Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 2, 2002, Pages 645-650

  Bhardwaj, Rajinder K ^a,b   Glaeser, Hartmut ^a,b   Becquemont, Laurent ^a,b   Klotz, Ulrich ^a,b   Gupta, Suresh K ^a,b   Fromm, Martin F ^a,b  

^a DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; CYTOCHROME P450 3A4; DEALKYLVERAPAMIL; DIGOXIN; DRUG METABOLIZING ENZYME; GLYCOPROTEIN P; HYPERICUM PERFORATUM EXTRACT; NORVERAPAMIL; PHENYTOIN; PIPERINE; RIFAMPICIN; VERAPAMIL;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DIETARY INTAKE; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EFFECT; DRUG METABOLISM; DRUG TRANSPORT; ENZYME INHIBITION; FIRST PASS EFFECT; FOOD DRUG INTERACTION; GRAPEFRUIT JUICE; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; INTESTINE CELL; LIVER CELL; LIVER MICROSOME; NONHUMAN; PEPPER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RODENT;

ALKALOIDS; BENZODIOXOLES; BIOLOGICAL TRANSPORT; COLONIC NEOPLASMS; CYCLOSPORINE; CYTOCHROME P-450 ENZYME SYSTEM; DIGOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; KINETICS; MIXED FUNCTION OXYGENASES; P-GLYCOPROTEIN; PIPERIDINES; POLYUNSATURATED ALKAMIDES; TUMOR CELLS, CULTURED;

EID: 0036070626     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.034728     Document Type: Article

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