Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21WAF1/CIP1 and C/EBPβ expressions and suppressing NF-κB activation

Prostate

Volumn 51, Issue 3, 2002, Pages 211-218

  Hour, Tzyh Chyuan ^a   Chen, Jun ^a   Huang, Chao Yuan ^a   Guan, Jing Yi ^a   Lu, Shiu Hui ^a   Pu, Yeong Shiau ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Cell cycle; Drug administration schedule; Drug synergism; Drug therapy; Protein p53

Indexed keywords

CURCUMIN; DOXORUBICIN; FLUOROURACIL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PACLITAXEL; PROTEIN P21; PROTEIN P53;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CELL CYCLE; CYTOTOXICITY; DRUG EFFECT; DRUG POTENTIATION; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; TRANSCRIPTION INITIATION;

ANTINEOPLASTIC AGENTS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL CYCLE; CELL NUCLEUS; CURCUMIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA; DRUG SYNERGISM; HUMANS; MALE; NF-KAPPA B; PREGNANCY-SPECIFIC BETA 1-GLYCOPROTEINS; PROSTATIC NEOPLASMS; SP1 TRANSCRIPTION FACTOR; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0037093926     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/pros.10089     Document Type: Article

References (28)

1. Prostate cancer in Taiwan: Epidemiology and risk factors
2. Genistein inhibits NF-kappa B activation in prostate cancer cells
3. Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor
4. The protein kinase C activator, phorbol ester, elicits disparate functional responses in androgen-sensitive and androgen-independent human prostatic cancer cells
5. Anti-tumour and antioxidant activity of natural curcuminoids
6. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer
7. Differential regulation of p53, c-Myc, bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells
8. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells
9. Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells
10. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane)
11. bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway
12. Inhibition of NF-kappaB activity through maintenance of IκBα levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter
13. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
14. Derivation and properties of Michaelis-Menten type and Hill type equations for reference ligands
15. Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
16. Inhibitors of mammalian G1 cyclin-dependent kinases
17. Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21WAF1/CIP1 via C/EBPbeta
18. Modulatory effects of curcumin on the chromosomal damage induced by doxorubicin in Chinese hamster ovary cells
19. Curcumin prevents adriamycin nephrotoxicity in rats
20. Curcumin attenuation of acute adriamycin myocardial toxicity in rats
21. A pilot study of AFL-T (doxorubicin, 5-fluorouracil, leucovorin, and tamoxifen) combination chemotherapy for hormonerefractory prostate cancer
22. Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles
23. WAF1, a potential mediator of p53 tumor suppression
24. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family
25. IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP
26. IL-6 and NF-IL6 in acute-phase response and viral infection
27. Anti-proliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines
28. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1