Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

Clinical Pharmacology and Therapeutics

Volumn 71, Issue 1, 2002, Pages 11-20

  Dresser, George K ^a,b,c   Bailey, David G ^a,b,c,d   Leake, Brenda F ^a,b,c   Schwarz, Ute I ^a,b,c   Dawson, Paul A ^a,b,c   Freeman, David J ^a,b,c   Kim, Richard B ^a,b,c  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

6',7' DIHYDROXYBERGAMOTTIN; BIOFLAVONOID; DIGOXIN; FEXOFENADINE; FUROCOUMARIN DERIVATIVE; GLYCOPROTEIN P; ORGANIC ANION TRANSPORTING POLYPEPTIDE; POLYPEPTIDE; UNCLASSIFIED DRUG; VINBLASTINE; WATER;

ADULT; ANION TRANSPORT; APPLE JUICE; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG UPTAKE; EPITHELIUM CELL; FEMALE; FOOD DRUG INTERACTION; FRUIT JUICE; GENETIC TRANSFECTION; GRAPEFRUIT JUICE; HALF LIFE TIME; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; KIDNEY CLEARANCE; MALE; NONHUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAT; URINARY EXCRETION; URINE VOLUME;

ADMINISTRATION, ORAL; ADULT; AREA UNDER CURVE; BEVERAGES; BIOLOGICAL AVAILABILITY; CARRIER PROTEINS; CITRUS; DOUBLE-BLIND METHOD; FEMALE; FLAVONOIDS; FOOD-DRUG INTERACTIONS; FRUIT; HELA CELLS; HISTAMINE H1 ANTAGONISTS; HUMANS; INTESTINAL ABSORPTION; MALE; MALUS; MEMBRANE TRANSPORT PROTEINS; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; P-GLYCOPROTEINS; SYMPORTERS; TERFENADINE;

EID: 0036159433     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2002.121152     Document Type: Article

References (26)

1. Catalytic selectivity of human cytochrome P450 enzymes: Relevance to drug metabolism and toxicity
2. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
3. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
4. Hepatocellular transport systems: From carrier identification in membrane vesicles to cloned proteins
5. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
6. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
7. Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein
8. Interaction of citrus juices with felodipine and nifedipine
9. Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression
10. Grapefruit juice-drug interactions
11. Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
12. Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in Caco-2 cells
13. Grapefruit juice activates P-glycoprotein-mediated drug transport
14. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
15. Grapefruit-felodipine interaction: Effect of unprocessed fruit and probable active ingredients
16. Transporters and drug disposition
17. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
18. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues
19. Seville orange juice-felodipine interaction: Comparison with dilute grapefruit juice and involvement of furocoumarins
20. 6′,7′-Dihydroxybergamottin in grapefruit juice and Seville orange juice: Effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein
21. Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man
22. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components
23. Liquid chromatographic determination of naringin and neohesperidin as a detector of grapefruit juice in orange juice
24. Expression, transport properties, and chromosomal location of organic anion transporter subtype 3
25. Mass balance and pharmacokinetics of MDL 16455A in healthy male volunteers