Effect of milk thistle on the pharmacokinetics of indinavir in healthy volunteers

Pharmacotherapy

Volumn 22, Issue 5, 2002, Pages 551-556

  Piscitelli, Stephen C ^a   Formentini, Elizabeth ^b   Burstein, Aaron H ^a   Alfaro, Raul ^a   Jagannatha, Shyla ^d   Falloon, Judith ^c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDINAVIR; SILYMARIN; THISILYN;

ADULT; ALTERNATIVE MEDICINE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EFFECT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; NORMAL HUMAN; PROSPECTIVE STUDY; SILYBUM MARIANUM; TIME SERIES ANALYSIS;

ADULT; ANTI-HIV AGENTS; ANTIOXIDANTS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; INDINAVIR; MALE; MIDDLE AGED; MILK THISTLE; PHYTOTHERAPY; SILYMARIN; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0036239016     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.22.8.551.33205     Document Type: Article

References (12)

1. Indinavir concentrations and St John's wort
2. The effect of garlic supplements on the pharmacokinetics of saquinavir
3. Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures
4. Inhibitory effects of silibinin on cytochrome P-450 enzymes in human liver microsomes
5. Milk thistle: Silybum marianum
6. Milk thistle (Silybum marianum) for the therapy of liver disease
7. Influence of silymarin on drug metabolizing enzymes in rat and man
8. Inhibition of human cytochrome P450 enzymes by constituents of St. John's wort, an herbal preparation used in the treatment of depression
9. Profound drop of cyclosporin A whole blood trough levels caused by St. John's wort (Hypericum perforatum)
10. Drug interaction between St. John's wort and nevirapine