Different effects of St John's Wort on the pharmacokinetics of simvastatin and pravastatin

Clinical Pharmacology and Therapeutics

Volumn 70, Issue 6, 2001, Pages 518-524

  Sugimoto, Koh Ichi ^b   Ohmori, Masami ^b   Tsuruoka, Shuichi ^b   Nishiki, Kenta ^b   Kawaguchi, Atsuhiro ^b   Harada, Ken Ichi ^b   Arakawa, Masashi ^b   Sakamoto, Koh Ichi ^b   Masada, Mikio ^b   Miyamori, Isamu ^b   Fujimura, Akio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

'ST JOHNS WORT'; CYTOCHROME P450 3A4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLACEBO; PRAVASTATIN; SIMVASTATIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; FIRST PASS EFFECT; HUMAN; HUMAN EXPERIMENT; HYPERICUM PERFORATUM; INTESTINE WALL; LIVER; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTICHOLESTEREMIC AGENTS; AREA UNDER CURVE; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; FEMALE; HUMANS; HYPERICUM; MALE; MASS SPECTROMETRY; PHYTOTHERAPY; PRAVASTATIN; SIMVASTATIN;

EID: 0035652201     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2001.120025     Document Type: Article

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