Coadministration of grapefruit juice increases systemic exposure of diltiazem in healthy volunteers

European Journal of Clinical Pharmacology

Volumn 58, Issue 8, 2002, Pages 515-520

  Christensen, Hege ^a   Åsberg, Anders ^a,b   Holmboe, Aase Britt ^a   Berg, Knut Joachim ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Diltiazem; Grapefruit juice; Pharmacokinetic interaction

Indexed keywords

DEACETYLDILTIAZEM; DILTIAZEM; DRUG METABOLITE; GLYCOPROTEIN P; N NORDILTIAZEM; WATER;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE MONITORING; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; GRAPEFRUIT JUICE; HEART RATE VARIABILITY; HUMAN; HUMAN EXPERIMENT; INTESTINE; MALE; NORMAL HUMAN; OPEN STUDY; PRIORITY JOURNAL; RANDOMIZATION; SAMPLE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADMINISTRATION, ORAL; ADULT; AREA UNDER CURVE; BEVERAGES; BIOLOGICAL AVAILABILITY; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CITRUS PARADISI; CROSS-OVER STUDIES; DILTIAZEM; FOOD-DRUG INTERACTIONS; HEART RATE; HUMANS; MALE; TIME FACTORS;

EID: 0036449361     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-002-0516-8     Document Type: Article

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