Grapefruit juice activates P-glycoprotein-mediated drug transport

Pharmaceutical Research

Volumn 16, Issue 4, 1999, Pages 478-485

  Soldner, Andrea ^a   Christians, Uwe ^a   Susanto, Miki ^a   Wacher, Vincent J ^b   Silverman, Jeffrey A ^b   Benet, Leslie Z ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b AvMax Inc   (United States)

Author keywords

Active transport; Bioavailability; Cytochrome P450 3A metabolism; Grapefruit juice; Intestine

Indexed keywords

CYCLOSPORIN; CYTOCHROME P450; DILTIAZEM; FELODIPINE; GLYCOPROTEIN P; NIFEDIPINE; NISOLDIPINE; NITRENDIPINE; SAQUINAVIR;

AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG METABOLISM; DRUG TRANSPORT; FOOD INTAKE; GRAPE; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ARYL HYDROCARBON HYDROXYLASES; BEVERAGES; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT, ACTIVE; CACO-2 CELLS; CELLS, CULTURED; CITRUS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DIURETICS, OSMOTIC; DOGS; HUMANS; KIDNEY; MANNITOL; OXIDOREDUCTASES, N-DEMETHYLATING; P-GLYCOPROTEIN; PHARMACOKINETICS; VINBLASTINE;

EID: 0032904977     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011902625609     Document Type: Article

References (26)

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