The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: The role of gut CYP3A and P-glycoprotein

Life Sciences

Volumn 71, Issue 10, 2002, Pages 1149-1160

  Di Marco, Marika Pasternyk ^a,d   Edwards, David J ^b   Wainer, Irving W ^a,c   Ducharme, Murray P ^a,d  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b WAYNE STATE UNIVERSITY   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

^d MDS Inc   (Canada)

Author keywords

CYP2D6; CYP3A; Dextromethorphan; Grapefruit juice (GJ); P glycoprotein (P gp); Seville orange juice (SOJ)

Indexed keywords

3 METHOXYMORPHINAN; BALMINIL; CYTOCHROME P450 2D6; CYTOCHROME P450 3A; DEXTROMETHORPHAN; DEXTRORPHAN; GLYCOPROTEIN P; MORPHINAN DERIVATIVE; NORLEVORPHANOL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME ACTIVITY; FEMALE; FLUORESCENCE; GASTROINTESTINAL TRACT; GRAPEFRUIT JUICE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; NORMAL HUMAN; ORANGE JUICE; PHENOTYPE; PROTEIN TRANSPORT; SOUR ORANGE; URINALYSIS; VALIDATION PROCESS;

ADOLESCENT; ADULT; ANTITUSSIVE AGENTS; ARYL HYDROCARBON HYDROXYLASES; BEVERAGES; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; CITRUS; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEALKYLATION; DEXTROMETHORPHAN; DIGESTIVE SYSTEM; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; MALE; MEMBRANE PROTEINS; OXIDOREDUCTASES, N-DEMETHYLATING; P-GLYCOPROTEIN; PHENOTYPE; REPRODUCIBILITY OF RESULTS;

CITRUS AURANTIUM; CITRUS X PARADISI;

EID: 0037178587     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)01799-X     Document Type: Article

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