Regulation of cardiac myocyte cell death

Pharmacology and Therapeutics

Volumn 97, Issue 3, 2003, Pages 223-261

  Clerk, Angela ^a   Cole, Sharon M ^a   Cullingford, Timothy E ^a   Harrison, Joanne G ^a   Jormakka, Mika ^a   Valks, Donna M ^a  

^a Faculty of Medicine   (United Kingdom)

Author keywords

Apoptosis; Bcl 2; Cardiac myocytes; Caspases; Death receptors; Mitochondria

Indexed keywords

CALPAIN; CASPASE; CATHEPSIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN P53; PROTEINASE;

APOPTOSIS; HEART MUSCLE NECROSIS; MITOCHONDRION; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SIGNAL TRANSDUCTION;

EID: 0037357698     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(02)00339-X     Document Type: Review

References (367)

1. Acehan D., Jiang X., Morgan D.G., Heuser J.E., Wang X., Akey C.W. Three-dimensional structure of the apoptosome. Implications for assembly, procaspase-9 binding, and activation. Mol Cell. 9:2002;423-432.
2. Adachi M., Suematsu S., Suda T., Watanabe D., Fukuyama H., Ogasawara J., Tanaka T., Yoshida N., Nagata S. Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc Natl Acad Sci USA. 93:1996;2131-2136.
3. Adamopoulos S., Parissis J.T., Kremastinos D.T. A glossary of circulating cytokines in chronic heart failure. Eur J Heart Fail. 3:2001;517-526.
4. Adams J.A., Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 26:2001;61-66.
5. Adams J.W., Pagel A.L., Means C.K., Oksenberg D., Armstrong R.C., Brown J.H. Cardiomyocyte apoptosis induced by Gαq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway. Circ Res. 87:2000;1180-1187.
6. Adrain C., Martin S.J. The mitochondrial apoptosome: a killer unleashed by cytochrome seas. Trends Biochem Sci. 26:2001;390-397.
7. Aikawa R., Komura I., Yamazaki T., Zou Y., Kudoh S., Tanaka M., Shiojima I., Hiroi Y., Yazaki Y. Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest. 100:1997;1813-1821.
8. Akao M., Ohler A., O'Rourke B., Marban E. Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells. Circ Res. 88:2001;1267-1275.
9. Andreka P., Zang J., Dougherty C., Slepak T.I., Webster K.A., Bishopric N.H. Cytoprotection by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis. Circ Res. 88:2001;305-312.
10. Angelastro J.M., Moon N.Y., Liu D.X., Yang A.-S., Greene L.A., Franke T.F. Characterization of a novel isoform of caspase-9 that inhibits apoptosis. J Biol Chem. 276:2001;12190-12200.
11. Antonsson B. Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim, the mitochondrion. Cell Tissue Res. 306:2001;347-361.
12. Antonsson B., Montessuit S., Lauper S., Eskes R., Martinou J.C. Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem J. 345:2000;271-278.
13. Antonsson B., Montessuit S., Sanchez B., Martinou J.C. Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. J Biol Chem. 276:2001;11615-11623.
14. Anversa P., Leri A., Kajstura J., Nadal-Ginard B. Myocyte growth and cardiac repair. J Mol Cell Cardiol. 34:2002;91-105.
15. Aoki H., Kang P.M., Hampe J., Yoshimura K., Noma T., Matsuzaki M., Izumo S. Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes. J Biol Chem. 277:2002;10244-10250.
16. L. Implications for the function of the Bcl-2 protein family. J Biol Chem. 272:1997;27886-27892.
17. Badorff C., Ruettem H., Mueller S., Stahmer M., Gehring D., Jung F., Ihling C., Zeiher A.M., Dimmeler S. Fas receptor signaling inhibits glycogen synthase kinase 3β and induces cardiac hypertrophy following pressure overload. J Clin Invest. 109:2002;373-381.
18. Bagrodia S., Cerione R.A. PAK to the future. Trends Cell Biol. 9:1999;350-355.
19. Barabcik M., Htun P., Strohm C., Kilian S., Schaper W. Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic death. J Cardiovasc Pharmacol. 35:2000;474-483.
20. Basu A., Woolard M.D., Johnson C.L. Involvement of protein kinase C-δ in DNA damage-induced apoptosis. Cell Death Differ. 8:2001;899-908.
21. Baud V., Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 11:2001;372-377.
22. Becker L.B., Vanden Hoek T.L., Shao S.H., Li C.Q., Schumacker P.T. Generation of superoxide in cardiomyocytes during ischemia before reperfusion. Am J Physiol. 277:1999;H2240-H2246.
23. Benedict M.A., Hu Y., Inohara N., Nunez G. Expression and functional analysis of Apaf-1 isoforms. Extra WD-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9. J Biol Chem. 275:2000;8461-8468.
24. Berglund H., Olerenshaw D., Sankar A., Federwisch M., McDonald N.Q., Driscoll P.C. The three-dimensional solution structure and dynamic properties of the human FADD death domain. J Mol Biol. 302:2000;171-188.
25. Bergmann M.W., Loser P., Dietz R., Von Harsdorf R. Effect of NF-κB inhibition on TNF-α-induced apoptosis and downstream pathways in cardiomyocytes. J Mol Cell Cardiol. 33:2001;1223-1232.
26. Bialik S., Geenen D.L., Sasson I.E., Cheng R., Horner J.W., Evans S.M., Lord E.M., Koch C.J., Kitsis R.N. Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest. 100:1997;1363-1372.
27. Bialik S., Cryns V.L., Drincic A., Miyata S., Wollowick A.L., Srinivasan A., Kitsis R.N. The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes. Circ Res. 85:1999;403-414.
28. Blagosklonny M.V. Unwinding the loop of Bcl-2 phosphorylation. Leukemia. 15:2001;869-874.
29. Blomgren K., Zhu C., Wang X., Karlsson J.-O., Leverin A.-L., Bahr B.A., Mallard C., Hagberg H. Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia. A mechanism of "pathological apoptosis"? J Biol Chem. 276:2001;10191-10198.
30. Borutaite V., Budriumaite A., Morkuniene R., Brown G.C. Release of mitochondrial cytochrome c and activation of cytosolic caspases induced by myocardial ischaemia. Biochim Biophys Acta. 1537:2001;101-109.
31. L, and Mcl-1 and promotes survival of human pancreatic cancer cells. J Cell Biochem. 79:2000;355-369.
32. Bowles N.E., Towbin J.A. Molecular aspects of myocarditis. Curr Opin Cardiol. 13:1998;179-184.
33. Bratton S.B., Walker G., Srinivasula S.M., Sun X.M., Butterworth M., Alnemri E.S., Cohen G.M. Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. EMBO J. 20:2001;998-1009.
34. Brenner B., Koppenhoefer U., Weinstock C., Linderkamp O., Lang F., Gulbins E. Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. J Biol Chem. 272:1997;22173-22181.
35. Brook M., Sully G., Clark A.R., Saklatvala J. Regulation of tumour necrosis factor α mRNA stability by the mitogen-activated protein kinase p38 signalling cascade. FEBS Lett. 483:2000;57-61.
36. Brown J.L., Stowers L., Baer M., Trejo J., Coughlin S., Chant J. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr Biol. 6:1996;598-605.
37. Buerke M., Murohara T., Skurk C., Nuss C., Tomaselli K., Lefer A.M. Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Proc Natl Acad Sci USA. 92:1995;8031-8035.
38. Camper-Kirby D., Welch S., Walker A., Shiraishi I., Setchell K.D.R., Schaefer E., Kajstura J., Anversa P., Sussman M.A. Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ Res. 88:2001;1020-1027.
39. Cantley L.C., Neel B.G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA. 96:1999;4240-4245.
40. Cardone M.H., Salveson G.S., Widmann C., Johnson G., Frisch S.M. The regulation of anoikis: MEKK1 activation requires cleavage by caspases. Cell. 90:1997;315-323.
41. Cardone M.H., Roy N., Stennicke H.R., Salvesan G.S., Franke T.F., Stanbridge E., Frisch S., Reed J.C. Regulation of cell death protease caspase-9 by phosphorylation. Science. 282:1998;1318-1321.
42. Catz S.D., Johnson J.L. Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancer. Oncogene. 20:2001;7342-7351.
43. Cesselli D., Jakoniuk I., Barlucchi L., Beltrami A.P., Hintze T.H., Nadal-Ginard B., Kajstura J., Leri A., Anversa P. Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy. Circ Res. 89:2001;279-286.
44. Chae H.J., So H.S., Chae S.W., Park J.S., Kim M.S., Oh J.M., Chung Y.T., Yang S.H., Jeong E.T., Kim H.M., Park R.K., Kim H.R. Sodium nitroprusside induces apoptosis of H9c2 cardiac muscle cells in a c-Jun N-terminal kinase-dependent manner. Int Immunopharmacol. 1:2001;967-978.
45. Chai J., Shiozaki E., Srinivasula S.M., Wu Q., Datta P., Alnemri E.S., Shi Y. Structural basis of caspase-7 inhibition by XIAP. Cell. 104:2001;769-780.
46. L and Bcl-2. EMBO J. 16:1997;968-977.
47. Chang H.S., Jeon K.W., Kim Y.H., Chung I.Y., Park C.S. Role of cAMP-dependent pathway in eosinophil apoptosis and survival. Cell Immunol. 203:2000;29-38.
48. Chen C.-H., Mochly-Rosen D. Opposing effects of δ and ε PKC in ethanol-induced cardioprotection. J Mol Cell Cardiol. 33:2001;581-585.
49. Chen L., Hahn H., Wu G., Chen C.-H., Liron T., Schechtman D., Cavallaro G., Banci L., Guo Y., Bolli R., Dorn G.W. II, Mochly-Rosen D. Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and εPKC. Proc Natl Acad Sci USA. 98:2001;11114-11119.
50. Chen M., He H., Zhan S., Krajewski S., Reed J.C., Gottlieb R.A. Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion. J Biol Chem. 276:2001;30724-30728.
51. Chen Z., Chua C.C., Ho Y.S., Hamdy R.C., Chua B.H. Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. Am J Physiol. 280:2001;H2313-H2320.
52. L sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell. 8:2001;705-711.
53. Chou J.J., Li H., Salvesen G.S., Yuan J., Wagner G. Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell. 96:1999;615-624.
54. Chu Z.-L., Pio F., Xie Z., Welsh K., Krajewska M., Krajewski S., Godzik A., Reed J.C. A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. J Biol Chem. 276:2001;9239-9245.
55. Chua B.T., Guo K., Li P. Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases. J Biol Chem. 275:2000;5131-5135.
56. Clerk A. Death by protein kinase C inhibitor: a stressful event. J Mol Cell Cardiol. 33:2001;1773-1776.
57. Clerk A., Fuller S.J., Michael A., Sugden P.H. Stimulation of "stress-regulated" mitogen-activated protein kinases (SAPKs/JNKs and p38-MAPKs) in perfused rat hearts by oxidative and other stresses. J Biol Chem. 273:1998;7228-7234.
58. Clerk A., Michael A., Sugden P.H. Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes. Biochem J. 333:1998;581-589.
59. Communal C., Singh K., Pimental D.R., Colucci W.S. Norepinephrine stimulates apoptosis in adult ventricular myocytes by activation of the β-adrenergic pathway. Circulation. 98:1998;1329-1334.
60. 2-adrenergic receptors on cardiac myocyte apoptosis: role of a pertussis toxin-sensitive G protein. Circulation. 100:1999;2210-2212.
61. Condorelli F., Salamoni P., Cotteret S., Cesi V., Srinivasula S.M., Alnemri E.S., Calabretta B. Caspase cleavage enhances the apoptosis-inducing effects of BAD. Mol Cell Biol. 21:2001;3025-3036.
62. Condorelli G., Roncarati R., Ross J., Pisani A., Stassi G., Todaro M., Trocha S., Drusco A., Gu Y., Russo M.A., Frati G., Jones S.P., Lefer D.J., Napoli C., Croce C.M. Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function. Proc Natl Acad Sci USA. 98:2001;9977-9982.
63. Conus S., Rosse T., Borner C. Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells. Cell Death Differ. 7:2000;947-954.
64. Cook S.A., Sugden P.H., Clerk A. Regulation of Bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes: association with changes in mitochondrial membrane potential. Circ Res. 85:1999;940-949.
65. Cortese J.D., Voglino A.L., Hackenbrock C.R. Multiple conformations of physiological membrane-bound cytochrome c. Biochemistry. 37:1998;6402-6409.
66. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J. 341:1999;233-249.
67. Cryns V.L., Byun Y., Rana A., Mellor H., Lustig K.D., Ghanem L., Parker P.J., Kirschner M.W., Yuan J. Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy. J Biol Chem. 272:1997;29449-29453.
68. Cummings O.W., King T.C., Holden J.A., Low R.L. Purification and characterization of the potent endonuclease in extracts of bovine heart mitochondria. J Biol Chem. 262:1987;2005-2015.
69. Datta R., Kojima H., Yoshida K., Kufe D. Caspase-3-mediated cleavage of protein kinase C θ in induction of apoptosis. J Biol Chem. 272:1997;20317-20320.
70. Datta S.R., Katsov A., Hu L., Petros A., Fesik A., Yaffe M.B., Greenberg M.E. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell. 6:2000;41-51.
71. Daugas E., Nochy D., Ravagnan L., Loeffler M., Susin S.A., Zamzami N., Kroemer G. Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett. 476:2000;118-123.
72. Davies S.P., Reddy H., Caivano M., Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 351:2000;95-105.
73. Davis R.J. Signal transduction by the JNK group of MAP kinases. Cell. 103:2000;239-252.
74. Denning M.F., Wang Y., Tobudin S., Alkan S., Nickoloff B.J., Qin J.Z. Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C. Cell Death Differ. 9:2002;40-52.
75. Desagher S., Osen-Sand A., Nichols A., Eskes R., Montessuit S., Lauper S., Maundrell K., Antonsson B., Martinou J.-C. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol. 144:1999;891-901.
76. Deveraux Q.L., Leo E., Stennicker H.R., Welsh K., Salvesen G.S., Reed J.C. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J. 18:1999;5242-5251.
77. De Windt L.J., Lim H.W., Taigen T., Wencker D., Condorelli G., Dorn G.W. II, Kitsis R.N., Molkentin J.D. Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: an apoptosis-independent model of dilated heart failure. Circ Res. 86:2000;255-263.
78. Dhalla N.S., Elmoselhi A.B., Hata T., Makino N. Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res. 47:2000;446-456.
79. Dorn G.W. II, Souroujon M.C., Liron T., Chen C.-H., Gray M.O., Zhou H.Z., Csukai M., Wu G., Lorenz J.N., Mochly-Rosen D. Sustained in vivo cardiac protection by a rationally designed peptide that causes ε protein kinase C translocation. Proc Natl Acad Sci USA. 96:1999;12798-12803.
80. Dougherty C.J., Kubasiak L.A., Prentice H., Andreka P., Bishopric N.H., Webster K.A. Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress. Biochem J. 362:2002;561-571.
81. Dramsi S., Scheid M.P., Maiti A., Hojabrpour P., Chen X., Schubert K., Goodlett D.R., Aebersold R., Duronio V. Identification of a novel phosphorylation site, Ser170, as a regulator of Bad pro-apoptotic activity. J Biol Chem. 277:2002;6399-6405.
82. Droin N., Beauchemin M., Solary E., Bertrand R. Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. Cancer Res. 60:2000;7039-7047.
83. Du C., Fang M., Li Y., Li L., Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 102:2000;33-42.
84. 2 radicals during reperfusion after prolonged myocardial ischemia. Am J Physiol Heart Circ Physiol. 280:2001;H2649-H2657.
85. Eberstadt M., Huang B., Chen Z., Meadows R.P., Ng S.-C., Zheng L., Lenardo M.J., Fesik S.W. NMR structure and mutagenesis of the FADD (Mort1) death-effector domain. Nature. 392:1998;941-945.
86. Ekhterae D., Lin Z., Lundberg M.S., Crow M.T., Brosius F.C., Nunez G. ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. Circ Res. 85:1999;70-77.
87. Elsä A., Suzuki K., Schaper J. Unresolved issues regarding the role of apoptosis in the pathogenesis of ischemic injury and heart failure. J Mol Cell Cardiol. 32:2000;711-724.
88. Emoto Y., Manome Y., Meinhardt G., Kisaki H., Kharbanda S., Robertson M., Ghayur T., Wong W.W., Kamen R., Weichselbaum R., Kufe D. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells. EMBO J. 14:1995;6148-6156.
89. Eskes R., Desagher S., Antonsson B., Martinou J.-C. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol. 20:2000;929-935.
90. Fang X., Yu S., Eder A., Mao M., Bast R.C. Jr., Boyd D., Mills G.B. Regulation of BAD phosphorylation by the Ras/mitogen-activated protein kinase pathway. Oncogene. 18:1999;6635-6640.
91. Ferrari R., Agnoletti L., Comini L., Gaia G., Bachetti T., Cacgnoni A., Ceconi C., Curello S., Visioli O. Oxidative stress during myocardial ischaemia and heart failure. Eur Heart J. 19(suppl. B):1998;B2-B11.
92. Ferri K.F., Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol. 3:2001;E255-E263.
93. Filippatos G., Leche C., Sunga R., Tsoukas A., Anthopoulos P., Joshi I., Bifero A., Pick R., Uhal B.D. Expression of FAS adjacent to fibrotic foci in the failing human heart is not associated with increased apoptosis. Am J Physiol. 277:1999;H445-H451.
94. Fiordaliso F., Leri A., Cesselli D., Limana F., Safai B., Nadal-Ginard B., Anversa P., Kajstura J. Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death. Diabetes. 50:2001;2363-2375.
95. Foghsgaard L., Wissing D., Mauch D., Lademann U., Bastholm L., Boes M., Elling F., Leist M., Jaattela M. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol. 153:2001;999-1010.
96. Fortuno M.A., Ravassa S., Fortuno A., Zalba G., Diez J. Cardiomyocyte apoptotic cell death in arterial hypertension: mechanisms and potential management. Hypertension. 38:2001;1406-1412.
97. Frodin M., Gammeltoft S. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol Cell Endocrinol. 151:1999;65-77.
98. Frutos S., Moscat J., Diaz-Meco M.T. Cleavage of ζPKC but not λ/ιPKC by caspase-3 during UV-induced apoptosis. J Biol Chem. 274:1999;10765-10770.
99. Fujio Y., Nguyen T., Wencker D., Kitsis R.N., Walsh K. Akt promotes survival of myocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation. 101:2000;660-667.
100. Fujita E., Jinbo A., Matuzaki H., Konishi H., Kikkawa U., Momoi T. Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9. Biochem Biophys Res Commun. 264:1999;550-555.
101. Garcia-Calvo M., Peterson E.P., Leiting B., Ruel R., Nicholson D.W., Thornberry N.A. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem. 273:1998;32608-32613.
102. ATP in the heart - what happens, and what does not happen. Basic Res Cardiol. 95:2000;275-279.
103. Gartel A.L., Tyner A.L. Transcriptional regulation of the p21(WAF1/CIP1) gene. Exp Cell Res. 246:1999;280-289.
104. Ghayur T. Proteolytic activation of protein kinase C δ by an ICE/CED 3-like protease induces characteristics of apoptosis. J Exp Med. 184:1996;2399-2404.
105. Glasgow J.N., Qiu J., Rassin D., Grafe M., Wood T., Perez-Pol J.R. Transcriptional regulation of the BCL-X gene by NF-κB is an element of hypoxic responses in the rat brain. Neurochem Res. 26:2001;359-647.
106. Gonzalez-Garcia M., Perez-Ballestero R., Ding L., Duan L., Boise L.H., Thompson C.B., Nunez G. Bcl-xL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development. 120:1994;3033-3042.
107. Goping I.S., Gross A., Lavoie J.N., Nguyen M., Jemmerson R., Roth K., Korsmeyer S.J., Shore G.C. Regulated targeting of BAX to mitochondria. J Cell Biol. 143:1998;207-215.
108. Gottlieb R.A., Gruol D.L., Zhu J.Y., Engler R.L. Preconditioning in rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis. J Clin Invest. 97:1996;2391-2398.
109. Goyal L. Cell death inhibition: keeping caspases in check. Cell. 104:2001;805-808.
110. Green D.R. Apoptotic pathways: paper wraps stone blunts scissors. Cell. 102:2001;1-4.
111. Griffiths G.J., Corfe B.M., Savory P., Leech S., Esposti M.D., Hickman J.A., Dive C. Cellular amage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak. Oncogene. 20:2001;7668-7676.
112. Grillot D.A.M., Gonzalez-Garcia M., Ekhterai D., Duan L., Inohara N., Ohta S., Seldin M.F., Nunez G. Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. J Immunol. 158:1997;4750-4757.
113. Grimes C.A., Jope R.S. CREB DNA binding activity is inhibited by glycogen synthase kinase-3β and facilitated by lithium. J Neurochem. 78:2001;1219-1232.
114. Grinberg M., Sarig R., Zaltsman Y., Frumkin D., Grammatikakis N., Reuveny E., Gross A. tBID homooligomerizes in the mitochondrial membrane to induce apoptosis. J Biol Chem. 277:2001;12237-12245.
115. ATP channels in cardioprotection. Basic Res Cardiol. 95:2000;280-284.
116. Grütter M.G. Caspases: key players in programmed cell death. Curr Opin Cell Biol. 10:2000;649-655.
117. Guicciardi M.E., Deussing J., Miyoshi H., Bronk S.F., Svingen P.A., Peters C., Kaufmann S.H., Gores G.J. Cathepsin B contributes to TNF-α-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest. 106:2000;1127-1137.
118. Gulbins E., Coggeshall K.M., Brenner B., Schlottmann K., Linderkamp O., Lang F. Fas-induced apoptosis is mediated by activation of a Ras and Rac protein-regulated signaling pathway. J Biol Chem. 271:1996;26389-26394.
119. Gulbins E., Hermisson M., Brenner B., Grassme H.U., Linderkamp O.J., Weller M., Lang F. Cellular stimulation via CD95 involves activation of phospho-inositide-3-kinase. Pflügers Arch. 435:1998;546-554.
120. Gupta S. Molecular steps of death receptor and mitochondrial pathways of apoptosis. Life Sci. 69:2001;2957-2964.
121. Harada H., Andersen J.S., Mann M., Terada N., Korsmeyer S.J. p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci USA. 98:2001;9666-9670.
122. L. J Cell Biol. 149:2000;623-634.
123. Hegde R., Srinivasula S.M., Ahmad M., Fernandes-Alnemri R., Alnemri E.S. Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. J Biol Chem. 273:1998;7783-7786.
124. Hegde R., Srinivasula S.M., Zhang Z., Wassell R., Mukattash R., Cilenti L., Dubois G., Lazebnik Y., Zervos A.S., Fernander-Alnemri T., Alnemri E.S. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J Biol Chem. 277:2002;432-438.
125. Heidkamp M.C., Bayer A.L., Martin J.L., Samarel A.M. Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C-ε and δ in neonatal rat ventricular myocytes. Circ Res. 89:2001;882-890.
126. Heinke M.Y., Yao M., Chang D., Einstein R., Dos Remedios C.G. Apoptosis of ventricular and atrial myocytes from pacing-induced canine heart failure. Cardiovasc Res. 49:2001;127-134.
127. Henaff M., Hatem S.N., Mercadier J.J. Low catecholamine concentrations protect adult rat ventricular myocytes against apoptosis through cAMP-dependent extracellular signal-regulated kinase activation. Mol Pharmacol. 58:2000;1546-1553.
128. Herberg J.A., Phillips S., Beck S., Jones T., Sheer D., Wu J.J., Prochazka V., Barr P.J., Kiefer M.C., Trowsdale J. Genomic structure and domain organisation of the human Bak gene. Gene. 211:1998;87-94.
129. Hirata H., Takahashi A., Kohayashi S., Yonehara S., Sawai H., Okazaki T., Yamamoto K., Sasada M. Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J Exp Med. 187:1998;587-600.
130. 2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis. J Biol Chem. 274:1999;20415-20420.
131. Hoffmeyer M.R., Jones S.P., Ross C.R., Sharp B., Grisham M.B., Laroux F.Z., Stalker T.J., Scalia R., Lefer D.J. Myocardial ischemia/reperfusion injury in NADPH oxidase-deficient mice. Circ Res. 87:2000;812-817.
132. Holly T.A., Drincic A., Byun Y., Nakamura S., Harris K., Klocke F.J., Cryns V.L. Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo. J Mol Cell Cardiol. 31:1999;1709-1715.
133. Hong F., Kwon S.J., Jhun B.S., Kim S.S., Ha J., Kim S.J., Sohn N.W., Kang C., Kang I. Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways. Life Sci. 68:2001;1095-1105.
134. Hoppe J., Hoppe V., Schafer R. Selective degradation of the PKC-ε isoform during cell death in AKR-2B fibroblasts. Exp Cell Res. 266:2001;64-73.
135. Horiuchi T., Himeji D., Tsukamoto H., Harashima S., Hayashi K. Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes. Biochem Biophys Res Commun. 272:2000;877-881.
136. Hreniuk D., Garay M., Gaarde W., Monia B.P., McKay R.A., Ioffi C.L. Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes. Mol Pharmacol. 59:2001;867-874.
137. 2+ channels. Am J Physiol. 279:2000;H2658-H2664.
138. Hu Y., Zou Y., Hala M., Deitrich H., Wick G., Xu Q. Prolonged survival of heart allografts from p53-deficient mice. Transplantation. 69:2000;2634-2640.
139. Huang B., Eberstadt M., Olejniczak E.T., Meadows R.P., Fesid S.W. NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain. Nature. 384:1996;638-641.
140. Huang D.C.S., Strasser A. BH3-only proteins - essential initiators of apoptotic cell death. Cell. 103:2000;839-842.
141. Huang D.C.S., Adams J.M., Cory S. The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. EMBO J. 17:1998;1029-1039.
142. Huang Y., Wang K.K.W. The calpain family and human disease. Trends Mol Med. 7:2001;355-362.
143. Huang Y., Park Y.C., Rich R.L., Segal D., Myszka D.G., Wu H. Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell. 104:2001;781-790.
144. Humke E.W., Ni J., Dixit V.M. ERICE, a novel FLICE-activatable caspase. J Biol Chem. 273:1998;15702-15707.
145. Ichijo H., Nishida E., Irie K., Ten Dijke P., Saitoh M., Moriguchi T., Takagi M., Matsumoto K., Miyazono K., Gotoh Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science. 275:1997;90-94.
146. Imanishi T., Murry C.E., Reinecke H., Hano T., Nishio I., Liles W.C., Hofsta L., Kim K., O'Brien K.D., Schwartz S.M., Han D.K. Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues. Cardiovasc Res. 48:2000;101-110.
147. Ing D.J., Zang J., Dzau V.J., Webster K.A., Bishopric N.H. Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bad, and Bcl-x. Circ Res. 84:1999;21-33.
148. Janicke R.U., Ng P., Sprengart M.L., Porter A.G. Caspase-3 is required for α-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. J Biol Chem. 273:1998;15540-15545.
149. Janicke R.U., Sprengart M.L., Wati M.R., Porter A.G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem. 273:1998;9357-9360.
150. Jeong E.-J., Bang S., Lee T.H., Park Y.I., Sim W.-S., Kim K.-S. The solution structure of FADD death domain. Structural basis of death domain interactions of Fas and FADD. J Biol Chem. 274:1999;16337-16342.
151. Jeremias I., Kupatt C., Martin-Villalba A., Habazettl H., Schenkel J., Boekstegers P., Debatin K.M. Involvement of CD95/Apo1/Fas in cell death after myocardial ischemia. Circulation. 102:2000;915-920.
152. Jiang X., Wang X. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. J Biol Chem. 275:2000;31199-31203.
153. Jin K.L., Graham S.H., Mao X.O., He X., Nagayama T., Simon R.P., Greenberg D.A. Bax κ, a novel Bax splice variant from ischemic rat brain lacking an ART domain, promotes neuronal cell death. J Neurochem. 77:2001;1508-1519.
154. Jonassen A.K., Brar B.K., Mjos O.D., Sack M.N., Latchman D.S., Yellon D.M. Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism. J Mol Cell Cardiol. 32:2000;757-764.
155. Juo P., Woo M.S., Kuo C.J., Signorelli P., Biemann H.P., Hannun Y.A., Blenis J. FADD is required for multiple signaling events downstream of the receptor Fas. Cell Growth Differ. 10:1999;797-804.
156. Kadokami T., Frye C., Lemster B., Wagner C.L., Feldman A.M., McTiernan C.F. Anti-tumor necrosis factor-α antibody limits heart failure in a transgenic model. Circulation. 104:2001;1094-1097.
157. Kang P.M., Izumo S. Apoptosis and heart failure: a critical review of the literature. Circ Res. 86:2000;1107-1113.
158. Kang P.M., Haunstetter A., Aoki H., Usheva A., Izumo S. Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation. Circ Res. 87:2000;118-125.
159. Kataoka T., Holler N., Micheau O., Martinou F., Tinel A., Hofmann K., Tschopp J. Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension. J Biol Chem. 276:2001;19548-19554.
160. Katso R., Okkenhaug K., Ahmadi K., White S., Timms J., Waterfield M.D. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol. 17:2001;615-675.
161. Kelekar A., Thompson C.B. Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol. 8:1998;324-330.
162. Kennedy N.J., Budd R.C. Phosphorylation of FADD/MORT1 and Fas by kinases that associate with the membrane-proximal cytoplasmic domain of Fas. J Immunol. 160:1998;4881-4888.
163. Keyse S.M. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr Opin Cell Biol. 12:2000;186-192.
164. Kharbanda S., Saxena S., Yoshida K., Pandey P., Kaneki M., Wang Q., Cheng K., Chen Y.-N., Campbell A., Sudha T., Yuan Z.-M., Narula J.,
165. Kirshenbaum L.A., de Moissac D. The bcl-2 gene product prevents programmed cell death of ventricular myocytes. Circulation. 96:1997;1580-1585.
166. Kloner R.A., Jennings R.B. Consequences of brief ischemia: stunning preconditioning, and their clinical implications: part 1. Circulation. 104:2001;2981-2989.
167. Kloner R.A., Jennings R.B. Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 2. Circulation. 104:2001;3158-3167.
168. Koenig U., Eckhart L., Tschachler E. Evidence that caspase-13 is not a human but a bovine gene. Biochem Biophys Res Commun. 285:2001;1150-1154.
169. Kontoyiannis D., Kotlyarov A., Carballo E., Alexopoulou L., Gaestel M., Davis R., Flavell R., Kollias G. Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. EMBO J. 20:2001;3760-3770.
170. Kops G.J.P.L., Burgering B.M.T. Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT). J Anat. 197:2000;571-574.
171. Koriyama H., Kouchi Z., Umeda T., Saido T.C., Momoi T., Ishiura S., Suzuki K. Proteolytic activation of protein kinase C δ and ε by caspase-3 in U937 cells during chemotherapeutic agent-induced apoptosis. Cell Signal. 11:1999;831-838.
172. Korsmeyer S.J., Wei M.C., Saito M., Weiler S., Oh K.J., Schlesinger P.H. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 7:2000;1166-1173.
173. Koseki T., Inohara N., Chen S., Nunez G. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc Natl Acad Sci USA. 95:1998;156-160.
174. Krajewski S., Tanaka S., Takayama S., Schibler M.J., Fenton W., Reed J.C. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 53:1993;4701-4714.
175. Kraulis P.J. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J Appl Crystallogr. 24:1991;946-950.
176. Kroemer G., Dallaporta B., Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol. 60:1998;619-642.
177. 2+/calmodulin-dependent protein kinase-like kinase facilitates neuronal apoptosis. J Biol Chem. 276:2001;38417-38425.
178. Kubota T., McTiernan R., Frye C.S., Slawson S.E., Lemster B.H., Koretsky A.P., Demetris A.J., Feldman A.M. Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-α Circ Res. 81:1997;627-635.
179. Kubota T., Miyagishima M., Frye C.S., Alber S.M., Bounoutas G.S., Kadokami T., Watkins S.C., McTiernan C.F., Feldman A.M. Overexpression of tumor necrosis factor-α activates both anti- and pro-apoptotic pathways in the myocardium. J Mol Cell Cardiol. 33:2001;1331-1344.
180. Kumar D., Kirshenbaum L., Li T., Danelisen I., Singal P. Apoptosis in isolated adult cardiomyocytes exposed to adriamycin. Ann N Y Acad Sci. 874:1999;156-168.
181. Kurland J.F., Kodym R., Story M.D., Spurgers K.B., McDonnell T.J., Meyn R.E. NF-κB1 (p50) homodimers contribute to transcription of the bcl-2 oncogene. J Biol Chem. 276:2001;45380-45386.
182. Kuwahara K., Saito Y., Kishimoto I., Miyamoto Y., Harada M., Ogawa E., Hamanaka I., Kajiyama N., Takahashi N., Izumi T., Kawakami R., Nakao K. Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes. J Mol Cell Cardiol. 32:2000;1385-1394.
183. Kyriakis J.M., Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev. 81:2001;807-869.
184. Laugwitz K.-L., Moretti A., Weig H.-J., Gillitzer A., Pinkernell K., Ott T., Pragst I., Stadele C., Seyfarth M., Schomig A., Ungerer M. Blocking caspase-activated apoptosis improves contractility in failing myocardium. Hum Gene Ther. 12:2001;2051-2063.
185. Lawlor M.A., Alessi D.R. PKB/Akt: a key mediator of cell proliferation, survival and insulin response? J Cell Sci. 114:2001;2903-2910.
186. Lee W.L., Chen J.W., Ting C.T., Ishiwata T., Lin S.J., Korc M., Wang P.H. Insulin-like growth factor I improves cardiovascular function and suppresses apoptosis of cardiomyocytes in dilated cardiomyopathy. Endocrinology. 140:1999;4831-4840.
187. Leist M., Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol. 2:2001;589-598.
188. Lelli J.L., Becks L.L., Dabrowska M.I., Hinshaw D.B. ATP converts necrosis to apoptosis in oxidant-injured endothelial cells. Free Radic Biol Med. 25:1998;694-702.
189. Lemasters J.J., Qian T., Bradham C.A., Brenner D.A., Cascio W.E., Trost L.C., Nishimura Y., Nieminen A.L., Herman B. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. J Bioenerg Biomembr. 31:1999;305-319.
190. Lemke L.E., Bloem L.J., Fouts R., Esterman M., Sandusky G., Vlahos C.J. Decreased p38 MAPK activity in end-stage failing human myocardium: p38 MAPK α is the predominant isoform expressed in human heart. J Mol Cell Cardiol. 33:2000;1527-1540.
191. Leri A., Malhotra A., Li Q., Stiegler P., Claudio P.P., Giordano A., Kajstura J., Hintze T.H., Anversa P. Pacing-induced heart failure in dogs enhances the expression of p53 and p53-dependent genes in ventricular myocytes. Circulation. 97:1998;194-203.
192. Leri A., Fiordaliso F., Setoguchi M., Limana F., Bishopric N.H., Kajstura J., Webster K., Anversa P. Inhibition of p53 function prevents renin-angiotensin system activation and stretch-mediated myocyte apoptosis. Am J Pathol. 157:2000;843-857.
193. Lesnefsky E.J., Tandler B., Ye J., Slabe T.J., Turkaly J., Hoppel C.L. Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria. Am J Physiol. 273:1997;H1544-H1554.
194. Li B., Setoguchi M., Dreoli A.M., Leri A., Malhotra A., Kajstura J., Anversa P. Insulin-like growth factor-1 attenuates the detrimental impact of nonocclusive coronary artery constriction on the heart. Circ Res. 84:1999;1007-1019.
195. Li H., Zhu H., Xu C.J., Yuan J. Cleavage of BID by caspase-8 mediates the mitochondrial in the Fas pathway of apoptosis. Cell. 94:1998;491-501.
196. Li L., Lorenzo P.S., Bogi K., Blumberg P.M., Yuspa S.H. Protein kinase C δ targets mitochondria, alters mitochondrial membrane potential and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Mol Cell Biol. 19:1999;8547-8558.
197. Li Q., Li B., Wang X., Leri A., Jana K.P., Liu Y., Baserga R., Anversa P. Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest. 100:1997;1991-1999.
198. Liebman C. Regulation of MAP kinase activity by peptide receptor signalling pathway: paradigms of multiplicity. Cell Signal. 13:2001;777-785.
199. Lithgow T., Van Driel R., Bertram J.F., Strasser A. The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane. Cell Growth Differ. 5:1994;411-417.
200. ATP channels and PKC-ε Am J Physiol. 282:2002;H1380-H1386.
201. Liu Z., Sun C., Olejniczak E.T., Meadows R.P., Betz S.F., Oost T., Herrmann J., Wu J.C., Fesik S.W. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature. 408:2000;1004-1008.
202. Lizcano J.M., Morrice N., Cohen P. Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem J. 349:2000;547-557.
203. Locksley R.M., Killeen N., Lenardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 104:2001;487-501.
204. Long X., Boluyt M.O., Hipolito M.L., Lundberg M.S., Zheng J.-S., O'Neill L., Cirielli C., Lakatta E.G., Crow M.T. p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes. J Clin Invest. 99:1997;2635-2643.
205. Luo X., Budihardjo I., Zou H., Slaughter C., Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 94:1998;481-490.
206. Mackay K., Mochly-Rosen D. An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocyte from ischemia. J Biol Chem. 274:1999;6272-6279.
207. Mackay K., Mochly-Rosen D. Localization, anchoring, and functions of protein kinase C isozymes in the heart. J Mol Cell Cardiol. 33:2001;1301-1307.
208. Madrir L.V., Wang C.Y., Guttridge D.C., Schottelius A.J., Baldwin A.S., Mayo M.W. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB. Mol Cell Biol. 20:2000;1626-1638.
209. Mahtani K.R., Brook M., Dean J.L., Sully G., Saklatvala J., Clark A.R. Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor α mRNA stability. Mol Cell Biol. 21:2001;6461-6469.
210. Majumder P.K., Pandey P., Sun X., Cheng K., Datta R., Saxena S., Kharbanda S., Kufe D. Mitochondrial translocation of protein kinase C δ in phorbol ester-induced cytochrome c release and apoptosis. J Biol Chem. 275:2000;21793-21796.
211. Majumber P.K., Mishra N.C., Sun X., Bharti A., Kharbanda S., Saxena S., Kufe D. Targeting of protein kinase C δ to mitochondria in the oxidative stress response. Cell Growth Differ. 12:2001;465-470.
212. Mak S., Newton G.E. The oxidative stress hypothesis of congestive heart failure. Chest. 120:2001;2035-2046.
213. Martin J.L., Avkiran M., Quinlan R.A., Cohen P., Marber M.S. Antiischemic effects of SB203580 are mediated through the inhibition of p38α mitogen-activated protein kinase: evidence from ectopic expression of an inhibition-resistant kinase. Circ Res. 89:2001;750-752.
214. Martin M.C., Dransfield I., Haslett C., Rossi A.G. Cyclic AMP regulation of neutrophil apoptosis occurs via a novel protein kinase A-independent signaling pathway. J Biol Chem. 276:2001;45041-45050.
215. Martins L.M., Iaccarino I., Tenev T., Gschmeissner S., Totty N.F., Lemoine N.R., Savapoulos J., Gray C.W., Creasy C.L., Dingwall C., Downward J. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J Biol Chem. 277:2002;439-444.
216. Matassa A.A., Carpenter L., Biden T.J., Humphries M.J., Reyland M.E. PKCδ is required for mitochondrial-dependent apoptosis in salivary epithelial cells. J Biol Chem. 276:2001;29719-29728.
217. Matsui T., Li L., Del Monte R., Fukui Y., Franke T.F., Hajjar R.J., Rosenzweig A. Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation. 100:1999;2373-2379.
218. Matsui T., Tao J., Del Monte F., Lee K.H., Li L., Picard M., Force T.L., Franke J.F., Hajjar R.J., Rosenzweig A. Akt activation preserves cardiac function and prevents ischemic injury after transient cardiac ischemia in vivo. Circulation. 104:2001;330-335.
219. Maulik N., Yoshida T., Engelman R.M., Deaton D., Flack J.E., Rousou J.A., Das D.K. Ischemic preconditioning attenuates apoptotic cell death associated with ischemia/reperfusion. Mol Cell Biochem. 186:1998;139-145.
220. Mehrhof F.B., Muller F.U., Bergmann M.W., Li P., Wang Y., Schmitz W., Dietz R., Von Harsdorf R. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. Circulation. 104:2001;2088-2094.
221. Mellor H., Parker P.J. The extended PKC superfamily. Biochem J. 332:1998;281-292.
222. Merritt E.A., Murphy M.E.P. Raster3D Version 2.0. A program for photorealistic molecular graphics. Acta Crystallogr Sect D. 50:1994;869-873.
223. Miller L.W., Granville D.J., Narula J., McManus B.M. Apoptosis in cardiac transplant rejection. Cardiol Clin. 19:2001;141-154.
224. Minatoguchi S., Kariya T., Uno Y., Arai M., Nishida Y., Hashimoto K., Wang N., Aoyama T., Takemura G., Fujiwara T., Fujiwara H. Caspase-dependent and serine protease-dependent DNA fragmentation of myocytes in the ischemia-reperfused rabbit heart: these inhibitors do not reduce infarct size. Jpn Circ J. 65:2001;907-911.
225. Morrow T.A., Muljo S.A., Zhang J., Hardwick J.M., Schlissel M.S. Pro-B-cell specific transcription and proapoptotic function of protein kinase C η Mol Cell Biol. 19:1999;5608-5618.
226. Muchmore S.W., Sattler M., Liang H., Meadows R.P., Harlan J.E., Yoon H.S., Nettesheim D., Chang B.S., Thompson C.B., Wong S.L., Ng S.L., Fesik S.W. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature. 381:1996;335-341.
227. 2+ overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection. Circ Res. 89:2001;891-898.
228. Muslin A.J., Xing H. 14-3-3 proteins: regulation of subcellular localization by molecular interference. Cell Signal. 12:2000;703-709.
229. Nagata S. Apoptotic DNA fragmentation. Exp Cell Res. 256:2000;12-18.
230. Nakagawa T., Yuan J. Cross-talk between two cysteine protease families: activation of caspase-12 by calpain in apoptosis. J Cell Biol. 150:2000;887-894.
231. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β Nature. 403:2000;98-103.
232. Nakamura T., Ueda Y., Juan Y., Katsuda S., Takahashi H., Koh E. Fas-mediated apoptosis in adriamycin-induced cardiomyopathy in rats. Circulation. 102:2000;572-578.
233. Narula J., Pandey P., Arbustini E., Haider N., Narula N., Kolodgie F.D., Dal Bello B., Semigran M.J., Bielsa-Masdeu A., Dec G.W., Israels S., Ballester M., Virmani R., Saxena S., Kharbanda S. Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy. Proc Natl Acad Sci USA. 96:1999;8144-8149.
234. Nechushtan A., Smith C.L., Lamensdorf I., Yoon S.-H., Youle R.J. Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. J Cell Biol. 153:2001;1265-1276.
235. Negrini M., Silini E., Kozak C., Tsujimoto Y., Croce C.M. Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell. 49:1987;455-463.
236. Nelson D.P., Setser E., Hall D.G., Schwartz S.M., Hewitt T., Klevitsky R., Osinska H., Bellgrau D., Duke R.C., Robbins J. Proinflammatory consequences of transgenic Fas ligand expression in the heart. J Clin Invest. 105:2000;1199-1208.
237. Nerheim P., Krishnan S.C., Olshansky B., Shivkumar K. Apoptosis in the genesis of cardiac rhythm disorders. Cardiol Clin. 19:2001;155-163.
238. Neuss M., Monticone R., Lundberg M.S., Chesley A.T., Fleck E., Crow M.T. The apoptotic regulatory protein ARC (apoptosis repressor with caspase recruitment domain) prevents oxidant stress-mediated cell death by preserving mitochondrial function. J Biol Chem. 276:2001;33915-33922.
239. Nicholls A., Sharp K., Honig B. Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins Struct Funct Genet. 11:1991;281-296.
240. Nicotera P., Leist M., Reffando-May E. Apoptosis and necrosis: different execution of the same death. Biochem Soc Symp. 66:1999;69-73.
241. Okamura T., Miura T., Takemura G., Fujiwara H., Iwamoto H., Kawamura S., Kimura M., Ideda Y., Iwatate M., Matsuzaki M. Effect of caspase inhibitor on myocardial infarct size and myocyte DNA fragmentation in the ischemia-reperfused rat heart. Cardiovasc Res. 45:2000;642-650.
242. Okuyama M., Yamaguchi S., Nozaki N., Yamaoka M., Shirakabe M., Tomoike H. Serum levels of soluble form of Fas molecular in patients with congestive heart failure. Am J Cardiol. 79:1997;1698-1701.
243. ATP channels in preconditioning. Circ Res. 87:2000;845-855.
244. Ott M., Robertson J.D., Gogvadze V., Shivotovsky B., Orrenius S. Cytochrome c release from mitochondria proceeds by a two-step process. Proc Natl Acad Sci USA. 99:2002;1259-1263.
245. Pass J.M., Zheng Y., Wead W.B., Zhang J., Li R.C., Bolli R., Ping P. PKCε activation induces dichotomous cardiac phenotypes and modulates PKCε-RACK interactions and RACK expression. Am J Physiol. 280:2001;H946-H955.
246. Petros A.M., Nettesheim D.G., Wang Y., Olejniczak E.T., Meadows R.P., Mack J., Swift K., Matayoshi E.D., Zhange H., Thompson C.B., Fesik S.W. Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci. 9:2000;2528-2534.
247. Petros A.M., Medek A., Nettesheim D.G., Kim D.H., Yoon H.S., Swift K., Matayoshi E.D., Oltersdorf T., Fesik S.W. Solution structure of the antiapoptotic protein bcl-2. Proc Natl Acad Sci USA. 98:2001;3012-3017.
248. Petrovic D., Zorc-Pleskovic R., Zorc M. Apoptosis and proliferation of cardiomyocytes in heart failure of different etiologies. Cardiovasc Pathol. 9:1999;149-152.
249. Pham F.H., Sugden P.H., Clerk A. Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes. Circ Res. 86:2000;1252-1258.
250. Piot C.A., Padmanaban D., Ursell P.C., Sievers R.E., Wolfe C.L. Ischemic preconditioning decreases apoptosis in rat hearts in vivo. Circulation. 96:1997;1598-1604.
251. Pomerantz B.J., Reznikow L.L., Harken A.H., Dinarello C.A. Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1β Proc Natl Acad Sci USA. 98:2001;2871-2876.
252. Pongracz J., Webb P., Wang K., Deacon E., Lunn O.J., Lord J.M. Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-δ J Biol Chem. 274:1999;37329-37334.
253. Pugazhenthi S., Nesterova A., Sable C., Heidenreich K.A., Boxer L.M., Healey L.E., Reusch J.E. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem. 275:2000;10761-10766.
254. Puthalakath H., Huang D.C., O'Reilly L.A., King S.M., Strasser A. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell. 3:1999;287-296.
255. Puthalakath H., Villunger A., O'Reilly L.A., Beaumont J.G., Coultas L., Cheney R.E., Huang D.C., Strasser A. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science. 293:2001;1784-1785.
256. Qin H., Srinivasula S.M., Wu G., Fernander-Alnemri T., Alnemri E.S., Shi Y. Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature. 399:1999;549-557.
257. Raha S., Robinson B.H. Mitochondria, oxygen free radicals, and apoptosis. Am J Med Genet. 106:2001;62-70.
258. Reddy S.A.G., Huang J.H., Liao W.S.-L. Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFκB and AP-1 activation. J Biol Chem. 272:1997;29167-29173.
259. Renatus M., Stennicke H.R., Scott F.L., Liddington R.C., Salvesen G.S. Dimer formation drives the activation of the cell death protease caspase 9. Proc Natl Acad Sci USA. 25:2001;14250-14255.
260. Riedl S.J., Renatus M., Schwarzenbacher R., Zhou Q., Sum C., Fesik S.W., Liddington R.C., Salvesen G.S. Structural basis for the inhibition of caspase-3 by XIAP. Cell. 104:2001;791-800.
261. Roberg K., Ollinger K. Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. Am J Pathol. 152:1998;1151-1156.
262. Roberg K., Johansson U., Ollinger K. Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress. Free Radic Biol Med. 27:1999;1228-1237.
263. 2-terminal kinase activation. J Exp Med. 192:2000;1165-1174.
264. Rudel T., Bokoch G.M. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science. 276:1997;1571-1574.
265. Rudel T., Zenke F.T., Chuang T.-H., Bokoch G.M. Cutting edge: p21-activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells. J Immunol. 160:1998;7-11.
266. Ruetten H., Badorff C., Ihling C., Zeiher A.M., Dimmeler S. Inhibition of caspase-3 improves contractile recovery of stunned myocardium, independent of apoptosis-inhibitory effects. J Am Coll Cardiol. 38:2001;2063-2070.
267. Ryan K.M., Phillips A.C., Vousden K.H. Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol. 13:2001;332-337.
268. Saavedra A.P., Tsygankova O.M., Prendergast G.V., Dworet J.H., Cheng G., Meinkoth J.L. Role of cAMP, PKA and Rap1A in thyroid follicular cell survival. Oncogene. 21:2002;778-788.
269. Sabbah H.N. Apoptotic cell death in heart failure. Cardiovasc Res. 45:2000;704-712.
270. ATP channels in cardioprotection. Basic Res Cardiol. 95:2000;285-289.
271. Saurin A.T., Martin J.L., Heads R.J., Foley C., Mockridge J.W., Wright M.J., Wang Y., Marber M.S. The role of differential activation of p38-mitogen-activated protein kinase in preconditioned myocytes. FASEB J. 14:2000;2237-2246.
272. L by the MAPK/Erk kinase. J Biol Chem. 274:1999;31108-31113.
273. Schendel S.L., Zimov R., Pawlowski K., Godzik A., Kagan B.L., Reed J.C. Ion channel activity of the BH3 only Bcl-2 family member, BID. J Biol Chem. 274:1999;21932-21936.
274. Scheubel R.J., Bartling B., Simm A., Silber R.-E., Drogaris K., Darmer D., Holtz J. Apoptotic pathway activation from mitochondria and death receptors without caspase-3 cleavage in failing human myocardium. J Am Coll Cardiol. 39:2002;481-488.
275. Schluter K.-D., Goldberg Y., Taimor G., Schafer M., Pipier H.M. Role of phosphatidylinositol 3-kinase activation in the hypertrophic growth of adult ventricular cardiomyocytes. Cardiovasc Res. 40:1998;174-181.
276. Schubert K.M., Duronio V. Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesis. Biochem J. 356:2001;473-480.
277. Schwartzbauer G., Robbins J. The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. J Biol Chem. 276:2001;35786-35793.
278. Sebbagh M., Renvoize C., Hamelin J., Riche N., Bertoglio J., Breard J. Caspase-3-mediated cleavage of ROCK1 induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol. 3:2001;346-352.
279. Seto M., Jaeger U., Hockett R.D., Graninger W., Bennett S., Goldman P., Korsmeyer S.J. Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBO J. 7:1988;123-131.
280. Shidoji Y., Hayashi K., Komura S., Ohishi N., Yagi K. Loss of molecular interaction between cytochrome c and cardiolipin due to lipid peroxidation. Biochem Biophys Res Commun. 264:1999;343-347.
281. Shimizu S., Ide T., Yanagida T., Tsujimoto Y. Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c. J Biol Chem. 275:2000;12321-12325.
282. Shimizu S., Konishi A., Kodama T., Tsujimoto Y. BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci USA. 97:2000;3100-3105.
283. Shiraishi J., Tatsumi T., Keira N., Akashi K., Mano A., Yamanaka S., Matoba S., Asayama J., Yaoi T., Fushiki S., Fliss H., Nakagawa M. Important role of energy-dependent mitochondrial pathways in cultured rat cardiac myocyte apoptosis. Am J Physiol. 281:2001;H1637-H1647.
284. Shiraiwa N., Inohara N., Okad S., Yuzaki M., Shoji S., Ohta S. An additional form of rat Bcl-x, Bcl-xβ, generated by an unspliced RNA, promotes apoptosis in promyeloid cells. J Biol Chem. 271:1996;13258-13265.
285. Shitashige M., Toi M., Yano T., Shibata M., Matsuo Y., Shibasaki F. Dissociation of Bax from a Bcl-2/Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2. J Biochem. 130:2001;741-748.
286. Simkhovich B.Z., Przyklenk K., Kloner R.A. Role of protein kinase C as a cellular mediator of ischemic preconditioning: a critical review. Cardiovasc Res. 40:1998;9-22.
287. Sizemore N., Leung S., Stark G.R. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit. Mol Cell Biol. 19:1999;4798-4805.
288. Slee E.A., Harte M.T., Kluck R.M., Wolf B.B., Casiano C.A., Newmeyer D.D., Wang H.-G., Reed J.C., Nicholson D.W., Alnemri E.S., Green D.R., Martin S.J. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8 and -10 in a caspase-9-dependent manner. Cell J Biol. 144:1999;281-292.
289. Slee E.A., Adrain C., Martin S.J. Executioner caspase-3, -6, and -7 perform distinct non-redundant roles during the demolition phase of apoptosis. J Biol Chem. 276:2001;7320-7326.
290. Song H., Conte J.V., Foster A.H., McLaughlin J.S., Wei C. Increased p53 protein expression in human failing myocardium. J Heart Lung Transplant. 18:1999;744-749.
291. Souren J.E., Van Der Mast C., Van Wijk R. NADPH-oxidase-dependent superoxide production by myocyte-derived H9c2 cells: influence of ischemia, heat shock, cycloheximide and cytochalasin D. J Mol Cell Cardiol. 29:1997;2803-2812.
292. Srinivasula S.M., Ahman M., Guo Y., Lazebnik Y., Fernandes-Alnemri T., Alnemri E.S. Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res. 59:1999;999-1002.
293. Srinivasula S.M., Hegde R., Saleh A., Datta P., Shiozaki E., Chai J., Lee R.-A., Robbins P.D., Fernandes-Alnemri T., Shi Y., Alnemri E.S. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature. 410:2001;112-116.
294. Srivastave R.K., Mi Q.S., Hardwick J.M., Longo D.L. Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis. Proc Natl Acad Sci USA. 96:1999;3775-3780.
295. Stennicke H.R., Renatus M., Meldal M., Salvesen G.S. Internally quenched fluorescent peptide substrates disclose the subsite references of human caspases 1, 3, 6, 7 and 8. Biochem J. 350:2000;563-568.
296. Stoka V., Turk B., Schendel S.L., Kin T.H., Cirman T., Snipas S.J., Ellerby L.M., Bredesen D., Freeze H., Abrahamson M., Bromme D., Krajewski S., Reed J.C., Yin X.M., Turk V., Salvesen G.S. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem. 276:2001;3149-3157.
297. Strait J.B. III, Martin J.L., Bayer A., Mestril R., Eble D.M., Samarel A.M. Role of protein kinase C-ε in hypertrophy of cultured neonatal rat ventricular myocytes. Am J Physiol. 280:2001;H756-H766.
298. Sugden P.H., Clerk A. Cellular mechanisms of cardiac hypertrophy. J Mol Med. 76:1998;725-746.
299. Sugden P.H., Clerk A. "Stress-responsive" mitogen-activated protein kinases in the myocardium. Circ Res. 83:1998;345-352.
300. Sukits S.F., Lin L.-L., Hsu S., Malakian K., Powers R., Xu G.-Y. Solution structure of the tumor necrosis factor receptor-1 death domain. J Mol Biol. 310:2001;895-906.
301. Suleiman M.-S., Halestrap A.P., Griffiths E.J. Mitochondria: a target for myocardial protection. Pharmacol Ther. 89:2001;29-46.
302. Sun C., Cai M., Meadows R.P., Xu N., Gunasekera A.H., Herrmann J., Wu J.C., Fesik S.W. NMR structure and mutagenesis of the third bir domain of the inhibitor of apoptosis protein. J Biol Chem. 275:2000;33777-33781.
303. Suzuki M., Youle R.J., Tjandra N. Structure of Bax: coregulation of dimer formation and intracellular localization. Cell. 103:2000;645-654.
304. Suzuki Y., Imai Y., Nakayama H., Takahashi K., Takio K., Takahashi R. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell. 8:2001;613-621.
305. Suzuki Y., Nakabayashi Y., Nakata K., Reed J.C., Takahashi R. X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes. J Biol Chem. 276:2001;27058-27063.
306. Takahashi H., Nakamura S., Asano K., Kinouchi M., Ishida-Yamamoto A., Izuka H. Fas antigen modulates ultraviolet B-induced apoptosis of SVHK cells: sequential activation of caspases 8, 3, and 1 in the apoptotic process. Exp Cell Res. 249:1999;291-298.
307. Takeishi Y., Ping P., Bolli R., Kirkpatrick D.L., Hoit B.D., Walsh R.A. Transgenic overexpression of constitutively active protein kinase C ε causes concentric cardiac hypertrophy. Circ Res. 86:2000;1218-1223.
308. Tan Y., Demeter M.R., Ruan H., Comb M.J. BAD Ser-155 phosphorylation regulates BAD:Bcl-XL interaction and cell survival. J Biol Chem. 275:2000;25865-25869.
309. Tanaka M., Ito H., Adachi S., Akimoto H., Nishikawa T., Kasajima T., Marumo F., Hiroe M. Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes. Circ Res. 75:1994;426-433.
310. Tang T.T.-L., Dowbenko D., Jackson A., Toney L., Lewin D.A., Dent A.L., Lasky L.A. The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. J Biol Chem. 277:2002;14255-14265.
311. Telliez J.-B., Xu G.-Y., Woronicz J.D., Hsu S., Wu J.-L., Lin L., Sukits S.F., Powers R., Lin L.-L. Mutational analysis and NMR studies of the death domain of the tumor necrosis factor receptor 1. J Mol Biol. 300:2000;1323-1333.
312. Thomas A., Giesler T., White E. p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway. Oncogene. 19:2000;5259-5269.
313. Thuerauf D.J., Glembotski C.C. Differential effects of protein kinase C, Ras, and Raf-1 kinase on the induction of the cardiac B-type natriuretic peptide gene through a critical promoter-proximal M-CAT element. J Biol Chem. 272:1997;7464-7472.
314. Toyoshima F., Moriguchi T., Nishida E. Fas induces cytoplasmic apoptosis responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases. J Cell Biol. 139:1997;1005-1015.
315. Toyozaki T., Hiroe M., Tanaka M., Nagata S., Ohwada H., Marumo F. Levels of soluble Fas ligand in myocarditis. Am J Cardiol. 82:1998;246-248.
316. Tschopp J., Irmler M., Thome M. Inhibition of Fas death signals by FLIPs. Curr Biol. 10:1998;552-558.
317. Turk B., Turk D., Turk V. Lysosomal cysteine proteases: more than scavengers. Biochim Biophys Acta. 1477:2000;98-111.
318. 2-terminal kinase pathway in H9c2 cardiac muscle cells. J Mol Cell Cardiol. 30:1998;1789-1801.
319. Tyas L., Brophy V.A., Pope A., Rivett A.J., Tavare J.M. Rapid caspase-3 activation during apoptosis revealed using fluorescence-resonance energy transfer. EMBO Rep. 1:2000;266-270.
320. Miyashita T., Shikama Y., Tadokoro K., Yamada M. Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family. FEBS Lett. 509:2001;135-141.
321. Ulrich E., Kauffmann-Zeh A., Hueber A.-O., Williamson J., Chittenden T., Ma A., Evan G. Gene structure, cDNA sequence, and expression of murine Bak, a proapoptotic Bcl-2 family member. Genomics. 44:1997;195-200.
322. Valks D.M., Cook S.A., Pham F.H., Morrison P.R., Clerk A., Sugden P.H. Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular signal-regulated kinases 1/22 and protein kinase A. J Mol Cell Cardiol. 34:2002;749-763.
323. Van De Craen M., Van Loo G., Pype S., Van Criekinge W., Vandenbrande I., Molemans F., Fiers W., Declercq W., Vandenabeele P. Identification of a new caspase homologue: caspase-14. Cell Death Differ. 5:1998;838-846.
324. van den Brink M.R.M., Kapeller R., Pratt J.C., Chang J., Burakoff S.J. The extracellular signal-regulated kinase pathway is required for activation-induced cell death of T cells. J Biol Chem. 274:1999;11178-11185.
325. Vanden Hoek T.L., Li C., Shao Z., Schumacker P.T., Becker L.B. Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion. J Mol Cell Cardiol. 29:1997;2571-2583.
326. Vanhaesebroeck B., Alessi D.R. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J. 346:2000;561-576.
327. Vanhaesebroeck B., Waterfield M.D. Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 253:1999;239-254.
328. Varfolomeev E.E., Schuchmann M., Luria V., Chiannilkulchai N., Beckmann J.S., Mett I.L., Rebrikov D., Brodianski V.M., Kemper O.C., Kollet O., Lapidot T., Soffer D., Sobe T., Avraham K.B., Goncharov T., Holtmann H., Lonai P., Wallach D. Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, the DR3 and is lethal prenatally. Immunity. 9:1998;267-276.
329. Verhagen A.M., Ekert P.G., Pakusch M., Silke J., Connolly L.M., Reid G.E., Moritz R.L., Simpson R.J. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 102:2000;43-53.
330. Verhagen A.M., Silke J., Ekert P.G., Pakusch M., Kaufmann H., Connolly L.M., Day C.L., Tikoo A., Burke R., Wrobel C., Moritz R.L., Simpson R.J., Vaux D.L. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J Biol Chem. 277:2002;445-454.
331. Virdee K., Parone P.A., Tolkovsky A.M. Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival. Curr Biol. 10:2000;1151-1154.
332. von Harsdorf R., Li P.-F., Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation. 99:1999;2934-2941.
333. Walter B.N., Huang Z., Jakobi R., Tuazon P.T., Alnemri E.S., Litwack G., Traugh J.A. Cleavage and activation of p21-activated protein kinase γ-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. J Biol Chem. 273:1998;28733-28739.
334. Wang G.W., Klein J.B., Kang Y.J. Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes. J Pharmacol Exp Ther. 298:2001;461-468.
335. Wang J., Lenardo M.J. Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies. J Cell Sci. 113:2000;753-757.
336. Wang L., Ma W., Markovich R., Chen J.W., Wang P.H. Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I. Circ Res. 83:1998;516-522.
337. Wang Z. The expanding role of mitochondria in apoptosis. Genes Dev. 15:2001;2922-2933.
338. Wasylyk B., Hagman J., Gutierrez-Hartmann A. Ets transcription factors: nuclear effectors of the Ras MAP-kinase signaling pathway. Trends Biochem Sci. 23:1998;213-216.
339. Webster K.A., Discher D.J., Kaiser S., Hernandez O., Sato B., Bishopric N.H. Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation of a pH shift and is independent of p53. J Clin Invest. 104:1999;239-252.
340. Wei M.C., Lindsten T., Mootha V.K., Weiler S., Gross A., Ashiya M., Thompson C.B., Korsmeyer S.J. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14:2000;2060-2071.
341. Wei M.C., Zong W.-X., Cheng E.H.Y., Lindsten T., Panoutsakapoulou V., Ross A.J., Roth K.A., MacGregor G.R., Thompson C.B., Korsmeyer S.J. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science. 292:2001;727-730.
342. Weinbrenner C., Liu G.-S., Cohen M.V., Downey J.M. Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinase correlates with the protection of preconditioning in the rabbit heart. J Mol Cell Cardiol. 29:1997;2383-2391.
343. Wen L.P., Fahrni J.A., Troie S., Guan J.L., Orth K., Rosen G.D. Cleavage of focal adhesion kinase by caspases during apoptosis. J Biol Chem. 272:1997;26056-26061.
344. Whitmarsh A.J., Davis R.J. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med. 74:1996;589-607.
345. Wilson B.E., Mochon E., Boxer L.M. Induction of Bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis. Mol Cell Biol. 16:1996;5546-5556.
346. Wolf B.B., Green D.R. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J Biol Chem. 274:1999;20049-20052.
347. Wollert K.C., Heineke J., Wetermann J., Lüdde M., Fiedler B., Zierhut W., Laurent D., Bauer M.K.A., Schulze-Osthoff K., Drexler H. The cardiac Fas (APO-1/CD95) receptor/Fas ligand system. Relation to diastolic wall stress in volume-overload hypertrophy in vivo and activation of the transcription factor AP-1 in cardiac myocytes. Circulation. 101:2000;1172-1178.
348. Wood D.E., Newcomb E.W. Cleavage of Bax enhances its cell death function. Exp Cell Res. 256:2000;375-382.
349. Wu C.F., Bishopric N.H., Pratt R.E. Atrial natriuretic peptide induces apoptosis in neonatal rat cardiac myocytes. J Biol Chem. 272:1997;14860-14866.
350. Wu G., Chai J., Suber T.L., Wu J.W., Du C., Wang X., Shi Y. Structural basis of IAP recognition by Smac/DIABLO. Nature. 408:2000;1008-1012.
351. Wu W., Lee W.L., Wu Y.Y., Chen D., Liu T.J., Jang A., Sharma P.M., Wang P.H. Expression of constitutively active phosphatidylinositol 3-kinase inhibits activation of caspase 3 and apoptosis in cardiac muscle cells. J Biol Chem. 275:2000;40113-40119.
352. Yamaguchi H., Wang H.-G. The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene. 20:2001;7779-7786.
353. Yamaguchi S., Yanaoka M., Okuyama M., Nitoube J., Fukui A., Shirakabe M., Shirakawa K., Nakamura N., Tomoike H. Elevated circulating levels and cardiac secretion of soluble Fas ligand in patients with congestive heart failure. Am J Cardiol. 83:1999;1500-1503.
354. Yamamoto S., Seta K., Morisco C., Vatner S.F., Sadoshima J. Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes. J Mol Cell Cardiol. 33:2001;1829-1848.
355. Yang X., Khozravi-Far R., Chang H.Y., Baltimore D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell. 89:1997;1067-1076.
356. Yang X.-F., Weber G.F., Cantor H. A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity. 7:1997;629-639.
357. Yaoita H., Ogawa K., Maehara K., Muruyama Y. Attenuation of ischaemia/reperfusion injury in rats by a caspase inhibitor. Circulation. 97:1998;276-281.
358. Yaoita H., Ogawa K., Maehara K., Maruyama Y. Apoptosis in relevant clinical situations: contribution of apoptosis in myocardial infarction. Cardiovasc Res. 45:2000;630-641.
359. Yeh W.C., Pompa J.L., McCurrach M.E., Shu H.B., Elia A.J., Shahinian A., Ng M., Wakeham A., Khoo W., Mitchell K., El-Deiry W.S., Lowe S.W., Goeddel D.V., Mak T.W. FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science. 279:1998;1954-1958.
360. Yin X.M. Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes. J Mol Med. 78:2000;203-211.
361. Yue T.L., Wang C., Romanic A.M., Kikly K., Keller P., DeWolf W.E., Hart T.K., Thomas H.C., Storer B., Gu J.L., Wang X., Feuerstein G.Z. Staurosporine-induced apoptosis in cardiomyocytes: a potential role of caspase 3. J Mol Cell Cardiol. 30:1998;495-507.
362. Zhou P., Chou J., Olea R.S., Yuan J., Wagner G. Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction. Proc Natl Acad Sci USA. 96:1999;11265-11270.
363. Zhou X.-M., Liu Y., Payne G., Lutz R.J., Chittenden T. Growth factors inactivate the cell death promoter, BAD, by phosphorylation of its BH3 domain on serine 155. J Biol Chem. 275:2000;25046-25051.
364. Zhu H., McElwee-Witmer S., Perrone M., Clark K.L., Zilberstein A. Phenylephrine protects neonatal rat cardiomyocytes from hypoxia and serum deprivation-induced apoptosis. Cell Death Differ. 7:2000;773-784.
365. Ziegler M., Oei S.L. A cellular survival switch: poly(ADP-ribosyl)ation stimulates DNA repair and silences transcription. Bioessays. 23:2001;543-548.
366. Zong W.-X., Lindsten T., Ross A.J., MacGregor G.R., Thompson C.B. BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev. 15:2001;1481-1486.
367. Zou H., Henzel W.J., Liu X., Lutschg A., Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 90:1997;405-413.