Transgenic overexpression of constitutively active protein kinase C ε causes concentric cardiac hypertrophy

Circulation Research

Volumn 86, Issue 12, 2000, Pages 1218-1223

  Takeishi, Yasuchika ^a   Ping, Peipei ^b   Bolli, Roberto ^b   Kirkpatrick, Darryl L ^a   Hoit, Brian D ^a   Walsh, Richard A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

Heart failure; Hypertrophy; Protein kinase C; Signal transduction; Transgenic mouse

Indexed keywords

ALPHA ACTIN; ISOENZYME; MESSENGER RNA; MYOSIN HEAVY CHAIN; PROTEIN KINASE C;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEART FAILURE; HEART HYPERTROPHY; HEART WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA ANALYSIS; TRANSGENE;

EID: 0034705485     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.86.12.1218     Document Type: Article

References (30)

1. Walsh RA, Dorn GW II. Growth and hypertrophy of the heart and blood vessels. In: Hurst JW, Schlant RC, Rackley CE, Sonnenblick EH, Wenger NK, eds. The Heart. 9th ed. New York, NY: McGraw-Hill, Inc; 1997: 155-168.
2. Walsh RA. The role of angiotensin II in stretch activated signal transduction of the normal, hypertrophied and failing adult heart. In: Dhalla NS, Zahradka P, Dixon IMC, Beamish RE, eds. Angiotensin II Blockade: Physiology and Clinical Implications. Boston, Mass: Kluwer Academic Publishers; 1998:423-434.
3. Steinberg SF, Goldberg M, Rybin VO. Protein kinase C isoform diversity in the heart. J Mol Cell Cardiol. 1995;27:141-153.
4. 2+-sensitive isoforms in the failing human heart. Circulation. 1999;99:384-391.
5. Takeishi Y, Jalili T, Ball NA, Walsh RA. Responses of cardiac protein kinase C isoforms to distinct pathologic stimuli are differentially regulated. Circ Res. 1999;85:264-271.
6. Wakasaki H, Koya D, Schoen FJ, Hoit BD, Jirousek MR, Ways DK, Walsh RA, King GL. Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy. Proc Natl Acad Sci U S A. 1997;94:9320-9325.
7. 2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts. J Clin Invest. 1998;102:72-78.
8. Ping P, Zhang J, Qui Y, Tang XL, Manchikalapudi S, Cao X, Bolli R. Ischemic preconditioning induces selective translocation of protein kinase C isoforms ∈ and η in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity. Circ Res. 1997;81: 404-414.
9. Qiu Y, Ping P, Tang X, Manchikalapudi S, Rizvi A, Zhang J, Takano H, Wu W, Teschner S, Bolli R. Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that ∈ is the isoform involved. J Clin Invest. 1998;101:2182-2198.
10. Zou Y, Komuro I, Yamazaki T, Aikawa R, Kudoh S, Shiojima I, Hiroi Y, Mizuno T, Yazaki Y. Protein kinase C, but not tyrosine kinase or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes. J Biol Chem. 1996;271:33592-33597.
11. Clerk A, Bogoyevitch MA, Andersson MB, Sugden PH. Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts. J Biol Chem. 1994;269:32848-32857.
12. Paul K, Ball NA, Dorn GW II, Walsh RA. Left ventricular stretch stimulates angiotensin II-mediated phosphatidylinositol hydrolysis and protein kinase C ∈ isoform translocation in adult guinea pig hearts. Circ Res. 1997;81:643-650.
13. Ping P, Zhang J, Cao X, Li RCX, Kong D, Tang XL, Qiu Y, Manchikalapudi S, Auchampach JA, Black RG, Bolli R. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits. Am J Physiol. 1999;276:H1468-H1481.
14. Ping P, Li RCX, Zhang J, Kong D, Jones K, Zheng YT, Cao X, Bolli R. Identification of 2 distinct mechanisms for the activation of p44/p42 mitogen-activated protein kinases (MAPKs) in vivo by a PKC isoform epsilon dependent signaling pathway in transgenic mice. Circulation. 1998;98(suppl I):I-416. Abstract.
15. Kadambi VJ, Ponniah S, Harrer JM, Hoit BD, Dorn GW II, Walsh RA, Kranias EG. Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice. J Clin Invest. 1996;97:533-539.
16. D'Angelo DD, Sakata Y, Lorenz JN, Boivin GP, Walsh RA, Liggett SB, Dorn GW II. Transgenic Gαq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci U S A. 1997;94:8121-8126.
17. 2+ ATPase. Circ Res. 1998;83:889-897.
18. Luo W, Chu G, Sato Y, Zhou Z, Kadambi VJ, Kranias EG. Transgenic approaches to define the functional role of dual site phospholamban phosphorylation. J Biol Chem. 1998;273:4734-4739.
19. Zhang J, Wead WB, Jones WK, Wu X, Gao J, Kong D, Li RCX, Zheng YT, Ping P. Activation of PKC∈ induces hypertrophy and heart failure in a dose-dependent fashion in mice. J Mol Cell Cardiol. 1999;31:A18. Abstract.
20. Gunteski-Hamblin A, Song G, Walsh RA, Frenzke M, Boivin GP, Dorn GW II, Kaetzel MA, Horseman ND, Dedman JR. Annexin VI overexpression targeted to heart alters cardiomyocyte function in transgenic mice. Am J Physiol. 1996;270:H1091-H1100.
21. Iwase M, Bishop SP, Uechi M, Vatner DE, Shannon RP, Kudej RK, Wight DC, Wagner TE, Ishikawa Y, Homcy CJ, Vatner SF. Adverse effects of chronic endogenous sympathetic drive induced by cardiac GSα overexpression. Circ Res. 1996;78:517-524.
22. Vikstrom KL, Bohlmeyer T, Factor SM, Leinwand LA. Hypertrophy, pathology, and molecular markers of cardiac pathogenesis. Circ Res. 1998;82:773-778.
23. 2+ transport and mechanics in compensated pressure-overload hypertrophy and congestive heart failure. Circ Res. 1995;77: 759-764.
24. Gomez AM, Valdivia HH, Cheng H, Lederer MR, Santana LF, Cannell MB, McCune SA, Altschuld RA, Lederer WJ. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science. 1997;276:800-806.
25. Mope L, McClellan GB, Winegrad S. Calcium sensitivity of the contractile system and phosphorylation of troponin in hyperpermeable cardiac cells. J Gen Physiol. 1980;75:271-281.
26. Reiser PJ, Westfall MV, Schiaffino S, Solaro RJ. Tension production and thin-filament protein isoforms in developing rat myocardium. Am J Physiol. 1994;267:H1589-H1596.
27. Fabiato A, Fabiato F. Effect of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiac and skeletal muscles. J Physiol. 1978;276:233-255.
28. 2+-stimulated actomyosin MgATPase activity. J Biol Chem. 1991;266:4974-4978.
29. Jideama NM, Noland TA Jr, Raynor RL, Blobe GC, Fabbro D, Kazanietz MG, Blumberg PM, Hannun YA, Kuo JF. Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem. 1996;271:23277-23283.
30. + exchanger. Circ Res. 1991; 68:269-279.