Grapefruit-felodipine interaction: Effect of unprocessed fruit and probable active ingredients

Clinical Pharmacology and Therapeutics

Volumn 68, Issue 5, 2000, Pages 468-477

  Bailey, David G ^a,b   Dresser, George K ^a,b   Kreeft, John H ^a,b   Munoz, Claudio ^a,b   Freeman, David J ^a,b   Bend, John R ^a,b  

^a LONDON HEALTH SCIENCES CENTRE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2,3 DICHLOROPHENYL) 2,6 DIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID ETHYL METHYL ESTER; 6',7' DIHYDROXYBERGAMOTTIN; BERGAMOTTIN; CYTOCHROME P450 3A4; FELODIPINE; FLAVONOID; FUROCOUMARIN; NARINGENIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CROSSOVER PROCEDURE; DRUG DISPOSITION; ENZYME ACTIVITY; FEMALE; FOOD DRUG INTERACTION; FOOD PROCESSING; GRAPE; HUMAN; HUMAN EXPERIMENT; ISOMER; MALE; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION;

ADMINISTRATION, ORAL; ADULT; ANTIOXIDANTS; AREA UNDER CURVE; BEVERAGES; CITRUS; CROSS-OVER STUDIES; CYTOCHROME P-450 ENZYME SYSTEM; DELAYED-ACTION PREPARATIONS; DRUG INTERACTIONS; FELODIPINE; FEMALE; FLAVANONES; FLAVONOIDS; HALF-LIFE; HUMANS; MALE; MIXED FUNCTION OXYGENASES; PSORALENS; RADIATION-SENSITIZING AGENTS;

EID: 0033713294     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2000.110774     Document Type: Article

References (29)

1. Interaction of citrus juices with felodipine and nifedipine
2. Grapefruit juice and drugs: How significant is the interaction?
3. Drug interactions with grapefruit juice
4. Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance
5. Grapefruit juice-drug interactions
6. Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression
7. Inhibitory effect of grapefruit juice and the active component naringenin on CYP1A2 dependent metabolism of caffeine in man
8. Lack of effect of grapefruit juice on diltiazem bioavailability in normal subjects
9. Grapefruit juice
10. Inactivation of cytochrome P450 3A4 by bergamottin, a component in grapefruit juice
11. Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice
12. Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit juice constituents: Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocourmarins
13. Specific CYP3A4 inhibitors in grapefruit juice: Furocoumarin dimers as components of drug interaction
14. Role of furanocoumain derivatives on grapefruit juice-mediated inhibition of human CYP3A activity
15. 1 activation in human liver microsomes by naringenin and other flavonoids
16. Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice
17. The fate of naringin in humans: A key to grapefruit juice-drug interactions?
18. Determination of felodipine in plasma by capillary gas chromatography with electron capture detection
19. CYP3A4 expressed by insect cells infected with a recombinant baculovirus containing both CYP3A4 and human NADPH-cytochrome P450 reductase is catalytically similar to human liver microsomal CYP3A4
20. Grapefruit juice-felodipine interaction: Effect of naringin and 6',7'-dihydroxybergamottin in humans
21. Grapefruit juice-felodipine interaction: Mechanism, predictability and effect of naringin
22. Felodipine kinetics in healthy men
23. A population study of the pharmacokinetics of felodipine
24. Pharmacokinetics and biotransformation of 1,4-dihydropyridine calcium antagonists
25. Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P450IIIA4
26. Erythromycin-felodipine interaction: Magnitude, mechanism, and comparison with grapefruit juice
27. Identification of rifampicin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes
28. Effects of grapefruit juice ingestion - Pharmacokinetics and haemodynamics of intravenously and orally administered felodipine in healthy men
29. Grapefruit juice-felodipine interaction: Reproducibility and characterization with the extended release drug formulation