P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

Journal of Clinical Investigation

Volumn 97, Issue 11, 1996, Pages 2517-2524

  Schinkel, Alfred H ^a   Wagenaar, Els ^a   Mol, Carla A A M ^a   Van Deemter, Liesbeth ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

central nervous system; Multidrug resistance; neurotoxicity; opiates; reversal agents

Indexed keywords

CLOZAPINE; CYCLOSPORIN A; DAUNORUBICIN; DEXAMETHASONE; DIGOXIN; DOMPERIDONE; ETOPOSIDE; FLUNITRAZEPAM; GLYCOPROTEIN P; HALOPERIDOL; IVERMECTIN; LOPERAMIDE; MORPHINE; ONDANSETRON; PACLITAXEL; PHENYTOIN; VINBLASTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL LINE; DOSE RESPONSE; DRUG ACTIVITY; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG SENSITIVITY; DRUG TISSUE LEVEL; DRUG TRANSPORT; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; LETHAL DOSE; MALE; MOUSE; MULTIDRUG RESISTANCE; NEUROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

EID: 0029892497     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118699     Document Type: Article

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