A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

Nature

Volumn 410, Issue 6824, 2001, Pages 112-116

  Srinivasula, Srinivasa M ^a   Hegde, Ramesh ^a   Saleh, Ayman ^b   Datta, Pinaki ^a   Shiozaki, Eric ^c   Chai, Jijie ^c   Lee, Ryung Ah ^a   Robbins, Paul D ^b   Fernandes Alnemri, Teresa ^a   Shi, Yigong ^c   Alnemri, Emad S ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CARRIER PROTEINS; CASPASE 9; CASPASES; CATALYSIS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA; ENZYME ACTIVATION; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; RECOMBINANT PROTEINS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 0035282570     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35065125     Document Type: Article

References (14)

1. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
2. NMR structure and mutagenesis of the third BIR domain of the inhibitor of apoptosis protein XIAP
3. XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage
4. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
5. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
6. Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway
7. Structural and biochemical basis of apoptotic activation by Smac/DIABLO
8. An emerging blueprint for apoptosis in Drosophila
9. Grim, a novel cell death gene in Drosophila
10. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
11. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
12. Caspase-9 and APAF-1 form an active holoenzyme
13. Structural basis of IAP recognition by Smac/DIABLO
14. Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation