Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: Roles of cytochromes P450 2C9, 2C19, and 3A4

Drug Metabolism and Disposition

Volumn 28, Issue 11, 2000, Pages 1361-1368

  Komatsu, Tomoko ^a   Yamazaki, Hiroshi ^a   Asahi, Satoru ^b   Gillam, Elizabeth M J ^c   Guengerich, F Peter ^d   Nakajima, Miki ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (3',4' DIHYDROXYPHENYL) 5 PHENYLHYDANTOIN; 5 (4' HYDROXYPHENYL) 5 PHENYLHYDANTOIN; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; FLUVOXAMINE; KETOCONAZOLE; PHENYTOIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG OXIDATION; HUMAN; HUMAN CELL; HYDROXYLATION; LIVER CYTOSOL; LIVER MICROSOME METABOLISM; PRIORITY JOURNAL;

CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; CYTOSOL; HUMANS; ISOENZYMES; MICROSOMES, LIVER; OXIDATION-REDUCTION; RECOMBINANT PROTEINS;

EID: 0033787393     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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