resistance transporter P-glycoprotein. Curr. Opin. Investig. Drugs 3:812-817.
284. Stohr, J. R., Xiao, P. G., Bauer, R. (2001). Constituents of Chinese Piper species and their inhibitory activity on prostaglandin and leukotriene biosynthesis in vitro. J. Ethnopharmacol. 75:133-139.
285. Sugimoto, K., Ohmori, M., Tsuruoka, S., Nishiki, K., Kawaguchi, A., Harada, K., Arakawa, M., Sakamoto, K., Masada, M., Miyamori, I., Fujimura, A. (2001). Different effects of St. John's wort on the pharmacokinetics of simvastatin and pravastatin. Clin. Pharmacol. Ther. 70:518-524.
286. Sun, H., Dai, H., Shaik, N., Elmquist, W. F. (2003). Drug efflux transporters in the CNS. Adv. Drug Deliv. Rev. 55:83-105.
287. Sussman, E. (2002). Garlic supplements can impede HIV medication. AIDS 16:N5.
288. Takanaga, H., Ohnishi, A., Matsuo, H., Sawada, Y. (1998). Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in caco-2 cells. Biol. Pharm. Bull. 21:1062-1066.
289. Takanaga, H., Ohnishi, A., Yamada, S., Matsuo, H., Morimoto, S., Shoyama, Y., Ohtani, H., Sawada, Y. (2000). Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J. Pharmacol. Exp. Ther. 293:230-236.
290. Tan, B., Piwnica-Worms, D., Rater, L. (2000). Multidrug resistance transporters and modulation. Curr. Opin. Oncol. 12:450-458.
291. Tankanow, R., Tamer, H. R., Streetman, D. S., Smith, S. G., Welton, J. L., Annesley, T., Aaronson, K. D., Bleske, B. E. (2003). Interaction study between, digoxin and a preparation of hawthorn (Crataegus oxyacantha). J. Clin. Pharmacol. 43:637-642.
292. Tian, R., Koyabu, N., Takanaga, H., Matsuo, H., Ohtani, H., Sawada, Y. (2002). Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates. Pharm. Res. 19:802-809.
293. Tsukamoto, S., Cha, B. C., Ohta, T. (2002). Dipiperamides A, B, and C: bisalkaloids from the white pepper Piper nigrum inhibiting CYP3A4 activity. Tetrahedron 58:1667-1671.
294. Tsunoda, S. M., Harris, R. Z., Christians, U., Velez, R. L., Freeman, R. B., Benet, L. Z., Warshaw, A. (2001). Red wine decreases cyclosporine bioavailability. Clin. Pharmacol. Ther. 70:462-467.
295. Tyagi, A. K., Singh, R. P., Agarwal, C., Chan, D. C., Agarwal, R. (2002). Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G2-M arrest, and apoptosis. Clin. Cancer Res. 8:3512-3519.
296. Ueda, K., Taguchi, Y., Morishima, M. (1997). How does P-gp recognise its substrates? Semin. Cancer Biol. 8:151-159.
297. Uno, T., Ohkubo, T., Sugawara, K., Higashiyama, A., Motomura, S., Ishizaki, T. (2000). Effects of grapefruit juice on the stereoselective disposition of nicardipine in humans: evidence for dominant presystemic elimination at the gut site. Eur. J. Clin. Pharmacol. 56:643-649.
298. Vaidyanathan, J., Walle, T. (2003). Cellular uptake and efflux of the tea flavonoid (-)-epicatechin-3-gallate in the human intestinal cell line Caco-2. J. Pharmacol. Exp. Ther. 307(2):745-752.
299. Valenzuela, A., Lagos, C., Schmidt, K., Videla, L. A. (1985). Silymarin protection against hepatic lipid peroxidation induced by acute ethanol intoxication in rats. Biochem. Pharmacol. 34:2209-2221.
300. van Rooij, J., van der Meer, F. J. M., Schoemaker, H. C., Cohen, A. F. (1993). Comparison of the effect of grapefruit juice and cimetidine on pharmacokinetics and anticoagulant effect of a single dose of acenocoumarol (Abstract). Br. J. Clin. Pharmacol. 35:548P.
301. Varga, Z., Czompa, A., Kakuk, G., Antus, S. (2001). Inhibition of the superoxide anion release and hydrogen peroxide formation in PMNLs by flavonolignans. Phytother. Res. 15:608-712.
302. Velpandian, T., Jasuja, R., Bhardwaj, R. K., Jaiswal, J., Gupta, S. K. (2001). Piperine in food: interference in the pharmacokinetics of phenytoin. Eur. J. Drug Metab. Pharmacokinet. 26:241-247.
303. Veronese, M. E., Mackenzie, P. I., Doecke, C. J., McManus, M. E., Miners, J. O., Birkett, D. J. (1991). Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9. Biochem. Biophys. Res. Commun. 175:1112-1118.
304. Veronese, M. L., Gillen, L. P., Burke, J. P., Dorval, E. P., Hauck, W. W., Pequignot, E., Waldman, S. A., Greenberg, H. E. (2003). Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice. J. Clin. Pharmacol. 43:831-839.
305. Vierling, W., Brand, N., Gaedcke, F., Sensch, K. H., Schneider, E., Scholz, M. (2003). Investigation of the pharmaceutical and pharmacological equivalence of different Hawthorn extracts. Phytomedicine 10:8-16.
306. Vincent, J., Harris, S. I., Foulds, G., Dogolo, L. C., Willavize, S., Friedman, H. L. (2000). Lack of effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of amlodipine. Br. J. Clin. Pharmacol. 50:455-463.
307. Wallace, S., Carrier, D., Clausen, E. (2003). Extraction of nutraceuticals from milk thistle: Part II. Extraction with organic solvents. Appl. Biochem. Biotechnol. 108:891-904.
308. Walter-Sack, I., Klotz, U. (1996). Influence of diet and nutritional status on drug metabolism. Clin. Pharmacokinet. 31:47-64.
309. Wang, E. J., Casciano, C. N., Clement, R. P., Johnson, W. W. (2001a). Inhibition of P-glycoprotein transport function by grapefruit juice psoralen. Pharm. Res. 18:432-438.
310. Wang, M. Q., Guilbert, L. J., Ling, L., Li, J., Wu, Y. Q., Xu, S., Pang, P., Shan, J. J. (2001b). Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium). J. Pharm. Pharmacol. 53:1515-1523.
311. Wang, Z. Q., Gorski, C., Hamman, M. A., Huang, S. M., Lesko, L. J., Hall, S. D. (2001c). The effects of St. John's wort (Hypericum perforatum) on human cytochrome P450 activity. Clin. Pharmacol. Ther. 70:317-326.
312. Wang, E. J., Barecki-Roach, M., Johnson, W. W. (2002a). Elevation of P-glycoprotein function by a catechin in green tea. Biochem. Biophys. Res. Commun. 297:412-418.
313. Wang, Z. Q., Hamman, M. A., Huang, S. M., Lesko, L. J., Hall, S. D. (2002b). Effect of St. John's wort on the pharmacokinetics of fexofenadine. Clin. Pharmacol. Ther. 71:414-420.
314. Warden, B. A., Smith, L. S., Beecher, G. R., Balentine, D. A., Clevidence, B. A. (2001). Catechins are bioavailable in men and women drinking black tea throughout the day. J. Nutr. 131:1731-1737.
315. Watkins, R. E., Wisely, G. B., Moore, L. B., Collins, J. L., Lambert, M. H., Williams, S. P., Willson, T. M., Kliewer, S. A., Redinbo, M. R. (2001). The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science 292:2329-2333.
316. Watkins, R. E., Maglich, J. M., Moore, L. B., Wisely, G. B., Noble, S. M., Davis-Searles, P. R., Lambert, M. H., Kliewer, S. A., Redinbo, M. R. (2003). 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. Biochemistry 42:1430-1438.
317. Weber, A., Jager, R., Borner, A., Klinger, G., Vollanth, R., Matthey; K., Balogh, A. (1996). Can grapefruit juice influence ethinylestradiol bioavailability? Contraception 53:41-47.
318. Wellington, K., Jarvis, B. (2001). Silymarin: a review of its clinical properties in the management of hepatic disorders. BioDrugs 15:465-489.
319. Wentworth, J. M., Agostini, M., Love, J., Schwabe, J. W., Chatterjee, V. K. (2000). St. John's wort, a herbal antidepressant, activates the steroid X receptor. J. Endocrinol. 166:R11-R16.
320. Weyhenmeyer, R., Mascher, H., Birkmayer, J. (1992). Study on dose-linearity of the pharmacokinetics of silibinin diastereomers using a new stereospecific assay. Int. J. Clin. Pharmacol. Ther. Toxicol. 30:134-141.
321. Wilkinson, G. R. (1997). The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans. Adv. Drug Deliv. Rev. 27:129-159.
322. Woelk, H. (2000). Comparison of St. John's wort and imipramine for treating depression: randomised controlled trial. Br. Med. J. 321:536-539.
323. Xie, W., Evans, R. M. (2001). Orphan nuclear receptors: the exotics of xenobiotics. J. Biol. Chem. 276:37739-37742.
324. Xu, J., Go, M. L., Lim, L. Y. (2003). Modulation of digoxin transport across Caco-2 cell monolayers by citrus fruit juices: lime, lemon, grapefruit and pummelo. Pharm. Res. 20:169-176.
325. Yang, C. S., Chen, L., Lee, M. J., Balentine, D., Kuo, M. C., Schantz, S. P. (1998). Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers. Cancer Epidemiol. Biomark. Prev. 7:351-354.
326. Yang, C. S., Maliakal, P., Meng, X. F. (2002). Inhibition of carcinogenesis by tea. Annu. Rev. Pharmacol. Toxicol. 42:25-54.
327. Yee, G. C., Stanley, D. L., Pessa, J. L., Costa, T. D., Beltz, S. E., Ruiz, J., Lowenthal, D. T. (1995). Effect of grapefruit juice on blood cyclosporin concentration. Lancet 345:955-956.
328. Yu, D. K. (1999). The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions. J. Clin. Pharmacol. 39:1203-1211.
329. Yue, Q. Y., Bergquist, C., Gerden, B. (2000). Safety of St. John's wort (Hypericum perforatum). Lancet 355:548-549.
330. Zaidenstein, R., Soback, S., Gips, M., Avni, B., Dishi, V., Weissgarten, Y., Golik, A., Scapa, E. (2001). Effect of grapefruit juice on the pharmacokinetics of losartan and its active metabolite E3174 in healthy volunteers. Ther. Drug Monit. 23:369-373.
331. Zhang, Y. C., Benet, L. Z. (2001). The gut as a barrier to drug absorption-combined role of cytochrome P450 3A and P-glycoprotein. Clin. Pharmacokinet. 40:159-168.
332. Zhang, S., Morris, M. E. (2003). Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport. J. Pharmacol. Exp. Ther. 304:1258-1267.
333. Zhou, S. F., Heng, P. W.S. (2003). Herb-drug interactions: pharmacokinetic and pharmacodynamic interactions. Drug Safety. in press.
334. Zhou, S. F., Gao, Y. H., Wen, Q. J., Huang, M., Xu, A. L., Paxton, J. W. (2003). Interactions of herbs with cytochrome P450. Drug Metab. Rev. 35:35-98.
335. Zhu, M., Chen, Y., Li, R. C. (2000). Oral absorption and bioavailability of tea catechins. Planta Med. 66:444-447.
336. Zutshi, R. K., Singh, R., Zutshi, U., Johri, R. K., Atal, C. K. (1985). Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. J. Assoc. Phys. India 33:223-224.