Phenytoin metabolism by human cytochrome P450: Involvement of P450 3A and 2C forms in secondary metabolism and drug-protein adduct formation

Drug Metabolism and Disposition

Volumn 28, Issue 8, 2000, Pages 945-950

  Cuttle, L ^a   Munns, A J ^a   Hogg, N A ^a   Scott, J R ^a   Hooper, W D ^a   Dickinson, R G ^a   Gillam, E M J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 HYDROXYPHENYL) 5 PHENYLHYDANTOIN; CATECHOL; CYTOCHROME P450; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A; CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; PHENYTOIN;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG DEGRADATION; DRUG METABOLISM; DRUG OXIDATION; DRUG PROTEIN BINDING; DRUG TARGETING; HUMAN; HUMAN CELL; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT;

ANTICONVULSANTS; ARYL HYDROCARBON HYDROXYLASES; AUTOIMMUNITY; CATECHOLS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; EPITOPES; HUMANS; OXIDOREDUCTASES, N-DEMETHYLATING; PHENYTOIN; RECOMBINANT PROTEINS;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STAPHYLOCOCCUS PHAGE 3A;

EID: 0033854025     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite
2. Allelic and functional variability of cytochrome P4502C9
3. Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae
4. Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme
5. Expression of cytochrome P450 3A5 in Escherichia coli: Effects of 5' modifications, purification, spectral characterization, reconstitution conditions, and catalytic activities
6. Expression of cytochrome P450 3A7 in Escherichia coli: Effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase
7. Phenytoin hypersensitivity: 38 cases
8. Cross sensitivity of skin rashes with antiepileptic drugs
9. In vitro bioactivation of phenytoin to a reactive free radical intermediate by prostaglandin synthetase, horseradish peroxidase and thyroid peroxidase
10. 4
11. Epitope mapping studies with human anti-cytochrome P450 3A antibodies
12. Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions
13. Metabolism of phenytoin and covalent binding of reactive intermediates in activated human neutrophils
14. Bioactivation of phenytoin by human cytochrome P450: Characterization of the mechanism and targets of covalent adduct formation
15. Bacterial catalysis of reactions important in mammalian drag and xenobiotic metabolism: Functional co-expression of six human microsomal cytochrome P450 enzymes with NADPH-cytochrome P450 reductase in Escherichia coli
16. Drug disposition and drug hypersensitivity
17. Phenytoin metabolic activation: Role of cytochrome P450, glutathione, age, and sex in rats and mice
18. Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity
19. Recombinant human cytochrome P450 1B1 expression in Escherichia coli
20. Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens, and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
21. Predisposition to phenytoin hypersensitivity assessed in vitro
22. Genetic analysis of the human cytochrome P450 CYP2C9 locus
23. N-Chlorination of phenytoin by myeloperoxidase to a reactive metabolite
24. Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase
25. Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily
26. Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9