The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

Journal of Clinical Investigation

Volumn 102, Issue 5, 1998, Pages 1016-1023

  Lehmann, Jürgen M ^a   McKee, David D ^a   Watson, Michael A ^a   Willson, Timothy M ^a   Moore, John T ^a   Kliewer, Steven A ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Cytochrome P450 3A; Drug interactions; Nuclear receptor; Orphan receptor; Transcription factor

Indexed keywords

CELL NUCLEUS RECEPTOR; CYTOCHROME P450 ISOENZYME;

ARTICLE; CELL NUCLEUS; GENE EXPRESSION REGULATION; HUMAN; MOLECULAR CLONING; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

EID: 0032169485     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3703     Document Type: Article

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