Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

Journal of Clinical Investigation

Volumn 99, Issue 10, 1997, Pages 2545-2553

  Lown, Kenneth S ^a   Bailey, David G ^b   Fontana, Robert J ^a   Janardan, Srinivas K ^a   Adair, Constance H ^a   Fortlage, Laurie A ^a   Brown, Morton B ^a   Guo, Wensheng ^a   Watkins, Paul B ^a,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c Urology Institute Case Medical Center University Hospitals   (United States)

Author keywords

breath tests; cytochrome P 450; erythromycin; multiple drug resistance; P glycoprotein

Indexed keywords

CYTOCHROME P450; FELODIPINE; GLYCOPROTEIN P;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; ENZYME INACTIVATION; ENZYME POLYMORPHISM; FOOD DRUG INTERACTION; FRUIT JUICE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTESTINE CELL; LIVER MICROSOME; MALE; MULTIDRUG RESISTANCE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SMALL INTESTINE ABSORPTION;

EID: 0030982634     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119439     Document Type: Article

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