2.1 Å crystal structure of human PXR in complex with the St. John's wort compound hyperforin

Biochemistry

Volumn 42, Issue 6, 2003, Pages 1430-1438

  Watkins, Ryan E ^a   Maglich, Jodi M ^b   Moore, Linda B ^b   Wisely, G Bruce ^b   Noble, Schroeder M ^a   Davis Searles, Paula R ^a   Lambert, Mill H ^b   Kliewer, Steven A ^b,c   Redinbo, Matthew R ^a  

^a The University of North Carolina at Chapel Hill   (United States)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CHEMICAL ACTIVATION; CONFORMATIONS; CRYSTAL STRUCTURE; DRUG DOSAGE; GENETIC ENGINEERING; METABOLISM; MOLECULAR STRUCTURE; MUTAGENESIS;

LIGANDS;

BIOCHEMISTRY;

HYPERFORIN; IMMUNOSUPPRESSIVE AGENT; ORAL CONTRACEPTIVE AGENT; PREGNANE X RECEPTOR; ANTIDEPRESSANT AGENT; BICYCLO COMPOUND; BIOPOLYMER; CELL RECEPTOR; CYTOCHROME P450; DRUG DERIVATIVE; LIGAND; PHLOROGLUCINOL; STEROID RECEPTOR; TERPENE;

ARTICLE; CONTROLLED STUDY; DRUG EXCRETION; DRUG METABOLISM; DRUG RECEPTOR BINDING; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; HUMAN; HUMAN CELL; HYPERICUM PERFORATUM; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; ANIMAL; BINDING SITE; CELL CULTURE; CELL LINE; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CRYSTALLIZATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HYPERICUM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

HYPERICUM; HYPERICUM PERFORATUM; MAMMALIA;

ANIMALS; ANTIDEPRESSIVE AGENTS; BICYCLO COMPOUNDS; BINDING SITES; BIOPOLYMERS; CELL LINE; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COMPUTER SIMULATION; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION REGULATION; HUMANS; HYPERICUM; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHLOROGLUCINOL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; STRUCTURE-ACTIVITY RELATIONSHIP; TERPENES; TRANSFECTION;

EID: 0037501542     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0268753     Document Type: Article

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