Bioactivation of phenytoin by human cytochrome P450: Characterization of the mechanism and targets of covalent adduct formation

Chemical Research in Toxicology

Volumn 10, Issue 9, 1997, Pages 1049-1058

  Munns, Andrew J ^a   De Voss, James J ^a   Hooper, Wayne D ^a   Dickinson, Ronald G ^a   Gillam, Elizabeth M J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

5 (3,4 DIHYDROXYPHENYL) 5 PHENYLHYDANTOIN; 5 (4 HYDROXYPHENYL) 5 PHENYLHYDANTOIN; ASCORBIC ACID; CARBON 14; CYTOCHROME P450; DRUG METABOLITE; GLUTATHIONE; MICROSOME ENZYME; PHENYTOIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG HYPERSENSITIVITY; DRUG TRANSFORMATION; FEMALE; HUMAN; HUMAN CELL; LIVER MICROSOME; MALE; RAT;

ANIMALS; BIOTRANSFORMATION; BLOTTING, NORTHERN; CATS; CHLOROPHYLL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; MALE; MICROSOMES, LIVER; MOLECULAR WEIGHT; PHENYTOIN; PHOTOSENSITIZING AGENTS; PROTEIN BINDING; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SPECTROMETRY, FLUORESCENCE;

ANIMALIA; FELIS CATUS;

EID: 0030869281     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx9700836     Document Type: Article

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