Effects of grapefruit juice and smoking on verapamil concentrations in steady state

European Journal of Clinical Pharmacology

Volumn 58, Issue 1, 2002, Pages 45-53

  Fuhr, Uwe ^a   Müller Peltzer, Herbert ^c   Kern, Rainer ^c   Lopez Rojas, Pablo ^b   Jünemann, Manfred ^b   Harder, Sebastian ^b   Staib, Horst A ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^c Knoll AG   (Germany)

Author keywords

Grapefruit juice; Smoking; Verapamil

Indexed keywords

6BETA HYDROXYHYDROCORTISONE; CYTOCHROME P450 3A; ISOPTIN KHK; NARINGENIN; NORVERAPAMIL; VERAPAMIL; WATER;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CIGARETTE SMOKING; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG INDICATION; ENANTIOMER; ENZYME INDUCTION; GRAPEFRUIT JUICE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PR INTERVAL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; STEADY STATE; URINARY EXCRETION;

ADULT; BEVERAGES; CALCIUM CHANNEL BLOCKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRUS; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; FLAVANONES; FLAVONOIDS; FOOD-DRUG INTERACTIONS; HUMANS; HYDROCORTISONE; MALE; MIXED FUNCTION OXYGENASES; SMOKING; STEREOISOMERISM; VERAPAMIL;

EID: 0036220634     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-002-0436-7     Document Type: Article

References (39)

1. Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance
2. Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression
3. Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins
4. Relationship between time of intake of grapefruit juice and its effect on pharmacokinetics and pharmacodynamics of felodipine in healthy subjects
5. Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin
6. Factors affecting the absolute bioavailability of nifedipine
7. Disposition of intravenous and oral cyclosporine after administration with grapefruit juice
8. Interaction between grapefruit juice and midazolam in humans
9. Effect of grapefruit juice dose on grapefruit juice-triazolam interaction: Repeated consumption prolongs triazolam half-life
10. Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4
11. Grapefruit juice activates P-glycoprotein-mediated drug transport
12. Specific CYP3A4 inhibitors in grapefruit juice: Furocoumarin dimers as components of drug interaction
13. Inhibition selectivity of grapefruit juice components on human cytochromes
14. In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids
15. Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in caco-2 cells
16. In vitro inhibition of simvastatin metabolism in rat and human liver by naringenin
17. Identification of P450 enzymes involved in metabolism of verapamil in humans
18. Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans
19. Verapamil and drug metabolism by the cytochrome P450 isoform CYP1A2
20. Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s
21. Clinical pharmacokinetics of verapamil, nifedipine and diltiazem
22. Affinities at the verapamil binding site of MDR1-encoded P-glycoprotein: Drugs and analogs, stereoisomers and metabolites
23. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein
24. The effect of grapefruit juice on the pharmacokinetics of orally administered verapamil
25. Effects of naringenin and naringin on verapamil metabolism in human liver microsomes
26. The effect of three different oral doses of verapamil on the disposition of theophylline
27. Verapamil-induced inhibition of theophylline elimination in healthy humans
28. Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test
29. Lack of pharmacokinetic interaction as an equivalence problem
30. Internally standardized simultaneous assay of verapamil and N-demethyl-verapamil enantiomers in human plasma by means of high performance liquid chromatography
31. The fate of naringin in humans: A key to grapefruit juice-drug interactions?
32. Phenotyping of drug-metabolizing enzymes in adults: A review of in-vivo cytochrome P450 phenotyping probes
33. Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers
34. Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil
35. Effects of long-term grapefruit juice ingestion on nifedipine pharmacokinetics: Induction of rat hepatic P-450 by grapefruit juice
36. Concentration/effect analysis of verapamil: Evaluation of different approaches
37. A comparative review of the adverse effects of calcium antagonists