An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

Cell

Volumn 92, Issue 1, 1998, Pages 73-82

  Kliewer, Steven A ^d   Moore, John T ^d   Wade, Laura ^d   Staudinger, Jeff L ^d   Watson, Michael A ^d   Jones, Stacey A ^d   McKee, David D ^d   Oliver, Beverly B ^d   Willson, Timothy M ^a   Zetterström, Rolf H ^b   Perlmann, Thomas ^c   Lehmann, Jürgen M ^d  

^a GLAXOSMITHKLINE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CELL NUCLEUS RECEPTOR; GLUCOCORTICOID; GLUCOCORTICOID ANTAGONIST; PREGNANE DERIVATIVE; PREGNENOLONE; PROGESTERONE; RECEPTOR SUBTYPE; STEROID MONOOXYGENASE; STEROID RECEPTOR;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; EMBRYO; ENZYME INDUCTION; GENE EXPRESSION; IN SITU HYBRIDIZATION; METABOLIC REGULATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEROID METABOLISM;

ANIMALIA; EUKARYOTA;

EID: 0032498303     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80900-9     Document Type: Article

References (57)

1. Baker, A.R., McDonnell, D.P., Hughes, M., Crisp, T.M., Mangelsdorf, D.J., Haussler, M.R., Pike, J.W., Shine, J., and O'Malley, B.W. (1988). Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc. Natl. Acad. Sci. USA 85, 3294-3298.
2. Beato, M., Herrlich, P., and Schütz, G. (1995). Steroid hormone receptors: many actors in search of a plot. Cell 83, 851-857.
3. Cadepond, F., Ulmann, A., and Baulieu, E.E. (1997). RU486 (mifepristone): mechanisms of action and clinical uses. Annu. Rev. Med. 48, 129-156.
4. Chang, C.S., Kokontis, J., and Liao, S.T. (1988). Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science 240, 324-326.
5. Dagerlind, A., Friberg, K., Bean, A.J., and Hokfelt, T. (1992). Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry. Histochemistry 98, 39-49.
6. Debri, K., Boobis, A.R., Davies, D.S., and Edwards, R.J. (1995). Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues. Biochem. Pharmacol. 50, 2047-2056.
7. Elshourbagy, N.A., and Guzelian, P.S. (1980). Separation, purification, and characterization of a novel form of cytochrome P-450 from rats treated with pregnenolone-16α-carbonitrile. J. Biol. Chem. 255, 1279-1285.
8. Enmark, E., and Gustafsson, J.-A. (1996). Orphan nuclear receptors - the first eight years. Mol. Endocrinol. 10, 1293-1307.
9. Evans, R.M. (1988). The steroid and thyroid hormone receptor superfamily. Science 240, 889-895.
10. Forman, B.M., Goode, E., Chen, J., Oro, A.E., Bradley, D.J., Perlmann, T., Noonan, D.J., Burka, L.T., McMorris, T., Lamph, W.W., et al. (1995). Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 81, 687-693.
11. Forman, B.M., Chen, J., and Evans, R.M. (1997). Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc. Natl. Acad. Sci. USA 94, 4312-4317.
12. Glass, C.K. (1994). Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers. Endocr. Rev. 15, 391-407.
13. Gonzalez, F.J., Nebert, D.W., Hardwick, J.P., and Kasper, C.B. (1985). Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family. J. Biol. Chem. 260, 7435-7441.
14. Green, S., Walter, P., Kumar, V., Krust, A., Bornet, J.-M., Argos, P., and Chambon, P. (1986). Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320, 134-139.
15. Hardwick, J.P., Gonzalez, F.J., and Kasper, C.B. (1983). Cloning of DNA complementary to cytochrome P-450 induced by pregnenolone-16 alpha-carbonitrile. Characterization of its mRNA, gene, and induction response. J. Biol. Chem. 258, 10182-10186.
16. Heery, D.M., Kalkhoven, E., Hoare, S., and Parker, M.G. (1997). A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387, 733-736.
17. Heuman, D.M., Gallagher, E.J., Barwick, J.L., Elshourbagy, N.A., and Guzelian, P.S. (1982). Immunochemical evidence for induction of a common form of hepatic cytochrome P-450 in rats treated with pregnenolone-16α-carbonitrile or other steroidal or non-steroidal agents. Mol. Pharmacol. 21, 753-760.
18. Heyman, R.A., Mangelsdorf, D.J., Dyck, J.A., Stein, R., Eichele, G., Evans, R.M., and Thaller, C. (1992). 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68, 397-406.
19. Horwitz, K.B., Jackson, T.A., Bain, D.L., Richer, J.K., Takimoto, G.S., and Tung, L. (1996). Nuclear receptor coactivators and corepressors. Mol. Endocrinol. 10, 1167-1177.
20. Huss, J.M., Wang, S.I., Astrom, A., McQuiddy, P., and Kasper, C.B. (1996). Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. J. Biol. Chem. 93, 4666-4670.
21. Janowski, B.A., Willy, P.J., Devi, T.R., Falck, J.R., and Mangelsdorf, D.J. (1996). An oxysterol signaling pathway mediated by the nuclear receptor LXRα. Nature 383, 728-731.
22. Juchau, M.R. (1990). Substrate specificities and functions of the P450 cytochromes. Life Sci. 47, 2385-2394.
23. Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R.A., Rose, D.W., Glass, C.K., and Rosenfeld, M.G. (1996). ACBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85, 403-414.
24. Kliewer, S.A., Sundseth, S.S., Jones, S.A., Brown, P.J., Wisely, G.B., Koble, C.S., Devchand, P., Wahli, W., Willson, T.M., Lenhard, J.M., and Lehmann, J.M. (1997). Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc. Natl. Acad. Sci. USA 94, 4318-4323.
25. Kourounakis, P., Selye, H., and Tache, Y. (1977). Catatoxic steroids. Adv. Steroid Biochem. Pharmacol. 6, 35-57.
26. Krey, G., Braissant, O., L'Horset, F., Kalkhoven, E., Perroud, M., Parker, M.G., and Wahli, W. (1997). Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol. 11, 779-791.
27. Lala, D.S., Syka, P.M., Lazarchik, S.B., Mangelsdorf, D.J., Parker, K.L., and Heyman, R.A. (1997). Activation of the nuclear orphan receptor steroidogenic factor 1 by oxysterols. Proc. Natl. Acad. Sci. USA 94, 4895-4900.
28. Lehmann, J.M., Moore, L.B., Smith-Oliver, T.A., Wilkison, W.O., Willson, T.M., and Kliewer, S.A. (1995). An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270, 12953-12956.
29. Lehmann, J.M., Kliewer, S.A., Moore, L.B., Smith-Oliver, T.A., Oliver, B.B., Su, J.-L., Sundseth, S.S., Winegar, D.A., Blanchard, D.E., Spencer, T.A., and Willson, T.M. (1997). Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272, 3137-3140.
30. Levin, A.A., Sturzenbecker, L.J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., Speck, J., Kratzeisen, C., Rosenberger, M., Lovey, A., and Grippo, J.F. (1992). 9-Cis retinoic acid steroisomer binds and activates the nuclear receptor RXRα. Nature 355, 359-361.
31. Lubahn, D.B., Joseph, D.R., Sullivan, P.M., Willard, H.F., French, F.S., and Wilson, E.M. (1988). Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science 240, 327-330.
32. Luckow, B., and Schütz, G. (1987). CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15, 5490.
33. Luo, X., Ikeda, Y., and Parker, K.L. (1994). A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77, 481-490.
34. Mangelsdorf, D.J., and Evans, R.M. (1995). The RXR heterodimers and orphan receptors. Cell 83, 841-850.
35. Mangelsdorf, D.J., Ong, E.S., Dyck, J.A., and Evans, R.M. (1990). Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345, 224-229.
36. Mangelsdorf, D.J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Kastner, P., Mark, M., Chambon, P., and Evans, R.M. (1995). The nuclear receptor superfamily: the second decade. Cell 83, 835-839.
37. Mason, J.I., and Boyd, G.S. (1978). The suppressive effect of the catatoxic steroid, pregnenolone-16alpha-carbonitrile, on liver microsomal cholesterol-7alpha-hydroxylase. Steroids 31, 849-854.
38. Miyata, M., Nagata, K., Yamazoe, Y., and Kato, R. (1995). Transcriptional elements directing a liver-specific expression of P450/6βA (CYP3A2) gene-encoding testosterone 6β-hydroxylase. Arch. Biochem. Biophysics 318, 71-79.
39. Nebert, D.W., and Gonzalez, F.J. (1987). P450 genes: structure, evolution, and regulation. Annu. Rev. Biochem. 56, 945-993.
40. Onate, S.A., Tsai, S.Y., Tsai, M.-J., and O'Malley, B.M. (1995). Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270, 1354-1357.
41. Pratt, W.B. (1993). The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor. J. Biol. Chem. 268, 21455-21458.
42. Punjabi, U., Deslypere, J.P., Verdonck, L., and Vermeulen, A. (1983). Androgen and precursor levels in serum and testes of adult rats under basal conditions and after hCG stimulation. J. Steroid Biochem. 19, 1481-1490.
43. Quattrochi, L.C., Mills, A.S., Barwick, J.L., Yockey, C.B., and Guzelian, P.S. (1995). A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids. J. Biol. Chem. 270, 28917-28923.
44. Schuetz, E.G., and Guzelian, P.S. (1984). Induction of cytochrome P-450 by glucocorticoids in rat liver. J. Biol. Chem. 259, 2007-2012.
45. Schuetz, E.G., Wrighton, S.A., Barwick, J.L., and Guzelian, P.S. (1984). Induction of cytochrome P-450 by glucocorticoids in rat liver. J. Biol. Chem. 259, 1999-2006.
46. Selye, H. (1971). Hormones and resistance. J. Pharm. Sci. 60, 1-28.
47. Smith, D.P., Mason, C.S., Jones, E.A., and Old, R.W. (1994). A novel nuclear receptor subfamily member in Xenopus that associates with RXR and shares extensive sequence similarity to the mammalian vitamin D3 receptor. Nucleic Acids Res. 22, 66-71.
48. Stahlberg, D. (1995). Effects of pregnenolone-16α-carbonitrile on the metabolism of cholesterol in rat liver microsomes. Lipids 30, 361-364.
49. Takeshita, A., Yen, P.M., Misiti, S., Cardona, G.R., Liu, Y., and Chin, W.W. (1996). Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. Endocrinology 137, 3594-3597.
50. Tietz, N.W. (1995). Clinical Guide to Laboratory Tests (Philadelphia: W. B. Saunders Co.).
51. Torchia, J., Rose, D.W., Inostroza, J., Kamei, Y., Westin, S., Glass, C.K., and Rosenfeld, M.G. (1997). The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387, 677-684.
52. Turley, S.D., and Dietschy, J.M. (1984). Modulation of the stimulatory effect of pregnenolone-16α-carbonitrile on biliary cholesterol output in the rat by the manipulation of the rate of hepatic cholesterol synthesis. Gastroenterology 87, 284-292.
53. Umesono, K., Murakami, K.K., Thompson, C.C., and Evans, R.M. (1991). Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell 65, 1255-1266.
54. von Bergmann, K., Schwartz, H.P., and Paumgartner, G. (1975). Effect of phenobarbital, spironolactone and pregnenolone-16α-carbonitrile on bile formation in the rat. Naunyn Schmiedebergs Arch. Pharmacol. 287, 33-45.
55. Wichmann, U., Wichmann, G., and Krause, W. (1984). Serum levels of testosterone precursors, testosterone and estradiol in 10 animal species. Exp. Clin. Endocrinol. 83, 283-290.
56. Wurtz, J.-M., Bourguet, W., Renaud, J.-P., Vivat, V., Chambon, P., Moras, D., and Gronemeyer, H. (1996). A canonical structure for the ligand-binding domain of nuclear receptors. Nature Struct. Biol. 3, 87-94.
57. Zavacki, A.M., Lehmann, J.M., Seol, W., Willson, T.M., Kliewer, S.A., and Moore, D.D. (1997). Activation of the orphan receptor RIP14 by retinoids. Proc. Natl. Acad. Sci. USA 94, 7909-7914.