-
1
-
-
0026489591
-
Esistance of HIV-1 to AZT might also involve the cellular expression of multidrug resistance P-glycoprotein
-
Antonelli G, Turriziani O, Cianfriglia M, Riva E, Dong G and Fattorossi A (1992) Resistance of HIV-1 to AZT might also involve the cellular expression of multidrug resistance P-glycoprotein. Aids Res Hum Retroviruses 8:1839-1844.
-
(1992)
Aids Res Hum Retroviruses
, vol.8
, pp. 1839-1844
-
-
Antonelli, G.1
Turriziani, O.2
Cianfriglia, M.3
Riva, E.4
Dong, G.F.5
Attorossi, A.6
-
2
-
-
0025311288
-
Epithelial transport of drugs in cell culture. I. A model fcr studying the passive diffusion of drugs over intestinal absorbative (Caco-2) cellü
-
Artursson P (1990) Epithelial transport of drugs in cell culture. I. A model fcr studying the passive diffusion of drugs over intestinal absorbative (Caco-2) cellü. JPharm Sei 79:476-482.
-
(1990)
JPharm Sei
, vol.79
, pp. 476-482
-
-
Artursson, P.1
-
3
-
-
0025804183
-
Correlation between oral drug absorption ii humans and apparent drug permeability coefficients in human intestinal epithe liai (caco-2) cells
-
Artursson P and Karlsson J (1991) Correlation between oral drug absorption ii humans and apparent drug permeability coefficients in human intestinal epithe liai (caco-2) cells. Biochem Biophys Res Commun 175:880-885.
-
(1991)
Biochem Biophys Res Commun
, vol.175
, pp. 880-885
-
-
Artursson, P.1
Karlsson, J.2
-
4
-
-
0027842835
-
Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals
-
Borst P, Schinkel AH, Smit JJM, Wagenaar E, Van Deemter L, Smith AJ, Eijdems WHM, Baas F and Zaman GJR (1993) Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals. Pharmacol Ther 60:289-299.
-
(1993)
Pharmacol Ther
, vol.60
, pp. 289-299
-
-
Borst, P.1
Schinkel, A.H.2
Jjm, S.3
Wagenaar, E.4
Van Deemter, L.5
Smith, A.J.6
Eijdems, W.H.M.7
Baas, F.8
Gjr, Z.9
-
5
-
-
0028964955
-
Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-typo (G185) or mutant (V185) multidrug transporters
-
Cardarelli CO, Aksentijevich I, Pastan I and Gottesman MM (1995) Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-typo (G185) or mutant (V185) multidrug transporters. Cancer Res 55:1086-1091.
-
(1995)
Cancer Res
, vol.55
, pp. 1086-1091
-
-
Cardarelli, C.O.1
Aksentijevich, I.2
Pastan, I.3
Gottesman, M.M.4
-
6
-
-
0026465461
-
Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes
-
Chaudhary PM, Metchener EB and Roninson IB (1992) Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood 80:2735-2739.
-
(1992)
Blood
, vol.80
, pp. 2735-2739
-
-
Chaudhary, P.M.1
Metchener, E.B.2
Roninson, I.B.3
-
7
-
-
0025799513
-
Expression and activity of P-glycoprotein, a multidrug efflux pump, in human and hematopoietic stem cells
-
Chaudhary PM and Roninson IB (1991) Expression and activity of P-glycoprotein, a multidrug efflux pump, in human and hematopoietic stem cells. Cell 66:85-94.
-
(1991)
Cell
, vol.66
, pp. 85-94
-
-
Chaudhary, P.M.1
Roninson, I.B.2
-
8
-
-
0026473238
-
Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters
-
Currier SJ, Kane SE, Willingham MC, Cardarelli CO, Pastan I and Gottesman MM (1992) Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters. J Bio' Chem 267:25153-25159.
-
(1992)
J Bio' Chem
, vol.267
, pp. 25153-25159
-
-
Currier, S.J.1
Kane, S.E.2
Willingham, M.C.3
Cardarelli, C.O.4
Pastan, I.5
Gottesman, M.M.6
-
9
-
-
0028149110
-
Zidovudine increases the expression of cellular resistance' affecting its antiviral activity
-
Dianzani F, Antonelli G. Turriziani O, Riva E, Simeoni E, Signoretti C, Strosselli S and Cianfriglia M (1994) Zidovudine increases the expression of cellular resistance' affecting its antiviral activity. Aids Res Hum Retroviruses 10:1471-1478.
-
(1994)
Aids Res Hum Retroviruses
, vol.10
, pp. 1471-1478
-
-
Dianzani, F.1
Turriziani O, A.G.2
Riva, E.3
Simeoni, E.4
Signoretti, C.5
Strosselli, S.6
Cianfriglia, M.7
-
10
-
-
0024329881
-
The biochemistry of P-glycoprotein mediated multidrug resistance
-
Endicott JA and Ling V (1989) The biochemistry of P-glycoprotein mediated multidrug resistance. Ann Rev Biochem 58:137-171.
-
(1989)
Ann Rev Biochem
, vol.58
, pp. 137-171
-
-
Endicott, J.A.1
Ling, V.2
-
11
-
-
0031024382
-
Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4
-
Fitzsimmons ME and Collins JM (1997) Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4. Drug Metab Dispos 24:256-266.
-
(1997)
Drug Metab Dispos
, vol.24
, pp. 256-266
-
-
Fitzsimmons, M.E.1
Collins, J.M.2
-
12
-
-
0042132423
-
Expression of a multidrug-resistance gene in human tumors and tissues
-
Fojo AT, Ueda K, Slamon DJ, Poplack DG, Gottesman MM and Pastan I (1987) Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sei USA 84:265-269.
-
(1987)
Proc Natl Acad Sei USA
, vol.84
, pp. 265-269
-
-
Fojo, A.T.1
Ueda, K.2
Slamon, D.J.3
Poplack, D.G.4
Gottesman, M.M.5
Pastan, I.6
-
13
-
-
0026327875
-
Regulation of 2-acetylaminofluorene and 3-methylcholanthrene mediated induction of mdr and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver
-
Gant TW, Silverman JA, Bisgaard HC, Burt RK, Marino PA and Thorgeirsson SS (1991) Regulation of 2-acetylaminofluorene and 3-methylcholanthrene mediated induction of mdr and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver. Mol Carcin 4:499-509.
-
(1991)
Mol Carcin
, vol.4
, pp. 499-509
-
-
Gant, T.W.1
Silverman, J.A.2
Bisgaard, H.C.3
Burt, R.K.4
Marino, P.A.5
Thorgeirsson, S.S.6
-
14
-
-
0025145490
-
Human immunodeficiency virus I-induced expression of P-glycoprotein
-
Gollapudi S and Gupta S (1990) Human immunodeficiency virus I-induced expression of P-glycoprotein. Biochem Biophys Res Commun 171:1002-1007.
-
(1990)
Biochem Biophys Res Commun
, vol.171
, pp. 1002-1007
-
-
Gollapudi, S.1
Gupta, S.2
-
15
-
-
0027218689
-
Biochemistry of multidrug resistance mediated by the multidrug transporter
-
Gottesman MM and Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Ann Reu Biochem 62:385-427.
-
(1993)
Ann Reu Biochem
, vol.62
, pp. 385-427
-
-
Gottesman, M.M.1
Pastan, I.2
-
16
-
-
0027275829
-
P-glycoprotein (MDR1 gene product) in cells of the immune system: Its possible physiologic role and alteration in aging and human immunodeficiency virus-1 (HIV-1) infection
-
Gupta S and Gollapudi S (1993) P-glycoprotein (MDR1 gene product) in cells of the immune system: Its possible physiologic role and alteration in aging and human immunodeficiency virus-1 (HIV-1) infection. J Clin Immunol 13:289-301.
-
(1993)
J Clin Immunol
, vol.13
, pp. 289-301
-
-
Gupta, S.1
Gollapudi, S.2
-
17
-
-
0026442430
-
Preferential expression and activity of multidrug resistance genel product (P-glycoprotein), a functionally active efflux pump, in human CDS + T cells: A role in cytotoxic effector function
-
Gupta S, Kirn CH, Tsuruo T and Gollapudi S (1992) Preferential expression and activity of multidrug resistance genel product (P-glycoprotein), a functionally active efflux pump, in human CDS + T cells: A role in cytotoxic effector function. J Clin Immunol 12:451-458.
-
(1992)
J Clin Immunol
, vol.12
, pp. 451-458
-
-
Gupta, S.1
Kirn, Ch.2
Tsuruo, T.3
Gollapudi, S.4
-
18
-
-
0024595042
-
Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill
-
Hansen MB, Nielsen SE and Berg K (1989) Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Meth 119:203-210.
-
(1989)
J Immunol Meth
, vol.119
, pp. 203-210
-
-
Hansen, M.B.1
Nielsen, S.E.2
Berg, K.3
-
19
-
-
0025912228
-
Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell lHCT-8 and T84 layers expressing Pglycoprotein
-
Hunter J, Hirst BH and Simmons NL (1991) Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell lHCT-8 and T84) layers expressing Pglycoprotein. Br J Cancer 64:437-444.
-
(1991)
Br J Cancer
, vol.64
, pp. 437-444
-
-
Hirst Bh, H.J.1
Simmons, N.L.2
-
20
-
-
0026040182
-
Characterization of multidrug resistance by fluorescent dyes
-
Kessel D, Beck WT, Kukuruga D and Schulz V (1991) Characterization of multidrug resistance by fluorescent dyes. Cancer Res 51:4665-4670.
-
(1991)
Cancer Res
, vol.51
, pp. 4665-4670
-
-
Kessel, D.1
Beck, W.T.2
Kukuruga, D.3
Schulz, V.4
-
21
-
-
0029826606
-
Rational approaches to resistance: Nucleoside analogues
-
Mayers D (1996) Rational approaches to resistance: Nucleoside analogues. AIDS 10:39-13.
-
(1996)
AIDS
, vol.10
, pp. 39-113
-
-
Mayers, D.1
-
22
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
-
(1983)
J Immunol Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
23
-
-
0023833803
-
Use of fluorescent probes as molecular probes for the study of multidrug resistance
-
Neyfakh A (1988) Use of fluorescent probes as molecular probes for the study of multidrug resistance. Exp Cell Res 174:168-176.
-
(1988)
Exp Cell Res
, vol.174
, pp. 168-176
-
-
Neyfakh, A.1
-
24
-
-
0029897059
-
Saquinavir: A review of its pharmacology and clinical potential in the management of HIV infection
-
Noble S and Faulds D (1996) Saquinavir: A review of its pharmacology and clinical potential in the management of HIV infection. Drugs 52:93-112.
-
(1996)
Drugs
, vol.52
, pp. 93-112
-
-
Noble, S.1
Faulds, D.2
-
25
-
-
0029614884
-
Drug-resistance patterns of saquinavir and other HIV proteinase inhibitors
-
Roberts NA (1995) Drug-resistance patterns of saquinavir and other HIV proteinase inhibitors. AIDS 9:827-32.
-
(1995)
AIDS
, vol.9
, pp. 827-832
-
-
Roberts, N.A.1
-
26
-
-
0028229150
-
Disruption of the mouse mdrJa P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
Schinkel AH, Smit JJM, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CAAM, van der Valk MA, Robanus-Maandag EC, te Riele HPJ, Berns AJM and Borst P (1994) Disruption of the mouse mdrJa P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. CM 77:491-502.
-
(1994)
CM
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Jjm, S.2
Van Tellingen, O.3
Beijnen, J.H.4
Wagenaar, E.5
Van Deemter, L.6
Caam, M.7
Van Der Valk, M.A.8
Robanus-Maandag, E.C.9
Te Riele, H.P.J.10
Berns, A.J.M.11
Borst, P.12
-
27
-
-
0029892497
-
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
-
Schinkel AH, Wagenaar E, Mol CAAM and van Deemter L (1996) P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 97:2517-2524.
-
(1996)
J Clin Invest
, vol.97
, pp. 2517-2524
-
-
Schinkel, A.H.1
Wagenaar, E.2
Caam, M.3
Van Deemter, L.4
-
28
-
-
12644278301
-
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
-
Sparreboom A, van Asperen J, Mayer U, Schinkel AH, Smit JW, Meijer DKF, Borst P, Nooijen WJ, Beijnen JH and van Tellingen 011997) Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc Natl Acad Sei USA 94:2031-2035.
-
(1997)
Proc Natl Acad Sei USA
, vol.94
, pp. 2031-2035
-
-
Sparreboom, A.1
Van Asperen, J.2
Mayer, U.3
Schinkel, A.H.4
Smit, J.W.5
Dkf, M.6
Borst, P.7
Nooijen, W.J.8
Beijnen, J.H.9
Van Tellingen10
-
29
-
-
0023447098
-
Cellular localization of the multidrug resistance gene product Pglycoprotein in normal human tissues
-
Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I and Willingham MC (1987) Cellular localization of the multidrug resistance gene product Pglycoprotein in normal human tissues. Proc Natl Acad Sei USA 84:7735-7738.
-
(1987)
Proc Natl Acad Sei USA
, vol.84
, pp. 7735-7738
-
-
Thiebaut, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
30
-
-
0024576304
-
Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: Evidence for localization in brain capillaries and crossreactivity on one antibody with a muscle protein
-
Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I and Willingham MC (1989) Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: Evidence for localization in brain capillaries and crossreactivity on one antibody with a muscle protein. J Histochem Cytochem 37:159-164.
-
(1989)
J Histochem Cytochem
, vol.37
, pp. 159-164
-
-
Thiebaut, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
31
-
-
0029614681
-
Clinical experience with saquinavir
-
Vella S (1995) Clinical experience with saquinavir. AIDS 9:821-25.
-
(1995)
AIDS
, vol.9
, pp. 821-825
-
-
Vella, S.1
-
32
-
-
0029028792
-
Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
-
Wacher VJ, Wu C-Y and Benêt LZ (1995) Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy. Afo/ Carcin 13:129-134.
-
(1995)
Afo/ Carcin
, vol.13
, pp. 129-134
-
-
Wacher, V.J.1
Wu, C.-Y.A.2
Benêt, L.Z.3
-
33
-
-
0030581087
-
Active secretion and enterocytic drug metabolism barriers to drug absorption
-
Wacher VJ, Salphati L and Benêt LZ (1996) Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv Drug Deliv Reu 20:99-112.
-
(1996)
Adv Drug Deliv Reu
, vol.20
, pp. 99-112
-
-
Wacher, V.J.1
Salphati, L.2
Benêt, L.Z.3
-
34
-
-
0025316847
-
Differential transport properties of two mdr gene products are distinguished by progesterone
-
Yang C-PH, Cohen D, Greenberger LM, Hsu SI-H and Horwitz SB (1990) Differential transport properties of two mdr gene products are distinguished by progesterone. J Blol Chem 265:10282-10288.
-
(1990)
J Blol Chem
, vol.265
, pp. 10282-10288
-
-
Yang, C.-P.H.1
Cohen, D.2
Greenberger, L.M.3
Hsu, S.I.-H.4
Horwitz, S.B.5
-
35
-
-
0024501045
-
Progesterone interacts with P-glycoprotein in multidrug resistant cells and in the endometrium of gravid uterus
-
Yang C-PH, DePinho SG, Greenberger LM, Arceci RJ and Horwitz SB (1989) Progesterone interacts with P-glycoprotein in multidrug resistant cells and in the endometrium of gravid uterus. J Biol Chem 264:782-788.
-
(1989)
J Biol Chem
, vol.264
, pp. 782-788
-
-
Yang, C.-P.H.1
Depinho, S.G.2
Greenberger, L.M.3
Arceci, R.J.4
Horwitz, S.B.5
-
36
-
-
0025293942
-
Cross-resistance to anti-HIV nucleoside analogs in multidrug-resistant human cells
-
Yusa K, Oh-hara T, Tsukahara S, Satoh W and Tsuruo T (1990) Cross-resistance to anti-HIV nucleoside analogs in multidrug-resistant human cells. Biochem Biophys Res Commun 169:986-990.
-
(1990)
Biochem Biophys Res Commun
, vol.169
, pp. 986-990
-
-
Yusa, K.1
Oh-hara, T.2
Tsukahara, S.3
Satoh, W.4
Tsuruo, T.5
-
37
-
-
0028264139
-
Inhibition of Pglycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH
-
Zacherl J, Hamilton G, Thalhammer T, Riegler M, Cosentini EP, Ellinger A, Bischof G, Schweitzer M, Teleky B, Koperna T and Wenzl E (1994) Inhibition of Pglycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH. Cancer Chemother Pharmacol 34:125-132.
-
(1994)
Cancer Chemother Pharmacol
, vol.34
, pp. 125-132
-
-
Zacherl, J.1
Hamilton, G.2
Thalhammer, T.3
Riegler, M.4
Cosentini, E.P.5
Ellinger, A.6
Bischof, G.7
Schweitzer, M.8
Teleky, B.9
Koperna, T.10
Wenzl, E.11
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