Effect of grapefruit juice on the pharmacokinetics of losartan and its active metabolite E3174 in healthy volunteers

Therapeutic Drug Monitoring

Volumn 23, Issue 4, 2001, Pages 369-373

  Zaidenstein, Ronit ^a   Soback, Stefan ^c   Gips, Marina ^c   Avni, Batya ^a   Dishi, Victor ^a,b   Weissgarten, Yehoshua ^a,b   Golik, Ahuva ^a   Scapa, Erez ^a,d  

^a ASSAF HAROFEH MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c KIMRON VETERINARY INSTITUTE   (Israel)

^d TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Grapefruit; Losartan; Pharmacokinetics

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; ANGIOTENSIN ANTAGONIST; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; LOSARTAN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CITRUS FRUIT; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; FOOD DRUG INTERACTION; FRUIT JUICE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MEAN RESIDENCE TIME; PRIORITY JOURNAL;

ADULT; ANTI-ARRHYTHMIA AGENTS; ANTIHYPERTENSIVE AGENTS; AREA UNDER CURVE; BEVERAGES; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRUS; CROSS-OVER STUDIES; FEMALE; HALF-LIFE; HUMANS; IMIDAZOLES; LOSARTAN; MALE; TETRAZOLES;

EID: 0034896135     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200108000-00008     Document Type: Article

References (17)

1. Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite E3174 in humans
2. Phenotypic and genotypic investigation of healthy volunteer deficient in conversion of losartan to its active metabolite E3174
3. Drug interactions with grapefruit juice
4. Grapefruit juice - Drug interactions
5. Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily members
6. Effect of fluconazole on the pharmacokinetics of eprosartan and losartan in healthy male volunteers
7. Fluconazole but not itraconazole decreases the metabolism of losartan to E-3174
8. The effects of fluvastatin, a CYP 3A4 inhibitor, on losartan pharmacokinetics in healthy volunteers
9. Effects of erythromycin or rifampin on losartan and pharmacokinetics in healthy volunteers
10. Grapefruit juice activates P-glycoprotein-mediated drug transport
11. Statistical moments in pharmacokinetics
12. Noncompartmental determination of the steady-state volume of distribution
13. Grapefruit juice has minimal effects on plasma concentrations of lovastatin-derived 3-hydroxy-3methylglutaryl coenzyme A reductase inhibitors
14. Influence of grapefruit juice on cisapride pharmacokinetics
15. Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy