메뉴 건너뛰기




Volumn 35, Issue 4, 1998, Pages 275-291

Ritonavir: Clinical pharmacokinetics and interactions with other anti-HIV agents

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANTIVIRUS AGENT; CLARITHROMYCIN; CYTOCHROME P450; DESIPRAMINE; GLUCURONOSYLTRANSFERASE; INDINAVIR; KETOCONAZOLE; NELFINAVIR; OROSOMUCOID; PROTEINASE INHIBITOR; RIFABUTIN; RIFAMPICIN; RITONAVIR; SAQUINAVIR;

EID: 0031751330     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-199835040-00002     Document Type: Article
Times cited : (440)

References (129)
  • 2
    • 0005241362 scopus 로고
    • Active human immunodeficiency virus protease is required for viral infectivity
    • Kohl NE, Emini EA, Schleif WA, et al. Active human immunodeficiency virus protease is required for viral infectivity. Proc Natl Acad Sci U S A 1988; 85: 4686-90
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 4686-4690
    • Kohl, N.E.1    Emini, E.A.2    Schleif, W.A.3
  • 3
    • 0030979361 scopus 로고    scopus 로고
    • Antiretroviral therapy for HIV infection in 1997: Updated recommendations of the International AIDS Society-USA panel
    • Carpenter CJ, Fischl MA, Hammer SM, et al. Antiretroviral therapy for HIV infection in 1997: updated recommendations of the International AIDS Society-USA panel. JAMA 1997; 277: 1962-9
    • (1997) JAMA , vol.277 , pp. 1962-1969
    • Carpenter, C.J.1    Fischl, M.A.2    Hammer, S.M.3
  • 4
    • 15144357022 scopus 로고    scopus 로고
    • The duration of viral suppression during protease inhibitor therapy for HIV-1 infection is predicted by plasma HIV-1 RNA at the nadir
    • Kempf DJ, Rode RA, Xu Y, et al. The duration of viral suppression during protease inhibitor therapy for HIV-1 infection is predicted by plasma HIV-1 RNA at the nadir. AIDS 1998; 12 (5): F9-F14
    • (1998) AIDS , vol.12 , Issue.5
    • Kempf, D.J.1    Rode, R.A.2    Xu, Y.3
  • 6
    • 0344881639 scopus 로고    scopus 로고
    • Demographic and laboratory predictors of virologic treatment failures in patients achieving viral load reductions to below quantifiable levels (BQL) by Amplicor assay receiving indinavir +/- DMP 266 efavirenz
    • Oct 11-15; Hamburg, Germany
    • Ruiz NM, Manion DJ, Labriola DF, et al. Demographic and laboratory predictors of virologic treatment failures in patients achieving viral load reductions to below quantifiable levels (BQL) by Amplicor assay receiving indinavir +/- DMP 266 (efavirenz) [abstract 908]. Sixth European Conference on Clinical Aspects and Treatment of HIV-Infection; 1997 Oct 11-15; Hamburg, Germany
    • (1997) Sixth European Conference on Clinical Aspects and Treatment of HIV-Infection
    • Ruiz, N.M.1    Manion, D.J.2    Labriola, D.F.3
  • 7
    • 0028874048 scopus 로고
    • Rapid turnover of plasma virions and CD-4 lymphocytes in HIV-1 infection
    • Ho DD, Neumann AU, Perelson AS, et al. Rapid turnover of plasma virions and CD-4 lymphocytes in HIV-1 infection. Nature 1995; 373: 123-6
    • (1995) Nature , vol.373 , pp. 123-126
    • Ho, D.D.1    Neumann, A.U.2    Perelson, A.S.3
  • 8
    • 0029967721 scopus 로고
    • HIV-1 dynamics in vivo: Vision clearance rate, infected cell lifespan, and viral generations
    • Perelson AS, Neumann AU, Markowitz M, et al. HIV-1 dynamics in vivo: vision clearance rate, infected cell lifespan, and viral generations. Science 1995; 271: 1582-6
    • (1995) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3
  • 9
    • 0028069547 scopus 로고
    • Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma: Application to acute retroviral infection
    • Mulder J, McKinney N, Christpherson C, et al. Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma: application to acute retroviral infection. J Clin Microbiol 1994; 32: 292-300
    • (1994) J Clin Microbiol , vol.32 , pp. 292-300
    • Mulder, J.1    McKinney, N.2    Christpherson, C.3
  • 10
    • 0028930817 scopus 로고
    • Rapid and precise quantification of HIV-1 RNA in plasma using a branched DNA signal amplification assay
    • Pachl C, Todd JA, Kern DG, et al. Rapid and precise quantification of HIV-1 RNA in plasma using a branched DNA signal amplification assay. J Acquir Immune Defic Syndr Hum Retrovirol 1995; 8: 446-54
    • (1995) J Acquir Immune Defic Syndr Hum Retrovirol , vol.8 , pp. 446-454
    • Pachl, C.1    Todd, J.A.2    Kern, D.G.3
  • 11
    • 0030997937 scopus 로고    scopus 로고
    • Randomized trial of addition of lamivudine or lamivudine plus loviride to zidovudine-containing regimens for patients with HIV-1 infection: The CAESAR trial
    • CAESAR Coordinating Committee. Randomized trial of addition of lamivudine or lamivudine plus loviride to zidovudine-containing regimens for patients with HIV-1 infection: the CAESAR trial. Lancet 1997; 349: 1413-21
    • (1997) Lancet , vol.349 , pp. 1413-1421
  • 12
    • 10144244674 scopus 로고    scopus 로고
    • A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter
    • Hammer SM, Katzenstein DA, Hughes MD, et al. A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter. N Engl J Med 1996; 335: 1081-90
    • (1996) N Engl J Med , vol.335 , pp. 1081-1090
    • Hammer, S.M.1    Katzenstein, D.A.2    Hughes, M.D.3
  • 13
    • 0030567824 scopus 로고    scopus 로고
    • Delta: A randomized double-blind trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals
    • Delta Coordinating Committee. Delta: a randomized double-blind trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals. Lancet 1996; 348: 283-91
    • (1996) Lancet , vol.348 , pp. 283-291
  • 14
    • 0003308625 scopus 로고    scopus 로고
    • Improved survival and decreased progression of HIV in patients treated with saquinavir (invirase, SQV) plus Hivid (zalcitabine, ddC)
    • Jul 7-12; Vancouver
    • Lalezari J, Haubrich R, Burger H, et al. Improved survival and decreased progression of HIV in patients treated with saquinavir (invirase, SQV) plus Hivid (zalcitabine, ddC) [abstract LB.B.6033]. XI International Conference on AIDS; 1996 Jul 7-12; Vancouver
    • (1996) XI International Conference on AIDS
    • Lalezari, J.1    Haubrich, R.2    Burger, H.3
  • 15
    • 0003204379 scopus 로고    scopus 로고
    • Prolongation of life and prevention of AIDS complications in advanced HIV immunodeficiency with RTV, update
    • Jul 7-12; Vancouver
    • Cameron DW, Heath-Chiozzi M, Kravcik S, et al. Prolongation of life and prevention of AIDS complications in advanced HIV immunodeficiency with RTV, update [abstract Mo.B.411]. XI International Conference on AIDS; 1996 Jul 7-12; Vancouver
    • (1996) XI International Conference on AIDS
    • Cameron, D.W.1    Heath-Chiozzi, M.2    Kravcik, S.3
  • 16
    • 0028846165 scopus 로고
    • Safety, pharmacokinetics, and preliminary efficacy of RTV, an inhibitor of HIV-1 protease
    • Danner SA, Carr A, Leonard JM, et al. Safety, pharmacokinetics, and preliminary efficacy of RTV, an inhibitor of HIV-1 protease. N Engl J Med 1995; 333: 1528-33
    • (1995) N Engl J Med , vol.333 , pp. 1528-1533
    • Danner, S.A.1    Carr, A.2    Leonard, J.M.3
  • 17
    • 0028806725 scopus 로고
    • A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treal HIV-1 infection
    • Markowitz M, Saag M, Powderly W, et al. A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treal HIV-1 infection. N Engl J Med 1995; 333: 1534-9
    • (1995) N Engl J Med , vol.333 , pp. 1534-1539
    • Markowitz, M.1    Saag, M.2    Powderly, W.3
  • 18
    • 0003308625 scopus 로고    scopus 로고
    • Improved survival and decreased progression of HIV in patients treated with saquinavir (invirase, SQV) plus hivid (zalcitabine, ddC)
    • Jul 7-12; Vancouver
    • Lalezari J, Haubrich R, Burger H, et al. Improved survival and decreased progression of HIV in patients treated with saquinavir (invirase, SQV) plus hivid (zalcitabine, ddC) [abstract LB.B.6033]. XI International Conference on AIDS; 1996 Jul 7-12; Vancouver
    • (1996) XI International Conference on AIDS
    • Lalezari, J.1    Haubrich, R.2    Burger, H.3
  • 19
    • 0003280764 scopus 로고    scopus 로고
    • Antiretroviral safety and durability of ritonavir (RIT)-saquinavir (SQV) in protease inhibitor-naive patients in year two of follow-up
    • Feb 1-5; Chicago
    • Cameron DW, Japour A, Mellors J, et al. Antiretroviral safety and durability of ritonavir (RIT)-saquinavir (SQV) in protease inhibitor-naive patients in year two of follow-up [abstract 388]. 5th Conference on Retroviruses and Opportunistic Infections; 1998 Feb 1-5; Chicago
    • (1998) 5th Conference on Retroviruses and Opportunistic Infections
    • Cameron, D.W.1    Japour, A.2    Mellors, J.3
  • 20
    • 0030317870 scopus 로고    scopus 로고
    • The effect of high dose saquinavir on viral load and CD4+ T-cell counts in HIV infected patients
    • Shapiro JM, Winters MA, Stewart F, et al. The effect of high dose saquinavir on viral load and CD4+ T-cell counts in HIV infected patients. Ann Intern Med 1996; 124 (12): 1039-50
    • (1996) Ann Intern Med , vol.124 , Issue.12 , pp. 1039-1050
    • Shapiro, J.M.1    Winters, M.A.2    Stewart, F.3
  • 22
    • 0003296732 scopus 로고    scopus 로고
    • Pharmacodynamics of 141W94 as determined by short term change in HIV RNA: Influence of viral isolate baseline EC50
    • Sep 28-Oct 1; Toronto
    • Drusano GL, Sadler BM, Millard J, et al. Pharmacodynamics of 141W94 as determined by short term change in HIV RNA: Influence of viral isolate baseline EC50 [abstract A-16]. 37th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1997 Sep 28-Oct 1; Toronto
    • (1997) 37th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Drusano, G.L.1    Sadler, B.M.2    Millard, J.3
  • 24
    • 0031035968 scopus 로고    scopus 로고
    • Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus by coadministration with ritonavir
    • Kempf DL, Marsh KC, Kumar G, et al. Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus by coadministration with ritonavir. Antimicrob Agents Chemother 1997; 41 (3): 654-60
    • (1997) Antimicrob Agents Chemother , vol.41 , Issue.3 , pp. 654-660
    • Kempf, D.L.1    Marsh, K.C.2    Kumar, G.3
  • 25
    • 0031054507 scopus 로고    scopus 로고
    • Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients
    • Mar
    • Merry C, Barry MG, Mulcahy F, et al. Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients. AIDS 1997 Mar; 11 (4): F29-33
    • (1997) AIDS , vol.11 , Issue.4
    • Merry, C.1    Barry, M.G.2    Mulcahy, F.3
  • 27
    • 0001864447 scopus 로고    scopus 로고
    • Overview of in-vitro and in vivo drug interaction studies of nelfinavir mesylate (NFV), a new HIV-1 protease inhibitor
    • Jan 22-26; Washington, DC
    • Kerr B, Lee C, Yuen G, et al. Overview of in-vitro and in vivo drug interaction studies of nelfinavir mesylate (NFV), a new HIV-1 protease inhibitor. 4th Conference on Retroviruses and Opportunistic Infections; 1997 Jan 22-26; Washington, DC
    • (1997) 4th Conference on Retroviruses and Opportunistic Infections
    • Kerr, B.1    Lee, C.2    Yuen, G.3
  • 29
    • 0004226349 scopus 로고    scopus 로고
    • Agouron Pharmaceuticals, Inc.
    • Viracept® package insert. Agouron Pharmaceuticals, Inc., 1997
    • (1997) Viracept® Package Insert
  • 31
    • 0028968902 scopus 로고
    • ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans
    • Kempf DJ, Marsh KC, Denissen JF, et al. ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc Natl Acad Sci U S A 1995; 92: 2484-8
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 2484-2488
    • Kempf, D.J.1    Marsh, K.C.2    Denissen, J.F.3
  • 34
    • 0030963109 scopus 로고    scopus 로고
    • Metabolism and disposition of the HIV-1 protease inhibitor ritonavir (ABT-538) in rats, dogs, and humans
    • Denissen JF, Grabowski BA, Johnson MK, et al. Metabolism and disposition of the HIV-1 protease inhibitor ritonavir (ABT-538) in rats, dogs, and humans. Drug Metab Dispos 1996; 25 (4): 489-501
    • (1996) Drug Metab Dispos , vol.25 , Issue.4 , pp. 489-501
    • Denissen, J.F.1    Grabowski, B.A.2    Johnson, M.K.3
  • 35
    • 0030430035 scopus 로고    scopus 로고
    • Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes
    • Kumar GN, Rodrigues AD, Buko AM, et al. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther 1996; 277 (1): 423-31
    • (1996) J Pharmacol Exp Ther , vol.277 , Issue.1 , pp. 423-431
    • Kumar, G.N.1    Rodrigues, A.D.2    Buko, A.M.3
  • 36
    • 0030896237 scopus 로고    scopus 로고
    • Multiple-dose pharmacokinetics of ritonavir in human immunodeficiency virus-infected subjects
    • Hsu A, Granneman GR, Witt G, et al. Multiple-dose pharmacokinetics of ritonavir in human immunodeficiency virus-infected subjects. Antimicrob Agents Chemother 1997; 41 (5): 898-905
    • (1997) Antimicrob Agents Chemother , vol.41 , Issue.5 , pp. 898-905
    • Hsu, A.1    Granneman, G.R.2    Witt, G.3
  • 37
    • 0141513208 scopus 로고    scopus 로고
    • Steady-state pharmacokinetic interactions between ritonavir (RTV), nelfinavir (NFV), and the nelfinavir active metabolite M8 (AG1402)
    • Jun 28-Jul 3; Geneva
    • Flexner C, Hsu A, Kerr B, et al. Steady-state pharmacokinetic interactions between ritonavir (RTV), nelfinavir (NFV), and the nelfinavir active metabolite M8 (AG1402). Submitted. 12th World Congress on AIDS; 1998 Jun 28-Jul 3; Geneva
    • (1998) 12th World Congress on AIDS
    • Flexner, C.1    Hsu, A.2    Kerr, B.3
  • 38
    • 0031857385 scopus 로고    scopus 로고
    • Effect of ritonavir on the pharmacokinetics of ethinyl estradiol in healthy female volunteers
    • Ouellet D, Hsu A, Qian J, et al. Effect of ritonavir on the pharmacokinetics of ethinyl estradiol in healthy female volunteers. Br J Clin Pharmacol. 1998; 46 (2): 111-6
    • (1998) Br J Clin Pharmacol. , vol.46 , Issue.2 , pp. 111-116
    • Ouellet, D.1    Hsu, A.2    Qian, J.3
  • 39
    • 0009872253 scopus 로고    scopus 로고
    • Assessment of multiple doses of ritonavir on the pharmacokinetics of theophylline
    • Jul 7-12; Vancouver
    • Hsu A, Granneman GR, Witt G, et al. Assessment of multiple doses of ritonavir on the pharmacokinetics of theophylline [abstract Mo.B.1200]. XI International Conference on AIDS; 1996 Jul 7-12; Vancouver
    • (1996) XI International Conference on AIDS
    • Hsu, A.1    Granneman, G.R.2    Witt, G.3
  • 40
    • 0031836653 scopus 로고    scopus 로고
    • Pharmacokinetics of ritonavir and zidovudine in human immunodeficiency virus-infected patients
    • Cato III A, Qian J, Hsu A, et al. Pharmacokinetics of ritonavir and zidovudine in human immunodeficiency virus-infected patients. Antimircob Agents Chemother 1998; 42 (7): 1788-93
    • (1998) Antimircob Agents Chemother , vol.42 , Issue.7 , pp. 1788-1793
    • Cato III, A.1    Qian, J.2    Hsu, A.3
  • 42
    • 0029863812 scopus 로고    scopus 로고
    • Hepatic drug-metabolizing activities in rats after 14 days of oral administration of the human immunodeficiency virus-type 1 protease inhibitor ritonavir (ABT-538)
    • Kumar GN, Grabowski B, Lee R, et al. Hepatic drug-metabolizing activities in rats after 14 days of oral administration of the human immunodeficiency virus-type 1 protease inhibitor ritonavir (ABT-538). Drug Metab Dispos 1996; 24 (5): 615-7
    • (1996) Drug Metab Dispos , vol.24 , Issue.5 , pp. 615-617
    • Kumar, G.N.1    Grabowski, B.2    Lee, R.3
  • 44
    • 0031455260 scopus 로고    scopus 로고
    • HIV protease inhibitors, saquinavir, indinavir and ritonavir: Inhibition of CYP3A4-mediated metabolism of testosterone and benzoxazinorifamycin, KRM-1648, in human liver microsomes
    • Inaba T, Fischer N, Riddick DS, et al. HIV protease inhibitors, saquinavir, indinavir and ritonavir: inhibition of CYP3A4-mediated metabolism of testosterone and benzoxazinorifamycin, KRM-1648, in human liver microsomes. Toxicol Lett 1997; 93: 215-9
    • (1997) Toxicol Lett , vol.93 , pp. 215-219
    • Inaba, T.1    Fischer, N.2    Riddick, D.S.3
  • 45
    • 0029872126 scopus 로고    scopus 로고
    • Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor
    • Chiba M, Hensleigh M, Nishime JA, et al. Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. Drug Metab Disp 1996; 24 (3): 307-14
    • (1996) Drug Metab Disp , vol.24 , Issue.3 , pp. 307-314
    • Chiba, M.1    Hensleigh, M.2    Nishime, J.A.3
  • 47
    • 0028877042 scopus 로고
    • Weak binding of VX-478 to human plasma proteins and implications for antihuman immunodeficiency virus therapy
    • Livington DJ, Pazhanisamy S, Porter DJ, et al. Weak binding of VX-478 to human plasma proteins and implications for antihuman immunodeficiency virus therapy. J Infect Dis 1995; 172 (5): 1238-45
    • (1995) J Infect Dis , vol.172 , Issue.5 , pp. 1238-1245
    • Livington, D.J.1    Pazhanisamy, S.2    Porter, D.J.3
  • 48
    • 0013508169 scopus 로고    scopus 로고
    • Pharmacokinetic (PK) interaction between 141W94 and rifabutin (RFB) and rifampin (RFP) after multiple-dose administration
    • Feb 1-5; Chicago
    • Polk RE, Israel DS, Patron R, et al. Pharmacokinetic (PK) interaction between 141W94 and rifabutin (RFB) and rifampin (RFP) after multiple-dose administration [abstract 340]. 5th Conference on Retroviruses and Opportunistic Infections; 1998 Feb 1-5; Chicago
    • (1998) 5th Conference on Retroviruses and Opportunistic Infections
    • Polk, R.E.1    Israel, D.S.2    Patron, R.3
  • 50
    • 0031804689 scopus 로고    scopus 로고
    • Amprenavir
    • Adkin JC, Faulds D. Amprenavir. Drugs 1998; 55 (6): 837-42
    • (1998) Drugs , vol.55 , Issue.6 , pp. 837-842
    • Adkin, J.C.1    Faulds, D.2
  • 51
    • 0345179369 scopus 로고    scopus 로고
    • Potent inhibition of the in vitro human liver microsomal metabolism of the HIV-1 protease inhibitor ABT-378 by ritonavir: Potential for a positive drug interaction
    • Jan 22-26; Washington, DC
    • Kumar GN, Dykstra J, Jayanti V, et al. Potent inhibition of the in vitro human liver microsomal metabolism of the HIV-1 protease inhibitor ABT-378 by ritonavir: potential for a positive drug interaction [abstract 211]. 4th Conference on Retroviruses and Opportunistic Infections; 1997 Jan 22-26; Washington, DC
    • (1997) 4th Conference on Retroviruses and Opportunistic Infections
    • Kumar, G.N.1    Dykstra, J.2    Jayanti, V.3
  • 53
    • 0003273648 scopus 로고    scopus 로고
    • Multiple dose safety, tolerability and pharmacokinetics of ABT-378 in combination with ritonavir
    • Feb 1-5; Chicago
    • Lal R, Hsu A, Granneman R, et al. Multiple dose safety, tolerability and pharmacokinetics of ABT-378 in combination with ritonavir [abstract 647]. 5th Conference on Retroviruses and Opportunistic Infections; 1998 Feb 1-5; Chicago
    • (1998) 5th Conference on Retroviruses and Opportunistic Infections
    • Lal, R.1    Hsu, A.2    Granneman, R.3
  • 54
    • 0042450393 scopus 로고    scopus 로고
    • Effect of food and antacid on bioavailability of the protease inhibitor PNU-140690 in healthy volunteers
    • Feb 1-5; Chicago
    • Baldwin JR, Borin MT, Wang Y, et al. Effect of food and antacid on bioavailability of the protease inhibitor PNU-140690 in healthy volunteers [abstract 649]. 5th Conference on Retroviruses and Opportunistic Infections; 1998 Feb 1-5; Chicago
    • (1998) 5th Conference on Retroviruses and Opportunistic Infections
    • Baldwin, J.R.1    Borin, M.T.2    Wang, Y.3
  • 55
    • 7844245269 scopus 로고    scopus 로고
    • Single-Dose safety, tolerance, and pharmacokinetics of PNU-140690, a new HIV protease inhibitor, in healthy volunteers
    • Sep 28-Oct 1; Toronto
    • Borin MT, Carlson GF, Wang Y, et al. Single-Dose safety, tolerance, and pharmacokinetics of PNU-140690, a new HIV protease inhibitor, in healthy volunteers [abstract I-195]. 37th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1997 Sep 28-Oct 1; Toronto
    • (1997) 37th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Borin, M.T.1    Carlson, G.F.2    Wang, Y.3
  • 56
    • 0013473689 scopus 로고    scopus 로고
    • Multiple-dose safety, tolerance, and pharmacokinetics of the protease inhibitor PNU-140690 in healthy volunteers
    • Feb 1-5; Chicago
    • Borin MT, Wang Y, Schneck DW, et al. Multiple-dose safety, tolerance, and pharmacokinetics of the protease inhibitor PNU-140690 in healthy volunteers [abstract 648]. 5th Conference on Retroviruses and Opportunistic Infections; 1998 Feb 1-5; Chicago
    • (1998) 5th Conference on Retroviruses and Opportunistic Infections
    • Borin, M.T.1    Wang, Y.2    Schneck, D.W.3
  • 57
    • 7844236206 scopus 로고    scopus 로고
    • Evaluation of the role of CYP3A inhibition in food and formulation effects on ritonavir absorption
    • Oct 20-24; San Diego
    • Cato III A, Bertz RJ, Cao G, et al. Evaluation of the role of CYP3A inhibition in food and formulation effects on ritonavir absorption. 7th North America ISSX Annual Meetings; 1996 Oct 20-24; San Diego
    • (1996) 7th North America ISSX Annual Meetings
    • Cato III, A.1    Bertz, R.J.2    Cao, G.3
  • 58
    • 7844237330 scopus 로고    scopus 로고
    • Effect of three vehicles, Advera®, Ensure®, and chocolate milk, on the bioavailability of an oral liquid formulation of ritonavir
    • Sep 15-18; New Orleans
    • Bertz RJ, Shi H, Cavanaugh JH, et al. Effect of three vehicles, Advera®, Ensure®, and chocolate milk, on the bioavailability of an oral liquid formulation of ritonavir [abstract A-5]. 36th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1996 Sep 15-18; New Orleans
    • (1996) 36th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Bertz, R.J.1    Shi, H.2    Cavanaugh, J.H.3
  • 59
    • 0031942263 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics of indinavir and the effect of food
    • Yeh KC, Deutsch PJ, Haddix H, et al. Single-dose pharmacokinetics of indinavir and the effect of food. Antimicrob Agents Chemother 1998; 42 (2): 332-8
    • (1998) Antimicrob Agents Chemother , vol.42 , Issue.2 , pp. 332-338
    • Yeh, K.C.1    Deutsch, P.J.2    Haddix, H.3
  • 60
  • 61
    • 0013506351 scopus 로고    scopus 로고
    • Cerebrospinal fluid (CSF) and plasma HIV RNA suppression with ritonavir (RIT)-saquinavir (SQV) in protease inhibitor naive patients
    • Sep 28-Oct 1; Toronto
    • Farthing C, Japour A, Cohen C, et al. Cerebrospinal fluid (CSF) and plasma HIV RNA suppression with ritonavir (RIT)-saquinavir (SQV) in protease inhibitor naive patients [abstract LB-3]. 37th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1997 Sep 28-Oct 1; Toronto
    • (1997) 37th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Farthing, C.1    Japour, A.2    Cohen, C.3
  • 62
    • 15144342918 scopus 로고    scopus 로고
    • Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection
    • Cavert W, Notermans DW, Staskus K, et al. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science 1997; 276 (1): 960-4
    • (1997) Science , vol.276 , Issue.1 , pp. 960-964
    • Cavert, W.1    Notermans, D.W.2    Staskus, K.3
  • 63
    • 0028237729 scopus 로고
    • Inter-individual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, et al. Inter-individual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994; 270: 414-23
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3
  • 64
    • 0011790924 scopus 로고    scopus 로고
    • Effect of ritonavir on the pharmacokinetics of desipramine
    • Jul 7-12; Vancouver
    • Bertz RJ, Cao G, Cavanaugh JH, et al. Effect of ritonavir on the pharmacokinetics of desipramine [abstract Mo.B.1201]. XI International Conference on AIDS; 1996 Jul 7-12; Vancouver
    • (1996) XI International Conference on AIDS
    • Bertz, R.J.1    Cao, G.2    Cavanaugh, J.H.3
  • 65
    • 0344548294 scopus 로고
    • Kinetics of ABT-538, a protease inhibitor, in humans after single oral rising doses
    • Hsu A, Granneman RG. Kinetics of ABT-538, a protease inhibitor, in humans after single oral rising doses [abstract PPDM 8272]. Pharm Res 1994; 11: S400
    • (1994) Pharm Res , vol.11
    • Hsu, A.1    Granneman, R.G.2
  • 66
    • 85087574973 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between ritonavir and indinavir in healthy volunteers
    • In press
    • Hsu A, Granneman GR, Cao G-L, et al. Pharmacokinetic interactions between ritonavir and indinavir in healthy volunteers. Antimicrob Agents Chemother. In press
    • Antimicrob Agents Chemother
    • Hsu, A.1    Granneman, G.R.2    Cao, G.-L.3
  • 67
    • 0005426635 scopus 로고    scopus 로고
    • Safety and efficacy of ritonavir administered at two potentially maximum tolerated doses
    • Jul 7-12; Vancouver
    • Hicks C, Lehman L, Eron, et al. Safety and efficacy of ritonavir administered at two potentially maximum tolerated doses [abstract Mo.B. 415]. XI International Conference on AIDS; 1996 Jul 7-12; Vancouver
    • (1996) XI International Conference on AIDS
    • Hicks, C.1    Lehman, L.2    Eron3
  • 68
    • 0018132387 scopus 로고
    • Time-course of interaction between carbamazepine and clonazepam in normal man
    • Lai AA, Levy RH, Cutler RE. Time-course of interaction between carbamazepine and clonazepam in normal man. Clin Pharmacol Ther 1979; 24: 316-23
    • (1979) Clin Pharmacol Ther , vol.24 , pp. 316-323
    • Lai, A.A.1    Levy, R.H.2    Cutler, R.E.3
  • 69
    • 0031024623 scopus 로고    scopus 로고
    • HIV-1 protease inhibitors. A review for clinicians
    • Decks SG, Smith M, Holodniy M, et al. HIV-1 protease inhibitors. A review for clinicians. JAMA 1997; 277 (2): 145-53
    • (1997) JAMA , vol.277 , Issue.2 , pp. 145-153
    • Decks, S.G.1    Smith, M.2    Holodniy, M.3
  • 70
    • 0031905451 scopus 로고    scopus 로고
    • A phase I/II study of protease inhibitor ritonavir in children with human immunodeficiency virus infection
    • Mar
    • Muller BU, Zuckerman J, Nelson RP, et al. A phase I/II study of protease inhibitor ritonavir in children with human immunodeficiency virus infection. J Pediatr 1998 Mar; 101 (3 Pt 1): 335-43
    • (1998) J Pediatr , vol.101 , Issue.3 PART 1 , pp. 335-343
    • Muller, B.U.1    Zuckerman, J.2    Nelson, R.P.3
  • 71
    • 0009018852 scopus 로고    scopus 로고
    • Virologic efficacy of ZDV +3TC versus d4T + RTV versus ZDV + 3TC +RTV in stable antiretroviral experienced HIV-Infected children
    • Sep 28-Oct 1; Toronto
    • Yogev R, Stanley K, Nachman SA, et al. Virologic efficacy of ZDV +3TC versus d4T + RTV versus ZDV + 3TC +RTV in stable antiretroviral experienced HIV-Infected children. 37th Interscience Conference on Antimicrobial Agents and Chemotherapy; 1997 Sep 28-Oct 1; Toronto
    • (1997) 37th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Yogev, R.1    Stanley, K.2    Nachman, S.A.3
  • 73
    • 7844242723 scopus 로고    scopus 로고
    • Assessment of the effect of fluoxetine on the pharmacokinetics of ritonavir
    • In press
    • Quellet D, Hsu A, Quian J, et al. Assessment of the effect of fluoxetine on the pharmacokinetics of ritonavir. Antimicrob Agents Chemother. In press
    • Antimicrob Agents Chemother
    • Quellet, D.1    Hsu, A.2    Quian, J.3
  • 74
    • 0026506140 scopus 로고
    • Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin
    • Bertilsson L, Lou Y-Q, Du Y-L, et al. Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin. Clin Pharmacol Ther 1992; 51: 388-97
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 388-397
    • Bertilsson, L.1    Lou, Y.-Q.2    Du, Y.-L.3
  • 75
    • 0032128592 scopus 로고    scopus 로고
    • Recent developments in HIV protease inhibitor therapy
    • In press
    • Molla A, Granneman GR, Sun E, et al. Recent developments in HIV protease inhibitor therapy. Antiviral Res 1998. In press
    • (1998) Antiviral Res
    • Molla, A.1    Granneman, G.R.2    Sun, E.3
  • 76
    • 0344796762 scopus 로고    scopus 로고
    • Synergistic anti-HIV activity of ritonavir and other protease inhibitors in the presence of human serum
    • Jun 28-Jul 3; Geneva
    • Molla A, Chernyavskiy T, Vasavanonda S, et al. Synergistic anti-HIV activity of ritonavir and other protease inhibitors in the presence of human serum. 12th World Congress on AIDS; 1998 Jun 28-Jul 3; Geneva
    • (1998) 12th World Congress on AIDS
    • Molla, A.1    Chernyavskiy, T.2    Vasavanonda, S.3
  • 77
    • 0345227650 scopus 로고    scopus 로고
    • Ritonavir-containing dual protease inhibitor regimens may have synergistic antiviral effects in patients - Based on in vitro model
    • Jun 28-Ju1 3; Geneva
    • Hsu A, Granneman GR, Molla A, et al. Ritonavir-containing dual protease inhibitor regimens may have synergistic antiviral effects in patients - based on in vitro model. 12th World Congress on AIDS; 1998 Jun 28-Ju1 3; Geneva
    • (1998) 12th World Congress on AIDS
    • Hsu, A.1    Granneman, G.R.2    Molla, A.3
  • 78
    • 0030610689 scopus 로고    scopus 로고
    • In vitro effect of alacid glycoprotein on the anti-human immunodeficiency virus (HIV) activity of the protease inhibitor CGP 61755: A comparative study with other relevant HIV protease inhibitors
    • Lazdins JK A, Mestan J, Goutte G, et al. In vitro effect of alacid glycoprotein on the anti-human immunodeficiency virus (HIV) activity of the protease inhibitor CGP 61755: a comparative study with other relevant HIV protease inhibitors. J Infect Dis 1997; 175: 1063-70
    • (1997) J Infect Dis , vol.175 , pp. 1063-1070
    • Lazdins, J.K.A.1    Mestan, J.2    Goutte, G.3
  • 79
    • 15444377672 scopus 로고    scopus 로고
    • Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
    • Molla A, Korneyeva M, Cao Q, et al. Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nature Med 1996; 2 (7): 760-6
    • (1996) Nature Med , vol.2 , Issue.7 , pp. 760-766
    • Molla, A.1    Korneyeva, M.2    Cao, Q.3
  • 80
    • 0031900568 scopus 로고    scopus 로고
    • The effect of multiple doses of ritonavir on the pharmacokinetics of rifabutin
    • Cato A, Cavanaugh JH, Shi H, et al. The effect of multiple doses of ritonavir on the pharmacokinetics of rifabutin. Clin Pharmacol Ther 1998; 63: 414-21
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 414-421
    • Cato, A.1    Cavanaugh, J.H.2    Shi, H.3
  • 81
    • 0031709406 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between ritonavir and clarithromycin
    • In press
    • Ouellet D, Hsu A, Granneman GR, et al. Pharmacokinetic interaction between ritonavir and clarithromycin. Clin Pharmacol Ther. In press
    • Clin Pharmacol Ther.
    • Ouellet, D.1    Hsu, A.2    Granneman, G.R.3
  • 82
    • 0001405585 scopus 로고    scopus 로고
    • Evaluation of the pharmacokinetics of multiple dose ritonavir and ketoconazole in combination
    • Bertz R, Wong C, Carothers L, et al. Evaluation of the pharmacokinetics of multiple dose ritonavir and ketoconazole in combination. Clin Pharmacol Ther 1998; 63: 230
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 230
    • Bertz, R.1    Wong, C.2    Carothers, L.3
  • 83
    • 7144257182 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between two human immunodeficiency virus protease inhibitors, ritonavir and saquinavir
    • Hsu A, Granneman GR, Cao G, et al. Pharmacokinetic interactions between two human immunodeficiency virus protease inhibitors, ritonavir and saquinavir. Clin Pharmacol Ther 1998; 63: 453-64
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 453-464
    • Hsu, A.1    Granneman, G.R.2    Cao, G.3
  • 86
    • 0003031788 scopus 로고    scopus 로고
    • Concurrent ritonavir and rifabutin increases risk of rifabutin-associated adverse events
    • Jul 7-12; Vancouver
    • Sun E, Heath-Chiozzi M, Cameron DW, et al. Concurrent ritonavir and rifabutin increases risk of rifabutin-associated adverse events [abstract Mo.B. 171]. XI International Conference on AIDS; 1996 Jul 7-12; Vancouver
    • (1996) XI International Conference on AIDS
    • Sun, E.1    Heath-Chiozzi, M.2    Cameron, D.W.3
  • 87
    • 0028279667 scopus 로고
    • Inhibitors of alprazolam metabolism in film: Effect of serotonin-reuptake inhibitor antidepressants, ketoconazole and quinidine
    • von Moltke LL, Greenblatt DJ, Cotreau-Bibbo MM, et al. Inhibitors of alprazolam metabolism in film: effect of serotonin-reuptake inhibitor antidepressants, ketoconazole and quinidine. Br J Clin Pharmacol 1994; 38: 23-31
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 23-31
    • Von Moltke, L.L.1    Greenblatt, D.J.2    Cotreau-Bibbo, M.M.3
  • 88
    • 0029944684 scopus 로고    scopus 로고
    • Involvment of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes
    • Iribarne C, Berthou F, Baird S, et al. Involvment of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes. Chem Res Toxicol 1996; 9: 365-73
    • (1996) Chem Res Toxicol , vol.9 , pp. 365-373
    • Iribarne, C.1    Berthou, F.2    Baird, S.3
  • 89
    • 0031566987 scopus 로고    scopus 로고
    • Interaction of methadone with substrates of human hepatic cytochrome P450 3A4
    • Iribarne C, Dreano Y, Bardou LG, et al. Interaction of methadone with substrates of human hepatic cytochrome P450 3A4. Toxicol 1997; 117; 13-23
    • (1997) Toxicol , vol.117 , pp. 13-23
    • Iribarne, C.1    Dreano, Y.2    Bardou, L.G.3
  • 91
    • 0028091180 scopus 로고
    • A pharmacokinetic and pharmacodynamic evaluation of the combined administration of alprazolam and fluvoxamine
    • Fleishaker JC, Hulst LK. A pharmacokinetic and pharmacodynamic evaluation of the combined administration of alprazolam and fluvoxamine. Eur J Clin Pharmacol 1994; 46: 35-9
    • (1994) Eur J Clin Pharmacol , vol.46 , pp. 35-39
    • Fleishaker, J.C.1    Hulst, L.K.2
  • 92
    • 0030894402 scopus 로고    scopus 로고
    • Nonlinear mixed effects modeling of single dose and multiple dose data for an immediate release (IR) and a controlled release (CR) dosage form of alprazolam
    • Hossain M, Wright E, Baweja R, et al. Nonlinear mixed effects modeling of single dose and multiple dose data for an immediate release (IR) and a controlled release (CR) dosage form of alprazolam. Pharm Res 1997; 14: 309-15
    • (1997) Pharm Res , vol.14 , pp. 309-315
    • Hossain, M.1    Wright, E.2    Baweja, R.3
  • 93
    • 7844251711 scopus 로고    scopus 로고
    • The effect of fluconazole on the clinical pharmacokinetics of methadone
    • Jul 7-12; Vancouver
    • Cobb M, Desai J, Brown LS, et al. The effect of fluconazole on the clinical pharmacokinetics of methadone [abstract Mo.B.1196]. XI International Conference on AIDS; 1996 Jul 7-12; Vancouver
    • (1996) XI International Conference on AIDS
    • Cobb, M.1    Desai, J.2    Brown, L.S.3
  • 94
    • 0030935086 scopus 로고    scopus 로고
    • Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions
    • Bertz RJ, Granneman GR. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clin Pharmacokinet 1997; 32 (3): 210-58
    • (1997) Clin Pharmacokinet , vol.32 , Issue.3 , pp. 210-258
    • Bertz, R.J.1    Granneman, G.R.2
  • 96
    • 0011790924 scopus 로고    scopus 로고
    • Effect of ritonavir on the pharmacokinetics of trimethoprim/sulfamethoxazole
    • Jul 7-12; Vancouver
    • Bertz RJ, Cao G, Cavanaugh JH, et al. Effect of ritonavir on the pharmacokinetics of trimethoprim/sulfamethoxazole [abstract Mo.B.1197]. XI International Conference on AIDS; 1996 Jul 7-12; Vancouver
    • (1996) XI International Conference on AIDS
    • Bertz, R.J.1    Cao, G.2    Cavanaugh, J.H.3
  • 97
    • 0028787051 scopus 로고
    • Cytochrome P450 isozymes and antiepileptic drug interactions
    • Levy RH. Cytochrome P450 isozymes and antiepileptic drug interactions. Epilepsia 1995; 36: S8-13
    • (1995) Epilepsia , vol.36
    • Levy, R.H.1
  • 98
    • 0003237186 scopus 로고    scopus 로고
    • Pharmacokinetics of efavirenz (EFV) and ritonavir (RIT) after multiple oral doses in healthy volunteers
    • Jun 28-Jul 3; Geneva
    • Fiske WD, Benedek IH, Kornhauser DM, et al. Pharmacokinetics of efavirenz (EFV) and ritonavir (RIT) after multiple oral doses in healthy volunteers. Submitted. 12th World Congress on AIDS; 1998 Jun 28-Jul 3; Geneva
    • (1998) 12th World Congress on AIDS
    • Fiske, W.D.1    Benedek, I.H.2    Kornhauser, D.M.3
  • 99
    • 0030766424 scopus 로고    scopus 로고
    • Evaluation of the effect of fluconazole on the pharmacokinetics of ritonavir
    • Cato III A, Cao G, Hsu A, et al. Evaluation of the effect of fluconazole on the pharmacokinetics of ritonavir. Drug Metab Dispos 1997; 25 (9): 1104-6
    • (1997) Drug Metab Dispos , vol.25 , Issue.9 , pp. 1104-1106
    • Cato III, A.1    Cao, G.2    Hsu, A.3
  • 101
  • 102
    • 0344723263 scopus 로고    scopus 로고
    • Assessment of single- and multiple-dose interactions between ritonavir and saquinavir
    • Jul 7-12; Vancouver
    • Hsu A, Granneman GR, Sun E, et al. Assessment of single- and multiple-dose interactions between ritonavir and saquinavir [abstract LB.B 6041]. XI International Conference on AIDS; 1996 Jul 7-12; Vancouver
    • (1996) XI International Conference on AIDS
    • Hsu, A.1    Granneman, G.R.2    Sun, E.3
  • 103
    • 0344364921 scopus 로고    scopus 로고
    • Indinavir can be given with regular meals when taken with ritonavir
    • Jun 28-Jul 3; Geneva
    • Hsu A, Granneman GR, Heath-Chiozzi M, et al. Indinavir can be given with regular meals when taken with ritonavir. 12th World Congress on AIDS; 1998 Jun 28-Jul 3; Geneva
    • (1998) 12th World Congress on AIDS
    • Hsu, A.1    Granneman, G.R.2    Heath-Chiozzi, M.3
  • 104
    • 0001235343 scopus 로고    scopus 로고
    • Plasma metabolites of nelfinavir, a potent HIV protease inhibitor, in HIV positive patients: Quantitation by LC-MS/MS and antiviral activities. 11: 128
    • Jun 30-Jul 3; Gothenburg, Sweden
    • Zhang K, Wu E, Patick A, et al. Plasma metabolites of nelfinavir, a potent HIV protease inhibitor, in HIV positive patients: quantitation by LC-MS/MS and antiviral activities. 11: 128. 6th European ISSX Meeting; 1997 Jun 30-Jul 3; Gothenburg, Sweden
    • (1997) 6th European ISSX Meeting
    • Zhang, K.1    Wu, E.2    Patick, A.3
  • 105
    • 0032529413 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between ritonavir and didanosine when administered concurrently to HIV-infected patients
    • Cato A, Qian J, Carothers, L, et al. Pharmacokinetic interactions between ritonavir and didanosine when administered concurrently to HIV-infected patients. J Acquir Immune Defic Syndr Hum Retrovirol 1998; 18: 466-72
    • (1998) J Acquir Immune Defic Syndr Hum Retrovirol , vol.18 , pp. 466-472
    • Cato, A.1    Qian, J.2    Carothers, L.3
  • 106
    • 7844237329 scopus 로고    scopus 로고
    • Pharmacia & Upjohn
    • ™ package insert. Pharmacia & Upjohn, 1998
    • (1998) ™ Package Insert
  • 109
    • 0004329246 scopus 로고    scopus 로고
    • Raxane Laboratories
    • ™ Package Insert. Raxane Laboratories, 1998
    • (1998) ™ Package Insert
  • 110
    • 0344511144 scopus 로고    scopus 로고
    • Effect of nevirapine (NVP) on pharmacokinetics (PK) of indinavir (IDV) and ritonavir (RTV) in HIV-1 patients
    • Jan 22-26: Washington, DC
    • Murphy R, Gagnier P, Lamson M, et al. Effect of nevirapine (NVP) on pharmacokinetics (PK) of indinavir (IDV) and ritonavir (RTV) in HIV-1 patients [abstract 374]. 4th Conference on Retroviruses and Opportunistic Infections; 1997 Jan 22-26: Washington, DC
    • (1997) 4th Conference on Retroviruses and Opportunistic Infections
    • Murphy, R.1    Gagnier, P.2    Lamson, M.3
  • 112
    • 0000748344 scopus 로고    scopus 로고
    • Delavirdine (DLV) and nelfinavir (NFV): A pharmacokinetic (PK) drug-drug interaction study in healthy adult volunteers
    • Feb 1-5; Chicago
    • Cox SR, Schneck DW, Herman BD, et al. Delavirdine (DLV) and nelfinavir (NFV): a pharmacokinetic (PK) drug-drug interaction study in healthy adult volunteers [abstract 345]. 5th Conference on Retroviruses and Opportunistic Infections: 1998 Feb 1-5; Chicago
    • (1998) 5th Conference on Retroviruses and Opportunistic Infections
    • Cox, S.R.1    Schneck, D.W.2    Herman, B.D.3
  • 113
    • 0345227631 scopus 로고    scopus 로고
    • Novel double protease combinations-combining indinavir (IDV) with ritonavir (RTV): Results from first study
    • Jun 28-Jul 3; Geneva
    • Workman C, Musson R, Dyer W, et al. Novel double protease combinations-combining indinavir (IDV) with ritonavir (RTV): results from first study. 12th World Congress on AIDS; 1998 Jun 28-Jul 3; Geneva
    • (1998) 12th World Congress on AIDS
    • Workman, C.1    Musson, R.2    Dyer, W.3
  • 114
    • 0030671536 scopus 로고    scopus 로고
    • In vitro combination of PNU140690, a human immunodeficiency virus type 1 protease inhibitor, with ritonavir against ritonavir-sensitive and -resistant clinical isolates
    • Chong KT, Pagano PJ. In vitro combination of PNU140690, a human immunodeficiency virus type 1 protease inhibitor, with ritonavir against ritonavir-sensitive and -resistant clinical isolates. Antimicrob Agents Chemother 1997; 41: 2367-73
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 2367-2373
    • Chong, K.T.1    Pagano, P.J.2
  • 115
    • 0028911385 scopus 로고
    • Clinical pharmacokinetics of nucleoside antiviral agents
    • Dudley MN. Clinical pharmacokinetics of nucleoside antiviral agents. J Infect Dis 1995; 171 Suppl. 2: S99-112
    • (1995) J Infect Dis , vol.171 , Issue.2 SUPPL.
    • Dudley, M.N.1
  • 116
    • 0026742905 scopus 로고
    • Pharmacokinetic interaction study of didanos?ine and ranitidine in patients seropositive for human immunodeficiency virus
    • Knupp CA, Graziano FM, Dixon RM, et al. Pharmacokinetic interaction study of didanos?ine and ranitidine in patients seropositive for human immunodeficiency virus. Antimicrob Agents Chemother 1992; 36: 2075-9
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 2075-2079
    • Knupp, C.A.1    Graziano, F.M.2    Dixon, R.M.3
  • 117
    • 0001925810 scopus 로고    scopus 로고
    • Delavirdine (D) and marketed protease inhibitors (Pls): Pharmacokinetic (PK) interaction studies in healthy volunteers
    • Jan 22-26; Washington, DC
    • Cox SR, Ferry JJ, Batts DH, et al. Delavirdine (D) and marketed protease inhibitors (Pls): pharmacokinetic (PK) interaction studies in healthy volunteers [abstract 372]. 4th Conference on Retroviruses and Opportunistic Infections; 1997 Jan 22-26; Washington, DC
    • (1997) 4th Conference on Retroviruses and Opportunistic Infections
    • Cox, S.R.1    Ferry, J.J.2    Batts, D.H.3
  • 118
    • 7844238064 scopus 로고    scopus 로고
    • Nevirapine hydroxylation, an in vitro probe for the simultaneous determination of CYP3A and CYP2B6 activity in human liver microsomes
    • Oct 26-30; Hilton Head, South Carolina
    • Erickson DA, Riske PS, Hattox SE, et al. Nevirapine hydroxylation, an in vitro probe for the simultaneous determination of CYP3A and CYP2B6 activity in human liver microsomes [abstract 98]. 8th North American ISSX Meeting; 1997 Oct 26-30; Hilton Head, South Carolina
    • (1997) 8th North American ISSX Meeting
    • Erickson, D.A.1    Riske, P.S.2    Hattox, S.E.3
  • 119
    • 0028930117 scopus 로고
    • High-Dose nevirapine: Safety, pharmacokinetics, and antiviral effect in patients iwth human immunodeficiency virus infection
    • Havlir D, Cheeseman SH, McLaughlin M, et al. High-Dose nevirapine: safety, pharmacokinetics, and antiviral effect in patients iwth human immunodeficiency virus infection. J Infect Dis 1995; 171: 537-45
    • (1995) J Infect Dis , vol.171 , pp. 537-545
    • Havlir, D.1    Cheeseman, S.H.2    McLaughlin, M.3
  • 121
    • 0003272510 scopus 로고    scopus 로고
    • Stavudine (d4T), nelfinavir (NFV) and nevirapine (NVP): Preliminary safety, activity and pharmacokinetic (PK) interactions
    • Feb 1-5; Chicago
    • Skowron G, Leoung G, Dusek A, et al. Stavudine (d4T), nelfinavir (NFV) and nevirapine (NVP): preliminary safety, activity and pharmacokinetic (PK) interactions [abstract 350]. 5th Conference on Retroviruses and Opportunistic Infections; 1998 Feb 1-5; Chicago
    • (1998) 5th Conference on Retroviruses and Opportunistic Infections
    • Skowron, G.1    Leoung, G.2    Dusek, A.3
  • 122
    • 0000677101 scopus 로고    scopus 로고
    • The novel non-nucleoside reverse transcriptase inhibitor DMP 266 produces autoinduction of metabolism in rats and rhesus monkeys
    • Oct 26-30; Hilton Head, South Carolina
    • Christ DD, Fiske WD, Grubb MF, et al. The novel non-nucleoside reverse transcriptase inhibitor DMP 266 produces autoinduction of metabolism in rats and rhesus monkeys [abstract 299]. 8th North American ISSX Meeting; 1997 Oct 26-30; Hilton Head, South Carolina
    • (1997) 8th North American ISSX Meeting
    • Christ, D.D.1    Fiske, W.D.2    Grubb, M.F.3
  • 123
    • 7844229319 scopus 로고    scopus 로고
    • Effects of non-nucleoside reverse transcriptase inhibitor DMP 266 on AZT glucuronidation in vitro
    • Oct 26-30; Hilton Head, South Carolina
    • Grubb M, Rao GP, Christ DD. effects of non-nucleoside reverse transcriptase inhibitor DMP 266 on AZT glucuronidation in vitro [abstract 188]. 8th North American ISSX Meeting; 1997 Oct 26-30; Hilton Head, South Carolina
    • (1997) 8th North American ISSX Meeting
    • Grubb, M.1    Rao, G.P.2    Christ, D.D.3
  • 124
    • 0003340456 scopus 로고    scopus 로고
    • Pharmacokinetics of DMP 266 and indinavir multiple oral doses in HIV-1 infected individuals
    • Jan 22-26; Washington, DC
    • Fiske WD, Mayers D, Wagner K, et al. pharmacokinetics of DMP 266 and indinavir multiple oral doses in HIV-1 infected individuals [abstract 568]. 4th Conference on Retroviruses and Opportunistic Infections; 1997 Jan 22-26; Washington, DC
    • (1997) 4th Conference on Retroviruses and Opportunistic Infections
    • Fiske, W.D.1    Mayers, D.2    Wagner, K.3
  • 126
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and p-glyeoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher VJ, Wu C-Y, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and p-glyeoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 1995; 13: 129-34
    • (1995) Mol Carcinog , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.-Y.2    Benet, L.Z.3
  • 127
    • 6844222160 scopus 로고    scopus 로고
    • Saquinavir is a high affinity substrate for the multidrug transporter, P-glycoprotein
    • Washington CB, Duran GE, Sikic BI, et al. Saquinavir is a high affinity substrate for the multidrug transporter, P-glycoprotein. Clin Pharmacol Ther 1997; 61 (2): 193
    • (1997) Clin Pharmacol Ther , vol.61 , Issue.2 , pp. 193
    • Washington, C.B.1    Duran, G.E.2    Sikic, B.I.3
  • 129
    • 0032518290 scopus 로고    scopus 로고
    • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
    • Kim RB, Fromm MF, Wandel C, et al. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 1998; 101 (2): 289-94
    • (1998) J Clin Invest , vol.101 , Issue.2 , pp. 289-294
    • Kim, R.B.1    Fromm, M.F.2    Wandel, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.