메뉴 건너뛰기




Volumn 36, Issue 1, 1998, Pages 9-13

Pharmacological insights from P-glycoprotein knockout mice

Author keywords

Blood brain barrier; Drug disposition; Multidrug resistance; P glycocoprotein; Pharmacokinetics

Indexed keywords

ANTINEOPLASTIC AGENT; GLYCOPROTEIN P;

EID: 0031982725     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (138)

References (27)
  • 1
    • 0008819588 scopus 로고
    • The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus
    • Arceci RJ, Croop JM, Horwitz SB, Housman D 1988 The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Proc Natl Acad Sci USA 85: 4350-4354
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4350-4354
    • Arceci, R.J.1    Croop, J.M.2    Horwitz, S.B.3    Housman, D.4
  • 2
    • 0030975889 scopus 로고    scopus 로고
    • Genetic dissection of the function of mammalian P-glycoproteins
    • Borst P, Schinkel AH 1997 Genetic dissection of the function of mammalian P-glycoproteins. Trends Genet 13: 217-222
    • (1997) Trends Genet , vol.13 , pp. 217-222
    • Borst, P.1    Schinkel, A.H.2
  • 3
    • 0025799513 scopus 로고
    • Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
    • Chaudhary PM, Roninson IB 1991 Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 66: 85-95
    • (1991) Cell , vol.66 , pp. 85-95
    • Chaudhary, P.M.1    Roninson, I.B.2
  • 5
    • 0024544045 scopus 로고
    • The three mouse multidrug resistance (mdr) genes are expressed in a tissue specific manner in normal mouse tissues
    • Croop JM, Raymond M, Haber D, Devault A, Arceci RJ, Gros P, Housman DE 1989 The three mouse multidrug resistance (mdr) genes are expressed in a tissue specific manner in normal mouse tissues. Mol Cell Biol 9: 1346-1350
    • (1989) Mol Cell Biol , vol.9 , pp. 1346-1350
    • Croop, J.M.1    Raymond, M.2    Haber, D.3    Devault, A.4    Arceci, R.J.5    Gros, P.6    Housman, D.E.7
  • 6
    • 0025253133 scopus 로고
    • Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities
    • Devault A, Gros P 1990 Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol Cell Biol 10: 1652-1663
    • (1990) Mol Cell Biol , vol.10 , pp. 1652-1663
    • Devault, A.1    Gros, P.2
  • 7
    • 0024329881 scopus 로고
    • The biochemistry of P-glycoprotein-mediated multidrug resistance
    • Endicott JA, Ling V 1989 The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem 58: 137-171
    • (1989) Annu Rev Biochem , vol.58 , pp. 137-171
    • Endicott, J.A.1    Ling, V.2
  • 8
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman MM, Pastan I 1993 Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427
    • (1993) Annu Rev Biochem , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 9
    • 0022993652 scopus 로고
    • Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins
    • Gros P, Croop J, Housman D 1986 Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47: 371-380
    • (1986) Cell , vol.47 , pp. 371-380
    • Gros, P.1    Croop, J.2    Housman, D.3
  • 11
    • 0024344261 scopus 로고
    • Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells
    • Hsu SI-H, Lothstein L, Horwitz SB 1989 Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. J Biol Chem 264: 12053-12062
    • (1989) J Biol Chem , vol.264 , pp. 12053-12062
    • Hsu, S.I.-H.1    Lothstein, L.2    Horwitz, S.B.3
  • 12
    • 0028210704 scopus 로고
    • P-glycoprotein expression and function in circulating blood cells from normal volunteers
    • Klimecki WT, Futscher BW, Grogan TM, Dalton WS 1994 P-glycoprotein expression and function in circulating blood cells from normal volunteers. Blood 83: 2451-2458
    • (1994) Blood , vol.83 , pp. 2451-2458
    • Klimecki, W.T.1    Futscher, B.W.2    Grogan, T.M.3    Dalton, W.S.4
  • 13
    • 0029860174 scopus 로고    scopus 로고
    • Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr1a P-glycoprotein
    • Mayer U, Wagenaar E, Beijnen JH, Smit JW, Meijer DKF, van Asperen J, Borst P, Schinkel AH 1996 Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr1a P-glycoprotein. Br J Cancer 119: 1038-1044
    • (1996) Br J Cancer , vol.119 , pp. 1038-1044
    • Mayer, U.1    Wagenaar, E.2    Beijnen, J.H.3    Smit, J.W.4    Meijer, D.K.F.5    Van Asperen, J.6    Borst, P.7    Schinkel, A.H.8
  • 14
    • 0026570652 scopus 로고
    • The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo
    • Roninson IB 1992 The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo. Biochem Pharmacol 43: 95-102
    • (1992) Biochem Pharmacol , vol.43 , pp. 95-102
    • Roninson, I.B.1
  • 15
    • 0028301989 scopus 로고
    • A mechanism for P-glycoprotein action in multidrug resistance: Are we there yet?
    • Ruetz S, Gros P 1994 A mechanism for P-glycoprotein action in multidrug resistance: are we there yet? Trends Pharmacol Sci 15: 260-263
    • (1994) Trends Pharmacol Sci , vol.15 , pp. 260-263
    • Ruetz, S.1    Gros, P.2
  • 17
    • 0028825399 scopus 로고
    • Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
    • Schinkel AH, Wagenaar E, van Deemter L, Mol CAAM, Borst P 1995 Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest 96: 1698-1705
    • (1995) J Clin Invest , vol.96 , pp. 1698-1705
    • Schinkel, A.H.1    Wagenaar, E.2    Van Deemter, L.3    Mol, C.A.A.M.4    Borst, P.5
  • 18
    • 0029892497 scopus 로고    scopus 로고
    • P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
    • Schinkel AH, Wagenaar E, Mol CAAM, van Deemter L 1996 P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 97: 2517-2524
    • (1996) J Clin Invest , vol.97 , pp. 2517-2524
    • Schinkel, A.H.1    Wagenaar, E.2    Mol, C.A.A.M.3    Van Deemter, L.4
  • 20
    • 0027165416 scopus 로고
    • Modulation of multidrug resistance: At the threshold
    • Sikic BI 1993 Modulation of multidrug resistance: at the threshold. J Clin Oncol 11: 1629-1635
    • (1993) J Clin Oncol , vol.11 , pp. 1629-1635
    • Sikic, B.I.1
  • 23
    • 0019430432 scopus 로고
    • Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
    • Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y 1981 Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 41: 1967-1972
    • (1981) Cancer Res , vol.41 , pp. 1967-1972
    • Tsuruo, T.1    Iida, H.2    Tsukagoshi, S.3    Sakurai, Y.4
  • 24
    • 0026487058 scopus 로고
    • Human P-glycoprotein transports Cortisol, aldosterone, and dexamethasone, but not progesterone
    • Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R 1992 Human P-glycoprotein transports Cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem 267: 24248-24252
    • (1992) J Biol Chem , vol.267 , pp. 24248-24252
    • Ueda, K.1    Okamura, N.2    Hirai, M.3    Tanigawara, Y.4    Saeki, T.5    Kioka, N.6    Komano, T.7    Hori, R.8
  • 27
    • 0030581087 scopus 로고    scopus 로고
    • Active secretion and enterocytic drug metabolism barriers to drug absorption
    • Wacher VJ, Salphati L, Benet LZ 1996 Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv Drug Deliv Rev 20: 99-112
    • (1996) Adv Drug Deliv Rev , vol.20 , pp. 99-112
    • Wacher, V.J.1    Salphati, L.2    Benet, L.Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.