-
1
-
-
0008819588
-
The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus
-
Arceci RJ, Croop JM, Horwitz SB, Housman D 1988 The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Proc Natl Acad Sci USA 85: 4350-4354
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 4350-4354
-
-
Arceci, R.J.1
Croop, J.M.2
Horwitz, S.B.3
Housman, D.4
-
2
-
-
0030975889
-
Genetic dissection of the function of mammalian P-glycoproteins
-
Borst P, Schinkel AH 1997 Genetic dissection of the function of mammalian P-glycoproteins. Trends Genet 13: 217-222
-
(1997)
Trends Genet
, vol.13
, pp. 217-222
-
-
Borst, P.1
Schinkel, A.H.2
-
3
-
-
0025799513
-
Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
-
Chaudhary PM, Roninson IB 1991 Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 66: 85-95
-
(1991)
Cell
, vol.66
, pp. 85-95
-
-
Chaudhary, P.M.1
Roninson, I.B.2
-
4
-
-
0000712439
-
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
-
Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, Bertino JR 1989 Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 86: 695-698
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 695-698
-
-
Cordon-Cardo, C.1
O'Brien, J.P.2
Casals, D.3
Rittman-Grauer, L.4
Biedler, J.L.5
Melamed, M.R.6
Bertino, J.R.7
-
5
-
-
0024544045
-
The three mouse multidrug resistance (mdr) genes are expressed in a tissue specific manner in normal mouse tissues
-
Croop JM, Raymond M, Haber D, Devault A, Arceci RJ, Gros P, Housman DE 1989 The three mouse multidrug resistance (mdr) genes are expressed in a tissue specific manner in normal mouse tissues. Mol Cell Biol 9: 1346-1350
-
(1989)
Mol Cell Biol
, vol.9
, pp. 1346-1350
-
-
Croop, J.M.1
Raymond, M.2
Haber, D.3
Devault, A.4
Arceci, R.J.5
Gros, P.6
Housman, D.E.7
-
6
-
-
0025253133
-
Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities
-
Devault A, Gros P 1990 Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol Cell Biol 10: 1652-1663
-
(1990)
Mol Cell Biol
, vol.10
, pp. 1652-1663
-
-
Devault, A.1
Gros, P.2
-
7
-
-
0024329881
-
The biochemistry of P-glycoprotein-mediated multidrug resistance
-
Endicott JA, Ling V 1989 The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58: 137-171
-
(1989)
Annu Rev Biochem
, vol.58
, pp. 137-171
-
-
Endicott, J.A.1
Ling, V.2
-
8
-
-
0027218689
-
Biochemistry of multidrug resistance mediated by the multidrug transporter
-
Gottesman MM, Pastan I 1993 Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427
-
(1993)
Annu Rev Biochem
, vol.62
, pp. 385-427
-
-
Gottesman, M.M.1
Pastan, I.2
-
9
-
-
0022993652
-
Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins
-
Gros P, Croop J, Housman D 1986 Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47: 371-380
-
(1986)
Cell
, vol.47
, pp. 371-380
-
-
Gros, P.1
Croop, J.2
Housman, D.3
-
11
-
-
0024344261
-
Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells
-
Hsu SI-H, Lothstein L, Horwitz SB 1989 Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. J Biol Chem 264: 12053-12062
-
(1989)
J Biol Chem
, vol.264
, pp. 12053-12062
-
-
Hsu, S.I.-H.1
Lothstein, L.2
Horwitz, S.B.3
-
12
-
-
0028210704
-
P-glycoprotein expression and function in circulating blood cells from normal volunteers
-
Klimecki WT, Futscher BW, Grogan TM, Dalton WS 1994 P-glycoprotein expression and function in circulating blood cells from normal volunteers. Blood 83: 2451-2458
-
(1994)
Blood
, vol.83
, pp. 2451-2458
-
-
Klimecki, W.T.1
Futscher, B.W.2
Grogan, T.M.3
Dalton, W.S.4
-
13
-
-
0029860174
-
Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr1a P-glycoprotein
-
Mayer U, Wagenaar E, Beijnen JH, Smit JW, Meijer DKF, van Asperen J, Borst P, Schinkel AH 1996 Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr1a P-glycoprotein. Br J Cancer 119: 1038-1044
-
(1996)
Br J Cancer
, vol.119
, pp. 1038-1044
-
-
Mayer, U.1
Wagenaar, E.2
Beijnen, J.H.3
Smit, J.W.4
Meijer, D.K.F.5
Van Asperen, J.6
Borst, P.7
Schinkel, A.H.8
-
14
-
-
0026570652
-
The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo
-
Roninson IB 1992 The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo. Biochem Pharmacol 43: 95-102
-
(1992)
Biochem Pharmacol
, vol.43
, pp. 95-102
-
-
Roninson, I.B.1
-
15
-
-
0028301989
-
A mechanism for P-glycoprotein action in multidrug resistance: Are we there yet?
-
Ruetz S, Gros P 1994 A mechanism for P-glycoprotein action in multidrug resistance: are we there yet? Trends Pharmacol Sci 15: 260-263
-
(1994)
Trends Pharmacol Sci
, vol.15
, pp. 260-263
-
-
Ruetz, S.1
Gros, P.2
-
16
-
-
0028229150
-
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
Schinkel AH, Smit JJM, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CAAM, van der Valk MA, Robanus Maandag EC, te Riele HPJ, Berns AJM, Borst P 1994 Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77: 491-502
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Smit, J.J.M.2
Van Tellingen, O.3
Beijnen, J.H.4
Wagenaar, E.5
Van Deemter, L.6
Mol, C.A.A.M.7
Van Der Valk, M.A.8
Robanus Maandag, E.C.9
Te Riele, H.P.J.10
Berns, A.J.M.11
Borst, P.12
-
17
-
-
0028825399
-
Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
-
Schinkel AH, Wagenaar E, van Deemter L, Mol CAAM, Borst P 1995 Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest 96: 1698-1705
-
(1995)
J Clin Invest
, vol.96
, pp. 1698-1705
-
-
Schinkel, A.H.1
Wagenaar, E.2
Van Deemter, L.3
Mol, C.A.A.M.4
Borst, P.5
-
18
-
-
0029892497
-
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
-
Schinkel AH, Wagenaar E, Mol CAAM, van Deemter L 1996 P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 97: 2517-2524
-
(1996)
J Clin Invest
, vol.97
, pp. 2517-2524
-
-
Schinkel, A.H.1
Wagenaar, E.2
Mol, C.A.A.M.3
Van Deemter, L.4
-
19
-
-
4243801613
-
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
-
Schinkel AH, Mayer U, Wagenaar E, Mol CAAM, van Deemter L, Smit JJM, van der Valk, MA, Voordouw AC, Spits H, van Tellingen O, Zijlmans JMJM, Fibbe WE, Borst P 1997 Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci USA 94: 4028-4033
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4028-4033
-
-
Schinkel, A.H.1
Mayer, U.2
Wagenaar, E.3
Mol, C.A.A.M.4
Van Deemter, L.5
Smit, J.J.M.6
Van Der Valk, M.A.7
Voordouw, A.C.8
Spits, H.9
Van Tellingen, O.10
Zijlmans, J.M.J.M.11
Fibbe, W.E.12
Borst, P.13
-
20
-
-
0027165416
-
Modulation of multidrug resistance: At the threshold
-
Sikic BI 1993 Modulation of multidrug resistance: at the threshold. J Clin Oncol 11: 1629-1635
-
(1993)
J Clin Oncol
, vol.11
, pp. 1629-1635
-
-
Sikic, B.I.1
-
21
-
-
12644278301
-
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
-
Sparreboom A, van Asperen J, Mayer U, Schinkel AH, Smit JW, Meijer DKF, Borst P, Nooijen WJ, Beijnen JH, van Tellingen O 1997 Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc Natl Acad Sci USA 94: 2031-2035
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2031-2035
-
-
Sparreboom, A.1
Van Asperen, J.2
Mayer, U.3
Schinkel, A.H.4
Smit, J.W.5
Meijer, D.K.F.6
Borst, P.7
Nooijen, W.J.8
Beijnen, J.H.9
Van Tellingen, O.10
-
22
-
-
0023447098
-
Cellular localization of the multidrug resistance gene product in normal human tissues
-
Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC 1987 Cellular localization of the multidrug resistance gene product in normal human tissues. Proc Natl Acad Sci USA 84: 7735-7738
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 7735-7738
-
-
Thiebaut, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
23
-
-
0019430432
-
Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
-
Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y 1981 Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 41: 1967-1972
-
(1981)
Cancer Res
, vol.41
, pp. 1967-1972
-
-
Tsuruo, T.1
Iida, H.2
Tsukagoshi, S.3
Sakurai, Y.4
-
24
-
-
0026487058
-
Human P-glycoprotein transports Cortisol, aldosterone, and dexamethasone, but not progesterone
-
Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R 1992 Human P-glycoprotein transports Cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem 267: 24248-24252
-
(1992)
J Biol Chem
, vol.267
, pp. 24248-24252
-
-
Ueda, K.1
Okamura, N.2
Hirai, M.3
Tanigawara, Y.4
Saeki, T.5
Kioka, N.6
Komano, T.7
Hori, R.8
-
25
-
-
0029952418
-
Altered pharmacokinetics of vinblastine in mdr1a P-glycoprotein-deficient mice
-
Van Asperen J, Schinkel AH, Beijnen JH, Nooijen WJ, Borst P, van Tellingen O 1996 Altered pharmacokinetics of vinblastine in mdr1a P-glycoprotein-deficient mice. J Natl Cancer Inst 88: 994-999
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 994-999
-
-
Van Asperen, J.1
Schinkel, A.H.2
Beijnen, J.H.3
Nooijen, W.J.4
Borst, P.5
Van Tellingen, O.6
-
26
-
-
0030613634
-
Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833
-
in press
-
Van Asperen J, van Tellingen O, Sparreboom A, Schinkel AH, Borst P, Nooijen WJ, Beijnen JH 1997 Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. Brit J Cancer in press
-
(1997)
Brit J Cancer
-
-
Van Asperen, J.1
Van Tellingen, O.2
Sparreboom, A.3
Schinkel, A.H.4
Borst, P.5
Nooijen, W.J.6
Beijnen, J.H.7
-
27
-
-
0030581087
-
Active secretion and enterocytic drug metabolism barriers to drug absorption
-
Wacher VJ, Salphati L, Benet LZ 1996 Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv Drug Deliv Rev 20: 99-112
-
(1996)
Adv Drug Deliv Rev
, vol.20
, pp. 99-112
-
-
Wacher, V.J.1
Salphati, L.2
Benet, L.Z.3
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