The mitochondrial apoptosome: A killer unleashed by the cytochrome seas

Trends in Biochemical Sciences

Volumn 26, Issue 6, 2001, Pages 390-397

  Adrain, Colin ^a   Martin, Seamus J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYSTEINE PROTEINASE; CYTOCHROME; CYTOCHROME C;

APOPTOSIS; CELL ACTIVATION; CELL DEATH; CYTOPLASM; KILLER CELL; MITOCHONDRION; PRIORITY JOURNAL; REVIEW;

ANIMALS; APOPTOSIS; CAENORHABDITIS ELEGANS; CASPASES; CYTOCHROME C GROUP; ENZYME ACTIVATION; MITOCHONDRIA; ORGANELLES; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0035369143     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(01)01844-8     Document Type: Review

References (50)

1. Programmed celldeath in animal development
2. Corpse clearance defines the meaning of cell death
3. Protease activation during apoptosis: Death by a thousand cuts?
4. Mammalian caspases: Structure, activation, substrates and functions during apoptosis
5. CD95's deadly missioninthe immune system
6. Mitochondria and apoptosis
7. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
8. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
9. Caspase activation involvesthe formation of the apoptosome, a large (approximately 700 kDa) caspase-activating complex
10. An APAF-1-cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
11. Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation
12. Caspase-9 and APAF-1 form an active holoenzyme
13. Mitochondrial control of apoptosis
14. Genetics of programmed cell death in C. elegans: Past, present and future
15. Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death
16. Interaction and regulation of subcellular localization of CED-4 by CED-9
17. Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death
18. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
19. Essential role of CED-4 oligomerization in CED-3 activation and apoptosis
20. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
21. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
22. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
23. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
24. BCL-2 family members and the mitochondria in apoptosis
25. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
26. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
27. BAX-dependent transport of cytochrome c reconstituted in pure liposomes
28. Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c bindingand regulated activation of procaspase-9
29. WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation
30. Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region
31. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis
32. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1
33. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
34. Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes
35. Caspase-9 can be activated without proteolytic processing
36. A conserved XIAP-interaction motif in caspase-9 and Smac/Diablo regulates caspase activity and apoptosis
37. Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-XL
38. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
39. Negative regulation of the Apaf-1 apoptosome by Hsp70
40. X-linked IAP is a direct inhibitor of cell-death proteases
41. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
42. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
43. Smac, a mitochondrial protein that promotes cytochrome c dependent caspase activation by eliminating IAP inhibition
44. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
45. Structural basis of IAP recognition by Smac/Diablo
46. Structural basis for binding of Smac/Diablo to the XIAP BIR3 domain
47. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
48. Executioner caspases -3, -6 and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis
49. Differential requirement for caspase-9 in apoptotic pathways in vivo
50. Molecular characterization of mitochondrial apoptosis-inducing factor