Carbamazepine is not a substrate for P-glycoprotein

British Journal of Clinical Pharmacology

Volumn 51, Issue 4, 2001, Pages 345-349

  Owen, Andrew ^b   Pirmohamed, Munir ^b   Tettey, Justice N ^b   Morgan, Paul ^a,b   Chadwick, David ^b   Kevin Park, B ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Carbamazepine; Epilepsy; P glycoprotein

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CYTOCHROME P450 3A4; GLYCOPROTEIN P; RHODAMINE 123; VALSPODAR; VERAPAMIL;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG PENETRATION; DRUG TRANSPORT; ENZYME INHIBITION; EPILEPSY; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE EPITHELIUM; LYMPHOCYTE; MONOLAYER CULTURE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTICONVULSANTS; BRAIN; CACO-2 CELLS; CALCIUM CHANNEL BLOCKERS; CARBAMAZEPINE; EPILEPSY; FLOW CYTOMETRY; HUMANS; LYMPHOCYTES; MICE; MICE, KNOCKOUT; P-GLYCOPROTEIN; VERAPAMIL;

EID: 0035036730     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2001.01359.x     Document Type: Article

References (16)

1. Epidemiology, classification, natural history, and genetics of epilepsy
2. Early identification of refractory epilepsy
3. Mdr1 gene-expression in brain of patients with medically intractable epilepsy
4. Safety and efficacy of vigabatrin and carbamazepine in newly diagnosed epilepsy: A multicentre randomised double-blind study
5. Human liver carbamazepine metabolism - Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation
6. Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein
7. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
8. P-glycoprotein and cytochrome P-450 3A inhibition: Dissociation of inhibitory potencies
9. Modulation of P-glycoprotein function in human lymphocytes and Caco-2 cell monolayers by HIV-1 protease inhibitors
10. Carbamazepine hypersensitivity: Assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine
11. P-glycoprotein in the blood-brain-barrier of mice influences the brain penetration and pharmacological activity of many drugs
12. P-glycoprotein - A mediator of multidrug-resistance in tumor-cells
13. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
14. PSC-833, a frontier in modulation of P-glycoprotein mediated multidrug resistance
15. Co-operative binding sites for transported substrates in the multiple drug resistance transporter Mdr1
16. Comparison of drug accumulation in P-glycoprotein-expressing and MRP-expressing human leukaemia cells