Chemoenzymatic preparation of silybin β-glucuronides and their biological evaluation

Drug Metabolism and Disposition

Volumn 28, Issue 12, 2000, Pages 1513-1517

  Křen, Vladimír ^a   Ulrichová, Jitka ^b   Kosina, Pavel ^b   Stevenson, David ^a,c   Sedmera, Petr ^b   Přikrylová, Věra ^a   Halada, Petr ^a   Šimánek, Vilím ^b  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b PALACKÝ UNIVERSITY   (Czech Republic)

^c CALLAGHAN INNOVATION   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

20 BETA DEXTRO GLUCURONATE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; SCAVENGER; SILIBININ; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG ACTIVITY; DRUG GLUCURONIDATION; DRUG OXIDATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PH; PRIORITY JOURNAL; SHEEP;

OVIS; OVIS ARIES;

EID: 0033668916     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Milk thistle (Silybum marianum) for the therapy of liver disease
2. Substituent effects in the free radical reactions of silybin: Radiation induced oxidation of the flavonoid at neutral pH
3. Pulse radiolysis of silybin: One-electron oxidation of the flavonoid at neutral pH
4. Silymarin and its components are inhibitors of β-glucuronidase
5. HPLC determination of silybin glycosides in biological materials
6. Glucosylation of silybin by plant cell cultures of Papaver somniferum var. setigerum
7. Glycosylation of silybin
8. Mechanism for the protective effect of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant
9. Diastereomeric separation of free and conjugated silibinin in plasma by reversed phase HPLC after specific extraction
10. Two high-performance liquid chromatographic assays for the determination of free and total silibinin diastereomers in plasma using column switching with electrochemical detection and reversed-phase chromatography with ultraviolet detection
11. Optimisation of β-D-glucuronide synthesis using UDP. Glucuronyl transferase
12. Biochemical effect of the flavonolignan silibinin on RNA protein and DNA synthesis in rat livers
13. High-performance liquid chromatographic separation of silymarins and their determination in a raw extract of Silybum marianum Gaertn
14. Study on dose-linearity of the pharmacokinetics of silibinin diastercomers using a new stereospecific assay