Effects of silymarin MZ-80 on oxidative stress in patients with alcoholic cirrhosis

International Journal of Clinical Pharmacology and Therapeutics

Volumn 40, Issue 1, 2002, Pages 2-8

  Lucena, M I ^a   Andrade, R J ^a   de la Cruz, J P ^a   Rodriguez Mendizabal, M ^a   Blanco, E ^a   Sanchez de la Cuesta F ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Alcoholic cirrhosis; Erythrocyte glutathione content; Malondialdehyde; Oxidative stress; Serum amino; Silymarin; Terminal propeptide of procollagen Type III

Indexed keywords

ALCOHOL; GLUTATHIONE; MALONALDEHYDE; MZ 80; PLACEBO; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; SILYMARIN;

ADULT; AGED; ALCOHOL LIVER CIRRHOSIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG TOLERABILITY; ECHOGRAPHY; ERYTHROCYTE LEVEL; HUMAN; IMPOTENCE; LIPID PEROXIDATION; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE; TREATMENT OUTCOME;

EID: 0036151676     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP40002     Document Type: Article

References (22)

1. Apolipoprotein distribution in HDL subfractions in alcohol consumers
2. Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: A double-blind, placebo-controlled trial
3. Silymarin in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid
4. Inhibitory action of silymarin on lipid peroxide formation in rat liver mitochondria and microsomes
5. Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats
6. Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake
7. Inhibition of Kupffer cell function as an explanation for the hepatoprotective properties of silibinin
8. Inhibition of ferrous-induced lipid peroxidation by pyrimido-pyrimidine derivatives in human liver membranes
9. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver
10. Identification of the antifibrogenic properties of silibinin: Effect on TGF-β and matrix gene expression on hepatic stellate cells
11. Effects of silibinin and of a synthetic analogue on isolated rat hepatic stellate cells and myofibroblasts
12. Effects of silymarin MZ-80 on hepatic oxidative stress in rats with biliary obstruction
13. A fluorimetric method of determination of oxidized and reduced glutathione on tissues
14. S-adenosylmethionine in alcoholic liver cirrhosis: A randomized, placebo-controlled, double-blind, multicenter clinical trial
15. Effects of silymarin (Legalon) treatment on the antioxidant defence system and lipid peroxidation in patients with chronic alcoholic liver diseases (a double-blind study)
16. Effects of silymarin in alcoholic patients with cirrhosis of the liver: Results of a controlled, double-blind, randomized and multicenter trial
17. Clinical studies with silymarin: Fibrosis progression is the end point
18. Silymarin: What is in the name...? An appeal for a change of editorial policy
19. Superoxide dismutase activity in serum of patients with acute cerebral ischemic injury
20. Insights into the pathogenesis of alcohol liver necrosis and fibrosis: Status report
21. Silymarin protection against hepatic lipid peroxidation induced by acute ethanol intoxication in the rat
22. Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients