Effect of St John's wort on the pharmacokenetics of fexofenadine

Clinical Pharmacology and Therapeutics

Volumn 71, Issue 6, 2002, Pages 414-420

  Wang, Zaiqi ^a   Hamman, Mitchell A ^a   Huang, Shiew Mei ^a   Lesko, Lawrence J ^a   Hall, Stephen D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FEXOFENADINE; HYPERICUM PERFORATUM EXTRACT;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EFFECT; DRUG HALF LIFE; FEMALE; HUMAN; HYPERICUM PERFORATUM; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; ANTI-ALLERGIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HISTAMINE H1 ANTAGONISTS; HUMANS; HYPERICUM; MALE; P-GLYCOPROTEIN; REFERENCE VALUES; TERFENADINE;

EID: 0036286921     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2002.124080     Document Type: Article

References (25)

1. St John's wort for depression: An overview and meta-analysis of randomized trials
2. Herbal medicine takes root in Germany
3. Herb-drug interaction
4. Indinavir concentrations and St John's wort
5. P-glycoprotein: A defense mechanism limiting oral bioavailability and CNS accumulation of drugs
6. Is the role of the small intestine in first-pass metabolism overemphasized?
7. OATP P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
8. Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr1a p-glycoprotein
9. Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)
10. Acute heart transplant rejection due to St John's wort
11. Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: Evidence of cytochrome P-450 3A and p-glycoprotein induction
12. The effect of rifampin administration on the disposition of fexofenadine
13. Pharmacokinetics, pharmacodynamics, and tolerance of single-dose and multiple dose fexofenadine hydrochloride in healthy male volunteers
14. +1
15. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin
16. Effects of quinidine on pharmacokinetics and pharmacodynamics of digitoxin achieving steady-state conditions
17. Fexofenadine: A review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria
18. Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein
19. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
20. Activation and inhibition of P-glycoprotein (P-gp) mediated efflux of digoxin by St John's Wort extract
21. St John's Wort induced intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4
22. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
23. St John's wort induces hepatic drug metabolism through activation of the pregnane X receptor