Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells

Biochemical Pharmacology

Volumn 64, Issue 4, 2002, Pages 573-582

  Anuchapreeda, Songyot ^a   Leechanachai, Pranee ^b   Smith, Melissa M ^c   Ambudkar, Suresh V ^c   Limtrakul, Porn ngarm ^a  

^a Faculty of Medicine Chiang Mai University   (Thailand)

^b CHIANG MAI UNIVERSITY   (Thailand)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

ATP hydrolysis; Chemosensitizers; Curcumin; KB V1 cells; Multidrug resistance; P glycoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CURCUMIN; GLYCOPROTEIN P; MESSENGER RNA; PRAZOSIN; RHODAMINE 123; VERAPAMIL; VINBLASTINE;

ARTICLE; CANCER CELL CULTURE; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG SENSITIVITY; DRUG TRANSPORT; ENZYME ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MULTIDRUG RESISTANCE; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATASES; ANTINEOPLASTIC AGENTS; AZIDES; BIOLOGICAL TRANSPORT; CELL SURVIVAL; CURCUMIN; DOWN-REGULATION; DRUG RESISTANCE, MULTIPLE; FLUORESCENT DYES; GENE EXPRESSION; HUMANS; KB CELLS; P-GLYCOPROTEIN; PHOTOAFFINITY LABELS; PRAZOSIN; RHODAMINE 123; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 0037103569     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01224-8     Document Type: Article

References (43)

1. Biochemical, cellular, and pharmacological aspects of the multidrug transporter
2. Multidrug resistance transporters and modulation
3. Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems and intact cells
4. Modulation of multidrug resistance: A paradigm for translational clinical research
5. Effects of modulators of multidrug resistance on the expression of the MDR1 gene on human KB cells in culture
6. Turmeric: Chemistry, technology and quality
7. Pharmacology of Curcuma longa
8. Oxygen radical scavenging activity of curcumin
9. Inhibition of chemical carcinogenesis by curcumin
10. Curcumin, an antioxidant and antitumor promoter, induces apoptosis in human leukemia cells
11. In vitro antimutagenicity of curcumin against environmental mutagens
12. Chemoprevention of colon cancer by dietary curcumin
13. Inhibitory effect of dietary curcumin on skin carcinogenesis in mice
14. Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin
15. Effect of curcumin on serum and liver cholesterol levels in the rat
16. Effect of curcumin on blood sugar as seen in a diabetic subject
17. Toxicity studies on Alpinia galanga and Curcuma longa
18. Toxicity studies on turmeric: Acute toxicity studies in rats, guinea pigs and monkeys
19. Cleavage of structural proteins during assembly of the head of bacteriophage T4
20. Protein measurement with the Folin phenol reagent
21. Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state
22. Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression
23. Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cells
24. Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein
25. Differential modulation of P-glycoprotein transport by protein kinase inhibition
26. Feasibility of drug screening with panels of human tumour cell lines using a microculture tetrazolium assay
27. Reciprocal correlation between expression of P-glycoprotein and accumulation of rhodamine 123 in human tumours
28. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
29. Immunohistochemical detection of P-glycoprotein: Prognostic correlation in soft-tissue sarcoma of childhood
30. Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction
31. Correlation of MDR1 gene expression with chemotherapy in neuroblastoma
32. Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells
33. Human multidrug-resistant cell lines: Increased mdr1 expression can precede gene amplification
34. Partial purification and reconstitution of the human multidrug-resistance pump: Characterization of the drug-stimulatable ATP hydrolysis
35. The effects of curcumin on the proliferation of cancer cell lines
36. Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines
37. Effect of curcumin on P-glycoprotein in primary cultures of rat hepatocytes
38. Increased AP-1 activity in drug resistant human breast cancer MCF-7 cells
39. The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-κB
40. Inhibitory effect of curcumin and caspacin on phorbol ester induced activation of eukaryotic transcription factors, NF kappa B and AP-1
41. Drug-stimulated ATPase activity of the human P-glycoprotein
42. Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system
43. Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein